FI971853A - N-aryyli- ja N-heteroaryyli-1,2-diaminosyklobuteeni-3,4-dioneja- joilla on sileitä lihaksia relaksoiva vaikutus - Google Patents
N-aryyli- ja N-heteroaryyli-1,2-diaminosyklobuteeni-3,4-dioneja- joilla on sileitä lihaksia relaksoiva vaikutus Download PDFInfo
- Publication number
- FI971853A FI971853A FI971853A FI971853A FI971853A FI 971853 A FI971853 A FI 971853A FI 971853 A FI971853 A FI 971853A FI 971853 A FI971853 A FI 971853A FI 971853 A FI971853 A FI 971853A
- Authority
- FI
- Finland
- Prior art keywords
- diaminocyclobutene
- diones
- heteroaryl
- aryl
- smooth muscle
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
- C07C225/20—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/58—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/58—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton
- C07C255/60—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton at least one of the singly-bound nitrogen atoms being acylated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/334,475 US5466712A (en) | 1994-11-04 | 1994-11-04 | Substituted n-aryl-1,2-diaminocyclobutene-3,4-diones |
| PCT/US1995/014597 WO1996014300A1 (en) | 1994-11-04 | 1995-10-25 | N-aryl and n-heteroaryl-1,2-diaminocyclobutene-3,4-diones with smooth muscle relaxing activities |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FI971853A0 FI971853A0 (fi) | 1997-04-30 |
| FI971853A true FI971853A (fi) | 1997-07-01 |
Family
ID=23307378
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI971853A FI971853A (fi) | 1994-11-04 | 1997-04-30 | N-aryyli- ja N-heteroaryyli-1,2-diaminosyklobuteeni-3,4-dioneja- joilla on sileitä lihaksia relaksoiva vaikutus |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US5466712A (fi) |
| EP (1) | EP0789690A1 (fi) |
| JP (1) | JPH10509703A (fi) |
| KR (1) | KR970707096A (fi) |
| AU (1) | AU714911B2 (fi) |
| FI (1) | FI971853A (fi) |
| HU (1) | HUT77444A (fi) |
| NZ (1) | NZ296442A (fi) |
| WO (1) | WO1996014300A1 (fi) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5872139A (en) * | 1996-06-17 | 1999-02-16 | American Home Products Corporation | Heterocyclymethylamino derivatives of cyclobutene-3,4-diones |
| CN1227543A (zh) * | 1996-06-17 | 1999-09-01 | 美国家用产品公司 | 作为钾通道调节剂的环丁烯－3,4－二酮的杂环甲基氨基衍生物 |
| US5846999A (en) * | 1996-07-17 | 1998-12-08 | American Home Products Corporation | Substituted N-arylmethylamino derivatives of cyclobutene-3,4-diones |
| EP0934257B1 (en) * | 1996-07-17 | 2002-12-11 | Wyeth | Substituted n-arylmethylamino derivatives of cyclobutene-3,4-diones |
| US5780505A (en) * | 1996-07-17 | 1998-07-14 | American Home Products Corporation | Substituted N-arylmethylamino derivatives of cyclobutene-3, 4-diones |
| US5750574A (en) * | 1996-07-17 | 1998-05-12 | American Home Products Corporation | Fluorinated N-arylmethylamino derivatives of cyclobutene-3,4-diones |
| US5763474A (en) * | 1996-07-17 | 1998-06-09 | American Home Products Corporation | Substituted N-arylmethylamino derivatives of cyclobutene-3,4-diones |
| US5840764A (en) * | 1997-01-30 | 1998-11-24 | American Home Products Corporation | Substituted hydroxy-anilino derivatives of cyclobutene-3,4-diones |
| ES2226205T3 (es) | 1997-12-19 | 2005-03-16 | Taro Pharmaceuticals U.S.A., Inc. | Formulaciones topicas de carbamazepina y procedimiento de utilizacion. |
| US6376555B1 (en) | 1998-12-04 | 2002-04-23 | American Home Products Corporation | 4-substituted-3-substituted-amino-cyclobut-3-ene-1,2-diones and analogs thereof as novel potassium channel openers |
| US20030204085A1 (en) * | 2001-02-02 | 2003-10-30 | Taveras Arthur G. | 3, 4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor antagonists |
| EP1355875A1 (en) * | 2001-02-02 | 2003-10-29 | Schering Corporation | 3,4-di-substituted cyclobutene-1, 2-diones as cxc chemokine receptor antagonists |
| US6495576B2 (en) | 2001-02-07 | 2002-12-17 | Abbott Laboratories | Aminal diones as potassium channel openers |
| US7132445B2 (en) * | 2001-04-16 | 2006-11-07 | Schering Corporation | 3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands |
| MY149050A (en) * | 2001-04-16 | 2013-07-15 | Merck Sharp & Dohme | 3,4 di-substituted cyclobutene-1,2-diones as cxc-chemokine receptor ligands |
| US20040106794A1 (en) * | 2001-04-16 | 2004-06-03 | Schering Corporation | 3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands |
| EP1434775A1 (en) * | 2001-10-12 | 2004-07-07 | Schering Corporation | 3,4-di-substituted maleimide compounds as cxc-chemokine receptor antagonists |
| US6878709B2 (en) * | 2002-01-04 | 2005-04-12 | Schering Corporation | 3,4-di-substituted pyridazinediones as CXC chemokine receptor antagonists |
| WO2003080053A1 (en) * | 2002-03-18 | 2003-10-02 | Schering Corporation | Combination treatments for chemokine-mediated diseases |
| US20030032802A1 (en) * | 2002-08-30 | 2003-02-13 | Palovich Michael R. | IL8-receptor antagonists |
| CN1720240B (zh) * | 2002-10-09 | 2010-10-27 | 先灵公司 | 作为cxc-和cc-趋化因子受体配体的噻二唑二氧化物和噻二唑氧化物 |
| KR100508992B1 (ko) * | 2003-03-31 | 2005-08-17 | 한국유나이티드제약 주식회사 | 쓴 맛을 개선한 클래리스로마이신 경구용 약제 조성물 및 그의 제조 방법 |
| CN1918138B (zh) * | 2003-12-19 | 2011-05-04 | 先灵公司 | 作为cxc-和cc-趋化因子受体配体的噻二唑化合物 |
| MXPA06007205A (es) * | 2003-12-22 | 2006-08-31 | Schering Corp | Dioxidos de isotiazol como ligandos del receptor cxc y cc-quimiocina. |
| DE602004021404D1 (de) * | 2004-12-23 | 2009-07-16 | Gpc Biotech Ag | Quadratsäurederivate mit antiproliferativer Wirkung |
| DE102005001053A1 (de) * | 2005-01-07 | 2006-07-20 | Merck Patent Gmbh | Quadratsäurederivate |
| CA2603478A1 (en) * | 2005-04-04 | 2006-10-12 | Merck Patent Gesellschaft Mit Beschraenkter Haftung | Indazole squaric acid derivatives as chk1-, chk2- and sgk- inhibitors |
| EP1907399B1 (en) * | 2005-06-29 | 2010-10-27 | Schering Corporation | 5,6-di-substituted oxadiazolopyrazines and thiadiazolopyrazines as cxc-chemokine receptor ligands |
| JP2009500334A (ja) * | 2005-06-29 | 2009-01-08 | シェーリング コーポレイション | Ｃｘｃ−ケモカインレセプターリガンドとしてのジ置換オキサジアゾール |
| MX2009000123A (es) * | 2006-07-07 | 2009-03-25 | Schering Corp | Ciclobuten-1,2-dionas 3,4-di-sustituidas como ligandos del receptor de quimiocina-cxc. |
| US8450348B2 (en) * | 2007-02-21 | 2013-05-28 | Forma Tm, Llc | Derivatives of squaric acid with anti-proliferative activity |
| AU2009264273B2 (en) | 2008-06-24 | 2015-01-22 | Onxeo Dk, Branch Of Onxeo S.A., France | Squaric acid derivatives as inhibitors of the nicotinamide |
| CN112672791B (zh) | 2018-09-21 | 2023-10-03 | 辉瑞公司 | 用作ccr6抑制剂的n-取代二氧代环丁烯基氨基-3-羟基-吡啶甲酰胺 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS54150036A (en) * | 1978-05-18 | 1979-11-24 | Sharp Corp | Lsi device |
| DE3069889D1 (en) * | 1979-01-18 | 1985-02-14 | Ici Plc | Guanidine derivatives, processes for their manufacture and pharmaceutical compositions containing them |
| US4390701A (en) * | 1981-05-18 | 1983-06-28 | Bristol-Myers Company | 1-Amino-2-[3-(3-piperidinomethylphenoxy)propylamino]cyclobutene-3,4-dione |
| JPS60255756A (ja) * | 1984-06-01 | 1985-12-17 | Ikeda Mohandou:Kk | アミノアルキルフエノキシ誘導体 |
| GB8924373D0 (en) * | 1989-10-30 | 1989-12-20 | Beecham Group Plc | Novel compounds |
| US5168103A (en) * | 1991-01-22 | 1992-12-01 | American Home Products Corporation | [[2-(amino-3,4-dioxo-1-cyclobuten-1-yl) amino]alkyl]-acid derivatives |
| JPH0692915A (ja) * | 1992-07-28 | 1994-04-05 | Sumitomo Metal Ind Ltd | １，２−ジアミノシクロブテン−３，４−ジオン誘導体及びその用途 |
| GB9312210D0 (en) * | 1993-06-14 | 1993-07-28 | Smithkline Beecham Plc | Chemical compounds |
| CA2130078A1 (en) * | 1993-09-16 | 1995-03-17 | Jonas A. Gylys | Antimigraine cyclobutenedione derivatives of indolylalkyl-pyridinyl and pyrimidinylpiperazines |
| US5354763A (en) * | 1993-11-17 | 1994-10-11 | American Home Products Corporation | Substituted N-heteroaryl and N-aryl-1,2-diaminocyclobutene-3,4-diones |
-
1994
- 1994-11-04 US US08/334,475 patent/US5466712A/en not_active Expired - Lifetime
-
1995
- 1995-06-07 US US08/477,840 patent/US5532245A/en not_active Expired - Lifetime
- 1995-10-25 AU AU41060/96A patent/AU714911B2/en not_active Ceased
- 1995-10-25 KR KR1019970702911A patent/KR970707096A/ko not_active Application Discontinuation
- 1995-10-25 JP JP8515517A patent/JPH10509703A/ja active Pending
- 1995-10-25 EP EP95939108A patent/EP0789690A1/en not_active Withdrawn
- 1995-10-25 NZ NZ296442A patent/NZ296442A/xx unknown
- 1995-10-25 WO PCT/US1995/014597 patent/WO1996014300A1/en not_active Application Discontinuation
- 1995-10-25 HU HU9702426A patent/HUT77444A/hu unknown
-
1996
- 1996-02-14 US US08/601,632 patent/US5605909A/en not_active Expired - Lifetime
-
1997
- 1997-04-30 FI FI971853A patent/FI971853A/fi unknown
Also Published As
| Publication number | Publication date |
|---|---|
| FI971853A0 (fi) | 1997-04-30 |
| MX9703093A (es) | 1997-07-31 |
| EP0789690A1 (en) | 1997-08-20 |
| US5466712A (en) | 1995-11-14 |
| NZ296442A (en) | 1999-11-29 |
| AU714911B2 (en) | 2000-01-13 |
| KR970707096A (ko) | 1997-12-01 |
| US5605909A (en) | 1997-02-25 |
| HUT77444A (hu) | 1998-04-28 |
| AU4106096A (en) | 1996-05-31 |
| JPH10509703A (ja) | 1998-09-22 |
| US5532245A (en) | 1996-07-02 |
| WO1996014300A1 (en) | 1996-05-17 |
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