FI963891A0 - Elastaasia inhiboivaa aktiivisuutta sisältävät alfa-l-antikymotrypsiinianalogit - Google Patents

Elastaasia inhiboivaa aktiivisuutta sisältävät alfa-l-antikymotrypsiinianalogit

Info

Publication number
FI963891A0
FI963891A0 FI963891A FI963891A FI963891A0 FI 963891 A0 FI963891 A0 FI 963891A0 FI 963891 A FI963891 A FI 963891A FI 963891 A FI963891 A FI 963891A FI 963891 A0 FI963891 A0 FI 963891A0
Authority
FI
Finland
Prior art keywords
antichymotrypsin
analogs
alpha
inhibitory activity
elastase inhibitory
Prior art date
Application number
FI963891A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI963891A (fi
Inventor
Barry S Cooperman
Harvey Rubin
Norman Schechter
Zhi Mei Wang
Original Assignee
Univ Pennsylvania
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Pennsylvania filed Critical Univ Pennsylvania
Publication of FI963891A0 publication Critical patent/FI963891A0/fi
Publication of FI963891A publication Critical patent/FI963891A/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8121—Serpins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8121—Serpins
    • C07K14/8125—Alpha-1-antitrypsin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
FI963891A 1994-03-31 1996-09-27 Elastaasia inhiboivaa aktiivisuutta sisältävät alfa-l-antikymotrypsiinianalogit FI963891A (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/221,078 US5674708A (en) 1989-06-23 1994-03-31 α-1-antichymotrypsin analogues having elastase inhibitory activity
PCT/US1994/004735 WO1995027055A1 (en) 1994-03-31 1994-04-29 α-1-ANTICHYMOTRYPSIN ANALOGUES HAVING ELASTASE INHIBITORY ACTIVITY

Publications (2)

Publication Number Publication Date
FI963891A0 true FI963891A0 (fi) 1996-09-27
FI963891A FI963891A (fi) 1996-09-27

Family

ID=22826247

Family Applications (1)

Application Number Title Priority Date Filing Date
FI963891A FI963891A (fi) 1994-03-31 1996-09-27 Elastaasia inhiboivaa aktiivisuutta sisältävät alfa-l-antikymotrypsiinianalogit

Country Status (17)

Country Link
US (1) US5674708A (hu)
EP (1) EP0754228A4 (hu)
JP (1) JPH09512423A (hu)
CN (1) CN1145637A (hu)
AU (1) AU696995B2 (hu)
BG (1) BG100939A (hu)
CA (1) CA2186908A1 (hu)
CZ (1) CZ281796A3 (hu)
FI (1) FI963891A (hu)
HU (1) HUT74901A (hu)
LV (1) LV11747B (hu)
NO (1) NO964022D0 (hu)
NZ (1) NZ269619A (hu)
PL (1) PL316433A1 (hu)
SI (1) SI9420082A (hu)
SK (1) SK138196A3 (hu)
WO (1) WO1995027055A1 (hu)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5827662A (en) * 1989-06-23 1998-10-27 The Trustees Of The University Of Pennsylvania Methods for detecting genetic mutations resulting in protease inhibitor insufficiencies
US5723316A (en) * 1989-06-23 1998-03-03 Trustees Of The University Of Pennsylvania α-1-antichymotrypsin analogues having chymase inhibiting activity
US6458777B1 (en) 1998-03-13 2002-10-01 Mucosal Therapeutics Llc Methods and compositions for treating and preventing mucositis
US6242473B1 (en) * 1999-01-08 2001-06-05 Maxim Pharmaceuticals, Inc. Treatment and prevention of reactive oxygen metabolite-mediated cellular damage
JPWO2002026230A1 (ja) * 2000-09-29 2004-02-05 小野薬品工業株式会社 炎症性腸疾患治療剤
DE10121255A1 (de) 2001-04-30 2002-11-07 Switch Biotech Ag Verwendung von alpha 1-Antichymotrypsin Polypeptiden oder diese kodierende Nukleinsäuren, oder einer ein ACT Polypeptid oder diese kodierende Nukleinsäure exprimierende Zelle, zur Behandlung und/oder Prävention von diabetes-assoziierten und/oder arteriellen schlecht heilenden Wunden und zur Identifizierung von pharmakologisch aktiven Substanzen
WO2002088180A2 (en) * 2001-04-30 2002-11-07 Switch Biotech Ag Use of alpha 1-antichymotrypsin for the manufacture of a composition for treatment, prevention or diagnosis of poorly healing diabetic or arterial wounds
EP1415664A1 (en) * 2002-10-30 2004-05-06 Switch Biotech Aktiengesellschaft Use of alpha 1-antichymotrypsin in combination with alpha-1-antitrypsin for treating/preventing diabetes associated or poorly healing arterial wounds
WO2007036028A1 (en) * 2005-09-29 2007-04-05 University Of Alberta Compositions for and methods of granzyme b inhibition
US10531655B2 (en) 2011-12-02 2020-01-14 The Regents Of The University Of California Reperfusion protection solution and uses thereof
WO2021020509A1 (ja) * 2019-07-31 2021-02-04 株式会社ステムリム 間葉系幹細胞の増殖促進または減少抑制のための組成物
CN112425608B (zh) * 2019-08-23 2023-07-21 香港科技大学 弹性蛋白酶抑制剂、具有抗生物膜活性的抑菌剂
CN114650819A (zh) 2019-09-17 2022-06-21 美莱奥生物制药第四有限公司 用于治疗移植物排斥、闭塞性细支气管炎综合征和移植物抗宿主病的阿维来司他
IL297211A (en) 2020-04-16 2022-12-01 Mereo Biopharma 4 Ltd Methods involving the neutrophil elastase inhibitor albalstat for the treatment of respiratory disease mediated by alpha-1 antitrypsin deficiency
AU2022373971A1 (en) 2021-10-20 2024-04-04 Mereo Biopharma 4 Limited Neutrophil elastase inhibitors for use in the treatment of fibrosis

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4732973A (en) * 1984-06-14 1988-03-22 Chiron Corporation Active site modified protease α-1-antitrypsin inhibitors
US5008242A (en) * 1986-12-24 1991-04-16 John Lezdey Treatment of inflammation using 1-antichymotrypsin
US4916117A (en) * 1986-12-24 1990-04-10 John Lezdey Treatment of inflammation using alpha 1-antichymotrypsin
US5723316A (en) * 1989-06-23 1998-03-03 Trustees Of The University Of Pennsylvania α-1-antichymotrypsin analogues having chymase inhibiting activity
US5079336A (en) * 1989-06-23 1992-01-07 The Trustees Of The University Of Pennsylvania α-1-antichymotrypsin, analogues and methods of production
US5266465A (en) * 1989-06-23 1993-11-30 The Trustees Of The University Of Pennsylvania α-1-antichymotrypsin, analogues and methods of production
US5252725A (en) * 1989-06-23 1993-10-12 The Trustees Of The University Of Pennsylvania α-1-antichymotrypsin, analogues and methods of production

Also Published As

Publication number Publication date
WO1995027055A1 (en) 1995-10-12
BG100939A (en) 1997-10-31
CA2186908A1 (en) 1995-10-12
PL316433A1 (en) 1997-01-06
EP0754228A4 (en) 1997-12-10
EP0754228A1 (en) 1997-01-22
LV11747A (lv) 1997-04-20
JPH09512423A (ja) 1997-12-16
SI9420082A (en) 1997-06-30
NO964022L (no) 1996-09-24
HU9602674D0 (en) 1996-11-28
NZ269619A (en) 1998-01-26
CZ281796A3 (en) 1997-05-14
FI963891A (fi) 1996-09-27
LV11747B (en) 1997-10-20
CN1145637A (zh) 1997-03-19
AU7393694A (en) 1995-10-23
AU696995B2 (en) 1998-09-24
NO964022D0 (no) 1996-09-24
US5674708A (en) 1997-10-07
HUT74901A (en) 1997-02-28
SK138196A3 (en) 1997-07-09

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