LV11747A - Alfa-1-antihimotripsina analogi kuriem piemit elastazi inhibejosa aktivitate - Google Patents

Alfa-1-antihimotripsina analogi kuriem piemit elastazi inhibejosa aktivitate

Info

Publication number
LV11747A
LV11747A LV960386A LV960386A LV11747A LV 11747 A LV11747 A LV 11747A LV 960386 A LV960386 A LV 960386A LV 960386 A LV960386 A LV 960386A LV 11747 A LV11747 A LV 11747A
Authority
LV
Latvia
Prior art keywords
inhibitosa
antihimotrypsin
elastase
analogues
alpha
Prior art date
Application number
LV960386A
Other languages
English (en)
Other versions
LV11747B (en
Inventor
Barry S Cooperman
Harvey Rubin
Norman Schechter
Zhi Mei Wang
Original Assignee
Univ Pennsylvania
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Pennsylvania filed Critical Univ Pennsylvania
Publication of LV11747A publication Critical patent/LV11747A/lv
Publication of LV11747B publication Critical patent/LV11747B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8121—Serpins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8121—Serpins
    • C07K14/8125—Alpha-1-antitrypsin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Rheumatology (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
LVP-96-386A 1994-03-31 1996-10-21 Alpha-1-antichymotrypsin analogues having elastase inhibitory activity LV11747B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/221,078 US5674708A (en) 1989-06-23 1994-03-31 α-1-antichymotrypsin analogues having elastase inhibitory activity
PCT/US1994/004735 WO1995027055A1 (en) 1994-03-31 1994-04-29 α-1-ANTICHYMOTRYPSIN ANALOGUES HAVING ELASTASE INHIBITORY ACTIVITY

Publications (2)

Publication Number Publication Date
LV11747A true LV11747A (lv) 1997-04-20
LV11747B LV11747B (en) 1997-10-20

Family

ID=22826247

Family Applications (1)

Application Number Title Priority Date Filing Date
LVP-96-386A LV11747B (en) 1994-03-31 1996-10-21 Alpha-1-antichymotrypsin analogues having elastase inhibitory activity

Country Status (17)

Country Link
US (1) US5674708A (lv)
EP (1) EP0754228A4 (lv)
JP (1) JPH09512423A (lv)
CN (1) CN1145637A (lv)
AU (1) AU696995B2 (lv)
BG (1) BG100939A (lv)
CA (1) CA2186908A1 (lv)
CZ (1) CZ281796A3 (lv)
FI (1) FI963891A (lv)
HU (1) HUT74901A (lv)
LV (1) LV11747B (lv)
NO (1) NO964022D0 (lv)
NZ (1) NZ269619A (lv)
PL (1) PL316433A1 (lv)
SI (1) SI9420082A (lv)
SK (1) SK138196A3 (lv)
WO (1) WO1995027055A1 (lv)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5827662A (en) * 1989-06-23 1998-10-27 The Trustees Of The University Of Pennsylvania Methods for detecting genetic mutations resulting in protease inhibitor insufficiencies
US5723316A (en) * 1989-06-23 1998-03-03 Trustees Of The University Of Pennsylvania α-1-antichymotrypsin analogues having chymase inhibiting activity
US6458777B1 (en) 1998-03-13 2002-10-01 Mucosal Therapeutics Llc Methods and compositions for treating and preventing mucositis
US6242473B1 (en) * 1999-01-08 2001-06-05 Maxim Pharmaceuticals, Inc. Treatment and prevention of reactive oxygen metabolite-mediated cellular damage
KR20030046469A (ko) * 2000-09-29 2003-06-12 오노 야꾸힝 고교 가부시키가이샤 염증성 장질환 치료제
DE10121255A1 (de) 2001-04-30 2002-11-07 Switch Biotech Ag Verwendung von alpha 1-Antichymotrypsin Polypeptiden oder diese kodierende Nukleinsäuren, oder einer ein ACT Polypeptid oder diese kodierende Nukleinsäure exprimierende Zelle, zur Behandlung und/oder Prävention von diabetes-assoziierten und/oder arteriellen schlecht heilenden Wunden und zur Identifizierung von pharmakologisch aktiven Substanzen
AU2002254999B2 (en) 2001-04-30 2007-07-26 Bayer Innovation Gmbh Use of alpha 1-antichymotrypsin for the manufacture of a composition for treatment, prevention or diagnosis of poorly healing diabetic or arterial wounds
EP1415664A1 (en) * 2002-10-30 2004-05-06 Switch Biotech Aktiengesellschaft Use of alpha 1-antichymotrypsin in combination with alpha-1-antitrypsin for treating/preventing diabetes associated or poorly healing arterial wounds
EP1940458A4 (en) * 2005-09-29 2010-03-03 Univ Alberta COMPOSITIONS AND METHODS OF INHIBITING GRANZYME B
US10531655B2 (en) 2011-12-02 2020-01-14 The Regents Of The University Of California Reperfusion protection solution and uses thereof
WO2021020509A1 (ja) * 2019-07-31 2021-02-04 株式会社ステムリム 間葉系幹細胞の増殖促進または減少抑制のための組成物
CN112425608B (zh) * 2019-08-23 2023-07-21 香港科技大学 弹性蛋白酶抑制剂、具有抗生物膜活性的抑菌剂
JP2023500182A (ja) 2019-09-17 2023-01-05 メレオ バイオファーマ ４ リミテッド 移植片拒絶反応、閉塞性細気管支炎症候群、及び移植片対宿主病の治療に使用するためのアルベレスタット
ES2962498T3 (es) 2020-04-16 2024-03-19 Mereo Biopharma 4 Ltd Métodos que implican el inhibidor de elastasa de neutrófilos alvelestat para el tratamiento de enfermedades respiratorias mediadas por deficiencia de alfa-1 antitripsina
TW202325294A (zh) 2021-10-20 2023-07-01 英商梅瑞奧生物製藥４有限公司 用於治療纖維化之嗜中性球彈性蛋白酶抑制劑

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4732973A (en) * 1984-06-14 1988-03-22 Chiron Corporation Active site modified protease α-1-antitrypsin inhibitors
US5008242A (en) * 1986-12-24 1991-04-16 John Lezdey Treatment of inflammation using 1-antichymotrypsin
US4916117A (en) * 1986-12-24 1990-04-10 John Lezdey Treatment of inflammation using alpha 1-antichymotrypsin
US5266465A (en) * 1989-06-23 1993-11-30 The Trustees Of The University Of Pennsylvania α-1-antichymotrypsin, analogues and methods of production
US5723316A (en) * 1989-06-23 1998-03-03 Trustees Of The University Of Pennsylvania α-1-antichymotrypsin analogues having chymase inhibiting activity
US5079336A (en) * 1989-06-23 1992-01-07 The Trustees Of The University Of Pennsylvania α-1-antichymotrypsin, analogues and methods of production
US5252725A (en) * 1989-06-23 1993-10-12 The Trustees Of The University Of Pennsylvania α-1-antichymotrypsin, analogues and methods of production

Also Published As

Publication number Publication date
PL316433A1 (en) 1997-01-06
FI963891A0 (fi) 1996-09-27
NO964022L (no) 1996-09-24
CZ281796A3 (en) 1997-05-14
AU7393694A (en) 1995-10-23
FI963891A (fi) 1996-09-27
HU9602674D0 (en) 1996-11-28
LV11747B (en) 1997-10-20
JPH09512423A (ja) 1997-12-16
NO964022D0 (no) 1996-09-24
CA2186908A1 (en) 1995-10-12
SK138196A3 (en) 1997-07-09
NZ269619A (en) 1998-01-26
HUT74901A (en) 1997-02-28
CN1145637A (zh) 1997-03-19
SI9420082A (en) 1997-06-30
BG100939A (en) 1997-10-31
WO1995027055A1 (en) 1995-10-12
EP0754228A4 (en) 1997-12-10
US5674708A (en) 1997-10-07
AU696995B2 (en) 1998-09-24
EP0754228A1 (en) 1997-01-22

Similar Documents

Publication Publication Date Title
DE69532553D1 (de) Entwicklungsgerät
DE69511326D1 (de) Spülgerät
DE69535538D1 (de) Entwicklungsgerät
LV11747A (lv) Alfa-1-antihimotripsina analogi kuriem piemit elastazi inhibejosa aktivitate
DE69517230D1 (de) Entwicklungsgerät
DE69515159D1 (de) Entwicklungsgerät
DE69521464D1 (de) Paralleler Prozessor
FI1516U1 (fi) Foerpackning foer i stapel anordnade smaoark
DE69431061D1 (de) Erntemaschine
KR950024232U (ko) 개량 권련 케이스
FI962961A0 (fi) Telebetalningssystem i realtid
KR950024201U (ko) 반죽기
KR960018679U (ko) 입간판
KR950032123U (ko) 개량목탁
KR960003822U (ko) 주방용 선반
DK9400264U3 (da) Bordskånedug
KR950025824U (ko) 조이스틱
KR960008984U (ko) 죠이스틱
SE9402608D0 (sv) Crosswater-ski
FIU940565U0 (fi) Sjaelvstaengande bom
KR950029517U (ko) 주방용 수세미
NO970672D0 (no) Böyningsbegrenser
BR7402076U (pt) Trigol/circulo
KR950026631U (ko) 개량 때밀이구
KR950026546U (ko) 개량 경침