BG100939A - -1-antichymotrypsin analogues having elastase inhibitory activity - Google Patents
-1-antichymotrypsin analogues having elastase inhibitory activityInfo
- Publication number
- BG100939A BG100939A BG100939A BG10093996A BG100939A BG 100939 A BG100939 A BG 100939A BG 100939 A BG100939 A BG 100939A BG 10093996 A BG10093996 A BG 10093996A BG 100939 A BG100939 A BG 100939A
- Authority
- BG
- Bulgaria
- Prior art keywords
- analogues
- present
- inhibitory activity
- elastase inhibitory
- antichymotrypsin
- Prior art date
Links
- 239000003541 chymotrypsin inhibitor Substances 0.000 title 1
- 230000002849 elastaseinhibitory effect Effects 0.000 title 1
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 abstract 1
- 101000678026 Homo sapiens Alpha-1-antichymotrypsin Proteins 0.000 abstract 1
- 101000851058 Homo sapiens Neutrophil elastase Proteins 0.000 abstract 1
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 abstract 1
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 abstract 1
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 abstract 1
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 abstract 1
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 abstract 1
- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 abstract 1
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 abstract 1
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 abstract 1
- 239000004473 Threonine Substances 0.000 abstract 1
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 abstract 1
- 235000004279 alanine Nutrition 0.000 abstract 1
- 235000001014 amino acid Nutrition 0.000 abstract 1
- 229940024606 amino acid Drugs 0.000 abstract 1
- 150000001413 amino acids Chemical group 0.000 abstract 1
- 235000003704 aspartic acid Nutrition 0.000 abstract 1
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 239000013604 expression vector Substances 0.000 abstract 1
- 235000013922 glutamic acid Nutrition 0.000 abstract 1
- 239000004220 glutamic acid Substances 0.000 abstract 1
- 102000052502 human ELANE Human genes 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 229960000310 isoleucine Drugs 0.000 abstract 1
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 abstract 1
- 235000014705 isoleucine Nutrition 0.000 abstract 1
- 229930182817 methionine Natural products 0.000 abstract 1
- 235000006109 methionine Nutrition 0.000 abstract 1
- 235000008521 threonine Nutrition 0.000 abstract 1
- 239000004474 valine Substances 0.000 abstract 1
- 235000014393 valine Nutrition 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8121—Serpins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8121—Serpins
- C07K14/8125—Alpha-1-antitrypsin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pain & Pain Management (AREA)
- Communicable Diseases (AREA)
- Rheumatology (AREA)
- Oncology (AREA)
- Urology & Nephrology (AREA)
- Pulmonology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/221,078 US5674708A (en) | 1989-06-23 | 1994-03-31 | α-1-antichymotrypsin analogues having elastase inhibitory activity |
| PCT/US1994/004735 WO1995027055A1 (en) | 1994-03-31 | 1994-04-29 | α-1-ANTICHYMOTRYPSIN ANALOGUES HAVING ELASTASE INHIBITORY ACTIVITY |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BG100939A true BG100939A (en) | 1997-10-31 |
Family
ID=22826247
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BG100939A BG100939A (en) | 1994-03-31 | 1996-10-28 | -1-antichymotrypsin analogues having elastase inhibitory activity |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US5674708A (hu) |
| EP (1) | EP0754228A4 (hu) |
| JP (1) | JPH09512423A (hu) |
| CN (1) | CN1145637A (hu) |
| AU (1) | AU696995B2 (hu) |
| BG (1) | BG100939A (hu) |
| CA (1) | CA2186908A1 (hu) |
| CZ (1) | CZ281796A3 (hu) |
| FI (1) | FI963891A (hu) |
| HU (1) | HUT74901A (hu) |
| LV (1) | LV11747B (hu) |
| NO (1) | NO964022D0 (hu) |
| NZ (1) | NZ269619A (hu) |
| PL (1) | PL316433A1 (hu) |
| SI (1) | SI9420082A (hu) |
| SK (1) | SK138196A3 (hu) |
| WO (1) | WO1995027055A1 (hu) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5723316A (en) * | 1989-06-23 | 1998-03-03 | Trustees Of The University Of Pennsylvania | α-1-antichymotrypsin analogues having chymase inhibiting activity |
| US5827662A (en) * | 1989-06-23 | 1998-10-27 | The Trustees Of The University Of Pennsylvania | Methods for detecting genetic mutations resulting in protease inhibitor insufficiencies |
| US6458777B1 (en) | 1998-03-13 | 2002-10-01 | Mucosal Therapeutics Llc | Methods and compositions for treating and preventing mucositis |
| US6242473B1 (en) * | 1999-01-08 | 2001-06-05 | Maxim Pharmaceuticals, Inc. | Treatment and prevention of reactive oxygen metabolite-mediated cellular damage |
| AU2001292306A1 (en) * | 2000-09-29 | 2002-04-08 | Ono Pharmaceutical Co. Ltd. | Remedies for inflammatory bowel diseases |
| JP4384855B2 (ja) | 2001-04-30 | 2009-12-16 | スウィッチ・バイオテック・アクチェンゲゼルシャフト | 糖尿病随伴性および／または動脈性難治創傷の治療および／または予防のための、そして薬理学的に活性な物質を同定するための、アルファ１−アンチキモトリプシンポリペプチド類またはそれらをコード化している核酸の使用、または、ａｃｔポリペプチドまたはそれをコード化している核酸を、発現している細胞の使用。 |
| DE10121255A1 (de) | 2001-04-30 | 2002-11-07 | Switch Biotech Ag | Verwendung von alpha 1-Antichymotrypsin Polypeptiden oder diese kodierende Nukleinsäuren, oder einer ein ACT Polypeptid oder diese kodierende Nukleinsäure exprimierende Zelle, zur Behandlung und/oder Prävention von diabetes-assoziierten und/oder arteriellen schlecht heilenden Wunden und zur Identifizierung von pharmakologisch aktiven Substanzen |
| EP1415664A1 (en) * | 2002-10-30 | 2004-05-06 | Switch Biotech Aktiengesellschaft | Use of alpha 1-antichymotrypsin in combination with alpha-1-antitrypsin for treating/preventing diabetes associated or poorly healing arterial wounds |
| US20070104699A1 (en) * | 2005-09-29 | 2007-05-10 | University Of Alberta | Compositions for and methods of granzyme B inhibition |
| WO2013082458A1 (en) | 2011-12-02 | 2013-06-06 | The Regents Of The University Of California | Reperfusion protection solution and uses thereof |
| JPWO2021020509A1 (hu) * | 2019-07-31 | 2021-02-04 | ||
| CN112425608B (zh) * | 2019-08-23 | 2023-07-21 | 香港科技大学 | 弹性蛋白酶抑制剂、具有抗生物膜活性的抑菌剂 |
| KR20220079527A (ko) | 2019-09-17 | 2022-06-13 | 메레오 바이오파마 4 리미티드 | 이식편 거부반응, 폐쇄성 세기관지염 증후군 및 이식편 대 숙주병의 치료에 사용하기 위한 알베레스타트 |
| IL297211A (en) | 2020-04-16 | 2022-12-01 | Mereo Biopharma 4 Ltd | Methods involving the neutrophil elastase inhibitor albalstat for the treatment of respiratory disease mediated by alpha-1 antitrypsin deficiency |
| AU2022373971A1 (en) | 2021-10-20 | 2024-04-04 | Mereo Biopharma 4 Limited | Neutrophil elastase inhibitors for use in the treatment of fibrosis |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4732973A (en) * | 1984-06-14 | 1988-03-22 | Chiron Corporation | Active site modified protease α-1-antitrypsin inhibitors |
| US4916117A (en) * | 1986-12-24 | 1990-04-10 | John Lezdey | Treatment of inflammation using alpha 1-antichymotrypsin |
| US5008242A (en) * | 1986-12-24 | 1991-04-16 | John Lezdey | Treatment of inflammation using 1-antichymotrypsin |
| US5266465A (en) * | 1989-06-23 | 1993-11-30 | The Trustees Of The University Of Pennsylvania | α-1-antichymotrypsin, analogues and methods of production |
| US5252725A (en) * | 1989-06-23 | 1993-10-12 | The Trustees Of The University Of Pennsylvania | α-1-antichymotrypsin, analogues and methods of production |
| US5723316A (en) * | 1989-06-23 | 1998-03-03 | Trustees Of The University Of Pennsylvania | α-1-antichymotrypsin analogues having chymase inhibiting activity |
| US5079336A (en) * | 1989-06-23 | 1992-01-07 | The Trustees Of The University Of Pennsylvania | α-1-antichymotrypsin, analogues and methods of production |
-
1994
- 1994-03-31 US US08/221,078 patent/US5674708A/en not_active Expired - Fee Related
- 1994-04-29 NZ NZ269619A patent/NZ269619A/en unknown
- 1994-04-29 EP EP94923869A patent/EP0754228A4/en not_active Ceased
- 1994-04-29 JP JP7525637A patent/JPH09512423A/ja active Pending
- 1994-04-29 CN CN94195058A patent/CN1145637A/zh active Pending
- 1994-04-29 HU HU9602674A patent/HUT74901A/hu unknown
- 1994-04-29 SK SK1381-96A patent/SK138196A3/sk unknown
- 1994-04-29 SI SI9420082A patent/SI9420082A/sl unknown
- 1994-04-29 CZ CZ962817A patent/CZ281796A3/cs unknown
- 1994-04-29 WO PCT/US1994/004735 patent/WO1995027055A1/en not_active Application Discontinuation
- 1994-04-29 PL PL94316433A patent/PL316433A1/xx unknown
- 1994-04-29 AU AU73936/94A patent/AU696995B2/en not_active Ceased
- 1994-04-29 CA CA002186908A patent/CA2186908A1/en not_active Abandoned
-
1996
- 1996-09-24 NO NO964022A patent/NO964022D0/no not_active Application Discontinuation
- 1996-09-27 FI FI963891A patent/FI963891A/fi unknown
- 1996-10-21 LV LVP-96-386A patent/LV11747B/en unknown
- 1996-10-28 BG BG100939A patent/BG100939A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PL316433A1 (en) | 1997-01-06 |
| FI963891A0 (fi) | 1996-09-27 |
| NZ269619A (en) | 1998-01-26 |
| WO1995027055A1 (en) | 1995-10-12 |
| US5674708A (en) | 1997-10-07 |
| LV11747B (en) | 1997-10-20 |
| NO964022L (no) | 1996-09-24 |
| LV11747A (lv) | 1997-04-20 |
| CA2186908A1 (en) | 1995-10-12 |
| HU9602674D0 (en) | 1996-11-28 |
| SK138196A3 (en) | 1997-07-09 |
| EP0754228A4 (en) | 1997-12-10 |
| SI9420082A (en) | 1997-06-30 |
| AU7393694A (en) | 1995-10-23 |
| EP0754228A1 (en) | 1997-01-22 |
| CN1145637A (zh) | 1997-03-19 |
| CZ281796A3 (en) | 1997-05-14 |
| FI963891A (fi) | 1996-09-27 |
| JPH09512423A (ja) | 1997-12-16 |
| NO964022D0 (no) | 1996-09-24 |
| AU696995B2 (en) | 1998-09-24 |
| HUT74901A (en) | 1997-02-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BG100939A (en) | -1-antichymotrypsin analogues having elastase inhibitory activity | |
| ATE440863T1 (de) | Chemokine peptide, varianten, derivate und analoge. ihre verwendung in methode für die hemmung oder erhíhung von einer entzündungsreaktion | |
| CA2236166A1 (en) | Enhancer-increased gene expression in plants | |
| IL205233A0 (en) | A polypeptide comprising the amino acid sequence of osteoprotegerin from residues 22 to 401 inclusive, or a fragment or trunaction thereof | |
| NZ335945A (en) | Presenilin proteins and genetic sequences that are related to Alzheimer's disease | |
| DE69333766D1 (de) | Herstellung von phytat-degradierenden enzymen in trichoderma | |
| CA2177827A1 (en) | Novel apoptosis-modulating proteins, dna encoding the proteins and methods of use thereof | |
| IT8119760A0 (it) | Polipeptide prodotto microbiologicamente con la sequenza di aminoacidi dell'interferone umano, dna e plasmidi che codificano per questa sequenza, microorganismi che contengono queste informazioni genetiche e processo per la loro preparazione. | |
| IL135688A0 (en) | Human checkpoint kinase, hcds1, compositions and methods | |
| AU8258591A (en) | Human mk gene and protein sequence | |
| EP2283852A3 (en) | Porphorymonas gingivalis polypeptides and polynucleotides | |
| DE69018926T2 (de) | Vakzine gegen Bordetella. | |
| WO1995030001A3 (en) | Novel p-selectin ligand protein | |
| CO4480058A1 (es) | Genes codificantes y procedimiento de expresion de una nueva enzima: ftalil amidasa | |
| CA2245584A1 (en) | Recombinant expression of s-layer proteins | |
| DE3688383D1 (de) | Rekombinantes vektorsystem fuer metalloproteinase-inhibitorsequenz und dessen verwendung und herstellung nach dem rekombinant-dns-verfahren. | |
| DE69526087D1 (de) | Or-1, ein wais-rezeptor der nuklearen rezeptoren familie | |
| AU8526691A (en) | Nucleotide and amino acid sequences of protein mtp40 of m. tuberculosis and synthetic peptides derived therefrom | |
| RU96121465A (ru) | Биосинтез рибофлавина в грибах | |
| DE69637429D1 (de) | Gene, die für lymphocyte spezifischen interferon-regulationsfaktor (lsirf) polypeptide kodiert | |
| ATE452903T1 (de) | Modifizierte peptide und deren verwendung zur behandlung von autoimmunkrankheiten | |
| DE59611131D1 (de) | Acarbose-Biosynthesegene aus Actinoplanes sp., Verfahren zu ihrer Isolierung sowie ihrer Verwendung | |
| AU7705296A (en) | Plant gene expression vector family based on the regulatory dna sequences of an alfalfa h3 histon gene variant (msh3g1) | |
| WO2000029564A3 (en) | Human glycine transporter type 2 | |
| CA2244928A1 (en) | Dna coding for serine/threonine kinase |