FI963884A - Diagnoosi, hoito ja solu- ja eläinmallit tauteja varten, joihin liittyy mitokondriodefektejä - Google Patents

Diagnoosi, hoito ja solu- ja eläinmallit tauteja varten, joihin liittyy mitokondriodefektejä Download PDF

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Publication number
FI963884A
FI963884A FI963884A FI963884A FI963884A FI 963884 A FI963884 A FI 963884A FI 963884 A FI963884 A FI 963884A FI 963884 A FI963884 A FI 963884A FI 963884 A FI963884 A FI 963884A
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FI
Finland
Prior art keywords
diagnosis
cell
treatment
animal models
diseases associated
Prior art date
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FI963884A
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English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI963884A0 (fi
Inventor
Corinna Herrnstadt
William Davis Parker
Robert E Davis
Scott William Miller
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Mitokor
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Filing date
Publication date
Priority claimed from US08/219,842 external-priority patent/US5565323A/en
Priority claimed from US08/397,808 external-priority patent/US5888498A/en
Application filed by Mitokor filed Critical Mitokor
Publication of FI963884A0 publication Critical patent/FI963884A0/fi
Publication of FI963884A publication Critical patent/FI963884A/fi

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4713—Autoimmune diseases, e.g. Insulin-dependent diabetes mellitus, multiple sclerosis, rheumathoid arthritis, systemic lupus erythematosus; Autoantigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
    • C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C07D219/08—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0053—Oxidoreductases (1.) acting on a heme group of donors (1.9)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Diabetes (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Toxicology (AREA)
  • Biotechnology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Neurology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Physics & Mathematics (AREA)
  • Endocrinology (AREA)
  • Rehabilitation Therapy (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Rheumatology (AREA)
FI963884A 1994-03-30 1996-09-27 Diagnoosi, hoito ja solu- ja eläinmallit tauteja varten, joihin liittyy mitokondriodefektejä FI963884A (fi)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/219,842 US5565323A (en) 1994-03-30 1994-03-30 Cytochrome oxidase mutations aiding diagnosis of sporadic alzheimer's disease
US08/397,808 US5888498A (en) 1995-03-03 1995-03-03 Cellular and animal models for diseases associated with mitochondrial defects
PCT/US1995/004063 WO1995026973A1 (en) 1994-03-30 1995-03-30 Diagnosis, therapy and cellular and animal models for diseases associated with mitochondrial defects

Publications (2)

Publication Number Publication Date
FI963884A0 FI963884A0 (fi) 1996-09-27
FI963884A true FI963884A (fi) 1996-11-26

Family

ID=26914309

Family Applications (1)

Application Number Title Priority Date Filing Date
FI963884A FI963884A (fi) 1994-03-30 1996-09-27 Diagnoosi, hoito ja solu- ja eläinmallit tauteja varten, joihin liittyy mitokondriodefektejä

Country Status (12)

Country Link
US (1) US20010021526A1 (es)
EP (1) EP0751951A4 (es)
JP (1) JPH09511398A (es)
CN (1) CN1150433A (es)
AU (1) AU705230B2 (es)
BR (1) BR9507241A (es)
CA (1) CA2186636A1 (es)
FI (1) FI963884A (es)
MX (1) MX9604400A (es)
NO (1) NO964073L (es)
NZ (1) NZ283660A (es)
WO (1) WO1995026973A1 (es)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6027880A (en) 1995-08-02 2000-02-22 Affymetrix, Inc. Arrays of nucleic acid probes and methods of using the same for detecting cystic fibrosis
US7115364B1 (en) 1993-10-26 2006-10-03 Affymetrix, Inc. Arrays of nucleic acid probes on biological chips
US20060229824A1 (en) 1993-10-26 2006-10-12 Affymetrix, Inc. Arrays of nucleic acid probes for analyzing biotransformation genes
US6309823B1 (en) 1993-10-26 2001-10-30 Affymetrix, Inc. Arrays of nucleic acid probes for analyzing biotransformation genes and methods of using the same
US5840493A (en) * 1994-03-30 1998-11-24 Mitokor Mitochondrial DNA mutations that segregate with late onset diabetes mellitus
US6291172B1 (en) 1995-03-03 2001-09-18 Mitokor Diagnostic assay for diabetes mellitus based on mutational burden
WO1996030545A1 (en) * 1995-03-24 1996-10-03 Mitokor Mutation detection by differential primer extension of mutant and wildtype target sequences
US6391550B1 (en) 1996-09-19 2002-05-21 Affymetrix, Inc. Identification of molecular sequence signatures and methods involving the same
GB9620028D0 (en) 1996-09-26 1996-11-13 Ludwig Inst Cancer Res Factors which interact with oncoproteins
WO1999055845A1 (en) * 1998-04-28 1999-11-04 Mitokor Cellular and animal models for diseases associated with altered mitochondrial function
US6489095B2 (en) 1998-06-15 2002-12-03 Mitokor Diagnostic method based on quantification of extramitochondrial DNA
US6441149B1 (en) * 1998-06-15 2002-08-27 Mitokor Diagnostic method based on quantification of extramitochondrial DNA
EP1171137B1 (en) * 1999-02-23 2007-12-26 The Regents of the University of California Use of triacetyluridine for the treatment of mitochondrial disorders
WO2000055323A1 (en) * 1999-03-16 2000-09-21 Mitokor Differential expression of organellar gene products
FR2798556B1 (fr) * 1999-09-17 2004-02-27 Aventis Pharma Sa Nouveau modele animal de la maladie d'alzheimer presentant a la fois des plaques amyloides et des dysfonctionnements mitochondriaux
EP1235482A1 (fr) * 1999-09-17 2002-09-04 Aventis Pharma S.A. Nouveau modele animal de la maladie d'alzheimer presentant a la fois des plaques amyloides et des dysfonctionnements mitochondriaux
CN1277995A (zh) * 1999-11-22 2000-12-27 上海博容基因开发有限公司 一种新的多肽——人细胞色素氧化酶相关蛋白37和编码这种多肽的多核苷酸
JP4472253B2 (ja) * 2000-12-04 2010-06-02 プリマゲン ベー．フェー． 内部共生体細胞小器官の検査およびそれで識別可能な化合物
JP2003116576A (ja) * 2001-10-17 2003-04-22 Gifu International Institute Of Biotechnology ヒトミトコンドリアｄｎａを用いた遺伝子検出方法
US7888334B2 (en) 2003-08-22 2011-02-15 Antipodean Pharmaceuticals, Inc. Mitoquinone derivatives used as mitochondrially targeted antioxidants
SG145715A1 (en) 2003-08-22 2008-09-29 Antipodean Pharmaceuticals Inc Mitoquinone derivatives used as mitochondrially targeted antioxidants
CA2599709A1 (en) * 2005-03-09 2006-09-21 Cepheid Polar dyes
CA2688125A1 (en) * 2007-05-02 2008-11-13 The Mclean Hospital Corporation Methods and compositions for mitochondrial replacement therapy
WO2013035101A1 (en) 2011-09-11 2013-03-14 Minovia Therapeutics Ltd. Compositions of functional mitochondria and uses thereof
AU2013326508A1 (en) * 2012-10-05 2015-03-19 Neurovive Pharmaceutical Ab Mitochondrial toxicity test
KR101556439B1 (ko) 2013-07-01 2015-10-15 서울대학교산학협력단 미토콘드리아 역행성 신호 경로와 관련된 ＲＸＲα의 기능 및 용도
AU2018266111A1 (en) 2017-05-08 2019-11-21 Flagship Pioneering Innovations V, Inc. Compositions for facilitating membrane fusion and uses thereof
CN107746889A (zh) * 2017-07-17 2018-03-02 国家海洋局北海环境监测中心 用于扩增底栖多毛类环节动物线粒体co i基因片段的引物
EP3823640A4 (en) 2018-07-22 2022-05-18 Minovia Therapeutics Ltd. MITOCHONDRIAL AUGMENTATION THERAPY OF MUSCULAR DISEASES
CN112912087A (zh) * 2018-09-14 2021-06-04 卢卡科学株式会社 线粒体向淋巴器官中的移植以及用于该移植的组合物
CN109796527B (zh) * 2019-03-07 2020-09-04 广西大学 一种红麻线粒体蛋白cox3抗原多肽及制备多克隆抗体的方法和应用
CN111034736B (zh) * 2019-12-13 2021-04-06 西北农林科技大学 一种杀虫组合物及其应用
CN111579763B (zh) * 2020-04-09 2023-04-07 北京博瑞世安科技有限公司 检测白细胞线粒体呼吸功能的方法及检测肾阴虚症的方法
CN111781175B (zh) * 2020-06-18 2023-04-21 中国人民解放军军事科学院国防科技创新研究院 一种用于提高细胞中线粒体活性的方法及装置和应用
WO2024015951A2 (en) * 2022-07-15 2024-01-18 Seq Biomarque, Llc Methods and materials for identifying biomarkers and/or pathways associated with alzheimer's disease
CN115960087B (zh) * 2022-09-16 2024-06-07 浙江工业大学 黏度响应型双光子荧光化合物及其合成与应用
CN117384269B (zh) * 2023-09-21 2024-06-18 南方医科大学南方医院 短肽mfrlp及其在制备动脉重塑相关疾病药物中的应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5185244A (en) * 1989-12-08 1993-02-09 Emory University Genetic test for hereditary neuromuscular disease
US5296349A (en) * 1990-06-14 1994-03-22 Emory University Molecular genetic test for myoclonic epilepsy
US5494794A (en) * 1992-10-20 1996-02-27 Emory University Detection of mitochondrial DNA mutations associated with Alzheimer's disease and Parkinson's disease
US5506101A (en) * 1993-06-30 1996-04-09 Cedars-Sinai Medical Center Method for detection of susceptibility mutations for ototoxic deafness

Also Published As

Publication number Publication date
JPH09511398A (ja) 1997-11-18
CN1150433A (zh) 1997-05-21
EP0751951A1 (en) 1997-01-08
AU2204295A (en) 1995-10-23
NO964073L (no) 1996-11-29
FI963884A0 (fi) 1996-09-27
AU705230B2 (en) 1999-05-20
WO1995026973A1 (en) 1995-10-12
BR9507241A (pt) 1997-09-16
NZ283660A (en) 1998-07-28
US20010021526A1 (en) 2001-09-13
EP0751951A4 (en) 2000-05-03
MX9604400A (es) 1997-12-31
NO964073D0 (no) 1996-09-27
CA2186636A1 (en) 1995-10-12

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