FI962954A - Substituoidut 3-arylideeni-7-atsaoksindoliyhdisteet ja menetelmä niiden valmistamiseksi - Google Patents
Substituoidut 3-arylideeni-7-atsaoksindoliyhdisteet ja menetelmä niiden valmistamiseksi Download PDFInfo
- Publication number
- FI962954A FI962954A FI962954A FI962954A FI962954A FI 962954 A FI962954 A FI 962954A FI 962954 A FI962954 A FI 962954A FI 962954 A FI962954 A FI 962954A FI 962954 A FI962954 A FI 962954A
- Authority
- FI
- Finland
- Prior art keywords
- nch2oh
- choh
- alkyl
- image
- pct
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9423997A GB9423997D0 (en) | 1994-11-28 | 1994-11-28 | Substituted 3-arylidene-7-azaoxindole compounds and process for their preparation |
PCT/EP1995/004247 WO1996016964A1 (en) | 1994-11-28 | 1995-10-30 | Substituted 3-arylidene-7-azaoxindole compounds and process for their preparation |
Publications (2)
Publication Number | Publication Date |
---|---|
FI962954A true FI962954A (fi) | 1996-07-24 |
FI962954A0 FI962954A0 (fi) | 1996-07-24 |
Family
ID=10765093
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI962954A FI962954A0 (fi) | 1994-11-28 | 1996-07-24 | Substituoidut 3-arylideeni-7-atsaoksindoliyhdisteet ja menetelmä niiden valmistamiseksi |
Country Status (22)
Country | Link |
---|---|
US (1) | US5719135A (ja) |
EP (1) | EP0741726B1 (ja) |
JP (1) | JPH09508924A (ja) |
CN (1) | CN1139929A (ja) |
AT (1) | ATE186727T1 (ja) |
AU (1) | AU3926295A (ja) |
CA (1) | CA2180730C (ja) |
DE (1) | DE69513383T2 (ja) |
DK (1) | DK0741726T3 (ja) |
ES (1) | ES2140717T3 (ja) |
FI (1) | FI962954A0 (ja) |
GB (1) | GB9423997D0 (ja) |
GR (1) | GR3032535T3 (ja) |
HU (1) | HUT74875A (ja) |
IL (1) | IL116002A0 (ja) |
MX (1) | MX9602838A (ja) |
NO (1) | NO963066D0 (ja) |
NZ (1) | NZ295668A (ja) |
PL (1) | PL315689A1 (ja) |
PT (1) | PT741726E (ja) |
WO (1) | WO1996016964A1 (ja) |
ZA (1) | ZA959927B (ja) |
Families Citing this family (46)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6316635B1 (en) | 1995-06-07 | 2001-11-13 | Sugen, Inc. | 2-indolinone derivatives as modulators of protein kinase activity |
US6147106A (en) | 1997-08-20 | 2000-11-14 | Sugen, Inc. | Indolinone combinatorial libraries and related products and methods for the treatment of disease |
US5880141A (en) * | 1995-06-07 | 1999-03-09 | Sugen, Inc. | Benzylidene-Z-indoline compounds for the treatment of disease |
US6906093B2 (en) | 1995-06-07 | 2005-06-14 | Sugen, Inc. | Indolinone combinatorial libraries and related products and methods for the treatment of disease |
GB9610964D0 (en) * | 1996-05-24 | 1996-07-31 | Pharmacia & Upjohn Spa | Substituted tetralylmethylen-oxindole analogues as tyrosine kinase inhibitors |
GB9611797D0 (en) * | 1996-06-06 | 1996-08-07 | Pharmacia Spa | Substituted quinolylmethylen-oxindole analogues as tyrosine kinase inhibitors |
GB9613021D0 (en) * | 1996-06-21 | 1996-08-28 | Pharmacia Spa | Bicyclic 4-aralkylaminopyrimidine derivatives as tyrosine kinase inhibitors |
US6316429B1 (en) | 1997-05-07 | 2001-11-13 | Sugen, Inc. | Bicyclic protein kinase inhibitors |
US6486185B1 (en) | 1997-05-07 | 2002-11-26 | Sugen, Inc. | 3-heteroarylidene-2-indolinone protein kinase inhibitors |
US6987113B2 (en) * | 1997-06-11 | 2006-01-17 | Sugen, Inc. | Tyrosine kinase inhibitors |
GB9718913D0 (en) | 1997-09-05 | 1997-11-12 | Glaxo Group Ltd | Substituted oxindole derivatives |
GB9721437D0 (en) * | 1997-10-10 | 1997-12-10 | Glaxo Group Ltd | Heteroaromatic compounds and their use in medicine |
US6531502B1 (en) | 1998-01-21 | 2003-03-11 | Sugen, Inc. | 3-Methylidenyl-2-indolinone modulators of protein kinase |
AU3363599A (en) * | 1998-03-26 | 1999-10-18 | Max-Planck Institut Fur Biochemie | Heterocyclic families of compounds for the modulation of tyrosine protein kinase |
US6514981B1 (en) | 1998-04-02 | 2003-02-04 | Sugen, Inc. | Methods of modulating tyrosine protein kinase function with indolinone compounds |
US6569868B2 (en) | 1998-04-16 | 2003-05-27 | Sugen, Inc. | 2-indolinone derivatives as modulators of protein kinase activity |
EP2020408B1 (en) * | 1998-05-29 | 2013-06-26 | Sugen, Inc. | Pyrrole substituted 2-indolinone protein kinase inhibitor |
CN1261098C (zh) | 1998-08-28 | 2006-06-28 | 西奥斯股份有限公司 | p38-α激酶的抑制剂 |
US6153634A (en) | 1998-12-17 | 2000-11-28 | Hoffmann-La Roche Inc. | 4,5-azolo-oxindoles |
KR20010101266A (ko) | 1998-12-17 | 2001-11-14 | 프리돌린 클라우스너, 롤란드 비. 보레르 | Jnk 단백질 키나제의 억제제로서의 4-아릴옥신돌 |
PT1157019E (pt) * | 1998-12-17 | 2003-06-30 | Hoffmann La Roche | 4-alcenil (e alcinil) oxindolos como inibidores dequinases dependentes de ciclina em particular cdk2 |
TR200101756T2 (tr) | 1998-12-17 | 2001-10-22 | F.Hoffmann-La Roche Ag | Protein kinaz inhibitörleri olarak 4,5-pirazinoksindoller. |
GB9904933D0 (en) | 1999-03-04 | 1999-04-28 | Glaxo Group Ltd | Compounds |
US6624171B1 (en) | 1999-03-04 | 2003-09-23 | Smithkline Beecham Corporation | Substituted aza-oxindole derivatives |
US6492398B1 (en) | 1999-03-04 | 2002-12-10 | Smithkline Beechman Corporation | Thiazoloindolinone compounds |
US6689806B1 (en) | 1999-03-24 | 2004-02-10 | Sugen, Inc. | Indolinone compounds as kinase inhibitors |
US6541477B2 (en) | 1999-08-27 | 2003-04-01 | Scios, Inc. | Inhibitors of p38-a kinase |
US6878733B1 (en) | 1999-11-24 | 2005-04-12 | Sugen, Inc. | Formulations for pharmaceutical agents ionizable as free acids or free bases |
US6313310B1 (en) | 1999-12-15 | 2001-11-06 | Hoffmann-La Roche Inc. | 4-and 5-alkynyloxindoles and 4-and 5-alkenyloxindoles |
JP2003518123A (ja) * | 1999-12-21 | 2003-06-03 | スージェン・インコーポレーテッド | 4−置換7−アザ−インドリン−2−オンおよびその蛋白質キナーゼ阻害剤としての使用 |
US6620818B1 (en) | 2000-03-01 | 2003-09-16 | Smithkline Beecham Corporation | Method for reducing the severity of side effects of chemotherapy and/or radiation therapy |
MY128450A (en) | 2000-05-24 | 2007-02-28 | Upjohn Co | 1-(pyrrolidin-1-ylmethyl)-3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives |
JP2003535847A (ja) | 2000-06-02 | 2003-12-02 | スージェン・インコーポレーテッド | 蛋白質キナーゼ/ホスファターゼ阻害剤としてのインドリノン誘導体 |
US6335342B1 (en) | 2000-06-19 | 2002-01-01 | Pharmacia & Upjohn S.P.A. | Azaindole derivatives, process for their preparation, and their use as antitumor agents |
EP1353693B1 (en) | 2001-01-16 | 2005-03-16 | Glaxo Group Limited | Pharmaceutical combination containing a 4-quinazolineamine and paclitaxel, carboplatin or vinorelbine for the treatment of cancer |
US6504034B2 (en) | 2001-01-23 | 2003-01-07 | Hoffmann-La Roche Inc. | Naphthostyrils |
US7015231B2 (en) * | 2001-09-27 | 2006-03-21 | Smithkline Beecham Corporation | Chemical compounds |
CA2636701C (en) * | 2006-01-27 | 2014-08-05 | Shanghai Hengrui Pharmaceutical Co. Ltd. | Pyrrolo [3,2-c] pyridine-4-one 2-indolinone protein kinase inhibitors |
CN101367801B (zh) * | 2007-08-15 | 2011-01-12 | 上海恒瑞医药有限公司 | 吡咯并六元n杂环羟基吗啡啉类衍生物的制备方法及其在医药上的应用 |
US9493452B2 (en) * | 2011-03-24 | 2016-11-15 | Southern Methodist University | Compounds and derivatives of 2H-pyrido (3,2-b)(1, 4) oxazin 3)4H)-ones as raf kinase and LRRK2 inhibitors |
US8669363B2 (en) | 2011-03-24 | 2014-03-11 | Southern Methodist University | Quinoxaline compounds and derivatives |
US9309208B2 (en) | 2012-03-23 | 2016-04-12 | Southern Methodist University | Methods of making and using thioxothiazolidine and rhodanine derivatives as HIV-1 and JSP-1 inhibitors |
CN103864784B (zh) * | 2014-02-28 | 2017-05-03 | 温州医科大学 | 一种新型氮杂吲哚‑2‑酮类fgfr1抑制剂及其抗肿瘤活性 |
WO2022006238A1 (en) * | 2020-07-01 | 2022-01-06 | Angion Biomedica Corp. | Solid forms of (z)-methyl 3-(((4-(n-methyl-2-(4-methylpiperazin-l- yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxo-2, 3-dihydro- lh-pyrrolo[2,3-b]pyridine-6-carboxylate and salts thereof |
WO2022120181A1 (en) | 2020-12-03 | 2022-06-09 | Mydecine Innovations Group Inc. | Novel psilocin analog compositions and methods of synthesizing the same |
WO2024071415A1 (ja) * | 2022-09-30 | 2024-04-04 | 日本ポリケム株式会社 | 化合物、金属錯体、オレフィン重合用触媒組成物、オレフィン重合用触媒、及び、オレフィン系重合体の製造方法 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9226855D0 (en) * | 1992-12-23 | 1993-02-17 | Erba Carlo Spa | Vinylene-azaindole derivatives and process for their preparation |
-
1994
- 1994-11-28 GB GB9423997A patent/GB9423997D0/en active Pending
-
1995
- 1995-10-30 JP JP8518113A patent/JPH09508924A/ja not_active Ceased
- 1995-10-30 DE DE69513383T patent/DE69513383T2/de not_active Expired - Fee Related
- 1995-10-30 MX MX9602838A patent/MX9602838A/es not_active Application Discontinuation
- 1995-10-30 WO PCT/EP1995/004247 patent/WO1996016964A1/en active IP Right Grant
- 1995-10-30 NZ NZ295668A patent/NZ295668A/en unknown
- 1995-10-30 ES ES95937030T patent/ES2140717T3/es not_active Expired - Lifetime
- 1995-10-30 EP EP95937030A patent/EP0741726B1/en not_active Expired - Lifetime
- 1995-10-30 AT AT95937030T patent/ATE186727T1/de not_active IP Right Cessation
- 1995-10-30 PT PT95937030T patent/PT741726E/pt unknown
- 1995-10-30 AU AU39262/95A patent/AU3926295A/en not_active Abandoned
- 1995-10-30 DK DK95937030T patent/DK0741726T3/da active
- 1995-10-30 PL PL95315689A patent/PL315689A1/xx unknown
- 1995-10-30 US US08/669,315 patent/US5719135A/en not_active Expired - Fee Related
- 1995-10-30 CN CN95191374A patent/CN1139929A/zh active Pending
- 1995-10-30 CA CA002180730A patent/CA2180730C/en not_active Expired - Fee Related
- 1995-10-30 HU HU9602357A patent/HUT74875A/hu unknown
- 1995-11-15 IL IL11600295A patent/IL116002A0/xx unknown
- 1995-11-22 ZA ZA959927A patent/ZA959927B/xx unknown
-
1996
- 1996-07-23 NO NO963066A patent/NO963066D0/no unknown
- 1996-07-24 FI FI962954A patent/FI962954A0/fi not_active Application Discontinuation
-
2000
- 2000-02-02 GR GR20000400231T patent/GR3032535T3/el not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
IL116002A0 (en) | 1996-01-31 |
ATE186727T1 (de) | 1999-12-15 |
AU3926295A (en) | 1996-06-19 |
JPH09508924A (ja) | 1997-09-09 |
US5719135A (en) | 1998-02-17 |
ES2140717T3 (es) | 2000-03-01 |
DK0741726T3 (da) | 2000-04-17 |
EP0741726A1 (en) | 1996-11-13 |
NZ295668A (en) | 1997-11-24 |
GR3032535T3 (en) | 2000-05-31 |
CA2180730A1 (en) | 1996-06-06 |
EP0741726B1 (en) | 1999-11-17 |
WO1996016964A1 (en) | 1996-06-06 |
NO963066L (no) | 1996-07-23 |
GB9423997D0 (en) | 1995-01-11 |
CN1139929A (zh) | 1997-01-08 |
MX9602838A (es) | 1997-06-28 |
PT741726E (pt) | 2000-04-28 |
HU9602357D0 (en) | 1996-11-28 |
DE69513383T2 (de) | 2000-05-18 |
PL315689A1 (en) | 1996-11-25 |
FI962954A0 (fi) | 1996-07-24 |
DE69513383D1 (de) | 1999-12-23 |
CA2180730C (en) | 2006-09-12 |
NO963066D0 (no) | 1996-07-23 |
HUT74875A (en) | 1997-02-28 |
ZA959927B (en) | 1996-06-10 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD | Application lapsed |