IL116002A0 - Substituted 3-arylidene-7-azaoxindole compounds their preparation and pharmaceutical compositions containing them - Google Patents

Substituted 3-arylidene-7-azaoxindole compounds their preparation and pharmaceutical compositions containing them

Info

Publication number
IL116002A0
IL116002A0 IL11600295A IL11600295A IL116002A0 IL 116002 A0 IL116002 A0 IL 116002A0 IL 11600295 A IL11600295 A IL 11600295A IL 11600295 A IL11600295 A IL 11600295A IL 116002 A0 IL116002 A0 IL 116002A0
Authority
IL
Israel
Prior art keywords
nch2oh
choh
alkyl
image
pct
Prior art date
Application number
IL11600295A
Other languages
English (en)
Original Assignee
Pharmacia Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia Spa filed Critical Pharmacia Spa
Publication of IL116002A0 publication Critical patent/IL116002A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
IL11600295A 1994-11-28 1995-11-15 Substituted 3-arylidene-7-azaoxindole compounds their preparation and pharmaceutical compositions containing them IL116002A0 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB9423997A GB9423997D0 (en) 1994-11-28 1994-11-28 Substituted 3-arylidene-7-azaoxindole compounds and process for their preparation

Publications (1)

Publication Number Publication Date
IL116002A0 true IL116002A0 (en) 1996-01-31

Family

ID=10765093

Family Applications (1)

Application Number Title Priority Date Filing Date
IL11600295A IL116002A0 (en) 1994-11-28 1995-11-15 Substituted 3-arylidene-7-azaoxindole compounds their preparation and pharmaceutical compositions containing them

Country Status (22)

Country Link
US (1) US5719135A (ja)
EP (1) EP0741726B1 (ja)
JP (1) JPH09508924A (ja)
CN (1) CN1139929A (ja)
AT (1) ATE186727T1 (ja)
AU (1) AU3926295A (ja)
CA (1) CA2180730C (ja)
DE (1) DE69513383T2 (ja)
DK (1) DK0741726T3 (ja)
ES (1) ES2140717T3 (ja)
FI (1) FI962954A (ja)
GB (1) GB9423997D0 (ja)
GR (1) GR3032535T3 (ja)
HU (1) HUT74875A (ja)
IL (1) IL116002A0 (ja)
MX (1) MX9602838A (ja)
NO (1) NO963066L (ja)
NZ (1) NZ295668A (ja)
PL (1) PL315689A1 (ja)
PT (1) PT741726E (ja)
WO (1) WO1996016964A1 (ja)
ZA (1) ZA959927B (ja)

Families Citing this family (46)

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US6147106A (en) 1997-08-20 2000-11-14 Sugen, Inc. Indolinone combinatorial libraries and related products and methods for the treatment of disease
US6316635B1 (en) 1995-06-07 2001-11-13 Sugen, Inc. 2-indolinone derivatives as modulators of protein kinase activity
US5880141A (en) * 1995-06-07 1999-03-09 Sugen, Inc. Benzylidene-Z-indoline compounds for the treatment of disease
US6906093B2 (en) 1995-06-07 2005-06-14 Sugen, Inc. Indolinone combinatorial libraries and related products and methods for the treatment of disease
GB9610964D0 (en) * 1996-05-24 1996-07-31 Pharmacia & Upjohn Spa Substituted tetralylmethylen-oxindole analogues as tyrosine kinase inhibitors
GB9611797D0 (en) * 1996-06-06 1996-08-07 Pharmacia Spa Substituted quinolylmethylen-oxindole analogues as tyrosine kinase inhibitors
GB9613021D0 (en) * 1996-06-21 1996-08-28 Pharmacia Spa Bicyclic 4-aralkylaminopyrimidine derivatives as tyrosine kinase inhibitors
US6316429B1 (en) 1997-05-07 2001-11-13 Sugen, Inc. Bicyclic protein kinase inhibitors
US6486185B1 (en) 1997-05-07 2002-11-26 Sugen, Inc. 3-heteroarylidene-2-indolinone protein kinase inhibitors
US6987113B2 (en) * 1997-06-11 2006-01-17 Sugen, Inc. Tyrosine kinase inhibitors
GB9718913D0 (en) 1997-09-05 1997-11-12 Glaxo Group Ltd Substituted oxindole derivatives
GB9721437D0 (en) * 1997-10-10 1997-12-10 Glaxo Group Ltd Heteroaromatic compounds and their use in medicine
US6531502B1 (en) 1998-01-21 2003-03-11 Sugen, Inc. 3-Methylidenyl-2-indolinone modulators of protein kinase
EP1066257A2 (en) * 1998-03-26 2001-01-10 Sugen, Inc. Heterocylic classes of compounds for the modulating tyrosine protein kinase
US6514981B1 (en) 1998-04-02 2003-02-04 Sugen, Inc. Methods of modulating tyrosine protein kinase function with indolinone compounds
US6569868B2 (en) 1998-04-16 2003-05-27 Sugen, Inc. 2-indolinone derivatives as modulators of protein kinase activity
CA2314156C (en) 1998-05-29 2010-05-25 Sugen, Inc. Pyrrole substituted 2-indolinone protein kinase inhibitors
CA2342251A1 (en) 1998-08-28 2000-03-09 Scios Inc. Use of piperidines and/or piperazines as inhibitors of p38-alpha kinase
US6153634A (en) 1998-12-17 2000-11-28 Hoffmann-La Roche Inc. 4,5-azolo-oxindoles
TR200101860T2 (tr) 1998-12-17 2001-12-21 F.Hoffmann-La Roche Ag Sikline bağlı kinaz inhibitörleri olarak 4-alkenil (ve alkinil) oksidoller
CN1158283C (zh) 1998-12-17 2004-07-21 霍夫曼-拉罗奇有限公司 作为蛋白激酶抑制剂的4-和5-吡嗪基羟吲哚
AU760039B2 (en) 1998-12-17 2003-05-08 F. Hoffmann-La Roche Ag 4-aryloxindoles as inhibitors of JNK protein kinases
US6492398B1 (en) 1999-03-04 2002-12-10 Smithkline Beechman Corporation Thiazoloindolinone compounds
US6624171B1 (en) 1999-03-04 2003-09-23 Smithkline Beecham Corporation Substituted aza-oxindole derivatives
GB9904933D0 (en) 1999-03-04 1999-04-28 Glaxo Group Ltd Compounds
US6689806B1 (en) 1999-03-24 2004-02-10 Sugen, Inc. Indolinone compounds as kinase inhibitors
US6541477B2 (en) 1999-08-27 2003-04-01 Scios, Inc. Inhibitors of p38-a kinase
US6878733B1 (en) 1999-11-24 2005-04-12 Sugen, Inc. Formulations for pharmaceutical agents ionizable as free acids or free bases
US6313310B1 (en) 1999-12-15 2001-11-06 Hoffmann-La Roche Inc. 4-and 5-alkynyloxindoles and 4-and 5-alkenyloxindoles
WO2001046196A1 (en) * 1999-12-21 2001-06-28 Sugen, Inc. 4-substituted 7-aza-indolin-2-ones and their use as protein kinase inhibitors
US6620818B1 (en) 2000-03-01 2003-09-16 Smithkline Beecham Corporation Method for reducing the severity of side effects of chemotherapy and/or radiation therapy
TWI270545B (en) 2000-05-24 2007-01-11 Sugen Inc Mannich base prodrugs of 3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives
CA2410509A1 (en) 2000-06-02 2001-12-13 Sugen, Inc. Indolinone derivatives as protein kinase/phosphatase inhibitors
US6335342B1 (en) 2000-06-19 2002-01-01 Pharmacia & Upjohn S.P.A. Azaindole derivatives, process for their preparation, and their use as antitumor agents
DE60203260T2 (de) 2001-01-16 2006-02-02 Glaxo Group Ltd., Greenford Pharmazeutische kombination, die ein 4-chinazolinamin und paclitaxel, carboplatin oder vinorelbin enthält, zur behandlung von krebs
US6504034B2 (en) 2001-01-23 2003-01-07 Hoffmann-La Roche Inc. Naphthostyrils
JP2005508337A (ja) * 2001-09-27 2005-03-31 スミスクライン ビーチャム コーポレーション 化合物
KR101452520B1 (ko) * 2006-01-27 2014-10-21 샹하이 헨그루이 파마수티컬 컴퍼니 리미티드 피롤로[3,2-ｃ]피리딘-4-온 2-인돌린온 단백질 키나제 억제제
CN101367801B (zh) * 2007-08-15 2011-01-12 上海恒瑞医药有限公司 吡咯并六元n杂环羟基吗啡啉类衍生物的制备方法及其在医药上的应用
US8669363B2 (en) 2011-03-24 2014-03-11 Southern Methodist University Quinoxaline compounds and derivatives
US9493452B2 (en) * 2011-03-24 2016-11-15 Southern Methodist University Compounds and derivatives of 2H-pyrido (3,2-b)(1, 4) oxazin 3)4H)-ones as raf kinase and LRRK2 inhibitors
US9309208B2 (en) 2012-03-23 2016-04-12 Southern Methodist University Methods of making and using thioxothiazolidine and rhodanine derivatives as HIV-1 and JSP-1 inhibitors
CN103864784B (zh) * 2014-02-28 2017-05-03 温州医科大学 一种新型氮杂吲哚‑2‑酮类fgfr1抑制剂及其抗肿瘤活性
WO2022006238A1 (en) * 2020-07-01 2022-01-06 Angion Biomedica Corp. Solid forms of (z)-methyl 3-(((4-(n-methyl-2-(4-methylpiperazin-l- yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxo-2, 3-dihydro- lh-pyrrolo[2,3-b]pyridine-6-carboxylate and salts thereof
EP4255422A1 (en) * 2020-12-03 2023-10-11 Mydecine Innovations Group Inc. Novel psilocin analog compositions and methods of synthesizing the same
WO2024071415A1 (ja) * 2022-09-30 2024-04-04 日本ポリケム株式会社 化合物、金属錯体、オレフィン重合用触媒組成物、オレフィン重合用触媒、及び、オレフィン系重合体の製造方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9226855D0 (en) * 1992-12-23 1993-02-17 Erba Carlo Spa Vinylene-azaindole derivatives and process for their preparation

Also Published As

Publication number Publication date
CA2180730A1 (en) 1996-06-06
MX9602838A (es) 1997-06-28
NO963066D0 (no) 1996-07-23
NO963066L (no) 1996-07-23
DE69513383D1 (de) 1999-12-23
US5719135A (en) 1998-02-17
ES2140717T3 (es) 2000-03-01
PL315689A1 (en) 1996-11-25
FI962954A0 (fi) 1996-07-24
AU3926295A (en) 1996-06-19
JPH09508924A (ja) 1997-09-09
FI962954A (fi) 1996-07-24
WO1996016964A1 (en) 1996-06-06
GR3032535T3 (en) 2000-05-31
GB9423997D0 (en) 1995-01-11
HUT74875A (en) 1997-02-28
ATE186727T1 (de) 1999-12-15
NZ295668A (en) 1997-11-24
ZA959927B (en) 1996-06-10
PT741726E (pt) 2000-04-28
DE69513383T2 (de) 2000-05-18
EP0741726B1 (en) 1999-11-17
HU9602357D0 (en) 1996-11-28
DK0741726T3 (da) 2000-04-17
CN1139929A (zh) 1997-01-08
CA2180730C (en) 2006-09-12
EP0741726A1 (en) 1996-11-13

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