FI960399A0 - Perhydroisoindolijohdannaisia P-aineen antagonisteina - Google Patents
Perhydroisoindolijohdannaisia P-aineen antagonisteinaInfo
- Publication number
- FI960399A0 FI960399A0 FI960399A FI960399A FI960399A0 FI 960399 A0 FI960399 A0 FI 960399A0 FI 960399 A FI960399 A FI 960399A FI 960399 A FI960399 A FI 960399A FI 960399 A0 FI960399 A0 FI 960399A0
- Authority
- FI
- Finland
- Prior art keywords
- pct
- antagonists
- substance
- derivatives
- perhydroisoindole derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Indole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9309400A FR2709752B1 (fr) | 1993-07-30 | 1993-07-30 | Nouveaux dérivés de perhydroisoindole, leur préparation et les compositions pharmaceutiques qui les contiennent. |
FR9311946A FR2710913B1 (fr) | 1993-10-07 | 1993-10-07 | Nouveaux dérivés de perhydroisoindole, leur préparation et les compositions pharmaceutiques qui les contiennent. |
PCT/FR1994/000952 WO1995004040A1 (fr) | 1993-07-30 | 1994-07-28 | Derives de perhydroisoindole comme antagonistes de la substance p |
Publications (2)
Publication Number | Publication Date |
---|---|
FI960399A FI960399A (fi) | 1996-01-29 |
FI960399A0 true FI960399A0 (fi) | 1996-01-29 |
Family
ID=26230522
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI960399A FI960399A0 (fi) | 1993-07-30 | 1996-01-29 | Perhydroisoindolijohdannaisia P-aineen antagonisteina |
Country Status (19)
Country | Link |
---|---|
US (1) | US5624950A (zh) |
EP (1) | EP0711280B1 (zh) |
JP (1) | JPH09500893A (zh) |
KR (1) | KR960703858A (zh) |
AT (1) | ATE171445T1 (zh) |
AU (1) | AU7386594A (zh) |
CA (1) | CA2168233A1 (zh) |
CZ (1) | CZ26396A3 (zh) |
DE (1) | DE69413542T2 (zh) |
DK (1) | DK0711280T3 (zh) |
ES (1) | ES2123149T3 (zh) |
FI (1) | FI960399A0 (zh) |
HU (1) | HUT75304A (zh) |
IL (1) | IL110494A0 (zh) |
NO (1) | NO960365L (zh) |
PL (1) | PL312739A1 (zh) |
SK (1) | SK13096A3 (zh) |
TW (1) | TW365603B (zh) |
WO (1) | WO1995004040A1 (zh) |
Families Citing this family (49)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2727411B1 (fr) * | 1994-11-30 | 1997-01-03 | Rhone Poulenc Rorer Sa | Nouveaux derives de perhydroisoindole, leur preparation et les compositions pharmaceutiques qui les contiennent |
DE19738339C2 (de) * | 1997-09-02 | 2000-08-31 | Siemens Ag | Verfahren zum benutzergesteuerten Abbauen von drahtlosen Telekommunikationsverbindungen in drahtlosen Telekommunikationssystemen, insbesondere DECT-Systemen |
US6061833A (en) * | 1998-12-17 | 2000-05-16 | Wdc Holdings, Inc. | Protective glove with improved wrist strap |
US6784200B2 (en) | 2000-10-13 | 2004-08-31 | Bristol-Myers Squibb Pharma Company | Bicyclic and tricyclic amines as modulators of chemokine receptor activity |
AU1201101A (en) | 1999-10-15 | 2001-04-30 | Du Pont Pharmaceuticals Company | Bicyclic and tricyclic amines as modulators of chemokine receptor activity |
JP5007226B2 (ja) | 2004-07-15 | 2012-08-22 | エーエムアール テクノロジー インコーポレイテッド | アリールおよびヘテロアリール置換テトラヒドロイソキノリンならびにノルエピネフリン、ドーパミン、およびセロトニンの再取り込みを遮断するためのその利用方法 |
US8362075B2 (en) | 2005-05-17 | 2013-01-29 | Merck Sharp & Dohme Corp. | Cyclohexyl sulphones for treatment of cancer |
US7956050B2 (en) | 2005-07-15 | 2011-06-07 | Albany Molecular Research, Inc. | Aryl- and heteroaryl-substituted tetrahydrobenzazepines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin |
JP4879988B2 (ja) | 2005-09-29 | 2012-02-22 | メルク・シャープ・エンド・ドーム・コーポレイション | メラノコルチン−4受容体モジュレーターとしてのアシル化スピロピペリジン誘導体 |
GB0603041D0 (en) | 2006-02-15 | 2006-03-29 | Angeletti P Ist Richerche Bio | Therapeutic compounds |
US7265247B1 (en) | 2006-07-28 | 2007-09-04 | Im&T Research, Inc. | Substituted phenylsulfur trifluoride and other like fluorinating agents |
EP2698157B1 (en) | 2006-09-22 | 2015-05-20 | Merck Sharp & Dohme Corp. | Method of treatment using fatty acid synthesis inhibitors |
US20110218176A1 (en) | 2006-11-01 | 2011-09-08 | Barbara Brooke Jennings-Spring | Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development |
GEP20115337B (en) | 2007-01-10 | 2011-11-25 | St Di Ricerche Di Biologia Molecolare P Angeletti Spa | Amide substituted indazoles as poly(adp-ribose)polymerase (parp) inhibitors |
US8399720B2 (en) | 2007-03-23 | 2013-03-19 | Ube Industries, Ltd. | Methods for producing fluorinated phenylsulfur pentafluorides |
CA2857831C (en) | 2007-03-23 | 2017-01-03 | Ube Industries, Ltd. | Process for producing arylsulfur pentafluorides |
US8106086B2 (en) | 2007-04-02 | 2012-01-31 | Msd K.K. | Indoledione derivative |
CA2690191C (en) | 2007-06-27 | 2015-07-28 | Merck Sharp & Dohme Corp. | 4-carboxybenzylamino derivatives as histone deacetylase inhibitors |
US8030516B2 (en) | 2007-10-19 | 2011-10-04 | Ube Industries, Ltd. | Methods for producing perfluoroalkanedi(sulfonyl chloride) |
WO2009111354A2 (en) | 2008-03-03 | 2009-09-11 | Tiger Pharmatech | Tyrosine kinase inhibitors |
US9156812B2 (en) | 2008-06-04 | 2015-10-13 | Bristol-Myers Squibb Company | Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine |
UA105182C2 (ru) | 2008-07-03 | 2014-04-25 | Ньюрексон, Інк. | Бензоксазины, бензотиазины и родственные соединения, которые имеют ингибирующую nos активность |
KR101676054B1 (ko) | 2008-09-22 | 2016-11-14 | 우베 고산 가부시키가이샤 | 폴리(펜타플루오로설파닐)방향족 화합물을 제조하기 위한 공정 |
WO2010081014A1 (en) | 2009-01-09 | 2010-07-15 | Im&T Research, Inc. | Novel 4-fluoropyrrolidine-2-carbonyl fluoride compounds and their preparative methods |
WO2010114780A1 (en) | 2009-04-01 | 2010-10-07 | Merck Sharp & Dohme Corp. | Inhibitors of akt activity |
EP2429293B1 (en) | 2009-05-12 | 2014-10-29 | Bristol-Myers Squibb Company | CRYSTALLINE FORMS OF (S)-7-([1,2,4]TRIAZOLO[1,5-a]PYRIDIN-6-YL)-4-(3,4-DICHLOROHPHENYL)-1,2,3,4-TETRAHYDROISOQUINOLINE AND USE THEREOF |
ES2446971T3 (es) | 2009-05-12 | 2014-03-11 | Albany Molecular Research, Inc. | Tetrahidroisoquinolinas sustituidas con arilo, heteroarilo, y heterociclo y su uso |
WO2010132442A1 (en) | 2009-05-12 | 2010-11-18 | Albany Molecular Reserch, Inc. | 7-([1,2,4,]triazolo[1,5,-a]pyridin-6-yl)-4-(3,4-dichlorophenyl)-1,2,3,4- tetrahydroisoquinoline and use thereof |
CA2777043C (en) | 2009-10-14 | 2015-12-15 | Schering Corporation | Substituted piperidines that increase p53 activity and the uses thereof |
US8999957B2 (en) | 2010-06-24 | 2015-04-07 | Merck Sharp & Dohme Corp. | Heterocyclic compounds as ERK inhibitors |
EP3330377A1 (en) | 2010-08-02 | 2018-06-06 | Sirna Therapeutics, Inc. | Rna interference mediated inhibition of catenin (cadherin-associated protein), beta 1 (ctnnb1) gene expression using short interfering nucleic acid (sina) |
EP4079856A1 (en) | 2010-08-17 | 2022-10-26 | Sirna Therapeutics, Inc. | Rna interference mediated inhibition of hepatitis b virus (hbv) gene expression using short interfering nucleic acid (sina) |
EP2608669B1 (en) | 2010-08-23 | 2016-06-22 | Merck Sharp & Dohme Corp. | NOVEL PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS |
EP2613782B1 (en) | 2010-09-01 | 2016-11-02 | Merck Sharp & Dohme Corp. | Indazole derivatives useful as erk inhibitors |
EP2615916B1 (en) | 2010-09-16 | 2017-01-04 | Merck Sharp & Dohme Corp. | Fused pyrazole derivatives as novel erk inhibitors |
US9260471B2 (en) | 2010-10-29 | 2016-02-16 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of gene expression using short interfering nucleic acids (siNA) |
WO2012087772A1 (en) | 2010-12-21 | 2012-06-28 | Schering Corporation | Indazole derivatives useful as erk inhibitors |
EP2699567A1 (en) | 2011-04-21 | 2014-02-26 | Merck Sharp & Dohme Corp. | Insulin-like growth factor-1 receptor inhibitors |
US9023865B2 (en) | 2011-10-27 | 2015-05-05 | Merck Sharp & Dohme Corp. | Compounds that are ERK inhibitors |
EP3358013B1 (en) | 2012-05-02 | 2020-06-24 | Sirna Therapeutics, Inc. | Short interfering nucleic acid (sina) compositions |
JP6280554B2 (ja) | 2012-09-28 | 2018-02-14 | メルク・シャープ・アンド・ドーム・コーポレーションMerck Sharp & Dohme Corp. | Erk阻害剤である新規化合物 |
SI2925888T1 (en) | 2012-11-28 | 2018-02-28 | Merck Sharp & Dohme Corp. | Compounds and methods for the treatment of cancer |
RU2690663C2 (ru) | 2012-12-20 | 2019-06-05 | Мерк Шарп И Доум Корп. | Замещенные имидазопиридины в качестве ингибиторов hdm2 |
US9540377B2 (en) | 2013-01-30 | 2017-01-10 | Merck Sharp & Dohme Corp. | 2,6,7,8 substituted purines as HDM2 inhibitors |
WO2015034925A1 (en) | 2013-09-03 | 2015-03-12 | Moderna Therapeutics, Inc. | Circular polynucleotides |
US10975084B2 (en) | 2016-10-12 | 2021-04-13 | Merck Sharp & Dohme Corp. | KDM5 inhibitors |
US10947234B2 (en) | 2017-11-08 | 2021-03-16 | Merck Sharp & Dohme Corp. | PRMT5 inhibitors |
EP3833667B1 (en) | 2018-08-07 | 2024-03-13 | Merck Sharp & Dohme LLC | Prmt5 inhibitors |
US11993602B2 (en) | 2018-08-07 | 2024-05-28 | Merck Sharp & Dohme Llc | PRMT5 inhibitors |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2654725B1 (fr) * | 1989-11-23 | 1992-02-14 | Rhone Poulenc Sante | Nouveaux derives de l'isoindolone, leur preparation et les compositions pharmaceutiques qui les contiennent. |
FR2654726B1 (fr) * | 1989-11-23 | 1992-02-14 | Rhone Poulenc Sante | Nouveaux derives de l'isoindolone et leur preparation. |
FR2676442B1 (fr) * | 1991-05-17 | 1993-08-06 | Rhone Poulenc Rorer Sa | Nouveau derives de perhydroisoindole, leur preparation et les compositions pharmaceutiques qui les contiennent. |
FR2676443B1 (fr) * | 1991-05-17 | 1993-08-06 | Rhone Poulenc Rorer Sa | Nouveaux derives de perhydroisoindole et leur preparation. |
FR2689889B1 (fr) * | 1992-04-10 | 1994-06-10 | Rhone Poulenc Rorer Sa | Nouveaux derives de perhydroisoindole, et leur preparation. |
FR2689888B1 (fr) * | 1992-04-10 | 1994-06-10 | Rhone Poulenc Rorer Sa | Nouveaux derives de perhydroisoindole, leur preparation et les compositions pharmaceutiques qui les contiennent. |
-
1994
- 1994-07-21 TW TW083106682A patent/TW365603B/zh active
- 1994-07-28 AT AT94923755T patent/ATE171445T1/de not_active IP Right Cessation
- 1994-07-28 IL IL11049494A patent/IL110494A0/xx unknown
- 1994-07-28 DE DE69413542T patent/DE69413542T2/de not_active Expired - Fee Related
- 1994-07-28 DK DK94923755T patent/DK0711280T3/da active
- 1994-07-28 EP EP94923755A patent/EP0711280B1/fr not_active Expired - Lifetime
- 1994-07-28 WO PCT/FR1994/000952 patent/WO1995004040A1/fr active IP Right Grant
- 1994-07-28 CZ CZ96263A patent/CZ26396A3/cs unknown
- 1994-07-28 JP JP7505618A patent/JPH09500893A/ja active Pending
- 1994-07-28 KR KR1019960700531A patent/KR960703858A/ko not_active Application Discontinuation
- 1994-07-28 PL PL94312739A patent/PL312739A1/xx unknown
- 1994-07-28 AU AU73865/94A patent/AU7386594A/en not_active Abandoned
- 1994-07-28 ES ES94923755T patent/ES2123149T3/es not_active Expired - Lifetime
- 1994-07-28 HU HU9503986A patent/HUT75304A/hu unknown
- 1994-07-28 CA CA002168233A patent/CA2168233A1/fr not_active Abandoned
- 1994-07-28 SK SK130-96A patent/SK13096A3/sk unknown
- 1994-07-28 US US08/586,708 patent/US5624950A/en not_active Expired - Fee Related
-
1996
- 1996-01-29 FI FI960399A patent/FI960399A0/fi unknown
- 1996-01-29 NO NO960365A patent/NO960365L/no unknown
Also Published As
Publication number | Publication date |
---|---|
PL312739A1 (en) | 1996-05-13 |
WO1995004040A1 (fr) | 1995-02-09 |
US5624950A (en) | 1997-04-29 |
HUT75304A (en) | 1997-05-28 |
FI960399A (fi) | 1996-01-29 |
NO960365D0 (no) | 1996-01-29 |
CZ26396A3 (en) | 1996-05-15 |
EP0711280B1 (fr) | 1998-09-23 |
TW365603B (en) | 1999-08-01 |
JPH09500893A (ja) | 1997-01-28 |
EP0711280A1 (fr) | 1996-05-15 |
HU9503986D0 (en) | 1996-03-28 |
KR960703858A (ko) | 1996-08-31 |
IL110494A0 (en) | 1994-10-21 |
SK13096A3 (en) | 1996-09-04 |
DK0711280T3 (da) | 1999-06-14 |
ES2123149T3 (es) | 1999-01-01 |
NO960365L (no) | 1996-01-29 |
ATE171445T1 (de) | 1998-10-15 |
DE69413542T2 (de) | 1999-03-25 |
CA2168233A1 (fr) | 1995-02-09 |
AU7386594A (en) | 1995-02-28 |
DE69413542D1 (de) | 1998-10-29 |
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