FI955905A0 - Trifunktionaalisia trombiinivastaisia ja verihiutalevastaisia peptidejä - Google Patents

Trifunktionaalisia trombiinivastaisia ja verihiutalevastaisia peptidejä

Info

Publication number
FI955905A0
FI955905A0 FI955905A FI955905A FI955905A0 FI 955905 A0 FI955905 A0 FI 955905A0 FI 955905 A FI955905 A FI 955905A FI 955905 A FI955905 A FI 955905A FI 955905 A0 FI955905 A0 FI 955905A0
Authority
FI
Finland
Prior art keywords
trifunctional
antithrombin
antiplatelet peptides
rgd
contain
Prior art date
Application number
FI955905A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI955905A7 (fi
Inventor
Jr Robert James Broersma
Thomas Joseph Owen
John Leonard Krstenansky
Original Assignee
Merrell Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Pharma Inc filed Critical Merrell Pharma Inc
Publication of FI955905A7 publication Critical patent/FI955905A7/fi
Publication of FI955905A0 publication Critical patent/FI955905A0/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/75—Fibrinogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FI955905A 1993-06-11 1995-12-08 Trifunktionaalisia trombiinivastaisia ja verihiutalevastaisia peptidejä FI955905A0 (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7606693A 1993-06-11 1993-06-11
PCT/US1994/005355 WO1994029349A1 (en) 1993-06-11 1994-05-13 Trifunctional antithrombin and antiplatelet peptides

Publications (2)

Publication Number Publication Date
FI955905A7 FI955905A7 (fi) 1995-12-08
FI955905A0 true FI955905A0 (fi) 1995-12-08

Family

ID=22129739

Family Applications (1)

Application Number Title Priority Date Filing Date
FI955905A FI955905A0 (fi) 1993-06-11 1995-12-08 Trifunktionaalisia trombiinivastaisia ja verihiutalevastaisia peptidejä

Country Status (20)

Country Link
US (1) US5681925A (enExample)
EP (1) EP0702696B1 (enExample)
JP (1) JP3532920B2 (enExample)
KR (1) KR100330465B1 (enExample)
CN (1) CN1124964A (enExample)
AT (1) ATE246203T1 (enExample)
AU (1) AU685470B2 (enExample)
CA (1) CA2164712C (enExample)
DE (1) DE69432983T2 (enExample)
DK (1) DK0702696T3 (enExample)
ES (1) ES2199963T3 (enExample)
FI (1) FI955905A0 (enExample)
HU (1) HUT73187A (enExample)
IL (1) IL109931A0 (enExample)
NO (1) NO954991L (enExample)
NZ (1) NZ268159A (enExample)
PT (1) PT702696E (enExample)
TW (1) TW295590B (enExample)
WO (1) WO1994029349A1 (enExample)
ZA (1) ZA943958B (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6235877B1 (en) 1999-08-04 2001-05-22 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Peptido-mimetic compounds containing RGD sequence useful as integrin inhibitors
CN101094867B (zh) 2004-10-19 2011-08-24 隆萨股份公司 用于固相肽合成的方法
WO2011079015A1 (en) * 2009-12-21 2011-06-30 The Regents Of The University Of California Rgd-containing cyclic peptides
CA3109702A1 (en) 2018-08-13 2020-02-20 Signablok, Inc. Peptides and compositions for targeted treatment and imaging
CN117143194B (zh) * 2023-11-01 2024-02-06 北京大学第一医院 抗血小板聚集多肽、其制备方法及应用

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4792525A (en) * 1982-08-04 1988-12-20 La Jolla Cancer Research Foundation Tetrapeptide
DE3438296A1 (de) * 1984-04-18 1985-11-07 Hoechst Ag, 6230 Frankfurt Neue polypeptide mit blutgerinnungshemmender wirkung, verfahren zu deren herstellung bzw. gewinnung, deren verwendung und diese enthaltende mittel
DE3445532A1 (de) * 1984-12-13 1986-06-19 Plantorgan Werk Heinrich G.E. Christensen, KG, 2903 Bad Zwischenahn Hirudin-pa, desulfatohirudine-pa, verfahren zur herstellung und pharmazeutische mittel, die diese wirkstoffe enthalten
CA1341032C (en) * 1987-01-23 2000-06-20 John L. Krstenansky Anticoagulant peptides
AU3098289A (en) * 1988-03-04 1989-09-07 Biogen, Inc. Hirudin peptides
FR2628429B1 (fr) * 1988-03-08 1990-12-28 Transgene Sa Variants de l'hirudine, leurs utilisations et les procedes pour les obtenir
NZ228995A (en) * 1988-05-10 1992-03-26 Merrell Dow Pharma Hirudin peptide derivatives and pharmaceutical compositions
DE58907266T2 (de) * 1988-06-11 1994-09-29 Ciba Geigy Ag Polypeptide mit einer die Koagulierung hemmenden Wirkung.
WO1990006128A1 (en) * 1988-12-05 1990-06-14 Biogen, Inc. Methods and compositions for inhibiting platelet aggregation
AU630132B2 (en) * 1988-12-07 1992-10-22 Merrell Dow Pharmaceuticals Inc. Anticoagulant peptides
US5182260A (en) * 1989-01-27 1993-01-26 Biogen, Inc. Dna sequences encoding snake venom inhibitors of platelet activation processes for producing those inhibitors and compositions using them
EP0382451A3 (en) * 1989-02-07 1991-05-29 Merck & Co. Inc. Viper venom polypeptides and variants
WO1990015072A1 (en) * 1989-06-07 1990-12-13 Genentech, Inc. Platelet aggregation inhibitors and related molecules
US5196404B1 (en) * 1989-08-18 1996-09-10 Biogen Inc Inhibitors of thrombin
ZA907742B (en) * 1989-10-03 1991-07-31 Merrell Dow Pharma Anticoagulant peptides
CA2026377A1 (en) * 1989-10-03 1991-04-04 John L. Krstenansky Radiolabeled anticoagulant peptides
WO1991011458A1 (en) * 1990-02-02 1991-08-08 Genentech, Inc. CYCLIC PEPTIDES CONTAINING Arg-Gly-Asp FLANKED BY PROLINE
JP2669510B2 (ja) * 1990-06-15 1997-10-29 ナショナル・リサーチ・カウンシル・オブ カナダ ヒルジンのアミノ酸配列に基づくトロンビン阻害剤
IT1243358B (it) * 1990-07-23 1994-06-10 Iketon Farmaceutici Srl Composizioni farmaceutiche per la somministrazione orale di irudina
AU640502B2 (en) * 1990-07-24 1993-08-26 Merrell Dow Pharmaceuticals Inc. Analogs of hirudin having antiplatelet activity
US5118790A (en) * 1990-07-24 1992-06-02 Sri International Analogs of hirudin
GB9023149D0 (en) * 1990-10-24 1990-12-05 British Bio Technology Proteins and nucleic acids
US5242810A (en) * 1990-12-07 1993-09-07 Biogen, Inc. Bifunctional inhibitors of thrombin and platelet activation

Also Published As

Publication number Publication date
CA2164712A1 (en) 1994-12-22
AU685470B2 (en) 1998-01-22
EP0702696A1 (en) 1996-03-27
FI955905A7 (fi) 1995-12-08
TW295590B (enExample) 1997-01-11
NO954991D0 (no) 1995-12-08
CN1124964A (zh) 1996-06-19
DK0702696T3 (da) 2003-11-17
AU7093894A (en) 1995-01-03
HU9503530D0 (en) 1996-02-28
JPH08511518A (ja) 1996-12-03
ZA943958B (en) 1995-02-22
IL109931A0 (en) 1994-10-07
JP3532920B2 (ja) 2004-05-31
ES2199963T3 (es) 2004-03-01
HUT73187A (en) 1996-06-28
EP0702696B1 (en) 2003-07-30
WO1994029349A1 (en) 1994-12-22
DE69432983D1 (de) 2003-09-04
PT702696E (pt) 2003-12-31
NO954991L (no) 1996-02-15
US5681925A (en) 1997-10-28
NZ268159A (en) 1997-03-24
CA2164712C (en) 2000-03-28
DE69432983T2 (de) 2004-04-29
KR100330465B1 (ko) 2002-11-23
ATE246203T1 (de) 2003-08-15

Similar Documents

Publication Publication Date Title
NO984928L (no) Pyrazinontrombininhibitorer
DE69411477D1 (de) Videosynchronisiering von mehrfachquellen.
SE9301270D0 (sv) Biosensor
ATE236656T1 (de) Eingeschränktes multifunktionelles reagens zur oberflächenmodifikation
DK0925319T3 (da) Triazinpolymerer og deres anvendelse i elektroluminescerende arrangementer
LU88295I2 (fr) Fosinopril (Fosinil)
ATE148130T1 (de) Typ-iv-dipeptidyl-aminopeptidase-inhibitoren
DE3873793D1 (de) Erzeugung von brennbarem gas.
DE69416070D1 (de) Propfung von monomeren auf polyolefinen in gegenwart organischer peroxide
FI953916A0 (fi) Fibrinogeenireseptoriantagonisteja
EP0627684A3 (en) Specifying contexts in callback style programming.
AU8600082A (en) Radioimmunoassay for fibrinopeptide a using a tripeptide thrombin inhibitor
ATE246203T1 (de) Trifunktionelle antithrombin-und antiplättchenpeptide
FI925696A7 (fi) Hirudiinin aminohapposekvenssiin perustuvia trombiininestäjiä
DK258283D0 (da) Fremgangsmade til fremstilling af et heparinfragment med en molekylvaegt pa 20000 til 5500 og kovalent bundet til antithrombin iii
DE69628951D1 (de) Verfahren zur herstellung von holzplatten durch kleben und eine platte
ATA75493A (de) Holzbeleimungsmaschine
DK0556906T3 (da) Kalibrator og dens anvendelse til en immunanalyse
FI955789A7 (fi) Vedetön itse-emulgoituva kemiallinen pehmennyskoostumus, joka on käyttökelpoinen kuitumaisissa selluloosamateriaaleissa
ATE154963T1 (de) Bauelement
MD930024A (ro) Procedeu pentru scaderea aciditatii mustului sau vinului din poama
GB9506212D0 (en) Bifunctional thrombin inhibitors bearing highly truncated fibrinogen recognition exosite binding component
ATA231493A (de) Holzentrindungsmaschine
SE8602020D0 (sv) Lopytebelag for skidor, speciellt langdistansskidor
ES2010863A6 (es) Envase para vinos y similares.

Legal Events

Date Code Title Description
FD Application lapsed

Free format text: APPLICATION REJECTED