KR100330465B1 - 삼관능성항트롬빈및항혈소판펩티드 - Google Patents

삼관능성항트롬빈및항혈소판펩티드 Download PDF

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Publication number
KR100330465B1
KR100330465B1 KR1019950705595A KR19950705595A KR100330465B1 KR 100330465 B1 KR100330465 B1 KR 100330465B1 KR 1019950705595 A KR1019950705595 A KR 1019950705595A KR 19950705595 A KR19950705595 A KR 19950705595A KR 100330465 B1 KR100330465 B1 KR 100330465B1
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KR
South Korea
Prior art keywords
peptide
seq
gly
pro
xaa
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Expired - Fee Related
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KR1019950705595A
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English (en)
Korean (ko)
Inventor
로버트 제이.쥬니어 브로어스마
토마스 제이. 오웬
존 엘. 크르스테난스키
Original Assignee
메렐 파마슈티칼스 인크.
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Publication of KR100330465B1 publication Critical patent/KR100330465B1/ko
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/75—Fibrinogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1019950705595A 1993-06-11 1994-05-13 삼관능성항트롬빈및항혈소판펩티드 Expired - Fee Related KR100330465B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US7606693A 1993-06-11 1993-06-11
US08/076066 1993-06-11
PCT/US1994/005355 WO1994029349A1 (en) 1993-06-11 1994-05-13 Trifunctional antithrombin and antiplatelet peptides

Publications (1)

Publication Number Publication Date
KR100330465B1 true KR100330465B1 (ko) 2002-11-23

Family

ID=22129739

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019950705595A Expired - Fee Related KR100330465B1 (ko) 1993-06-11 1994-05-13 삼관능성항트롬빈및항혈소판펩티드

Country Status (20)

Country Link
US (1) US5681925A (enExample)
EP (1) EP0702696B1 (enExample)
JP (1) JP3532920B2 (enExample)
KR (1) KR100330465B1 (enExample)
CN (1) CN1124964A (enExample)
AT (1) ATE246203T1 (enExample)
AU (1) AU685470B2 (enExample)
CA (1) CA2164712C (enExample)
DE (1) DE69432983T2 (enExample)
DK (1) DK0702696T3 (enExample)
ES (1) ES2199963T3 (enExample)
FI (1) FI955905A0 (enExample)
HU (1) HUT73187A (enExample)
IL (1) IL109931A0 (enExample)
NO (1) NO954991L (enExample)
NZ (1) NZ268159A (enExample)
PT (1) PT702696E (enExample)
TW (1) TW295590B (enExample)
WO (1) WO1994029349A1 (enExample)
ZA (1) ZA943958B (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6235877B1 (en) 1999-08-04 2001-05-22 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Peptido-mimetic compounds containing RGD sequence useful as integrin inhibitors
CN101094867B (zh) 2004-10-19 2011-08-24 隆萨股份公司 用于固相肽合成的方法
WO2011079015A1 (en) * 2009-12-21 2011-06-30 The Regents Of The University Of California Rgd-containing cyclic peptides
CA3109702A1 (en) 2018-08-13 2020-02-20 Signablok, Inc. Peptides and compositions for targeted treatment and imaging
CN117143194B (zh) * 2023-11-01 2024-02-06 北京大学第一医院 抗血小板聚集多肽、其制备方法及应用

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4792525A (en) * 1982-08-04 1988-12-20 La Jolla Cancer Research Foundation Tetrapeptide
DE3438296A1 (de) * 1984-04-18 1985-11-07 Hoechst Ag, 6230 Frankfurt Neue polypeptide mit blutgerinnungshemmender wirkung, verfahren zu deren herstellung bzw. gewinnung, deren verwendung und diese enthaltende mittel
DE3445532A1 (de) * 1984-12-13 1986-06-19 Plantorgan Werk Heinrich G.E. Christensen, KG, 2903 Bad Zwischenahn Hirudin-pa, desulfatohirudine-pa, verfahren zur herstellung und pharmazeutische mittel, die diese wirkstoffe enthalten
CA1341032C (en) * 1987-01-23 2000-06-20 John L. Krstenansky Anticoagulant peptides
AU3098289A (en) * 1988-03-04 1989-09-07 Biogen, Inc. Hirudin peptides
FR2628429B1 (fr) * 1988-03-08 1990-12-28 Transgene Sa Variants de l'hirudine, leurs utilisations et les procedes pour les obtenir
NZ228995A (en) * 1988-05-10 1992-03-26 Merrell Dow Pharma Hirudin peptide derivatives and pharmaceutical compositions
DE58907266T2 (de) * 1988-06-11 1994-09-29 Ciba Geigy Ag Polypeptide mit einer die Koagulierung hemmenden Wirkung.
WO1990006128A1 (en) * 1988-12-05 1990-06-14 Biogen, Inc. Methods and compositions for inhibiting platelet aggregation
AU630132B2 (en) * 1988-12-07 1992-10-22 Merrell Dow Pharmaceuticals Inc. Anticoagulant peptides
US5182260A (en) * 1989-01-27 1993-01-26 Biogen, Inc. Dna sequences encoding snake venom inhibitors of platelet activation processes for producing those inhibitors and compositions using them
EP0382451A3 (en) * 1989-02-07 1991-05-29 Merck & Co. Inc. Viper venom polypeptides and variants
WO1990015072A1 (en) * 1989-06-07 1990-12-13 Genentech, Inc. Platelet aggregation inhibitors and related molecules
US5196404B1 (en) * 1989-08-18 1996-09-10 Biogen Inc Inhibitors of thrombin
ZA907742B (en) * 1989-10-03 1991-07-31 Merrell Dow Pharma Anticoagulant peptides
CA2026377A1 (en) * 1989-10-03 1991-04-04 John L. Krstenansky Radiolabeled anticoagulant peptides
WO1991011458A1 (en) * 1990-02-02 1991-08-08 Genentech, Inc. CYCLIC PEPTIDES CONTAINING Arg-Gly-Asp FLANKED BY PROLINE
JP2669510B2 (ja) * 1990-06-15 1997-10-29 ナショナル・リサーチ・カウンシル・オブ カナダ ヒルジンのアミノ酸配列に基づくトロンビン阻害剤
IT1243358B (it) * 1990-07-23 1994-06-10 Iketon Farmaceutici Srl Composizioni farmaceutiche per la somministrazione orale di irudina
AU640502B2 (en) * 1990-07-24 1993-08-26 Merrell Dow Pharmaceuticals Inc. Analogs of hirudin having antiplatelet activity
US5118790A (en) * 1990-07-24 1992-06-02 Sri International Analogs of hirudin
GB9023149D0 (en) * 1990-10-24 1990-12-05 British Bio Technology Proteins and nucleic acids
US5242810A (en) * 1990-12-07 1993-09-07 Biogen, Inc. Bifunctional inhibitors of thrombin and platelet activation

Also Published As

Publication number Publication date
CA2164712A1 (en) 1994-12-22
AU685470B2 (en) 1998-01-22
EP0702696A1 (en) 1996-03-27
FI955905A7 (fi) 1995-12-08
TW295590B (enExample) 1997-01-11
NO954991D0 (no) 1995-12-08
CN1124964A (zh) 1996-06-19
DK0702696T3 (da) 2003-11-17
AU7093894A (en) 1995-01-03
HU9503530D0 (en) 1996-02-28
JPH08511518A (ja) 1996-12-03
ZA943958B (en) 1995-02-22
IL109931A0 (en) 1994-10-07
JP3532920B2 (ja) 2004-05-31
ES2199963T3 (es) 2004-03-01
HUT73187A (en) 1996-06-28
EP0702696B1 (en) 2003-07-30
WO1994029349A1 (en) 1994-12-22
DE69432983D1 (de) 2003-09-04
PT702696E (pt) 2003-12-31
NO954991L (no) 1996-02-15
FI955905A0 (fi) 1995-12-08
US5681925A (en) 1997-10-28
NZ268159A (en) 1997-03-24
CA2164712C (en) 2000-03-28
DE69432983T2 (de) 2004-04-29
ATE246203T1 (de) 2003-08-15

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