FI955905A0 - Trifunktionaalisia trombiinivastaisia ja verihiutalevastaisia peptidejä - Google Patents

Trifunktionaalisia trombiinivastaisia ja verihiutalevastaisia peptidejä

Info

Publication number
FI955905A0
FI955905A0 FI955905A FI955905A FI955905A0 FI 955905 A0 FI955905 A0 FI 955905A0 FI 955905 A FI955905 A FI 955905A FI 955905 A FI955905 A FI 955905A FI 955905 A0 FI955905 A0 FI 955905A0
Authority
FI
Finland
Prior art keywords
trifunctional
antithrombin
antiplatelet peptides
rgd
contain
Prior art date
Application number
FI955905A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI955905A7 (fi
Inventor
Jr Robert James Broersma
Thomas Joseph Owen
John Leonard Krstenansky
Original Assignee
Merrell Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Pharma Inc filed Critical Merrell Pharma Inc
Publication of FI955905A7 publication Critical patent/FI955905A7/fi
Publication of FI955905A0 publication Critical patent/FI955905A0/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/75—Fibrinogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Toxicology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Zoology (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FI955905A 1993-06-11 1995-12-08 Trifunktionaalisia trombiinivastaisia ja verihiutalevastaisia peptidejä FI955905A0 (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7606693A 1993-06-11 1993-06-11
PCT/US1994/005355 WO1994029349A1 (en) 1993-06-11 1994-05-13 Trifunctional antithrombin and antiplatelet peptides

Publications (2)

Publication Number Publication Date
FI955905A7 FI955905A7 (fi) 1995-12-08
FI955905A0 true FI955905A0 (fi) 1995-12-08

Family

ID=22129739

Family Applications (1)

Application Number Title Priority Date Filing Date
FI955905A FI955905A0 (fi) 1993-06-11 1995-12-08 Trifunktionaalisia trombiinivastaisia ja verihiutalevastaisia peptidejä

Country Status (20)

Country Link
US (1) US5681925A (cs)
EP (1) EP0702696B1 (cs)
JP (1) JP3532920B2 (cs)
KR (1) KR100330465B1 (cs)
CN (1) CN1124964A (cs)
AT (1) ATE246203T1 (cs)
AU (1) AU685470B2 (cs)
CA (1) CA2164712C (cs)
DE (1) DE69432983T2 (cs)
DK (1) DK0702696T3 (cs)
ES (1) ES2199963T3 (cs)
FI (1) FI955905A0 (cs)
HU (1) HUT73187A (cs)
IL (1) IL109931A0 (cs)
NO (1) NO954991L (cs)
NZ (1) NZ268159A (cs)
PT (1) PT702696E (cs)
TW (1) TW295590B (cs)
WO (1) WO1994029349A1 (cs)
ZA (1) ZA943958B (cs)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6235877B1 (en) 1999-08-04 2001-05-22 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Peptido-mimetic compounds containing RGD sequence useful as integrin inhibitors
CN102225966B (zh) 2004-10-19 2012-12-26 隆萨股份公司 用于固相肽合成的方法
US9073974B2 (en) * 2009-12-21 2015-07-07 The Regents Of The University Of California RGD-containing cyclic peptides
EP3836951A1 (en) 2018-08-13 2021-06-23 Signablok, Inc. Peptides and compositions for targeted treatment and imaging
CN117143194B (zh) * 2023-11-01 2024-02-06 北京大学第一医院 抗血小板聚集多肽、其制备方法及应用

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4792525A (en) * 1982-08-04 1988-12-20 La Jolla Cancer Research Foundation Tetrapeptide
DE3438296A1 (de) * 1984-04-18 1985-11-07 Hoechst Ag, 6230 Frankfurt Neue polypeptide mit blutgerinnungshemmender wirkung, verfahren zu deren herstellung bzw. gewinnung, deren verwendung und diese enthaltende mittel
DE3445532A1 (de) * 1984-12-13 1986-06-19 Plantorgan Werk Heinrich G.E. Christensen, KG, 2903 Bad Zwischenahn Hirudin-pa, desulfatohirudine-pa, verfahren zur herstellung und pharmazeutische mittel, die diese wirkstoffe enthalten
CA1341032C (en) * 1987-01-23 2000-06-20 John L. Krstenansky Anticoagulant peptides
EP0333356A3 (en) * 1988-03-04 1990-12-19 Biogen, Inc. Hirudin peptides
FR2628429B1 (fr) * 1988-03-08 1990-12-28 Transgene Sa Variants de l'hirudine, leurs utilisations et les procedes pour les obtenir
NZ228995A (en) * 1988-05-10 1992-03-26 Merrell Dow Pharma Hirudin peptide derivatives and pharmaceutical compositions
DE58907266T2 (de) * 1988-06-11 1994-09-29 Ciba Geigy Ag Polypeptide mit einer die Koagulierung hemmenden Wirkung.
FI904329A7 (fi) * 1988-12-05 1990-09-03 Biogen Inc Menetelmiä ja koostumuksia verihiutaleiden aggregaation ehkäisemiseksi
AU630132B2 (en) * 1988-12-07 1992-10-22 Merrell Dow Pharmaceuticals Inc. Anticoagulant peptides
US5182260A (en) * 1989-01-27 1993-01-26 Biogen, Inc. Dna sequences encoding snake venom inhibitors of platelet activation processes for producing those inhibitors and compositions using them
EP0382451A3 (en) * 1989-02-07 1991-05-29 Merck & Co. Inc. Viper venom polypeptides and variants
WO1990015072A1 (en) * 1989-06-07 1990-12-13 Genentech, Inc. Platelet aggregation inhibitors and related molecules
US5196404B1 (en) * 1989-08-18 1996-09-10 Biogen Inc Inhibitors of thrombin
ZA907742B (en) * 1989-10-03 1991-07-31 Merrell Dow Pharma Anticoagulant peptides
CA2026377A1 (en) * 1989-10-03 1991-04-04 John L. Krstenansky Radiolabeled anticoagulant peptides
CA2073696A1 (en) * 1990-02-02 1991-08-03 Peter L. Barker Cyclic peptides containing arg-gly-asp flanked by proline
KR100212162B1 (ko) * 1990-06-15 1999-08-02 루시에 라포인테-쇼우, 카르타 커티 케이 히루딘의 아미노산 시퀸스를 기재로 한 트롬빈 억제제
IT1243358B (it) * 1990-07-23 1994-06-10 Iketon Farmaceutici Srl Composizioni farmaceutiche per la somministrazione orale di irudina
AU640502B2 (en) * 1990-07-24 1993-08-26 Merrell Dow Pharmaceuticals Inc. Analogs of hirudin having antiplatelet activity
US5118790A (en) * 1990-07-24 1992-06-02 Sri International Analogs of hirudin
GB9023149D0 (en) * 1990-10-24 1990-12-05 British Bio Technology Proteins and nucleic acids
US5242810A (en) * 1990-12-07 1993-09-07 Biogen, Inc. Bifunctional inhibitors of thrombin and platelet activation

Also Published As

Publication number Publication date
KR100330465B1 (ko) 2002-11-23
ZA943958B (en) 1995-02-22
AU7093894A (en) 1995-01-03
EP0702696A1 (en) 1996-03-27
HU9503530D0 (en) 1996-02-28
DE69432983D1 (de) 2003-09-04
JPH08511518A (ja) 1996-12-03
HUT73187A (en) 1996-06-28
ES2199963T3 (es) 2004-03-01
IL109931A0 (en) 1994-10-07
DE69432983T2 (de) 2004-04-29
US5681925A (en) 1997-10-28
EP0702696B1 (en) 2003-07-30
NO954991D0 (no) 1995-12-08
CA2164712A1 (en) 1994-12-22
PT702696E (pt) 2003-12-31
NZ268159A (en) 1997-03-24
NO954991L (no) 1996-02-15
FI955905A7 (fi) 1995-12-08
DK0702696T3 (da) 2003-11-17
CN1124964A (zh) 1996-06-19
ATE246203T1 (de) 2003-08-15
WO1994029349A1 (en) 1994-12-22
TW295590B (cs) 1997-01-11
CA2164712C (en) 2000-03-28
AU685470B2 (en) 1998-01-22
JP3532920B2 (ja) 2004-05-31

Similar Documents

Publication Publication Date Title
NO984928L (no) Pyrazinontrombininhibitorer
LU88295I2 (fr) Fosinopril (Fosinil)
DE3873793D1 (de) Erzeugung von brennbarem gas.
DE58902347D1 (de) Anlage zur verdichtung von wasserstoffgas.
ATE234091T1 (de) Thrombin inhibitoren
DE59802763D1 (de) Vorrichtung zum verbinden von armierten betonteilen
DE69416070D1 (de) Propfung von monomeren auf polyolefinen in gegenwart organischer peroxide
FI955905A0 (fi) Trifunktionaalisia trombiinivastaisia ja verihiutalevastaisia peptidejä
SE9704118D0 (sv) Regel för trävägg
FI925696A7 (fi) Hirudiinin aminohapposekvenssiin perustuvia trombiininestäjiä
DK258283A (da) Fremgangsmaade til fremstilling af et heparinfragment med en molekylvaegt paa 2000 til 5500 og kovalent bundet til antithrombin iii
DE69628951D1 (de) Verfahren zur herstellung von holzplatten durch kleben und eine platte
DK0556906T3 (da) Kalibrator og dens anvendelse til en immunanalyse
GB9506212D0 (en) Bifunctional thrombin inhibitors bearing highly truncated fibrinogen recognition exosite binding component
ATA231493A (de) Holzentrindungsmaschine
DK0612596T3 (da) Naturtræsplade, naturtræslaminatplade og fremgangsmåde til at fremstille disse
DE68902269D1 (de) Hygroskopische, insektenbestaendigmachende zusammensetzung.
FI96264B (fi) Laitteisto puun kaatamiseksi
ITMI930102A0 (it) Inibitori della trombina
FI930043L (fi) Polttopuiden halkaisulaite
SU1596698A1 (ru) 5-α,α-ДИМЕТИЛБЕНЗИЛ-2-ГИДРОКСИБЕНЗОАТ БЕНЗИЛГЕКСАМЕТИЛЕНТЕТРАММОНИЯ В КАЧЕСТВЕ ИНГИБИТОРА КОРРОЗИИ СТАЛИ В МИНЕРАЛИЗОВАННЫХ СРЕДАХ
ES1020627U (es) Modulo de alambre apilable.
KR940023943U (ko) 목재 박판 신발창
SE8306306D0 (sv) The improvements in timber handling machinery
KR940024531U (ko) 합지 무늬목

Legal Events

Date Code Title Description
FD Application lapsed

Free format text: APPLICATION REJECTED