ZA943958B - Trifunctional antithrombin and antiplatelet peptides - Google Patents
Trifunctional antithrombin and antiplatelet peptidesInfo
- Publication number
- ZA943958B ZA943958B ZA943958A ZA943958A ZA943958B ZA 943958 B ZA943958 B ZA 943958B ZA 943958 A ZA943958 A ZA 943958A ZA 943958 A ZA943958 A ZA 943958A ZA 943958 B ZA943958 B ZA 943958B
- Authority
- ZA
- South Africa
- Prior art keywords
- trifunctional
- antithrombin
- antiplatelet peptides
- rgd
- contain
- Prior art date
Links
- 239000003146 anticoagulant agent Substances 0.000 title abstract 2
- 230000000702 anti-platelet effect Effects 0.000 title 1
- 239000004019 antithrombin Substances 0.000 title 1
- 102000004196 processed proteins & peptides Human genes 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 title 1
- 108090000190 Thrombin Proteins 0.000 abstract 1
- 150000001450 anions Chemical class 0.000 abstract 1
- 229940127219 anticoagulant drug Drugs 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 229960004072 thrombin Drugs 0.000 abstract 1
- 230000001732 thrombotic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/75—Fibrinogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Hematology (AREA)
- Toxicology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Zoology (AREA)
- Diabetes (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Materials For Medical Uses (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7606693A | 1993-06-11 | 1993-06-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA943958B true ZA943958B (en) | 1995-02-22 |
Family
ID=22129739
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA943958A ZA943958B (en) | 1993-06-11 | 1994-06-06 | Trifunctional antithrombin and antiplatelet peptides |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US5681925A (cs) |
| EP (1) | EP0702696B1 (cs) |
| JP (1) | JP3532920B2 (cs) |
| KR (1) | KR100330465B1 (cs) |
| CN (1) | CN1124964A (cs) |
| AT (1) | ATE246203T1 (cs) |
| AU (1) | AU685470B2 (cs) |
| CA (1) | CA2164712C (cs) |
| DE (1) | DE69432983T2 (cs) |
| DK (1) | DK0702696T3 (cs) |
| ES (1) | ES2199963T3 (cs) |
| FI (1) | FI955905A0 (cs) |
| HU (1) | HUT73187A (cs) |
| IL (1) | IL109931A0 (cs) |
| NO (1) | NO954991L (cs) |
| NZ (1) | NZ268159A (cs) |
| PT (1) | PT702696E (cs) |
| TW (1) | TW295590B (cs) |
| WO (1) | WO1994029349A1 (cs) |
| ZA (1) | ZA943958B (cs) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6235877B1 (en) | 1999-08-04 | 2001-05-22 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Peptido-mimetic compounds containing RGD sequence useful as integrin inhibitors |
| CN102225966B (zh) | 2004-10-19 | 2012-12-26 | 隆萨股份公司 | 用于固相肽合成的方法 |
| US9073974B2 (en) * | 2009-12-21 | 2015-07-07 | The Regents Of The University Of California | RGD-containing cyclic peptides |
| EP3836951A1 (en) | 2018-08-13 | 2021-06-23 | Signablok, Inc. | Peptides and compositions for targeted treatment and imaging |
| CN117143194B (zh) * | 2023-11-01 | 2024-02-06 | 北京大学第一医院 | 抗血小板聚集多肽、其制备方法及应用 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4792525A (en) * | 1982-08-04 | 1988-12-20 | La Jolla Cancer Research Foundation | Tetrapeptide |
| DE3438296A1 (de) * | 1984-04-18 | 1985-11-07 | Hoechst Ag, 6230 Frankfurt | Neue polypeptide mit blutgerinnungshemmender wirkung, verfahren zu deren herstellung bzw. gewinnung, deren verwendung und diese enthaltende mittel |
| DE3445532A1 (de) * | 1984-12-13 | 1986-06-19 | Plantorgan Werk Heinrich G.E. Christensen, KG, 2903 Bad Zwischenahn | Hirudin-pa, desulfatohirudine-pa, verfahren zur herstellung und pharmazeutische mittel, die diese wirkstoffe enthalten |
| CA1341032C (en) * | 1987-01-23 | 2000-06-20 | John L. Krstenansky | Anticoagulant peptides |
| EP0333356A3 (en) * | 1988-03-04 | 1990-12-19 | Biogen, Inc. | Hirudin peptides |
| FR2628429B1 (fr) * | 1988-03-08 | 1990-12-28 | Transgene Sa | Variants de l'hirudine, leurs utilisations et les procedes pour les obtenir |
| NZ228995A (en) * | 1988-05-10 | 1992-03-26 | Merrell Dow Pharma | Hirudin peptide derivatives and pharmaceutical compositions |
| DE58907266T2 (de) * | 1988-06-11 | 1994-09-29 | Ciba Geigy Ag | Polypeptide mit einer die Koagulierung hemmenden Wirkung. |
| FI904329A7 (fi) * | 1988-12-05 | 1990-09-03 | Biogen Inc | Menetelmiä ja koostumuksia verihiutaleiden aggregaation ehkäisemiseksi |
| AU630132B2 (en) * | 1988-12-07 | 1992-10-22 | Merrell Dow Pharmaceuticals Inc. | Anticoagulant peptides |
| US5182260A (en) * | 1989-01-27 | 1993-01-26 | Biogen, Inc. | Dna sequences encoding snake venom inhibitors of platelet activation processes for producing those inhibitors and compositions using them |
| EP0382451A3 (en) * | 1989-02-07 | 1991-05-29 | Merck & Co. Inc. | Viper venom polypeptides and variants |
| WO1990015072A1 (en) * | 1989-06-07 | 1990-12-13 | Genentech, Inc. | Platelet aggregation inhibitors and related molecules |
| US5196404B1 (en) * | 1989-08-18 | 1996-09-10 | Biogen Inc | Inhibitors of thrombin |
| ZA907742B (en) * | 1989-10-03 | 1991-07-31 | Merrell Dow Pharma | Anticoagulant peptides |
| CA2026377A1 (en) * | 1989-10-03 | 1991-04-04 | John L. Krstenansky | Radiolabeled anticoagulant peptides |
| CA2073696A1 (en) * | 1990-02-02 | 1991-08-03 | Peter L. Barker | Cyclic peptides containing arg-gly-asp flanked by proline |
| KR100212162B1 (ko) * | 1990-06-15 | 1999-08-02 | 루시에 라포인테-쇼우, 카르타 커티 케이 | 히루딘의 아미노산 시퀸스를 기재로 한 트롬빈 억제제 |
| IT1243358B (it) * | 1990-07-23 | 1994-06-10 | Iketon Farmaceutici Srl | Composizioni farmaceutiche per la somministrazione orale di irudina |
| AU640502B2 (en) * | 1990-07-24 | 1993-08-26 | Merrell Dow Pharmaceuticals Inc. | Analogs of hirudin having antiplatelet activity |
| US5118790A (en) * | 1990-07-24 | 1992-06-02 | Sri International | Analogs of hirudin |
| GB9023149D0 (en) * | 1990-10-24 | 1990-12-05 | British Bio Technology | Proteins and nucleic acids |
| US5242810A (en) * | 1990-12-07 | 1993-09-07 | Biogen, Inc. | Bifunctional inhibitors of thrombin and platelet activation |
-
1994
- 1994-05-13 ES ES94920004T patent/ES2199963T3/es not_active Expired - Lifetime
- 1994-05-13 KR KR1019950705595A patent/KR100330465B1/ko not_active Expired - Fee Related
- 1994-05-13 DE DE69432983T patent/DE69432983T2/de not_active Expired - Fee Related
- 1994-05-13 JP JP50179095A patent/JP3532920B2/ja not_active Expired - Fee Related
- 1994-05-13 EP EP94920004A patent/EP0702696B1/en not_active Expired - Lifetime
- 1994-05-13 WO PCT/US1994/005355 patent/WO1994029349A1/en active IP Right Grant
- 1994-05-13 AU AU70938/94A patent/AU685470B2/en not_active Ceased
- 1994-05-13 DK DK94920004T patent/DK0702696T3/da active
- 1994-05-13 PT PT94920004T patent/PT702696E/pt unknown
- 1994-05-13 CA CA002164712A patent/CA2164712C/en not_active Expired - Fee Related
- 1994-05-13 HU HU9503530A patent/HUT73187A/hu unknown
- 1994-05-13 AT AT94920004T patent/ATE246203T1/de not_active IP Right Cessation
- 1994-05-13 CN CN94192393A patent/CN1124964A/zh active Pending
- 1994-05-13 NZ NZ268159A patent/NZ268159A/en unknown
- 1994-06-06 ZA ZA943958A patent/ZA943958B/xx unknown
- 1994-06-07 TW TW083105188A patent/TW295590B/zh active
- 1994-06-08 IL IL10993194A patent/IL109931A0/xx unknown
-
1995
- 1995-07-17 US US08/502,989 patent/US5681925A/en not_active Expired - Lifetime
- 1995-12-08 FI FI955905A patent/FI955905A0/fi not_active Application Discontinuation
- 1995-12-08 NO NO954991A patent/NO954991L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR100330465B1 (ko) | 2002-11-23 |
| AU7093894A (en) | 1995-01-03 |
| EP0702696A1 (en) | 1996-03-27 |
| HU9503530D0 (en) | 1996-02-28 |
| DE69432983D1 (de) | 2003-09-04 |
| JPH08511518A (ja) | 1996-12-03 |
| HUT73187A (en) | 1996-06-28 |
| ES2199963T3 (es) | 2004-03-01 |
| IL109931A0 (en) | 1994-10-07 |
| DE69432983T2 (de) | 2004-04-29 |
| US5681925A (en) | 1997-10-28 |
| EP0702696B1 (en) | 2003-07-30 |
| NO954991D0 (no) | 1995-12-08 |
| CA2164712A1 (en) | 1994-12-22 |
| PT702696E (pt) | 2003-12-31 |
| NZ268159A (en) | 1997-03-24 |
| NO954991L (no) | 1996-02-15 |
| FI955905A7 (fi) | 1995-12-08 |
| DK0702696T3 (da) | 2003-11-17 |
| CN1124964A (zh) | 1996-06-19 |
| ATE246203T1 (de) | 2003-08-15 |
| WO1994029349A1 (en) | 1994-12-22 |
| FI955905A0 (fi) | 1995-12-08 |
| TW295590B (cs) | 1997-01-11 |
| CA2164712C (en) | 2000-03-28 |
| AU685470B2 (en) | 1998-01-22 |
| JP3532920B2 (ja) | 2004-05-31 |
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