FI951129A - PNA-synteesi käyttämällä emästen suhteen labiilia aminonsuojaryhmää - Google Patents

PNA-synteesi käyttämällä emästen suhteen labiilia aminonsuojaryhmää Download PDF

Info

Publication number
FI951129A
FI951129A FI951129A FI951129A FI951129A FI 951129 A FI951129 A FI 951129A FI 951129 A FI951129 A FI 951129A FI 951129 A FI951129 A FI 951129A FI 951129 A FI951129 A FI 951129A
Authority
FI
Finland
Prior art keywords
polymer
formula
base
opt
coupling
Prior art date
Application number
FI951129A
Other languages
English (en)
Swedish (sv)
Other versions
FI120262B (fi
FI951129A0 (fi
Inventor
Gerhard Breipohl
Eugen Uhlmann
Jochen Knolle
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of FI951129A0 publication Critical patent/FI951129A0/fi
Publication of FI951129A publication Critical patent/FI951129A/fi
Application granted granted Critical
Publication of FI120262B publication Critical patent/FI120262B/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • C07K14/003—Peptide-nucleic acids (PNAs)
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
    • C08G69/02—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids
    • C08G69/08—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids derived from amino-carboxylic acids
    • C08G69/10—Alpha-amino-carboxylic acids
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Polymers & Plastics (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polyamides (AREA)
FI951129A 1994-03-14 1995-03-10 PNA-synteesi käyttämällä emästen suhteen labiilia aminonsuojaryhmää FI120262B (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4408533A DE4408533A1 (de) 1994-03-14 1994-03-14 PNA-Synthese unter Verwendung einer basenlabilen Amino-Schutzgruppe
DE4408533 1994-03-14

Publications (3)

Publication Number Publication Date
FI951129A0 FI951129A0 (fi) 1995-03-10
FI951129A true FI951129A (fi) 1995-09-15
FI120262B FI120262B (fi) 2009-08-31

Family

ID=6512697

Family Applications (1)

Application Number Title Priority Date Filing Date
FI951129A FI120262B (fi) 1994-03-14 1995-03-10 PNA-synteesi käyttämällä emästen suhteen labiilia aminonsuojaryhmää

Country Status (12)

Country Link
US (2) US6121418A (fi)
EP (1) EP0672701B1 (fi)
JP (1) JP4098836B2 (fi)
AT (1) ATE182602T1 (fi)
AU (1) AU683714B2 (fi)
CA (1) CA2144473C (fi)
DE (2) DE4408533A1 (fi)
DK (1) DK0672701T3 (fi)
ES (1) ES2136755T3 (fi)
FI (1) FI120262B (fi)
GR (1) GR3031265T3 (fi)
NO (1) NO321035B1 (fi)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7825215B1 (en) 1993-04-26 2010-11-02 Peter E. Nielsen Substituted nucleic acid mimics
US6133444A (en) * 1993-12-22 2000-10-17 Perseptive Biosystems, Inc. Synthons for the synthesis and deprotection of peptide nucleic acids under mild conditions
DE69632324T2 (de) 1995-06-07 2005-06-16 PerSeptive Biosystems, Inc., Framingham Pna-dna-chimäre und pna-synthone zu deren herstellung
DE19712530A1 (de) * 1997-03-25 1998-10-01 Boehringer Mannheim Gmbh Neue Monomerbausteine zur Markierung von peptidischen Nukleinsäuren
US20030228619A1 (en) * 2002-06-10 2003-12-11 Xenoport, Inc. Peptide nucleic acids as tags in encoded libraries
JP4588451B2 (ja) * 2002-09-08 2010-12-01 アプライド バイオシステムズ， エルエルシー Ｐｎａダイマーおよびｐｎａオリゴマー合成に関する方法、組成物およびライブラリー
EP1981507A4 (en) * 2006-02-01 2011-10-19 Merck Sharp & Dohme INHIBITORS OF THE POTASSIUM CANAL
ES2745504T3 (es) 2011-04-08 2020-03-02 Univ Carnegie Mellon Acidos nucleicos peptídicos gamma que contienen miniPEG preorganizados conformacionalmente
CN104211619B (zh) * 2014-08-19 2016-08-17 苏州维泰生物技术有限公司 一种N-(2-Fmoc-氨乙基)甘氨酸甲酯盐酸盐的合成方法
AU2018240467B2 (en) * 2017-03-23 2022-09-15 Neubase Therapeutics, Inc. Peptide nucleic acid (PNA) monomers with an orthogonally protected ester moiety

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUT41715A (en) * 1984-12-28 1987-05-28 Monsanto Co Process for preparing n-substituted alpha-aminoacids and derivatives thereof
DE3635670A1 (de) 1986-10-21 1988-04-28 Hoechst Ag Synthese von peptid-aminoalkylamiden und peptidhydraziden mittels festphasenmethode
DE3713433A1 (de) 1987-04-22 1988-11-03 Werner Grossmann Einrichtung zum entfernen von schmutzteilchen vom plattenzylinder einer offsetdruckmaschine
ES2061714T3 (es) 1987-12-22 1994-12-16 Hoechst Ag Grupos de anclaje inestables frente a acidos para la sintesis de amidas peptidicas mediante el metodo en fase solida.
DE4016596A1 (de) 1990-05-23 1991-11-28 Hoechst Ag Ein neues kupplungsreagenz fuer die peptidsynthese
US5539082A (en) * 1993-04-26 1996-07-23 Nielsen; Peter E. Peptide nucleic acids
DK51092D0 (da) * 1991-05-24 1992-04-15 Ole Buchardt Oligonucleotid-analoge betegnet pna, monomere synthoner og fremgangsmaade til fremstilling deraf samt anvendelser deraf
MX9207334A (es) * 1991-12-18 1993-08-01 Glaxo Inc Acidos nucleicos peptidicos y formulacion farma- ceutica que los contiene
US5527675A (en) * 1993-08-20 1996-06-18 Millipore Corporation Method for degradation and sequencing of polymers which sequentially eliminate terminal residues
US5539083A (en) * 1994-02-23 1996-07-23 Isis Pharmaceuticals, Inc. Peptide nucleic acid combinatorial libraries and improved methods of synthesis

Also Published As

Publication number Publication date
NO950958D0 (no) 1995-03-13
DE4408533A1 (de) 1995-09-28
JPH07291909A (ja) 1995-11-07
AU1480095A (en) 1995-09-21
NO321035B1 (no) 2006-03-06
DE59506432D1 (de) 1999-09-02
EP0672701B1 (de) 1999-07-28
ATE182602T1 (de) 1999-08-15
GR3031265T3 (en) 1999-12-31
NO950958L (no) 1995-09-15
ES2136755T3 (es) 1999-12-01
JP4098836B2 (ja) 2008-06-11
CA2144473C (en) 2008-07-15
FI120262B (fi) 2009-08-31
CA2144473A1 (en) 1995-09-15
EP0672701A1 (de) 1995-09-20
FI951129A0 (fi) 1995-03-10
US6316595B1 (en) 2001-11-13
AU683714B2 (en) 1997-11-20
US6121418A (en) 2000-09-19
DK0672701T3 (da) 2000-01-03

Similar Documents

Publication Publication Date Title
NO950957D0 (no) PNA-syntese ved anvendelse av en labil amino-beskyttelsesgruppe
FI951129A (fi) PNA-synteesi käyttämällä emästen suhteen labiilia aminonsuojaryhmää
JP2003530311A5 (fi)
US6172226B1 (en) Synthons for the synthesis and deprotection of peptide nucleic acids under mild conditions
HUP0102900A2 (hu) Javított szilárd fázisú peptidszintézis és a szintézisben alkalmazható anyagok
HUP0203149A2 (en) Heterobifunctional poly(ethylene glycol) derivatives and methods for their preparation
DK1442198T3 (da) Fremgangsmåde til opbrydning af en underjordisk formation ved brug af gelerende syrer
Hernández et al. Synthesis and ring‐opening (co) polymerization of L‐lysine N‐carboxyanhydrides containing labile side‐chain protective groups
EP0702682B1 (en) Process for the preparation of amino acid esters of nucleoside analogues
CA2245496A1 (en) Receptor protein designated 2f1
CA2210031A1 (en) Solid phase synthesis of oligonucleotides
CA2382931A1 (en) Synthesis of template-fixed .beta.-hairpin loop mimetics
Wang et al. Solid phase synthesis of neutral oligonucleotide analogues
Aldrian‐Herrada et al. Solid‐phase synthesis of peptide nucleic acid (PNA) monomers and their oligomerization using disulphide anchoring linkers
Uhlmann et al. Synthesis of polyamide nucleic acids (PNAs), PNA/DNA-chimeras and phosphonic ester nucleic acids (PHONAs)
Sigmund et al. A new type of fluorescence labeling of nucleosides, nucleotides and oligonucleotides
FR2732344A1 (fr) Oligonucleotides a liaison covalente transversale, procede de preparation et synthon utile dans le procede
Adamiak et al. STUDIES ON OLIGORIBONUCLEOTIDES
JPS6163696A (ja) 新しいペプチド
Repkova et al. Oligoribonucleotides containing an aminoalkyl group at the N (4) atom of cytosine as precursors of new reagents for site-specific modifications of biopolymers
HUP0100831A2 (hu) Eljárás n2-(1(s)karboxi-3-fenilpropil)-L-lizil-L-prolin előállítására
CS260187B1 (cs) Způsob výroby polyaramidů
UY25090A1 (es) Un procedimiento para preparar eprosartano

Legal Events

Date Code Title Description
FG Patent granted

Ref document number: 120262

Country of ref document: FI

MM Patent lapsed