ES2136755T3 - Sintesis de acidos nucleicos peptidicos (pna) con utilizacion de un grupo protector de amino inestable frente a bases. - Google Patents
Sintesis de acidos nucleicos peptidicos (pna) con utilizacion de un grupo protector de amino inestable frente a bases.Info
- Publication number
- ES2136755T3 ES2136755T3 ES95103319T ES95103319T ES2136755T3 ES 2136755 T3 ES2136755 T3 ES 2136755T3 ES 95103319 T ES95103319 T ES 95103319T ES 95103319 T ES95103319 T ES 95103319T ES 2136755 T3 ES2136755 T3 ES 2136755T3
- Authority
- ES
- Spain
- Prior art keywords
- polymer
- formula
- pna
- opt
- synthesis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom
- C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
- C07K14/003—Peptide-nucleic acids (PNAs)
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
- C08G69/02—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids
- C08G69/08—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids derived from amino-carboxylic acids
- C08G69/10—Alpha-amino-carboxylic acids
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biophysics (AREA)
- General Chemical & Material Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Polymers & Plastics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Polyamides (AREA)
Abstract
SE DESCRIBE UN PROCESO PARA LA ELABORACION DE OLIGOMEROS PNA DONDE R0 SIGNIFICA HIDROGENO, ALCANOIL, ALCOXICARBONIL, CICLOALCANOIL, AROIL, HETEROAROIL, O UN GRUPO, QUE ES ADECUADO PARA LA RECEPCION INTRACELULAR DE OLIGOMERO, A Y Q SON RESTOS AMINOACIDOS, K Y L SON 0 HASTA 20, N SIGNIFICA 1 HASTA 50, B ES UNA NUCLEOBASE HABITUAL EN LA QUIMICA DE NUCLEOTIDOS Y Q0 SIGNIFICA OH, NH2 O ALQUILAMINO QUE PUEDE SER SUSTITUIDO POR ON O NH2. CON ELLO SE DESDOBLAN LOS RESTOS AMINOACIDO Y LOS COMPONENTES DONDE PG ES UN GRUPO DE PROTECCION AMINO INESTABLE DE BASE Y B'' ES UNA NUCLEOBASE PROTEGIDA EN AMINOFUNCION EXOCICLICA, EN FORMA DE ETAPAS DE ACUERDO CON EL METODO DE FASE SOLIDA SOBRE UN SOPORTE POLIMERO, QUE ESTA PROVISTO CON UN GRUPO DE ANCLAJE. SIENDO ACOPLADO Y, DESPUES DE TERMINADA LA CONSTITUCION, SE DESDOBLAN LOS COMPUESTOS OBJETIVO POR MEDIO DE UNA REACCION DE DESDOBLAMIENTO DE SOPORTE POLIMERO. SE DESCRIBEN ADEMAS PRODUCTOS INTERMEDIOS DE OLIGOMEROS PNA ASI COMO PROCESO PARA SU ELABORACION.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4408533A DE4408533A1 (de) | 1994-03-14 | 1994-03-14 | PNA-Synthese unter Verwendung einer basenlabilen Amino-Schutzgruppe |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2136755T3 true ES2136755T3 (es) | 1999-12-01 |
Family
ID=6512697
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES95103319T Expired - Lifetime ES2136755T3 (es) | 1994-03-14 | 1995-03-08 | Sintesis de acidos nucleicos peptidicos (pna) con utilizacion de un grupo protector de amino inestable frente a bases. |
Country Status (12)
Country | Link |
---|---|
US (2) | US6121418A (es) |
EP (1) | EP0672701B1 (es) |
JP (1) | JP4098836B2 (es) |
AT (1) | ATE182602T1 (es) |
AU (1) | AU683714B2 (es) |
CA (1) | CA2144473C (es) |
DE (2) | DE4408533A1 (es) |
DK (1) | DK0672701T3 (es) |
ES (1) | ES2136755T3 (es) |
FI (1) | FI120262B (es) |
GR (1) | GR3031265T3 (es) |
NO (1) | NO321035B1 (es) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7825215B1 (en) * | 1993-04-26 | 2010-11-02 | Peter E. Nielsen | Substituted nucleic acid mimics |
US6133444A (en) * | 1993-12-22 | 2000-10-17 | Perseptive Biosystems, Inc. | Synthons for the synthesis and deprotection of peptide nucleic acids under mild conditions |
EP0840741B1 (en) * | 1995-06-07 | 2004-04-28 | Perseptive Biosystems, Inc. | Pna-dna chimeras and pna synthons for their preparation |
DE19712530A1 (de) * | 1997-03-25 | 1998-10-01 | Boehringer Mannheim Gmbh | Neue Monomerbausteine zur Markierung von peptidischen Nukleinsäuren |
US20030228619A1 (en) * | 2002-06-10 | 2003-12-11 | Xenoport, Inc. | Peptide nucleic acids as tags in encoded libraries |
US20040137469A1 (en) * | 2002-09-08 | 2004-07-15 | Casale Ralph A | Methods, compositions and libraries pertaining PNA dimer and PNA oligomer synthesis |
EP1981507A4 (en) * | 2006-02-01 | 2011-10-19 | Merck Sharp & Dohme | INHIBITORS OF THE POTASSIUM CANAL |
EP3913065A1 (en) | 2011-04-08 | 2021-11-24 | Carnegie Mellon University | Conformationally-preorganized, minipeg-containing gamma-peptide nucleic acids |
CN104211619B (zh) * | 2014-08-19 | 2016-08-17 | 苏州维泰生物技术有限公司 | 一种N-(2-Fmoc-氨乙基)甘氨酸甲酯盐酸盐的合成方法 |
CN110740994A (zh) * | 2017-03-23 | 2020-01-31 | 特鲁科德基因修复公司 | 具有受正交保护的酯部分的肽核酸(pna)单体 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HUT41715A (en) * | 1984-12-28 | 1987-05-28 | Monsanto Co | Process for preparing n-substituted alpha-aminoacids and derivatives thereof |
DE3635670A1 (de) | 1986-10-21 | 1988-04-28 | Hoechst Ag | Synthese von peptid-aminoalkylamiden und peptidhydraziden mittels festphasenmethode |
DE3713433A1 (de) | 1987-04-22 | 1988-11-03 | Werner Grossmann | Einrichtung zum entfernen von schmutzteilchen vom plattenzylinder einer offsetdruckmaschine |
EP0322348B1 (de) | 1987-12-22 | 1994-02-02 | Hoechst Aktiengesellschaft | Säurelabile Ankergruppen zur Synthese von Peptidamiden mittels Festphasenmethode |
DE4016596A1 (de) | 1990-05-23 | 1991-11-28 | Hoechst Ag | Ein neues kupplungsreagenz fuer die peptidsynthese |
DK51092D0 (da) * | 1991-05-24 | 1992-04-15 | Ole Buchardt | Oligonucleotid-analoge betegnet pna, monomere synthoner og fremgangsmaade til fremstilling deraf samt anvendelser deraf |
US5539082A (en) * | 1993-04-26 | 1996-07-23 | Nielsen; Peter E. | Peptide nucleic acids |
MX9207334A (es) * | 1991-12-18 | 1993-08-01 | Glaxo Inc | Acidos nucleicos peptidicos y formulacion farma- ceutica que los contiene |
US5527675A (en) * | 1993-08-20 | 1996-06-18 | Millipore Corporation | Method for degradation and sequencing of polymers which sequentially eliminate terminal residues |
US5539083A (en) * | 1994-02-23 | 1996-07-23 | Isis Pharmaceuticals, Inc. | Peptide nucleic acid combinatorial libraries and improved methods of synthesis |
-
1994
- 1994-03-14 DE DE4408533A patent/DE4408533A1/de not_active Withdrawn
-
1995
- 1995-03-08 ES ES95103319T patent/ES2136755T3/es not_active Expired - Lifetime
- 1995-03-08 DE DE59506432T patent/DE59506432D1/de not_active Expired - Lifetime
- 1995-03-08 DK DK95103319T patent/DK0672701T3/da active
- 1995-03-08 AT AT95103319T patent/ATE182602T1/de active
- 1995-03-08 EP EP95103319A patent/EP0672701B1/de not_active Expired - Lifetime
- 1995-03-10 FI FI951129A patent/FI120262B/fi not_active IP Right Cessation
- 1995-03-10 AU AU14800/95A patent/AU683714B2/en not_active Ceased
- 1995-03-13 CA CA002144473A patent/CA2144473C/en not_active Expired - Fee Related
- 1995-03-13 NO NO19950958A patent/NO321035B1/no not_active IP Right Cessation
- 1995-03-14 JP JP05464195A patent/JP4098836B2/ja not_active Expired - Fee Related
-
1997
- 1997-10-29 US US08/967,197 patent/US6121418A/en not_active Expired - Lifetime
-
1999
- 1999-09-22 GR GR990402363T patent/GR3031265T3/el unknown
-
2000
- 2000-02-01 US US09/495,457 patent/US6316595B1/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
JPH07291909A (ja) | 1995-11-07 |
US6316595B1 (en) | 2001-11-13 |
EP0672701A1 (de) | 1995-09-20 |
NO950958D0 (no) | 1995-03-13 |
AU683714B2 (en) | 1997-11-20 |
FI951129A0 (fi) | 1995-03-10 |
JP4098836B2 (ja) | 2008-06-11 |
DE59506432D1 (de) | 1999-09-02 |
EP0672701B1 (de) | 1999-07-28 |
ATE182602T1 (de) | 1999-08-15 |
AU1480095A (en) | 1995-09-21 |
FI120262B (fi) | 2009-08-31 |
US6121418A (en) | 2000-09-19 |
GR3031265T3 (en) | 1999-12-31 |
DE4408533A1 (de) | 1995-09-28 |
CA2144473C (en) | 2008-07-15 |
CA2144473A1 (en) | 1995-09-15 |
NO950958L (no) | 1995-09-15 |
NO321035B1 (no) | 2006-03-06 |
FI951129A (fi) | 1995-09-15 |
DK0672701T3 (da) | 2000-01-03 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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