FI950485A0 - Imidatsolikarboksyylihappojen prodrugmuotoja angiotensiini II-reseptorin antagonisteina - Google Patents

Imidatsolikarboksyylihappojen prodrugmuotoja angiotensiini II-reseptorin antagonisteina

Info

Publication number
FI950485A0
FI950485A0 FI950485A FI950485A FI950485A0 FI 950485 A0 FI950485 A0 FI 950485A0 FI 950485 A FI950485 A FI 950485A FI 950485 A FI950485 A FI 950485A FI 950485 A0 FI950485 A0 FI 950485A0
Authority
FI
Finland
Prior art keywords
angiotensin
receptor antagonists
prodrug forms
imidazolecarboxylic
acids
Prior art date
Application number
FI950485A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI950485A (fi
Inventor
Robert John Ardecky
Carol Lee Ensinger
James Russell Pruitt
Original Assignee
Du Pont
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Du Pont filed Critical Du Pont
Publication of FI950485A publication Critical patent/FI950485A/fi
Publication of FI950485A0 publication Critical patent/FI950485A0/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
FI950485A 1992-08-06 1995-02-03 Imidatsolikarboksyylihappojen prodrugmuotoja angiotensiini II-reseptorin antagonisteina FI950485A0 (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/926,795 US5310929A (en) 1992-08-06 1992-08-06 Prodrugs of imidazole carboxylic acids as angiotensin II receptor antagonists
PCT/US1993/007103 WO1994003435A1 (en) 1992-08-06 1993-08-02 Prodrugs of imidazole carboxylic acids as angiotensin ii receptor antagonists

Publications (2)

Publication Number Publication Date
FI950485A FI950485A (fi) 1995-02-03
FI950485A0 true FI950485A0 (fi) 1995-02-03

Family

ID=25453732

Family Applications (1)

Application Number Title Priority Date Filing Date
FI950485A FI950485A0 (fi) 1992-08-06 1995-02-03 Imidatsolikarboksyylihappojen prodrugmuotoja angiotensiini II-reseptorin antagonisteina

Country Status (18)

Country Link
US (1) US5310929A (ja)
EP (1) EP0654027A1 (ja)
JP (1) JP2892838B2 (ja)
CN (1) CN1090275A (ja)
AU (1) AU688735B2 (ja)
BR (1) BR9306911A (ja)
CA (1) CA2141692C (ja)
FI (1) FI950485A0 (ja)
HU (1) HU9500349D0 (ja)
IL (1) IL106553A0 (ja)
MX (1) MX9304787A (ja)
NO (1) NO950404D0 (ja)
PL (1) PL307309A1 (ja)
SG (1) SG47108A1 (ja)
SK (1) SK13195A3 (ja)
TW (1) TW239131B (ja)
WO (1) WO1994003435A1 (ja)
ZA (1) ZA935693B (ja)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5616599A (en) * 1991-02-21 1997-04-01 Sankyo Company, Limited Angiotensin II antagosist 1-biphenylmethylimidazole compounds and their therapeutic use
CA2111662C (en) * 1992-12-17 2004-11-23 Hiroaki Yanagisawa Biphenyl derivatives, their preparation and their use for the treatment of hypertension and cardiac disease
HUT74734A (en) * 1994-03-16 1997-02-28 Sankyo Co Use of biphenyl methyl imidazole derivatives for producing pharmaceutical compositions having ocular tension derpessant activity
US6221335B1 (en) * 1994-03-25 2001-04-24 Isotechnika, Inc. Method of using deuterated calcium channel blockers
US5510495A (en) * 1994-09-19 1996-04-23 The Du Pont Merck Pharmaceutical Company Process for the isolation and purification of ester functionalized imidazole intermediates by selective hydrolysis
US5965738A (en) * 1994-09-20 1999-10-12 Wakunaga Seiyaku Kabushiki Kaisha Process for producing N-biphenylmethylthiadiazoline derivative or salt thereof and intermediate for producing the same
IT1292437B1 (it) * 1997-06-30 1999-02-08 Zambon Spa Processo di orto-metallazione utile per la sintesi di 1 - tetrazol- 5-il) benzeni 2-sostituiti
IT1295405B1 (it) * 1997-09-30 1999-05-12 Merck Sharp & Dohme Italia S P Uso di un antagonista recettoriale di angiotensina ii per la preparazione di farmaci per aumentare il tasso di sopravvivenza di
DE19820064A1 (de) * 1998-05-06 1999-11-11 Hoechst Marion Roussel De Gmbh Substituierte Sulfonylcyanamide, Verfahren zu ihrer Herstellung und ihre Verwendung als Medikament
DE19832428A1 (de) * 1998-07-18 2000-01-20 Hoechst Marion Roussel De Gmbh Imidazolderivate mit Biphenylsulfonylsubstitution, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE19832429A1 (de) * 1998-07-18 2000-01-20 Hoechst Marion Roussel De Gmbh Imidazolderivate mit Biphenylsulfonylsubstitution, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
ES2154191B1 (es) * 1998-11-24 2001-10-16 Ferrer Int Nuevos acetales derivados de los 2-alquil-5-halo-3-(2'-(tetrazol-5-il)-bifenil-4-ilmetil)-3h-imidazol-4-carbaldehidos.
GR20000100281A (el) * 2000-08-17 2002-05-24 Ιωαννης Ματσουκας Ανταγωνιστες του υποδοχεα της αγγεοτενσινης ιι και συνθετικες μεθοδοι για την θεραπεια της υπερτασης και καρδιοαγγειακων ασθενειων
AU2002257970B2 (en) 2001-05-31 2007-08-02 Vicore Pharma Ab Tricyclic compounds useful as angiotensin II agonists
CN101165062A (zh) * 2003-01-16 2008-04-23 特瓦制药工业有限公司 伊贝沙坦的新合成方法
JP4779067B2 (ja) 2004-01-20 2011-09-21 愛知県 ＨＬＡ−Ａ２４０２拘束性Ｅｐ−ＣＡＭ特異的ＣＴＬが認識するエピトープ・ペプチド及びその用途
US7157584B2 (en) * 2004-02-25 2007-01-02 Takeda Pharmaceutical Company Limited Benzimidazole derivative and use thereof
CA2575177A1 (en) * 2004-09-02 2006-03-16 Teva Pharmaceutical Industries Ltd. Purification of olmesartan medoxomil
US20070054948A1 (en) * 2004-09-02 2007-03-08 Lilach Hedvati Purification of olmesartan medoxomil
CA2604190A1 (en) * 2005-04-20 2006-11-02 Merck & Co., Inc. Angiotensin ii receptor antagonists
EP1931648A2 (en) * 2006-08-29 2008-06-18 Teva Pharmaceutical Industries Ltd. Processes for the synthesis of 5-phenyl -1 trityl-1h-tetrazole
AU2007306171B2 (en) * 2006-10-09 2013-02-21 Cipla Limited Process for preparing trityl olmesartan medoxomil and olmesartan medoxomil
AU2006351517B8 (en) * 2006-12-06 2012-01-19 Shenzhen Salubris Pharmaceuticals Co., Ltd. The salts of imidazol-5-carboxylic acid derivatives, preparation methods and use thereof
US9107911B2 (en) 2010-01-07 2015-08-18 Alkermes Pharma Ireland Limited Prodrugs of heteraromatic compounds
EP2455388A1 (en) 2010-11-23 2012-05-23 LanthioPep B.V. Novel angiotensin type 2 (AT2) receptor agonists and uses thereof.
CN111018841B (zh) * 2013-11-01 2023-04-07 深圳信立泰药业股份有限公司 阿利沙坦酯无定形及其制备方法及含所述无定形的药物组合物
US20220257698A1 (en) 2019-08-02 2022-08-18 Lanthiopep B.V. Angiotensin type 2 (at2) receptor agonists for use in the treatment of cancer

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5138069A (en) * 1986-07-11 1992-08-11 E. I. Du Pont De Nemours And Company Angiotensin II receptor blocking imidazoles
CA1338238C (en) * 1988-01-07 1996-04-09 David John Carini Angiotensin ii receptor blocking imidazoles and combinations thereof with diuretics and nsaids
EP0479892A1 (en) * 1989-06-30 1992-04-15 E.I. Du Pont De Nemours And Company Fused-ring aryl substituted imidazoles
WO1991000277A1 (en) * 1989-06-30 1991-01-10 E.I. Du Pont De Nemours And Company Substituted imidazoles
GB8927277D0 (en) * 1989-12-01 1990-01-31 Glaxo Group Ltd Chemical compounds
US5196444A (en) * 1990-04-27 1993-03-23 Takeda Chemical Industries, Ltd. 1-(cyclohexyloxycarbonyloxy)ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylate and compositions and methods of pharmaceutical use thereof
US5137902A (en) * 1990-07-13 1992-08-11 E. I. Du Pont De Nemours And Company 4-alkylimidazole derivatives and anti-hypertensive use thereof
DK0573218T3 (da) * 1992-06-02 2001-06-18 Sankyo Co 4-carboxyimidazolderivater som angiotensin-II antagonister og deres terapeutiske anvendelse

Also Published As

Publication number Publication date
PL307309A1 (en) 1995-05-15
EP0654027A1 (en) 1995-05-24
CA2141692C (en) 2006-05-30
FI950485A (fi) 1995-02-03
JP2892838B2 (ja) 1999-05-17
SG47108A1 (en) 1998-03-20
ZA935693B (en) 1995-02-06
WO1994003435A1 (en) 1994-02-17
TW239131B (ja) 1995-01-21
HU9500349D0 (en) 1995-03-28
NO950404D0 (no) 1995-02-03
CA2141692A1 (en) 1994-02-17
CN1090275A (zh) 1994-08-03
AU688735B2 (en) 1998-03-19
IL106553A0 (en) 1993-12-08
AU4790393A (en) 1994-03-03
JPH08500103A (ja) 1996-01-09
BR9306911A (pt) 1998-12-08
SK13195A3 (en) 1995-07-11
MX9304787A (es) 1995-01-31
US5310929A (en) 1994-05-10

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