FI944217A0 - Substituoidut pipekoliinihappojohdannaiset HIV-proteaasin estäjinä - Google Patents
Substituoidut pipekoliinihappojohdannaiset HIV-proteaasin estäjinäInfo
- Publication number
- FI944217A0 FI944217A0 FI944217A FI944217A FI944217A0 FI 944217 A0 FI944217 A0 FI 944217A0 FI 944217 A FI944217 A FI 944217A FI 944217 A FI944217 A FI 944217A FI 944217 A0 FI944217 A0 FI 944217A0
- Authority
- FI
- Finland
- Prior art keywords
- acid derivatives
- protease inhibitors
- hiv protease
- pipecolic acid
- substituted pipecolic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Virology (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- AIDS & HIV (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US85071692A | 1992-03-13 | 1992-03-13 | |
| PCT/CA1993/000096 WO1993018003A1 (fr) | 1992-03-13 | 1993-03-12 | Derivets substitues de l'acide pinecolinique comme inhibiteurs de la protease du virus de l'immunodeficience humaine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FI944217A FI944217A (fi) | 1994-09-13 |
| FI944217A0 true FI944217A0 (fi) | 1994-09-13 |
Family
ID=25308925
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI944217A FI944217A0 (fi) | 1992-03-13 | 1994-09-13 | Substituoidut pipekoliinihappojohdannaiset HIV-proteaasin estäjinä |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US5807870A (fr) |
| EP (1) | EP0560268B1 (fr) |
| JP (1) | JP3258422B2 (fr) |
| KR (1) | KR950700253A (fr) |
| AP (1) | AP393A (fr) |
| AT (1) | ATE116640T1 (fr) |
| AU (1) | AU670582B2 (fr) |
| CA (1) | CA2131185C (fr) |
| CZ (1) | CZ285589B6 (fr) |
| DE (1) | DE69300043T2 (fr) |
| DK (1) | DK0560268T3 (fr) |
| ES (1) | ES2066623T3 (fr) |
| FI (1) | FI944217A0 (fr) |
| GR (1) | GR3015622T3 (fr) |
| HU (2) | HUT70617A (fr) |
| IL (1) | IL105035A (fr) |
| NO (1) | NO302570B1 (fr) |
| NZ (1) | NZ251267A (fr) |
| OA (1) | OA10092A (fr) |
| PH (1) | PH30734A (fr) |
| PL (1) | PL176362B1 (fr) |
| RU (1) | RU2140911C1 (fr) |
| SK (1) | SK280161B6 (fr) |
| WO (1) | WO1993018003A1 (fr) |
| ZA (1) | ZA931776B (fr) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5679688A (en) | 1992-03-11 | 1997-10-21 | Narhex Limited | Quinaldoyl-amine derivatives of oxo-and hydroxy-substituted hydrocarbons |
| US6071895A (en) | 1992-03-11 | 2000-06-06 | Narhex Limited | Polar-substituted hydrocarbons |
| US5888992A (en) | 1992-03-11 | 1999-03-30 | Narhex Limited | Polar substituted hydrocarbons |
| MXPA93002392A (es) | 1992-03-11 | 2005-02-04 | Narhex Ltd | Derivados amino de hidrocarburos-oxo e hidroxi-substituidos. |
| US5559256A (en) * | 1992-07-20 | 1996-09-24 | E. R. Squibb & Sons, Inc. | Aminediol protease inhibitors |
| ES2123065T3 (es) | 1992-08-25 | 1999-01-01 | Searle & Co | Hidroxietilamino-sulfonamidas utiles como inhibidores de proteasas retroviricas. |
| US5484926A (en) * | 1993-10-07 | 1996-01-16 | Agouron Pharmaceuticals, Inc. | HIV protease inhibitors |
| US5846993A (en) * | 1992-12-22 | 1998-12-08 | Agouron Pharmaceuticals, Inc. | HIV protease inhibitors |
| EP0610745A3 (en) * | 1993-02-09 | 1994-09-28 | Miles Inc | Novel aminomethylene derivatives as immunosuppressants. |
| IL110898A0 (en) * | 1993-09-10 | 1994-11-28 | Narhex Australia Pty Ltd | Polar-substituted hydrocarbons |
| US5527829A (en) * | 1994-05-23 | 1996-06-18 | Agouron Pharmaceuticals, Inc. | HIV protease inhibitors |
| CA2137406C (fr) * | 1994-12-06 | 2005-09-13 | Pierre Louis Beaulieu | Procede de synthese d'intermediaires essentiels a la preparation d'inhibiteurs de la protease de vih |
| US6037157A (en) | 1995-06-29 | 2000-03-14 | Abbott Laboratories | Method for improving pharmacokinetics |
| US5914332A (en) | 1995-12-13 | 1999-06-22 | Abbott Laboratories | Retroviral protease inhibiting compounds |
| US5883252A (en) * | 1996-01-26 | 1999-03-16 | Vertex Pharmaceuticals Incorporated | Aspartyl protease inhibitors |
| US5962725A (en) | 1996-09-05 | 1999-10-05 | Agouron Pharmaceuticals, Inc. | Intermediate compounds useful for making HIV protease inhibitors such as nelfinavir |
| US5705647A (en) * | 1996-09-05 | 1998-01-06 | Agouron Pharmaceuticals, Inc. | Intermediates for making HIV-protease inhibitors |
| US5925759A (en) | 1996-09-05 | 1999-07-20 | Agouron Pharmaceuticals, Inc. | Methods of making HIV-protease inhibitors and intermediates for making HIV-protease inhibitors |
| US6232333B1 (en) | 1996-11-21 | 2001-05-15 | Abbott Laboratories | Pharmaceutical composition |
| US6001851A (en) * | 1997-03-13 | 1999-12-14 | Agouron Pharmaceuticals, Inc. | HIV protease inhibitors |
| US6084107A (en) * | 1997-09-05 | 2000-07-04 | Agouron Pharmaceuticals, Inc. | Intermediates for making HIV-protease inhibitors |
| US6251906B1 (en) | 1998-05-15 | 2001-06-26 | Abbott Laboratories | Retroviral protease inhibiting compounds |
| CA2395987C (fr) | 2000-01-19 | 2009-12-22 | Abbott Laboratories | Formulations pharmaceutiques ameliorees |
| DE60124080T2 (de) * | 2000-03-23 | 2007-03-01 | Elan Pharmaceuticals, Inc., San Francisco | Verbindungen und verfahren zur behandlung der alzheimerschen krankheit |
| US6992081B2 (en) | 2000-03-23 | 2006-01-31 | Elan Pharmaceuticals, Inc. | Compounds to treat Alzheimer's disease |
| US6846813B2 (en) * | 2000-06-30 | 2005-01-25 | Pharmacia & Upjohn Company | Compounds to treat alzheimer's disease |
| EP1666452A2 (fr) | 2000-06-30 | 2006-06-07 | Elan Pharmaceuticals, Inc. | Composés pour le traitement de la maladie d'Alzheimer |
| EP1299352B1 (fr) | 2000-06-30 | 2005-12-28 | Elan Pharmaceuticals, Inc. | Composes pour traiter la maladie d'alzheimer |
| US20030096864A1 (en) * | 2000-06-30 | 2003-05-22 | Fang Lawrence Y. | Compounds to treat alzheimer's disease |
| PE20020276A1 (es) | 2000-06-30 | 2002-04-06 | Elan Pharm Inc | COMPUESTOS DE AMINA SUSTITUIDA COMO INHIBIDORES DE ß-SECRETASA PARA EL TRATAMIENTO DE ALZHEIMER |
| WO2003002122A1 (fr) * | 2001-06-27 | 2003-01-09 | Elan Pharmaceuticals, Inc. | Derives de beta-hydroxyamine utiles dans le traitement de la maladie d'alzheimer |
| US20070213407A1 (en) * | 2001-06-29 | 2007-09-13 | Elan Pharmaceuticals And Pharmacia & Upjohn Company Llc | Compounds to treat Alzheimer's disease |
| JP4482883B2 (ja) | 2003-05-22 | 2010-06-16 | リードケミカル株式会社 | 抗ウイルス作用を有する化合物およびその配合剤 |
| EP2301919A1 (fr) | 2004-06-10 | 2011-03-30 | Board of Trustees of Michigan State University | Synthèse du caprolactam à partir de la lysine |
| ES2426345T3 (es) * | 2005-07-20 | 2013-10-22 | Eli Lilly And Company | Compuesto unidos en posición 1-amino |
| CN101541746B (zh) * | 2007-02-20 | 2013-01-02 | 密执安州立大学董事会 | 用于生产己内酰胺的催化脱氨基 |
| CN101631568B (zh) | 2007-03-12 | 2012-08-22 | 尼克塔治疗公司 | 低聚物-蛋白酶抑制剂偶联物 |
| WO2009114151A1 (fr) | 2008-03-12 | 2009-09-17 | Nektar Therapeutics | Conjugués oligomères-acides aminés et oligomères-atazanavir |
| CN102105450A (zh) * | 2008-07-24 | 2011-06-22 | Draths公司 | 制备环酰胺单体的方法和相关的衍生物和方法 |
| EP2440249A2 (fr) | 2009-06-12 | 2012-04-18 | Nektar Therapeutics | Conjugués covalents comprenant un inhibiteurs de protéase, un oligomère non-peptidique soluble dans l'eau et une partie lipophilique |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3789347D1 (de) * | 1986-10-14 | 1994-04-21 | Banyu Pharma Co Ltd | 5-Substituierte Amino-4-hydroxy-pentansäure-Derivate und deren Verwendung. |
| CA1340588C (fr) * | 1988-06-13 | 1999-06-08 | Balraj Krishan Handa | Derive d'aminoacides |
| GB8927915D0 (en) * | 1989-12-11 | 1990-02-14 | Hoffmann La Roche | Novel alcohols |
| GB8927913D0 (en) * | 1989-12-11 | 1990-02-14 | Hoffmann La Roche | Amino acid derivatives |
| MY110227A (en) * | 1991-08-12 | 1998-03-31 | Ciba Geigy Ag | 1-acylpiperindine compounds. |
| ZA931777B (en) * | 1992-03-13 | 1993-09-23 | Bio Mega Boehringer Ingelheim | Substituted pyrrolidine derivatives as HIV protease inhibitors. |
| IL110255A (en) * | 1993-07-16 | 1998-12-06 | Merck & Co Inc | Creation and resolution of 2 tert-butylcarboxamidopiprazine |
| US5480887A (en) * | 1994-02-02 | 1996-01-02 | Eli Lilly And Company | Protease inhibitors |
| GB2292146A (en) * | 1994-08-11 | 1996-02-14 | Merck & Co Inc | HIV protease inhibitors useful for the treatment of AIDS |
-
1993
- 1993-03-09 EP EP93103712A patent/EP0560268B1/fr not_active Expired - Lifetime
- 1993-03-09 ES ES93103712T patent/ES2066623T3/es not_active Expired - Lifetime
- 1993-03-09 DK DK93103712.1T patent/DK0560268T3/da active
- 1993-03-09 DE DE69300043T patent/DE69300043T2/de not_active Expired - Lifetime
- 1993-03-09 AT AT93103712T patent/ATE116640T1/de active
- 1993-03-10 AP APAP/P/1993/000495A patent/AP393A/en active
- 1993-03-11 PH PH45862A patent/PH30734A/en unknown
- 1993-03-12 NZ NZ251267A patent/NZ251267A/en unknown
- 1993-03-12 SK SK1090-94A patent/SK280161B6/sk unknown
- 1993-03-12 PL PL93305166A patent/PL176362B1/pl unknown
- 1993-03-12 CA CA002131185A patent/CA2131185C/fr not_active Expired - Lifetime
- 1993-03-12 ZA ZA931776A patent/ZA931776B/xx unknown
- 1993-03-12 HU HU9402613A patent/HUT70617A/hu unknown
- 1993-03-12 IL IL105035A patent/IL105035A/xx not_active IP Right Cessation
- 1993-03-12 WO PCT/CA1993/000096 patent/WO1993018003A1/fr active IP Right Grant
- 1993-03-12 RU RU94040841A patent/RU2140911C1/ru active
- 1993-03-12 CZ CZ942232A patent/CZ285589B6/cs not_active IP Right Cessation
- 1993-03-12 AU AU38808/93A patent/AU670582B2/en not_active Ceased
- 1993-03-15 JP JP05414293A patent/JP3258422B2/ja not_active Expired - Fee Related
-
1994
- 1994-08-05 OA OA60550A patent/OA10092A/en unknown
- 1994-09-12 NO NO943383A patent/NO302570B1/no unknown
- 1994-09-13 KR KR1019940703190A patent/KR950700253A/ko active IP Right Grant
- 1994-09-13 FI FI944217A patent/FI944217A0/fi unknown
-
1995
- 1995-03-27 GR GR950400700T patent/GR3015622T3/el unknown
- 1995-06-23 HU HU95P/P00429P patent/HU211854A9/hu unknown
-
1996
- 1996-12-11 US US08/763,464 patent/US5807870A/en not_active Expired - Lifetime
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GB | Transfer or assigment of application |
Owner name: BOEHRINGER INGELHEIM (CANADA) LTD. |