FI943207A - 4,5-dihydrogeldanamysiinin ja sen hydrokinonin valmistusmenetelmä ja käyttö - Google Patents

4,5-dihydrogeldanamysiinin ja sen hydrokinonin valmistusmenetelmä ja käyttö Download PDF

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Publication number
FI943207A
FI943207A FI943207A FI943207A FI943207A FI 943207 A FI943207 A FI 943207A FI 943207 A FI943207 A FI 943207A FI 943207 A FI943207 A FI 943207A FI 943207 A FI943207 A FI 943207A
Authority
FI
Finland
Prior art keywords
dihydrogeldanamycin
hydroquinone
preparation process
preparation
Prior art date
Application number
FI943207A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI943207A0 (fi
Inventor
Walter P Cullen
Mark T Jefferson
Mikel P Moyer
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of FI943207A0 publication Critical patent/FI943207A0/fi
Publication of FI943207A publication Critical patent/FI943207A/fi

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10—Nitrogen as only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D225/00—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom
    • C07D225/04—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D225/06—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems condensed with one six-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
FI943207A 1992-01-06 1994-07-05 4,5-dihydrogeldanamysiinin ja sen hydrokinonin valmistusmenetelmä ja käyttö FI943207A (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US81723592A 1992-01-06 1992-01-06
PCT/US1992/010189 WO1993014215A1 (en) 1992-01-06 1992-12-03 Process and uses for 4,5-dihydrogeldanamycin and its hydroquinone

Publications (2)

Publication Number Publication Date
FI943207A0 FI943207A0 (fi) 1994-07-05
FI943207A true FI943207A (fi) 1994-07-05

Family

ID=25222638

Family Applications (1)

Application Number Title Priority Date Filing Date
FI943207A FI943207A (fi) 1992-01-06 1994-07-05 4,5-dihydrogeldanamysiinin ja sen hydrokinonin valmistusmenetelmä ja käyttö

Country Status (15)

Country Link
JP (1) JPH06510913A (ja)
KR (1) KR940703923A (ja)
CN (1) CN1074937A (ja)
AU (1) AU3225693A (ja)
BR (1) BR9207024A (ja)
CA (1) CA2127457A1 (ja)
CZ (1) CZ390592A3 (ja)
FI (1) FI943207A (ja)
HU (1) HU9401936D0 (ja)
IL (1) IL104289A0 (ja)
MX (1) MX9300011A (ja)
NO (1) NO942532L (ja)
PT (1) PT101169A (ja)
WO (1) WO1993014215A1 (ja)
ZA (1) ZA9333B (ja)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0706516A1 (en) * 1993-06-29 1996-04-17 Pfizer Inc. Ansamycin derivatives as antioncogene and anticancer agents
US5932566A (en) * 1994-06-16 1999-08-03 Pfizer Inc. Ansamycin derivatives as antioncogene and anticancer agents
US6852496B1 (en) 1997-08-12 2005-02-08 Oregon Health And Science University Methods of screening for agents that promote nerve cell growth
US6872715B2 (en) 2001-08-06 2005-03-29 Kosan Biosciences, Inc. Benzoquinone ansamycins
EP1923061A1 (en) 2001-09-24 2008-05-21 Conforma Therapeutic Corporation Process for preparing 17-Allyl amino geldanamycin (17-AAG) and other ansamycins
EP1435939B1 (en) 2001-09-24 2008-02-27 Conforma Therapeutic Corporation Process for preparing 17-allyl amino geldanamycin (17-aag) and other ansamycins
US7465718B2 (en) 2002-02-08 2008-12-16 Conforma Therapeutics Corporation Ansamycins having improved pharmacological and biological properties
TW200303363A (en) * 2002-02-25 2003-09-01 Upjohn Co Process to prepare and isolate geldanamycin
WO2005009345A2 (en) 2003-06-13 2005-02-03 Kosan Biosciences, Inc. 2-desmethyl ansamycin compounds
US6875863B1 (en) 2003-11-12 2005-04-05 Kosan Biosciences, Inc. 11-O-methylgeldanamycin compounds
US6870049B1 (en) 2003-11-12 2005-03-22 Kosan Biosciences, Inc. 11-O-methylgeldanamycin compounds
US6887993B1 (en) 2003-11-12 2005-05-03 Kosan Biosciences, Inc. 11-O-methylgeldanamycin compounds
US6855705B1 (en) 2003-11-12 2005-02-15 Kosan Biosciences, Inc. 11-O-methylgeldanamycin compounds
US20050148496A1 (en) * 2003-11-26 2005-07-07 Entelos, Inc. Treatment of rheumatoid arthritis with hypoxia inducible factor-1alpha antagonists
WO2005063714A1 (en) 2003-12-23 2005-07-14 Infinity Pharmaceuticals, Inc Analogs of benzoquinone-containing ansamycins for the treatment of cancer
US20060019941A1 (en) * 2003-12-23 2006-01-26 Infinity Pharmaceuticals, Inc. Analogs of benzoquinone-containing ansamycins and methods of use thereof
ZA200604863B (en) * 2003-12-23 2007-12-27 Infinity Pharmaceuticals Inc Analogs of benzoquinone-containing ansamycins for the treatment of cancer
CN101180297A (zh) 2005-03-30 2008-05-14 康福玛医药公司 作为hsp90-抑制剂的炔基吡咯并嘧啶及相关类似物
EP1973883B1 (en) * 2006-11-09 2012-07-11 Bristol-Myers Squibb Company Novel compounds and methods for their production
PE20081506A1 (es) 2006-12-12 2008-12-09 Infinity Discovery Inc Formulaciones de ansamicina
CN100500668C (zh) * 2006-12-19 2009-06-17 中国人民解放军军事医学科学院毒物药物研究所 格尔德霉素衍生物及其制备方法和制备药物的用途
WO2008094438A1 (en) 2007-01-26 2008-08-07 Kosan Biosciences Incorporated Macrolactams by engineered biosynthesis
US20110034686A1 (en) * 2008-04-21 2011-02-10 Nitin Sopanrao Patil Process for Isolation and Purification of Geldanamycin
WO2010045442A1 (en) 2008-10-15 2010-04-22 Infinity Discovery, Inc. Ansamycin hydroquinone compositions
CN102030764B (zh) * 2010-11-12 2012-07-04 中国医学科学院医药生物技术研究所 4，5双氢噻嗪酮格尔德霉素及其制备方法
CN103305563B (zh) * 2013-06-14 2014-12-03 湖南农业大学 一种以链霉菌提制阿里沙霉素的方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3595955A (en) * 1969-03-26 1971-07-27 Upjohn Co Geldanamycin and process for producing same

Also Published As

Publication number Publication date
JPH06510913A (ja) 1994-12-08
FI943207A0 (fi) 1994-07-05
NO942532D0 (no) 1994-07-05
AU3225693A (en) 1993-08-03
HU9401936D0 (en) 1994-09-28
NO942532L (no) 1994-07-05
KR940703923A (ko) 1994-12-12
ZA9333B (en) 1994-07-05
WO1993014215A1 (en) 1993-07-22
CZ390592A3 (en) 1993-08-11
CA2127457A1 (en) 1993-07-22
MX9300011A (es) 1993-12-01
CN1074937A (zh) 1993-08-04
PT101169A (pt) 1994-03-31
BR9207024A (pt) 1995-12-05
IL104289A0 (en) 1993-05-13

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