FI942248A0 - N-trityyliasparagiinihapon johdannaiset fosfonaatti-NMDA-antagonistien valmistamiseksi - Google Patents
N-trityyliasparagiinihapon johdannaiset fosfonaatti-NMDA-antagonistien valmistamiseksiInfo
- Publication number
- FI942248A0 FI942248A0 FI942248A FI942248A FI942248A0 FI 942248 A0 FI942248 A0 FI 942248A0 FI 942248 A FI942248 A FI 942248A FI 942248 A FI942248 A FI 942248A FI 942248 A0 FI942248 A0 FI 942248A0
- Authority
- FI
- Finland
- Prior art keywords
- preparation
- tritylaspartic
- acid derivatives
- nmda antagonists
- phosphonate
- Prior art date
Links
- HOKKHZGPKSLGJE-GSVOUGTGSA-N N-Methyl-D-aspartic acid Chemical compound CN[C@@H](C(O)=O)CC(O)=O HOKKHZGPKSLGJE-GSVOUGTGSA-N 0.000 title abstract 2
- 239000005557 antagonist Substances 0.000 title abstract 2
- KGMHYPXNXMMYOA-FQEVSTJZSA-N (2s)-2-(tritylamino)butanedioic acid Chemical class C=1C=CC=CC=1C(C=1C=CC=CC=1)(N[C@@H](CC(=O)O)C(O)=O)C1=CC=CC=C1 KGMHYPXNXMMYOA-FQEVSTJZSA-N 0.000 title 1
- UEZVMMHDMIWARA-UHFFFAOYSA-M phosphonate Chemical compound [O-]P(=O)=O UEZVMMHDMIWARA-UHFFFAOYSA-M 0.000 title 1
- HYHXAZMLKDGXEI-JOCHJYFZSA-N dimethyl (2r)-2-(tritylamino)butanedioate Chemical compound C=1C=CC=CC=1C(C=1C=CC=CC=1)(N[C@H](CC(=O)OC)C(=O)OC)C1=CC=CC=C1 HYHXAZMLKDGXEI-JOCHJYFZSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3808—Acyclic saturated acids which can have further substituents on alkyl
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/24—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one carboxyl group bound to the carbon skeleton, e.g. aspartic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Neurosurgery (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurology (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US79283491A | 1991-11-15 | 1991-11-15 | |
| PCT/US1992/008739 WO1993010075A1 (en) | 1991-11-15 | 1992-10-13 | N-trityl aspartic acid derivatives for preparing phosphonate nmda antagonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FI942248A0 true FI942248A0 (fi) | 1994-05-13 |
| FI942248A FI942248A (fi) | 1994-05-13 |
Family
ID=25158215
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI942248A FI942248A (fi) | 1991-11-15 | 1994-05-13 | N-trityyliasparagiinihapon johdannaiset fosfonaatti-NMDA-antagonistien valmistamiseksi |
Country Status (16)
| Country | Link |
|---|---|
| EP (1) | EP0613459B1 (de) |
| JP (1) | JP3168563B2 (de) |
| KR (1) | KR100241480B1 (de) |
| AT (1) | ATE134989T1 (de) |
| AU (1) | AU667845B2 (de) |
| CA (1) | CA2121835A1 (de) |
| DE (1) | DE69208888T2 (de) |
| DK (1) | DK0613459T3 (de) |
| ES (1) | ES2087555T3 (de) |
| FI (1) | FI942248A (de) |
| GR (1) | GR3019587T3 (de) |
| HU (1) | HU214055B (de) |
| IL (1) | IL103710A (de) |
| MX (1) | MX9206448A (de) |
| NO (1) | NO305314B1 (de) |
| WO (1) | WO1993010075A1 (de) |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2025326C (en) * | 1989-09-19 | 2001-04-24 | Jeffrey P. Whitten | Nmda antagonists |
-
1992
- 1992-10-13 AT AT92921774T patent/ATE134989T1/de not_active IP Right Cessation
- 1992-10-13 DE DE69208888T patent/DE69208888T2/de not_active Expired - Fee Related
- 1992-10-13 DK DK92921774.3T patent/DK0613459T3/da active
- 1992-10-13 HU HU9401469A patent/HU214055B/hu not_active IP Right Cessation
- 1992-10-13 KR KR1019940701634A patent/KR100241480B1/ko not_active IP Right Cessation
- 1992-10-13 CA CA002121835A patent/CA2121835A1/en not_active Abandoned
- 1992-10-13 WO PCT/US1992/008739 patent/WO1993010075A1/en active IP Right Grant
- 1992-10-13 AU AU28642/92A patent/AU667845B2/en not_active Ceased
- 1992-10-13 JP JP50924593A patent/JP3168563B2/ja not_active Expired - Fee Related
- 1992-10-13 ES ES92921774T patent/ES2087555T3/es not_active Expired - Lifetime
- 1992-10-13 EP EP92921774A patent/EP0613459B1/de not_active Expired - Lifetime
- 1992-11-10 MX MX9206448A patent/MX9206448A/es not_active IP Right Cessation
- 1992-11-11 IL IL103710A patent/IL103710A/en not_active IP Right Cessation
-
1994
- 1994-05-13 NO NO941820A patent/NO305314B1/no not_active IP Right Cessation
- 1994-05-13 FI FI942248A patent/FI942248A/fi unknown
-
1996
- 1996-04-09 GR GR960400979T patent/GR3019587T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NO305314B1 (no) | 1999-05-10 |
| KR100241480B1 (ko) | 2000-03-02 |
| EP0613459B1 (de) | 1996-03-06 |
| HU214055B (en) | 1997-12-29 |
| IL103710A0 (en) | 1993-04-04 |
| ES2087555T3 (es) | 1996-07-16 |
| HU9401469D0 (en) | 1994-08-29 |
| IL103710A (en) | 1998-02-08 |
| JPH07501523A (ja) | 1995-02-16 |
| EP0613459A1 (de) | 1994-09-07 |
| CA2121835A1 (en) | 1993-05-27 |
| NO941820L (no) | 1994-05-13 |
| NO941820D0 (no) | 1994-05-13 |
| JP3168563B2 (ja) | 2001-05-21 |
| DE69208888D1 (de) | 1996-04-11 |
| FI942248A (fi) | 1994-05-13 |
| ATE134989T1 (de) | 1996-03-15 |
| HUT70551A (en) | 1995-10-30 |
| AU2864292A (en) | 1993-06-15 |
| DE69208888T2 (de) | 1996-08-01 |
| WO1993010075A1 (en) | 1993-05-27 |
| DK0613459T3 (da) | 1996-04-01 |
| MX9206448A (es) | 1993-05-01 |
| GR3019587T3 (en) | 1996-07-31 |
| AU667845B2 (en) | 1996-04-18 |
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