FI935360A - Guanidiinialkyyli-1,1-bifosfonihappojohdannaisia, menetelmä niiden valmistamiseksi ja niiden käyttö - Google Patents
Guanidiinialkyyli-1,1-bifosfonihappojohdannaisia, menetelmä niiden valmistamiseksi ja niiden käyttö Download PDFInfo
- Publication number
- FI935360A FI935360A FI935360A FI935360A FI935360A FI 935360 A FI935360 A FI 935360A FI 935360 A FI935360 A FI 935360A FI 935360 A FI935360 A FI 935360A FI 935360 A FI935360 A FI 935360A
- Authority
- FI
- Finland
- Prior art keywords
- processes
- preparation
- acid derivatives
- biphosphonic acid
- guanidine alkyl
- Prior art date
Links
- ZRALSGWEFCBTJO-UHFFFAOYSA-N Guanidine Chemical compound NC(N)=N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 title 2
- CHJJGSNFBQVOTG-UHFFFAOYSA-N N-methyl-guanidine Natural products CNC(N)=N CHJJGSNFBQVOTG-UHFFFAOYSA-N 0.000 title 1
- 239000002253 acid Substances 0.000 title 1
- SWSQBOPZIKWTGO-UHFFFAOYSA-N dimethylaminoamidine Natural products CN(C)C(N)=N SWSQBOPZIKWTGO-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 208000020084 Bone disease Diseases 0.000 abstract 1
- 230000003412 degenerative effect Effects 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3839—Polyphosphonic acids
- C07F9/3873—Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4025—Esters of poly(thio)phosphonic acids
- C07F9/405—Esters of poly(thio)phosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/5532—Seven-(or more) membered rings
- C07F9/5535—Seven-(or more) membered rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/572—Five-membered rings
- C07F9/5728—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/60—Quinoline or hydrogenated quinoline ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4240422 | 1992-12-02 | ||
| DE4240422 | 1992-12-02 | ||
| DE19934316019 DE4316019A1 (de) | 1993-05-13 | 1993-05-13 | Benzoylguanidinalkyl-1,1-bisphosphonsäuren, Verfahren zu ihrer Herstellung und ihre Verwendung |
| DE4316019 | 1993-05-13 | ||
| DE4332362 | 1993-09-23 | ||
| DE4332362 | 1993-09-23 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI935360A0 FI935360A0 (fi) | 1993-11-30 |
| FI935360A true FI935360A (fi) | 1994-06-03 |
| FI108034B FI108034B (fi) | 2001-11-15 |
Family
ID=27204511
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI935360A FI108034B (fi) | 1992-12-02 | 1993-11-30 | Menetelmä terapeuttisesti tai profylaktisesti käyttökelpoisten guanidiinialkyyli-1,1-bisfosfonihappojohdannaisten valmistamiseksi |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US5395826A (fi) |
| EP (1) | EP0600371B1 (fi) |
| JP (1) | JP3499905B2 (fi) |
| KR (1) | KR100347423B1 (fi) |
| AT (1) | ATE176476T1 (fi) |
| AU (1) | AU663983B2 (fi) |
| BR (1) | BR9304910A (fi) |
| CA (1) | CA2110443C (fi) |
| DE (1) | DE59309360D1 (fi) |
| DK (1) | DK0600371T3 (fi) |
| ES (1) | ES2129485T3 (fi) |
| FI (1) | FI108034B (fi) |
| GR (1) | GR3030020T3 (fi) |
| NZ (1) | NZ250322A (fi) |
| RU (1) | RU2114855C1 (fi) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4223940A1 (de) * | 1992-07-21 | 1994-01-27 | Boehringer Mannheim Gmbh | Neue acyclische Amidingruppen-haltige Diphosphonsäurederivate, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel |
| DK0600371T3 (da) * | 1992-12-02 | 1999-09-20 | Hoechst Ag | Guanidinalkyl-1,1-bisphosphonsyrederivater, fremgangsmåde til deres fremstilling samt deres anvendelse |
| US6169107B1 (en) | 1993-04-28 | 2001-01-02 | Sumitomo Pharmaceutical Co., Ltd. | Indoloylguanidine derivatives |
| DE4404183A1 (de) * | 1994-02-10 | 1995-08-17 | Merck Patent Gmbh | 4-Amino-1-piperidylbenzoylguanidine |
| DE4421495A1 (de) * | 1994-06-20 | 1995-12-21 | Merck Patent Gmbh | Heterocyclyloxy-benzoylguanidine |
| CA2160600A1 (en) * | 1994-10-18 | 1996-04-19 | Masahumi Kitano | Indoloylguanidine derivatives |
| DE19540995A1 (de) * | 1995-11-03 | 1997-05-07 | Hoechst Ag | Substituierte Sulfonimidamide, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| DE19542306A1 (de) * | 1995-11-14 | 1997-05-15 | Hoechst Ag | Sulfonylamino-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| PL316439A1 (en) * | 1995-11-20 | 1997-05-26 | Hoechst Ag | Novel substituted derivatives of benzoyloguanidine, method of obtaining them, their application in production of pharmaceutic and diagnostic agents and pharmaceutic agent as such |
| DE19601303A1 (de) * | 1996-01-16 | 1997-07-17 | Boehringer Ingelheim Kg | Neuartige Benzoylguanidin-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung bei der Herstellung von Arzneimitteln |
| EP0970095B1 (en) | 1997-03-07 | 2003-10-29 | Metabasis Therapeutics, Inc. | Novel benzimidazole inhibitors of fructose-1,6-bisphosphatase |
| US6054587A (en) | 1997-03-07 | 2000-04-25 | Metabasis Therapeutics, Inc. | Indole and azaindole inhibitors of fructose-1,6-bisphosphatase |
| AU6452098A (en) | 1997-03-07 | 1998-09-22 | Metabasis Therapeutics, Inc. | Novel purine inhibitors of fructose-1,6-bisphosphatase |
| US6558784B1 (en) | 1999-03-02 | 2003-05-06 | Adc Composites, Llc | Composite footwear upper and method of manufacturing a composite footwear upper |
| JP2003519183A (ja) * | 2000-01-04 | 2003-06-17 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 心臓および動脈の石灰化を抑制する低用量ビスホスホネートの使用 |
| CA2444718A1 (en) * | 2001-05-02 | 2002-11-14 | Novartis Ag | Method of administration of bisphosphonates by inhalation in the treatment or prevention of bone resorption and osteoporosis |
| KR100620672B1 (ko) * | 2002-12-14 | 2006-09-13 | 주식회사 하이닉스반도체 | 포토레지스트 조성물 |
| WO2005090370A1 (en) * | 2004-02-05 | 2005-09-29 | The Regents Of The University Of California | Pharmacologically active agents containing esterified phosphonates and methods for use thereof |
| US20070003608A1 (en) * | 2005-04-08 | 2007-01-04 | Almond Merrick R | Compounds, compositions and methods for the treatment of viral infections and other medical disorders |
| JP2008535862A (ja) | 2005-04-08 | 2008-09-04 | キメリクス，インコーポレイテッド | ポックスウイルス感染の治療のための化合物、組成物および方法 |
| WO2008063865A2 (en) * | 2006-11-21 | 2008-05-29 | Teikoku Pharma Usa, Inc. | Biphosphonate inhalant formulations and methods for using the same |
| ES2572631T3 (es) * | 2008-01-25 | 2016-06-01 | Chimerix, Inc. | Métodos de tratamiento de infecciones virales |
| US20100034752A1 (en) * | 2008-08-11 | 2010-02-11 | Toru Hibi | Inhalant formulations comprising a bisphosphonate and a pyrazolone derivative and methods for using the same |
| US8614200B2 (en) | 2009-07-21 | 2013-12-24 | Chimerix, Inc. | Compounds, compositions and methods for treating ocular conditions |
| BR112012002551A2 (pt) | 2009-08-03 | 2017-06-13 | Chimerix Inc | composição e métodos de tratamento de infecções virais e tumores induzidos por vírus |
| CA2789443C (en) | 2010-02-12 | 2016-09-13 | Chimerix, Inc. | Nucleoside phosphonate salts |
| CA2797601A1 (en) | 2010-04-26 | 2011-11-10 | Chimerix, Inc. | Methods of treating retroviral infections and related dosage regimes |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2838437A1 (de) * | 1978-09-02 | 1980-03-20 | Benckiser Gmbh Joh A | N,n'-dialkyl-ureidomethan-diphosphonsaeure, deren herstellung und verwendung |
| IL77243A (en) * | 1984-12-21 | 1996-11-14 | Procter & Gamble | Pharmaceutical compositions containing geminal diphosphonic acid compounds and certain such novel compounds |
| DE3623397A1 (de) * | 1986-07-11 | 1988-01-14 | Boehringer Mannheim Gmbh | Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel |
| IL86951A (en) * | 1987-07-06 | 1996-07-23 | Procter & Gamble Pharma | Methylene phosphonoalkylphosphinates and pharmaceutical preparations containing them |
| JPH0248587A (ja) * | 1988-08-10 | 1990-02-19 | Yamanouchi Pharmaceut Co Ltd | 複素環置換ビスフォスフォン酸誘導体及びその医薬 |
| DE3929582A1 (de) * | 1989-09-06 | 1991-03-07 | Hoechst Ag | Benzoylguanidine, verfahren zu ihrer herstellung, ihre verwendung als medikament sowie sie enthaltendes medikament |
| TW222637B (fi) * | 1991-12-12 | 1994-04-21 | Hoechst Ag | |
| DK0600371T3 (da) * | 1992-12-02 | 1999-09-20 | Hoechst Ag | Guanidinalkyl-1,1-bisphosphonsyrederivater, fremgangsmåde til deres fremstilling samt deres anvendelse |
-
1993
- 1993-11-25 DK DK93118992T patent/DK0600371T3/da active
- 1993-11-25 EP EP93118992A patent/EP0600371B1/de not_active Expired - Lifetime
- 1993-11-25 ES ES93118992T patent/ES2129485T3/es not_active Expired - Lifetime
- 1993-11-25 DE DE59309360T patent/DE59309360D1/de not_active Expired - Fee Related
- 1993-11-25 AT AT93118992T patent/ATE176476T1/de not_active IP Right Cessation
- 1993-11-30 FI FI935360A patent/FI108034B/fi not_active IP Right Cessation
- 1993-11-30 US US08/159,119 patent/US5395826A/en not_active Expired - Fee Related
- 1993-11-30 NZ NZ250322A patent/NZ250322A/en unknown
- 1993-11-30 AU AU52040/93A patent/AU663983B2/en not_active Ceased
- 1993-12-01 RU RU93054537A patent/RU2114855C1/ru not_active IP Right Cessation
- 1993-12-01 CA CA002110443A patent/CA2110443C/en not_active Expired - Fee Related
- 1993-12-01 BR BR9304910A patent/BR9304910A/pt not_active Application Discontinuation
- 1993-12-01 JP JP30142893A patent/JP3499905B2/ja not_active Expired - Fee Related
- 1993-12-02 KR KR1019930026202A patent/KR100347423B1/ko not_active IP Right Cessation
-
1994
- 1994-11-23 US US08/346,239 patent/US5498617A/en not_active Expired - Fee Related
-
1996
- 1996-03-01 US US08/609,473 patent/US5661174A/en not_active Expired - Fee Related
-
1999
- 1999-04-21 GR GR990401101T patent/GR3030020T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0600371B1 (de) | 1999-02-03 |
| US5661174A (en) | 1997-08-26 |
| ATE176476T1 (de) | 1999-02-15 |
| DE59309360D1 (de) | 1999-03-18 |
| ES2129485T3 (es) | 1999-06-16 |
| CA2110443C (en) | 2006-02-21 |
| KR100347423B1 (ko) | 2002-10-30 |
| JPH06279470A (ja) | 1994-10-04 |
| AU5204093A (en) | 1994-06-16 |
| AU663983B2 (en) | 1995-10-26 |
| DK0600371T3 (da) | 1999-09-20 |
| KR940014421A (ko) | 1994-07-18 |
| EP0600371A1 (de) | 1994-06-08 |
| JP3499905B2 (ja) | 2004-02-23 |
| US5395826A (en) | 1995-03-07 |
| NZ250322A (en) | 1995-12-21 |
| US5498617A (en) | 1996-03-12 |
| FI108034B (fi) | 2001-11-15 |
| CA2110443A1 (en) | 1994-06-03 |
| FI935360A0 (fi) | 1993-11-30 |
| BR9304910A (pt) | 1994-08-16 |
| GR3030020T3 (en) | 1999-07-30 |
| RU2114855C1 (ru) | 1998-07-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MA | Patent expired |