FI935072L - Nya perhydroisoindoler och deras framstaellning - Google Patents

Nya perhydroisoindoler och deras framstaellning Download PDF

Info

Publication number
FI935072L
FI935072L FI935072A FI935072A FI935072L FI 935072 L FI935072 L FI 935072L FI 935072 A FI935072 A FI 935072A FI 935072 A FI935072 A FI 935072A FI 935072 L FI935072 L FI 935072L
Authority
FI
Finland
Prior art keywords
perhydroisoindoler
nya
deras framstaellning
och deras
och
Prior art date
Application number
FI935072A
Other languages
English (en)
Finnish (fi)
Other versions
FI935072A7 (fi
FI935072A0 (fi
Inventor
Daniel Achard
Serge Grisoni
Stephen Hanessian
Claude Moutonnier
Jean-Francois Peyronel
Michel Tabart
Alain Truchon
Original Assignee
Rhone Poulenc Rorer Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Rorer Sa filed Critical Rhone Poulenc Rorer Sa
Publication of FI935072A7 publication Critical patent/FI935072A7/fi
Publication of FI935072A0 publication Critical patent/FI935072A0/fi
Publication of FI935072L publication Critical patent/FI935072L/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
FI935072A 1991-05-17 1992-05-15 Nya perhydroisoindoler och deras framstaellning FI935072L (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9106036A FR2676443B1 (fr) 1991-05-17 1991-05-17 Nouveaux derives de perhydroisoindole et leur preparation.
PCT/FR1992/000430 WO1992020654A1 (fr) 1991-05-17 1992-05-15 Nouveaux derives de perhydroisoindole et leur preparation

Publications (3)

Publication Number Publication Date
FI935072A7 FI935072A7 (fi) 1993-11-16
FI935072A0 FI935072A0 (fi) 1993-11-16
FI935072L true FI935072L (fi) 1993-11-16

Family

ID=9412908

Family Applications (1)

Application Number Title Priority Date Filing Date
FI935072A FI935072L (fi) 1991-05-17 1992-05-15 Nya perhydroisoindoler och deras framstaellning

Country Status (23)

Country Link
US (1) US5508433A (enFirst)
EP (2) EP0586471B1 (enFirst)
JP (1) JPH06507628A (enFirst)
AT (1) ATE116295T1 (enFirst)
AU (1) AU1884092A (enFirst)
CA (1) CA2109297A1 (enFirst)
CZ (1) CZ244893A3 (enFirst)
DE (1) DE69201058T2 (enFirst)
DK (1) DK0586471T3 (enFirst)
ES (1) ES2066620T3 (enFirst)
FI (1) FI935072L (enFirst)
FR (1) FR2676443B1 (enFirst)
HU (1) HUT68913A (enFirst)
IE (1) IE921579A1 (enFirst)
IL (1) IL101867A0 (enFirst)
MX (1) MX9202288A (enFirst)
NO (1) NO933976D0 (enFirst)
NZ (1) NZ242773A (enFirst)
SK (1) SK126893A3 (enFirst)
TW (1) TW226991B (enFirst)
WO (1) WO1992020654A1 (enFirst)
YU (1) YU51692A (enFirst)
ZA (1) ZA923541B (enFirst)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2676442B1 (fr) * 1991-05-17 1993-08-06 Rhone Poulenc Rorer Sa Nouveau derives de perhydroisoindole, leur preparation et les compositions pharmaceutiques qui les contiennent.
FR2689889B1 (fr) * 1992-04-10 1994-06-10 Rhone Poulenc Rorer Sa Nouveaux derives de perhydroisoindole, et leur preparation.
US5508424A (en) * 1993-03-26 1996-04-16 Ortho Pharmaceutical Corporation 4-arylisoindole analgesics
FR2703679B1 (fr) * 1993-04-05 1995-06-23 Rhone Poulenc Rorer Sa Nouveaux derives de perhydroisoindole, leur preparation et les compositions pharmaceutiques qui les contiennent.
FR2709752B1 (fr) * 1993-07-30 1995-10-06 Rhone Poulenc Rorer Sa Nouveaux dérivés de perhydroisoindole, leur préparation et les compositions pharmaceutiques qui les contiennent.
TW365603B (en) * 1993-07-30 1999-08-01 Rhone Poulenc Rorer Sa Novel perhydroisoindole derivatives, their preparation and pharmaceutical compositions which contain them
FR2710913B1 (fr) * 1993-10-07 1995-11-24 Rhone Poulenc Rorer Sa Nouveaux dérivés de perhydroisoindole, leur préparation et les compositions pharmaceutiques qui les contiennent.
FR2728169A1 (fr) 1994-12-19 1996-06-21 Oreal Utilisation d'un antagoniste de substance p pour le traitement des prurits et des dysesthesies oculaires ou palpebrales
FR2728166A1 (fr) 1994-12-19 1996-06-21 Oreal Composition topique contenant un antagoniste de substance p
FR2728165A1 (fr) 1994-12-19 1996-06-21 Oreal Utilisation d'un antagoniste de substance p pour le traitement des rougeurs cutanees d'origine neurogene
FR2741262B1 (fr) 1995-11-20 1999-03-05 Oreal Utilisation d'un antagoniste de tnf-alpha pour le traitement des rougeurs cutanees d'origine neurogene
US7163949B1 (en) 1999-11-03 2007-01-16 Amr Technology, Inc. 4-phenyl substituted tetrahydroisoquinolines and use thereof
DK1246806T3 (da) 1999-11-03 2008-06-16 Amr Technology Inc Aryl- og heteroarylsubstituerede tetrahydroisoquinoliner og anvendelse deraf til blokering af genoptagelse af norepinefrin, dopsmin og serotonin
MXPA03000275A (es) 2000-07-11 2004-12-13 Albany Molecular Res Inc Nuevas tetrahidroisoquinolinas substituidas con 4-fenilo y su uso terapeutico.
US6709651B2 (en) 2001-07-03 2004-03-23 B.M.R.A. Corporation B.V. Treatment of substance P-related disorders
UA91341C2 (ru) 2004-07-15 2010-07-26 Амр Текнолоджи, Інк. Арил- и гетероарилзамещенные тетрагидроизохинолины и их применение для блокирования обратного захвата норэпинефрина, допамина и серотонина
ATE550019T1 (de) 2005-05-17 2012-04-15 Merck Sharp & Dohme Cis-4-ä(4-chlorophenyl)sulfonylü-4-(2,5- difluorophenyl)cyclohexanepropansäure zur behandlug von krebs
US7956050B2 (en) 2005-07-15 2011-06-07 Albany Molecular Research, Inc. Aryl- and heteroaryl-substituted tetrahydrobenzazepines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin
GB0603041D0 (en) 2006-02-15 2006-03-29 Angeletti P Ist Richerche Bio Therapeutic compounds
US20110218176A1 (en) 2006-11-01 2011-09-08 Barbara Brooke Jennings-Spring Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development
BRPI0806245B1 (pt) 2007-01-10 2022-01-25 Msd Italia S.R.L. Compostos de fórmula i e seus usos
WO2009002495A1 (en) 2007-06-27 2008-12-31 Merck & Co., Inc. 4-carboxybenzylamino derivatives as histone deacetylase inhibitors
AR071997A1 (es) 2008-06-04 2010-07-28 Bristol Myers Squibb Co Forma cristalina de 6-((4s)-2-metil-4-(2-naftil)-1,2,3,4-tetrahidroisoquinolin-7-il)piridazin-3-amina
US9156812B2 (en) 2008-06-04 2015-10-13 Bristol-Myers Squibb Company Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine
EP2413932A4 (en) 2009-04-01 2012-09-19 Merck Sharp & Dohme HAMMER OF ACT ACTIVITY
JP5739415B2 (ja) 2009-05-12 2015-06-24 ブリストル−マイヤーズ スクウィブ カンパニー （Ｓ）−７−（［１，２，４］トリアゾロ［１，５−ａ］ピリジン−６−イル）−４−（３，４−ジクロロフェニル）−１，２，３，４−テトラヒドロイソキノリンの結晶形態およびその使用
ES2446971T3 (es) 2009-05-12 2014-03-11 Albany Molecular Research, Inc. Tetrahidroisoquinolinas sustituidas con arilo, heteroarilo, y heterociclo y su uso
CN102595902B (zh) 2009-05-12 2015-04-29 阿尔巴尼分子研究公司 7-([1,2,4]三唑并[1,5-a]吡啶-6-基)-4-(3,4-二氯苯基)-1,2,3,4-四氢异喹啉及其用途
CA2777043C (en) 2009-10-14 2015-12-15 Schering Corporation Substituted piperidines that increase p53 activity and the uses thereof
CN103068980B (zh) 2010-08-02 2017-04-05 瑟纳治疗公司 使用短干扰核酸（siNA）的RNA干扰介导的联蛋白（钙粘蛋白关联蛋白质），β1（CTNNB1）基因表达的抑制
RU2745848C2 (ru) 2010-08-17 2021-04-01 Сирна Терапьютикс, Инк. ОПОСРЕДУЕМОЕ РНК-ИНТЕРФЕРЕНЦИЕЙ ИНГИБИРОВАНИЕ ЭКСПРЕССИИ ГЕНОВ ВИРУСА ГЕПАТИТА B (HBV) С ПРИМЕНЕНИЕМ МАЛОЙ ИНТЕРФЕРИРУЮЩЕЙ НУКЛЕИНОВОЙ КИСЛОТЫ (миНК)
US8883801B2 (en) 2010-08-23 2014-11-11 Merck Sharp & Dohme Corp. Substituted pyrazolo[1,5-a]pyrimidines as mTOR inhibitors
EP2613782B1 (en) 2010-09-01 2016-11-02 Merck Sharp & Dohme Corp. Indazole derivatives useful as erk inhibitors
US9242981B2 (en) 2010-09-16 2016-01-26 Merck Sharp & Dohme Corp. Fused pyrazole derivatives as novel ERK inhibitors
WO2012058210A1 (en) 2010-10-29 2012-05-03 Merck Sharp & Dohme Corp. RNA INTERFERENCE MEDIATED INHIBITION OF GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACIDS (siNA)
WO2012087772A1 (en) 2010-12-21 2012-06-28 Schering Corporation Indazole derivatives useful as erk inhibitors
WO2012143879A1 (en) 2011-04-21 2012-10-26 Piramal Healthcare Limited A crystalline form of a salt of a morpholino sulfonyl indole derivative and a process for its preparation
EP2770987B1 (en) 2011-10-27 2018-04-04 Merck Sharp & Dohme Corp. Novel compounds that are erk inhibitors
EP3919620A1 (en) 2012-05-02 2021-12-08 Sirna Therapeutics, Inc. Short interfering nucleic acid (sina) compositions
CA2882950A1 (en) 2012-09-28 2014-04-03 Merck Sharp & Dohme Corp. Novel compounds that are erk inhibitors
SMT201700595T1 (it) 2012-11-28 2018-03-08 Merck Sharp & Dohme Composizioni e metodi per trattare il cancro
WO2014100065A1 (en) 2012-12-20 2014-06-26 Merck Sharp & Dohme Corp. Substituted imidazopyridines as hdm2 inhibitors
WO2014120748A1 (en) 2013-01-30 2014-08-07 Merck Sharp & Dohme Corp. 2,6,7,8 substituted purines as hdm2 inhibitors
WO2015034925A1 (en) 2013-09-03 2015-03-12 Moderna Therapeutics, Inc. Circular polynucleotides
US10975084B2 (en) 2016-10-12 2021-04-13 Merck Sharp & Dohme Corp. KDM5 inhibitors
WO2019094312A1 (en) 2017-11-08 2019-05-16 Merck Sharp & Dohme Corp. Prmt5 inhibitors
EP3706742B1 (en) 2017-11-08 2023-03-15 Merck Sharp & Dohme LLC Prmt5 inhibitors
WO2020033282A1 (en) 2018-08-07 2020-02-13 Merck Sharp & Dohme Corp. Prmt5 inhibitors
CA3108388A1 (en) 2018-08-07 2020-02-13 Merck Sharp & Dohme Corp. Prmt5 inhibitors
EP3833667B1 (en) 2018-08-07 2024-03-13 Merck Sharp & Dohme LLC Prmt5 inhibitors

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4042707A (en) * 1976-02-19 1977-08-16 E. I. Du Pont De Nemours And Company 3α-Arylhydroisoindoles
AU502760B2 (en) * 1977-02-28 1979-08-09 Science Union Et Cie, Societe Francaise De Recherche Medicale Azabicycloalkanes and their preparation
DE3260423D1 (en) * 1981-02-17 1984-08-30 Warner Lambert Co Substituted acyl derivatives of octahydro-1h-isoindole-1-carboxylic acids and esters
US4439229A (en) * 1981-06-29 1984-03-27 Rohm And Haas Company Substituted phthalimides herbicides
JPH0278659A (ja) * 1988-09-12 1990-03-19 Shionogi & Co Ltd アザビシクロアルカン類化合物
FR2654725B1 (fr) * 1989-11-23 1992-02-14 Rhone Poulenc Sante Nouveaux derives de l'isoindolone, leur preparation et les compositions pharmaceutiques qui les contiennent.

Also Published As

Publication number Publication date
ZA923541B (en) 1993-01-27
US5508433A (en) 1996-04-16
WO1992020654A1 (fr) 1992-11-26
EP0586471A1 (fr) 1994-03-16
CZ244893A3 (en) 1994-04-13
FR2676443B1 (fr) 1993-08-06
CA2109297A1 (fr) 1992-11-18
NO933976L (no) 1993-11-03
DE69201058T2 (de) 1995-05-11
TW226991B (enFirst) 1994-07-21
ES2066620T3 (es) 1995-03-01
IL101867A0 (en) 1992-12-30
DK0586471T3 (da) 1995-06-06
EP0514274A1 (fr) 1992-11-19
IE921579A1 (en) 1992-11-18
FR2676443A1 (fr) 1992-11-20
NZ242773A (en) 1994-06-27
ATE116295T1 (de) 1995-01-15
FI935072A7 (fi) 1993-11-16
AU1884092A (en) 1992-12-30
HU9303250D0 (en) 1994-03-28
EP0586471B1 (fr) 1994-12-28
YU51692A (sh) 1994-06-10
SK126893A3 (en) 1994-11-09
HUT68913A (en) 1995-08-28
MX9202288A (es) 1992-11-01
FI935072A0 (fi) 1993-11-16
JPH06507628A (ja) 1994-09-01
NO933976D0 (no) 1993-11-03
DE69201058D1 (de) 1995-02-09

Similar Documents

Publication Publication Date Title
FI924226L (fi) Nya furyl- och tienylsubstituerade taxaner och farmaceutiska kompositioner innehaollande dessa
FI924228A7 (fi) Nya substituerade taxaner och farmaceutiska kompositioner innehaollandedessa
FI924227L (fi) Nya alkoxisubstituerade taxaner och farmaceutiska kompositioner innehaollande dessa
FI932103L (fi) Nya 4-arylpiperaziner och 4-arylpiperidiner
FI922735L (fi) Nya behaollarsystem och vattenhaltiga kompositioner
FI934438L (fi) Nya konjugater och foerfaranden foer samtidig detektering av flera ligander
FI925937L (fi) Nya polyamider och foeremaol erhaollna av dessa
FI934332L (fi) Nya proteaser
FI923515L (fi) Nya herbicider
FI925549L (fi) Nya azaheterocyklylmetyl-kromaner
FI924453L (fi) Nya 9-amino-7-(substituerad)-6-demetyl-6-deoxitetracykliner
FI924557A0 (fi) Nya fenylpyrazolfungicider
FI934575A7 (fi) Nya centralt verkande substituerade fenylazacykloalkaner
FI923264L (fi) Nya herbicider
FI933451A0 (fi) Nya steroidestrar
FI933253A0 (fi) Nya amylinantagonistpeptider och anvaendning som amylinantagonister
FI933450A0 (fi) Nya steroider
FI925665L (fi) Nya pyridylderivat, dessa foereningar innehaollande laekemedel och foerfarande foer deras framstaellning
FI925086A0 (fi) Nya hybrid-vaextfaktorer
FI921614A7 (fi) Nya herbicider
FI923050L (fi) Nya benzomorfaner och deras anvaendning som laekemedel
FI932145L (fi) Nya b-karbolinderivat, deras framstaellning och anvaendning i laekemedel
FI934331L (fi) Nya proteaser
FI930293A0 (fi) Nya heteroaryloxi-b-karboliner, deras framstaellning och anvaendning i laekemedel
FI922428L (fi) Nya 2-amino-5-cyan-1,4-dihydropyridiner, foerfarande foer deras framstaellning och deras anvaendning i laekemedel

Legal Events

Date Code Title Description
FD Application lapsed