FI933423A - Syntes av mellanprodukter vid framstaellning av acat-inhibitorer - Google Patents

Syntes av mellanprodukter vid framstaellning av acat-inhibitorer Download PDF

Info

Publication number
FI933423A
FI933423A FI933423A FI933423A FI933423A FI 933423 A FI933423 A FI 933423A FI 933423 A FI933423 A FI 933423A FI 933423 A FI933423 A FI 933423A FI 933423 A FI933423 A FI 933423A
Authority
FI
Finland
Prior art keywords
pct
framstaellning
synthesis
connector
acat inhibitor
Prior art date
Application number
FI933423A
Other languages
English (en)
Other versions
FI933423A0 (fi
Inventor
Sarah E Kelly
George Chang
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of FI933423A publication Critical patent/FI933423A/fi
Publication of FI933423A0 publication Critical patent/FI933423A0/fi

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72Nitrogen atoms
    • C07D213/75Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/26Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
    • C07C211/27Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring having amino groups linked to the six-membered aromatic ring by saturated carbon chains
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63Esters of sulfonic acids
    • C07C309/64Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms
    • C07C309/65Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms of a saturated carbon skeleton
    • C07C309/66Methanesulfonates
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63Esters of sulfonic acids
    • C07C309/72Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/73Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton to carbon atoms of non-condensed six-membered aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/52Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/60Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C53/00Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
    • C07C53/15Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen containing halogen
    • C07C53/19Acids containing three or more carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/01Saturated compounds having only one carboxyl group and containing hydroxy or O-metal groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D215/00Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38Nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Connector Housings Or Holding Contact Members (AREA)
  • Coupling Device And Connection With Printed Circuit (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Threshing Machine Elements (AREA)
  • Extrusion Moulding Of Plastics Or The Like (AREA)
FI933423A 1991-01-31 1993-07-30 Syntes av mellanprodukter vid framstaellning av acat-inhibitorer FI933423A0 (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US64824391A 1991-01-31 1991-01-31
PCT/US1991/008758 WO1992013843A1 (en) 1991-01-31 1991-11-27 Synthesis of intermediates in the preparation of acat inhibitors

Publications (2)

Publication Number Publication Date
FI933423A true FI933423A (fi) 1993-07-30
FI933423A0 FI933423A0 (fi) 1993-07-30

Family

ID=24600007

Family Applications (1)

Application Number Title Priority Date Filing Date
FI933423A FI933423A0 (fi) 1991-01-31 1993-07-30 Syntes av mellanprodukter vid framstaellning av acat-inhibitorer

Country Status (22)

Country Link
US (1) US5498786A (fi)
EP (1) EP0569482B1 (fi)
JP (1) JPH06500337A (fi)
KR (1) KR930703256A (fi)
AT (1) ATE125798T1 (fi)
AU (1) AU655237B2 (fi)
CA (1) CA2099564A1 (fi)
DE (1) DE69111828T2 (fi)
DK (1) DK0569482T3 (fi)
ES (1) ES2075685T3 (fi)
FI (1) FI933423A0 (fi)
GR (1) GR3017357T3 (fi)
HU (2) HUT69721A (fi)
IE (1) IE920302A1 (fi)
IL (1) IL100761A0 (fi)
MX (1) MX9200388A (fi)
NO (1) NO932749D0 (fi)
NZ (2) NZ241466A (fi)
PT (1) PT100062A (fi)
TW (1) TW206964B (fi)
WO (1) WO1992013843A1 (fi)
ZA (1) ZA92648B (fi)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996026925A1 (fr) * 1995-03-01 1996-09-06 Banyu Pharmaceutical Co., Ltd. Derives de l'arylthioacetamide
EP1600438A4 (en) * 2003-02-28 2007-05-02 Kaneka Corp METHODS FOR PRODUCING OPTICALLY ACTIVE COMPOUNDS COMPRISING SUBSTITUENTS IN POSITION 2

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX22406A (es) * 1989-09-15 1994-01-31 Pfizer Nuevos derivados de n-aril y n-heteroarilamidas y urea como inhibidores de acil coenzima a: acil transferasa del colesterol (acat).
JP3010497B2 (ja) * 1990-05-31 2000-02-21 チッソ株式会社 光学活性α―ヒドロキシエステル類の製造方法

Also Published As

Publication number Publication date
AU1271392A (en) 1992-09-07
DE69111828D1 (de) 1995-09-07
PT100062A (pt) 1993-03-31
US5498786A (en) 1996-03-12
KR930703256A (ko) 1993-11-29
DE69111828T2 (de) 1995-12-14
DK0569482T3 (da) 1995-09-25
AU655237B2 (en) 1994-12-08
ES2075685T3 (es) 1995-10-01
EP0569482A1 (en) 1993-11-18
JPH06500337A (ja) 1994-01-13
CA2099564A1 (en) 1992-08-01
IL100761A0 (en) 1992-09-06
GR3017357T3 (en) 1995-12-31
NO932749L (no) 1993-07-30
ZA92648B (en) 1993-07-30
HU9302221D0 (en) 1993-10-28
IE920302A1 (en) 1992-07-29
MX9200388A (es) 1992-08-01
NO932749D0 (no) 1993-07-30
EP0569482B1 (en) 1995-08-02
NZ241466A (en) 1995-03-28
ATE125798T1 (de) 1995-08-15
NZ248408A (en) 1995-03-28
WO1992013843A1 (en) 1992-08-20
TW206964B (fi) 1993-06-01
FI933423A0 (fi) 1993-07-30
HUT69721A (en) 1995-09-28

Similar Documents

Publication Publication Date Title
PT98710A (pt) Processo de preparacao de compostos de indolilo substituidos e de composicoes farmaceuticas que os contem
TW334418B (en) Stilbene derivatives and pharmaceutical compositions
YU53899A (sh) Primena inhibitora ciklooksigenaze-2 u prevenciji kardiovaskularnih poremećaja
KR950700323A (ko) 엔케팔리나제 및 안지오텐신 전환 효소의 억제제로서 유용한 아미노아세틸머캅토아세틸아미드 유도체(Aminoacetylmercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ACE)
ATE423562T1 (de) Alpha-ketoamidhaltige multikatalytische protease inhibitoren
ATE112239T1 (de) Vaterit und verfahren zu dessen herstellung.
MX9801190A (es) Inhibidores de prolil endopeptidasa.
FI933423A (fi) Syntes av mellanprodukter vid framstaellning av acat-inhibitorer
PT901492E (pt) Derivados do taxano, processo para a sua preparacao e as formulacoes que os contem
IL112630A0 (en) Indane-2-mercaptoacetylamide disulfide derivatives useful as inhibitors or enkephalinase
NO975413D0 (no) Koboltmetallagglomerater, samt fremgangsmåte for fremstilling og anvendelse derav
ES2163001T3 (es) Nuevos derivados de borneol, procedimiento para su preparacion y su utilizacion farmaceutica.
MX9603087A (es) Procedimiento para la obtencion de aminocarboniltriazolinonas substituidas.
GR3029660T3 (en) Novel mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase and ace
KR960700223A (ko) C-치환 디에틸렌 트리아민의 제조 방법(Process for the Production of C-Substituted Diethylenetriamines)
MX9704677A (es) Procedimientos novedosos para preparar intermediarios de inhibidores de encefalinasa y enzima de conversion a angiotensina y sus intermediarios.
ZA966372B (en) The preparation of α-(N,N-dialkylamino) carboxamides.
ATE206127T1 (de) Inhibitoren retroviraler proteasen

Legal Events

Date Code Title Description
FD Application lapsed