FI930552L - Nytt foerfarande foer framstaellning av nukleotider - Google Patents

Nytt foerfarande foer framstaellning av nukleotider Download PDF

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Publication number
FI930552L
FI930552L FI930552A FI930552A FI930552L FI 930552 L FI930552 L FI 930552L FI 930552 A FI930552 A FI 930552A FI 930552 A FI930552 A FI 930552A FI 930552 L FI930552 L FI 930552L
Authority
FI
Finland
Prior art keywords
nukleotider
now
foerfarande foer
foer framstaellning
framstaellning
Prior art date
Application number
FI930552A
Other languages
English (en)
Other versions
FI930552A0 (fi
FI930552A7 (fi
Inventor
Purushotham Vemishetti
Paul R Brodfuehrer
Henry G Howell
Jr Chester Sapino
Original Assignee
Inst Of Organic Chemistry Czec
Rega Stichting
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inst Of Organic Chemistry Czec, Rega Stichting filed Critical Inst Of Organic Chemistry Czec
Publication of FI930552A0 publication Critical patent/FI930552A0/fi
Publication of FI930552L publication Critical patent/FI930552L/fi
Publication of FI930552A7 publication Critical patent/FI930552A7/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6509—Six-membered rings
    • C07F9/6512—Six-membered rings having the nitrogen atoms in positions 1 and 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
FI930552A 1990-08-10 1991-08-06 Uusi menetelmä nukleotidien valmistamiseksi FI930552A7 (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US56620090A 1990-08-10 1990-08-10
PCT/US1991/005578 WO1992002511A1 (en) 1990-08-10 1991-08-06 Novel process for the preparation of nucleotides

Publications (3)

Publication Number Publication Date
FI930552A0 FI930552A0 (fi) 1993-02-09
FI930552L true FI930552L (fi) 1993-02-22
FI930552A7 FI930552A7 (fi) 1993-02-22

Family

ID=24261919

Family Applications (1)

Application Number Title Priority Date Filing Date
FI930552A FI930552A7 (fi) 1990-08-10 1991-08-06 Uusi menetelmä nukleotidien valmistamiseksi

Country Status (11)

Country Link
US (2) US5476938A (fi)
EP (1) EP0574386B1 (fi)
JP (1) JP3116079B2 (fi)
KR (1) KR100221981B1 (fi)
AT (1) ATE194142T1 (fi)
AU (1) AU653552B2 (fi)
CA (1) CA2088363C (fi)
DE (1) DE69132276T2 (fi)
ES (1) ES2149157T3 (fi)
FI (1) FI930552A7 (fi)
WO (1) WO1992002511A1 (fi)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CS387190A3 (en) * 1990-08-06 1992-03-18 Ustav Organicke Chemie A Bioch (2r)-2-/di(2-propyl)phosphonylmethoxy/-3-p-toluenesulfonyloxy -1- trimethylacetoxypropane and process for preparing thereof
EP0574386B1 (en) * 1990-08-10 2000-06-28 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Novel process for the preparation of nucleotides
ATE167679T1 (de) * 1990-09-14 1998-07-15 Acad Of Science Czech Republic Wirkstoffvorläufer von phosphonaten
US6057305A (en) * 1992-08-05 2000-05-02 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Antiretroviral enantiomeric nucleotide analogs
US6448373B1 (en) * 1994-01-11 2002-09-10 Isis Pharmaceuticals, Inc. Phosphate linked oligomers formed of monomeric diols and processes for preparing same
EP3235823A1 (en) 2000-07-21 2017-10-25 Gilead Sciences, Inc. Prodrugs of phosphonate nucleotide analogues and methods for selecting and making same
CA2512475C (en) * 2003-01-14 2009-06-02 Gilead Sciences, Inc. Compositions and methods for combination antiviral therapy
US20060252729A1 (en) * 2003-07-30 2006-11-09 Krawczyk Steven H Nucleobase phosphonate analogs for antiviral treatment
WO2006110655A2 (en) 2005-04-08 2006-10-19 Chimerix, Inc. Compounds, compositions and methods for the treatment of poxvirus infections
EP2842559A3 (en) * 2005-04-08 2015-03-18 Chimerix, Inc. Compounds, compositions and methods for the treatment of viral infections and other medical disorders
TWI471145B (zh) 2005-06-13 2015-02-01 Bristol Myers Squibb & Gilead Sciences Llc 單一式藥學劑量型
TWI375560B (en) 2005-06-13 2012-11-01 Gilead Sciences Inc Composition comprising dry granulated emtricitabine and tenofovir df and method for making the same
CN102772415A (zh) 2007-04-13 2012-11-14 南方研究所 抗血管生成剂和使用方法
CN105055432A (zh) 2008-01-25 2015-11-18 奇默里克斯公司 治疗病毒感染的方法
WO2011011519A1 (en) 2009-07-21 2011-01-27 Chimerix, Inc. Compounds, compositions and methods for treating ocular conditions
AU2011216243B2 (en) 2010-02-12 2015-07-09 Chimerix, Inc. Nucleoside phosphonate salts
EP2563367A4 (en) 2010-04-26 2013-12-04 Chimerix Inc Methods of treating retroviral infections and related dosage regimes
CN103209985B (zh) * 2010-08-31 2016-08-24 奇默里克斯公司 膦酸酯衍生物及其合成方法
MX2013006127A (es) 2010-12-10 2013-09-26 Sigmapharm Lab Llc Composiciones sumamente estables de analogos nucleotidicoas oralmente activos o profarmacos analogos nucleotidicos oralmente activos.
JP6113185B2 (ja) 2011-12-22 2017-04-12 ジェロン・コーポレーションＧｅｒｏｎ Ｃｏｒｐｏｒａｔｉｏｎ テロメラーゼ基質およびテロメア長作用因子としてのグアニンアナログ
CN111777639A (zh) * 2013-11-15 2020-10-16 奇默里克斯公司 十六烷氧基丙基膦酸酯的形态
CN103951703A (zh) * 2014-04-28 2014-07-30 中国人民解放军军事医学科学院微生物流行病研究所 制备膦酯衍生物的方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CS233665B1 (en) * 1983-01-06 1985-03-14 Antonin Holy Processing of isomere o-phosphonylmethylderivative of anantiomere racemic vicinal diene
JPH0625061B2 (ja) * 1984-07-03 1994-04-06 ザ ウエルカム フアウンデ−シヨン リミテツド 抗ウイルス性化合物
CS263951B1 (en) * 1985-04-25 1989-05-12 Antonin Holy 9-(phosponylmethoxyalkyl)adenines and method of their preparation
IL82998A0 (en) * 1986-07-07 1987-12-20 Koller Werner Dental sleeve,its production and its use for producing a ceramic crown
CS264222B1 (en) * 1986-07-18 1989-06-13 Holy Antonin N-phosphonylmethoxyalkylderivatives of bases of pytimidine and purine and method of use them
EP0574386B1 (en) * 1990-08-10 2000-06-28 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Novel process for the preparation of nucleotides

Also Published As

Publication number Publication date
KR930702349A (ko) 1993-09-08
FI930552A0 (fi) 1993-02-09
CA2088363A1 (en) 1992-02-11
JP3116079B2 (ja) 2000-12-11
US5591852A (en) 1997-01-07
EP0574386A1 (en) 1993-12-22
DE69132276T2 (de) 2001-03-01
KR100221981B1 (ko) 1999-09-15
EP0574386A4 (en) 1993-10-27
JPH06503807A (ja) 1994-04-28
DE69132276D1 (de) 2000-08-03
AU653552B2 (en) 1994-10-06
FI930552A7 (fi) 1993-02-22
ATE194142T1 (de) 2000-07-15
ES2149157T3 (es) 2000-11-01
US5476938A (en) 1995-12-19
EP0574386B1 (en) 2000-06-28
WO1992002511A1 (en) 1992-02-20
AU8492891A (en) 1992-03-02
CA2088363C (en) 2002-05-28

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