FI930552L - Nytt foerfarande foer framstaellning av nukleotider - Google Patents

Nytt foerfarande foer framstaellning av nukleotider Download PDF

Info

Publication number
FI930552L
FI930552L FI930552A FI930552A FI930552L FI 930552 L FI930552 L FI 930552L FI 930552 A FI930552 A FI 930552A FI 930552 A FI930552 A FI 930552A FI 930552 L FI930552 L FI 930552L
Authority
FI
Finland
Prior art keywords
nukleotider
now
foerfarande foer
foer framstaellning
framstaellning
Prior art date
Application number
FI930552A
Other languages
English (en)
Other versions
FI930552A0 (fi
FI930552A7 (fi
Inventor
Purushotham Vemishetti
Paul R Brodfuehrer
Henry G Howell
Jr Chester Sapino
Original Assignee
Inst Of Organic Chemistry Czec
Rega Stichting
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inst Of Organic Chemistry Czec, Rega Stichting filed Critical Inst Of Organic Chemistry Czec
Publication of FI930552A0 publication Critical patent/FI930552A0/fi
Publication of FI930552L publication Critical patent/FI930552L/fi
Publication of FI930552A7 publication Critical patent/FI930552A7/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6509—Six-membered rings
    • C07F9/6512—Six-membered rings having the nitrogen atoms in positions 1 and 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
FI930552A 1990-08-10 1991-08-06 Uusi menetelmä nukleotidien valmistamiseksi FI930552A7 (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US56620090A 1990-08-10 1990-08-10
PCT/US1991/005578 WO1992002511A1 (en) 1990-08-10 1991-08-06 Novel process for the preparation of nucleotides

Publications (3)

Publication Number Publication Date
FI930552A0 FI930552A0 (fi) 1993-02-09
FI930552L true FI930552L (fi) 1993-02-22
FI930552A7 FI930552A7 (fi) 1993-02-22

Family

ID=24261919

Family Applications (1)

Application Number Title Priority Date Filing Date
FI930552A FI930552A7 (fi) 1990-08-10 1991-08-06 Uusi menetelmä nukleotidien valmistamiseksi

Country Status (11)

Country Link
US (2) US5476938A (fi)
EP (1) EP0574386B1 (fi)
JP (1) JP3116079B2 (fi)
KR (1) KR100221981B1 (fi)
AT (1) ATE194142T1 (fi)
AU (1) AU653552B2 (fi)
CA (1) CA2088363C (fi)
DE (1) DE69132276T2 (fi)
ES (1) ES2149157T3 (fi)
FI (1) FI930552A7 (fi)
WO (1) WO1992002511A1 (fi)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CS387190A3 (en) * 1990-08-06 1992-03-18 Ustav Organicke Chemie A Bioch (2r)-2-/di(2-propyl)phosphonylmethoxy/-3-p-toluenesulfonyloxy -1- trimethylacetoxypropane and process for preparing thereof
JP3116079B2 (ja) * 1990-08-10 2000-12-11 インスティチュート オブ オーガニック ケミストリ アンド バイオケミストリ アカデミー オブ サイエンス オブ ザ チェコ リパブリック ヌクレオチドの新規な製法
DE10399025I2 (de) * 1990-09-14 2007-11-08 Acad Of Science Czech Republic Wirkstoffvorläufer von Phosphonaten
US6057305A (en) 1992-08-05 2000-05-02 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Antiretroviral enantiomeric nucleotide analogs
US6448373B1 (en) * 1994-01-11 2002-09-10 Isis Pharmaceuticals, Inc. Phosphate linked oligomers formed of monomeric diols and processes for preparing same
EP2682397B1 (en) 2000-07-21 2017-04-19 Gilead Sciences, Inc. Prodrugs of phosphonate nucleotide analogues and methods for selecting and making same
US20040224917A1 (en) 2003-01-14 2004-11-11 Gilead Sciences, Inc. Compositions and methods for combination antiviral therapy
EP1656387A2 (en) * 2003-07-30 2006-05-17 Gilead Sciences, Inc. Nucleobase phosphonate analogs for antiviral treatment
WO2006110655A2 (en) 2005-04-08 2006-10-19 Chimerix, Inc. Compounds, compositions and methods for the treatment of poxvirus infections
JP2008538354A (ja) * 2005-04-08 2008-10-23 キメリクス，インコーポレイテッド ウイルス感染症およびその他の内科疾患を治療するための化合物、組成物および方法
TWI471145B (zh) 2005-06-13 2015-02-01 Bristol Myers Squibb & Gilead Sciences Llc 單一式藥學劑量型
TWI375560B (en) 2005-06-13 2012-11-01 Gilead Sciences Inc Composition comprising dry granulated emtricitabine and tenofovir df and method for making the same
NZ592289A (en) 2007-04-13 2013-03-28 Southern Res Inst Anti-Angiogenic Agents and Methods of Use
MX2010008148A (es) 2008-01-25 2010-10-20 Chimerix Inc Métodos de tratamiento de infecciones virales.
WO2011011519A1 (en) 2009-07-21 2011-01-27 Chimerix, Inc. Compounds, compositions and methods for treating ocular conditions
WO2011100698A2 (en) 2010-02-12 2011-08-18 Chimerix, Inc. Methods of treating viral infection
EP2563367A4 (en) 2010-04-26 2013-12-04 Chimerix Inc Methods of treating retroviral infections and related dosage regimes
CN103209985B (zh) * 2010-08-31 2016-08-24 奇默里克斯公司 膦酸酯衍生物及其合成方法
FI2648701T3 (fi) 2010-12-10 2023-06-12 Sigmapharm Laboratories Llc Hyvin stabiileja adefovirdipivoksiilin koostumuksia
US9593137B2 (en) 2011-12-22 2017-03-14 Geron Corporation Guanine analogs as telomerase substrates and telomere length affectors
WO2015073148A1 (en) 2013-11-15 2015-05-21 Chimerix Inc. Morphic forms of hexadecyloxypropyl-phosphonate esters
CN103951703A (zh) * 2014-04-28 2014-07-30 中国人民解放军军事医学科学院微生物流行病研究所 制备膦酯衍生物的方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CS233665B1 (en) * 1983-01-06 1985-03-14 Antonin Holy Processing of isomere o-phosphonylmethylderivative of anantiomere racemic vicinal diene
DE3585643D1 (de) * 1984-07-03 1992-04-23 Wellcome Found Antiviren-verbindungen, behandlung und formulierungen.
CS263951B1 (en) * 1985-04-25 1989-05-12 Antonin Holy 9-(phosponylmethoxyalkyl)adenines and method of their preparation
IL82998A0 (en) * 1986-07-07 1987-12-20 Koller Werner Dental sleeve,its production and its use for producing a ceramic crown
CS264222B1 (en) * 1986-07-18 1989-06-13 Holy Antonin N-phosphonylmethoxyalkylderivatives of bases of pytimidine and purine and method of use them
JP3116079B2 (ja) * 1990-08-10 2000-12-11 インスティチュート オブ オーガニック ケミストリ アンド バイオケミストリ アカデミー オブ サイエンス オブ ザ チェコ リパブリック ヌクレオチドの新規な製法

Also Published As

Publication number Publication date
EP0574386B1 (en) 2000-06-28
JPH06503807A (ja) 1994-04-28
DE69132276T2 (de) 2001-03-01
EP0574386A1 (en) 1993-12-22
US5476938A (en) 1995-12-19
CA2088363C (en) 2002-05-28
FI930552A0 (fi) 1993-02-09
US5591852A (en) 1997-01-07
WO1992002511A1 (en) 1992-02-20
ES2149157T3 (es) 2000-11-01
EP0574386A4 (en) 1993-10-27
AU653552B2 (en) 1994-10-06
ATE194142T1 (de) 2000-07-15
KR930702349A (ko) 1993-09-08
CA2088363A1 (en) 1992-02-11
DE69132276D1 (de) 2000-08-03
KR100221981B1 (ko) 1999-09-15
AU8492891A (en) 1992-03-02
JP3116079B2 (ja) 2000-12-11
FI930552A7 (fi) 1993-02-22

Similar Documents

Publication Publication Date Title
FI930862L (fi) En doseringsform foer tidsvarierande moenster av laekemedeloeverlaotelse
FI930886L (fi) Foerfarande foer hindrande av avstoetning av transplanterad vaevnad
FI930848A0 (fi) Foerfarande foer separering av ilmenit
FI923931L (fi) Anordning foer granskning av insidan av en foergrenad roerlinje
FI930736L (fi) Foerfarande foer framstaellning av ramnos fraon ramnolipider
FI930763A7 (fi) Framstaellning av klordioxid fraon klorsyra
FI925884A7 (fi) Avlaegsning av signaldistorsion
FI930165L (fi) Framstaellning av synnerligen aktiva tvaettmedelspartiklar
FI924569L (fi) Foerfarande foer enantioselektiv framstaellning av fenylisoserinderivat
FI924568L (fi) Foerfarande foer stereoselektiv framstaellning av fenylisoserinderivat
FI931355A0 (fi) Fasoeverfoeringsmedierat foerfarande foer framstaellning av glukamidtvaettmedel
FI930552L (fi) Nytt foerfarande foer framstaellning av nukleotider
FI925988L (fi) Foerfarande foer framstaellning av b-laktamer
FI925515L (fi) Foerfarande foer framstaellning av alfa-2-interferonkristaller
FI925415L (fi) Framstaellning av substituerade piperidiner
FI925435A7 (fi) Foerfarande foer beredning av en vattenloesning av natriumfoereningar
FI931354L (fi) Hoegkatalytiskt foerfarande foer framstaellning av glukamidtvaettmedel
FI924436A7 (fi) Foerfarande foer tillverkning av expanderade polystyrenfolier
FI931356A0 (fi) Foerbaettrat katalytiskt foerfarande foer framstaellning av glukamidtvaettmedel
FI925805L (fi) Framstaellning av kompositmaterial
FI924826L (fi) Fettkompositioner innehaollande polyestrar av polyolfettsyror
FI925609A0 (fi) Foerfarande foer framstaellning av sykliska sulfater
FI924371L (fi) Foerfarande foer tillverkning av en elektromagnetisk omvandlare
FI923776A7 (fi) Foerfarande foer formning av pappersark
FI924374L (fi) Foerfarande foer dubbelsidig belaeggning av en roerlig materialbana