FI930552L - Nytt foerfarande foer framstaellning av nukleotider - Google Patents

Nytt foerfarande foer framstaellning av nukleotider Download PDF

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Publication number
FI930552L
FI930552L FI930552A FI930552A FI930552L FI 930552 L FI930552 L FI 930552L FI 930552 A FI930552 A FI 930552A FI 930552 A FI930552 A FI 930552A FI 930552 L FI930552 L FI 930552L
Authority
FI
Finland
Prior art keywords
nukleotider
now
foerfarande foer
foer framstaellning
framstaellning
Prior art date
Application number
FI930552A
Other languages
English (en)
Other versions
FI930552A0 (fi
FI930552A7 (fi
Inventor
Purushotham Vemishetti
Paul R Brodfuehrer
Henry G Howell
Jr Chester Sapino
Original Assignee
Inst Of Organic Chemistry Czec
Rega Stichting
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inst Of Organic Chemistry Czec, Rega Stichting filed Critical Inst Of Organic Chemistry Czec
Publication of FI930552A0 publication Critical patent/FI930552A0/fi
Publication of FI930552A7 publication Critical patent/FI930552A7/fi
Publication of FI930552L publication Critical patent/FI930552L/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6509—Six-membered rings
    • C07F9/6512—Six-membered rings having the nitrogen atoms in positions 1 and 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
FI930552A 1990-08-10 1991-08-06 Nytt foerfarande foer framstaellning av nukleotider FI930552L (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US56620090A 1990-08-10 1990-08-10
PCT/US1991/005578 WO1992002511A1 (en) 1990-08-10 1991-08-06 Novel process for the preparation of nucleotides

Publications (3)

Publication Number Publication Date
FI930552A0 FI930552A0 (fi) 1993-02-09
FI930552A7 FI930552A7 (fi) 1993-02-22
FI930552L true FI930552L (fi) 1993-02-22

Family

ID=24261919

Family Applications (1)

Application Number Title Priority Date Filing Date
FI930552A FI930552L (fi) 1990-08-10 1991-08-06 Nytt foerfarande foer framstaellning av nukleotider

Country Status (11)

Country Link
US (2) US5476938A (fi)
EP (1) EP0574386B1 (fi)
JP (1) JP3116079B2 (fi)
KR (1) KR100221981B1 (fi)
AT (1) ATE194142T1 (fi)
AU (1) AU653552B2 (fi)
CA (1) CA2088363C (fi)
DE (1) DE69132276T2 (fi)
ES (1) ES2149157T3 (fi)
FI (1) FI930552L (fi)
WO (1) WO1992002511A1 (fi)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CS387190A3 (en) * 1990-08-06 1992-03-18 Ustav Organicke Chemie A Bioch (2r)-2-/di(2-propyl)phosphonylmethoxy/-3-p-toluenesulfonyloxy -1- trimethylacetoxypropane and process for preparing thereof
JP3116079B2 (ja) * 1990-08-10 2000-12-11 インスティチュート オブ オーガニック ケミストリ アンド バイオケミストリ アカデミー オブ サイエンス オブ ザ チェコ リパブリック ヌクレオチドの新規な製法
EP0481214B1 (en) * 1990-09-14 1998-06-24 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Prodrugs of phosphonates
US6057305A (en) * 1992-08-05 2000-05-02 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Antiretroviral enantiomeric nucleotide analogs
US6448373B1 (en) * 1994-01-11 2002-09-10 Isis Pharmaceuticals, Inc. Phosphate linked oligomers formed of monomeric diols and processes for preparing same
AU8294101A (en) 2000-07-21 2002-02-05 Gilead Sciences Inc Prodrugs of phosphonate nucleotide analogues and methods for selecting and making same
EA201100293A1 (ru) 2003-01-14 2011-08-30 Джилид Сайэнс, Инк. Способ (варианты) и фармацевтическая композиция (варианты) для лечения или профилактики симптомов вич-инфекции
US7579332B2 (en) * 2003-07-30 2009-08-25 Gilead Sciences, Inc. Nucleobase phosphonate analogs for antiviral treatment
WO2006110655A2 (en) 2005-04-08 2006-10-19 Chimerix, Inc. Compounds, compositions and methods for the treatment of poxvirus infections
JP2008538354A (ja) * 2005-04-08 2008-10-23 キメリクス，インコーポレイテッド ウイルス感染症およびその他の内科疾患を治療するための化合物、組成物および方法
TWI471145B (zh) 2005-06-13 2015-02-01 Bristol Myers Squibb & Gilead Sciences Llc 單一式藥學劑量型
TWI375560B (en) 2005-06-13 2012-11-01 Gilead Sciences Inc Composition comprising dry granulated emtricitabine and tenofovir df and method for making the same
AU2008287285B2 (en) 2007-04-13 2013-05-16 Southern Research Institute Anti-angiogenic agents and methods of use
AU2009206673B2 (en) 2008-01-25 2015-04-23 Chimerix, Inc. Methods of treating viral infections
WO2011011519A1 (en) 2009-07-21 2011-01-27 Chimerix, Inc. Compounds, compositions and methods for treating ocular conditions
HUE032860T2 (en) 2010-02-12 2017-11-28 Chimerix Inc A method for treating a virus infection
CA2797601A1 (en) 2010-04-26 2011-11-10 Chimerix, Inc. Methods of treating retroviral infections and related dosage regimes
CA2809679C (en) * 2010-08-31 2018-03-20 Chimerix, Inc. Phosphonate ester derivatives and methods of synthesis thereof
CN104666315A (zh) 2010-12-10 2015-06-03 西格玛制药实验有限责任公司 口服活性核苷酸类似物或口服活性核苷酸类似物前药的高度稳定组合物
ES2734495T3 (es) 2011-12-22 2019-12-10 Geron Corp Análogos de guanina como sustratos de telomerasa y afectores de la longitud de los telómeros
US8962829B1 (en) * 2013-11-15 2015-02-24 Chimerix, Inc. Morphic forms of hexadecyloxypropyl-phosphonate esters and methods of synthesis thereof
CN103951703A (zh) * 2014-04-28 2014-07-30 中国人民解放军军事医学科学院微生物流行病研究所 制备膦酯衍生物的方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CS233665B1 (en) * 1983-01-06 1985-03-14 Antonin Holy Processing of isomere o-phosphonylmethylderivative of anantiomere racemic vicinal diene
DE3585643D1 (de) * 1984-07-03 1992-04-23 Wellcome Found Antiviren-verbindungen, behandlung und formulierungen.
CS263951B1 (en) * 1985-04-25 1989-05-12 Antonin Holy 9-(phosponylmethoxyalkyl)adenines and method of their preparation
IL82998A0 (en) * 1986-07-07 1987-12-20 Koller Werner Dental sleeve,its production and its use for producing a ceramic crown
CS264222B1 (en) * 1986-07-18 1989-06-13 Holy Antonin N-phosphonylmethoxyalkylderivatives of bases of pytimidine and purine and method of use them
JP3116079B2 (ja) * 1990-08-10 2000-12-11 インスティチュート オブ オーガニック ケミストリ アンド バイオケミストリ アカデミー オブ サイエンス オブ ザ チェコ リパブリック ヌクレオチドの新規な製法

Also Published As

Publication number Publication date
EP0574386A1 (en) 1993-12-22
KR930702349A (ko) 1993-09-08
ES2149157T3 (es) 2000-11-01
WO1992002511A1 (en) 1992-02-20
KR100221981B1 (ko) 1999-09-15
JP3116079B2 (ja) 2000-12-11
EP0574386B1 (en) 2000-06-28
AU8492891A (en) 1992-03-02
DE69132276T2 (de) 2001-03-01
CA2088363C (en) 2002-05-28
US5476938A (en) 1995-12-19
FI930552A0 (fi) 1993-02-09
AU653552B2 (en) 1994-10-06
CA2088363A1 (en) 1992-02-11
FI930552A7 (fi) 1993-02-22
DE69132276D1 (de) 2000-08-03
JPH06503807A (ja) 1994-04-28
ATE194142T1 (de) 2000-07-15
EP0574386A4 (en) 1993-10-27
US5591852A (en) 1997-01-07

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