FI930552A0 - Nytt foerfarande foer framstaellning av nukleotider - Google Patents
Nytt foerfarande foer framstaellning av nukleotiderInfo
- Publication number
- FI930552A0 FI930552A0 FI930552A FI930552A FI930552A0 FI 930552 A0 FI930552 A0 FI 930552A0 FI 930552 A FI930552 A FI 930552A FI 930552 A FI930552 A FI 930552A FI 930552 A0 FI930552 A0 FI 930552A0
- Authority
- FI
- Finland
- Prior art keywords
- nucleotider
- foerfarande foer
- foer framstaellning
- nytt foerfarande
- nytt
- Prior art date
Links
- 238000000034 method Methods 0.000 abstract 2
- VWFCHDSQECPREK-LURJTMIESA-N Cidofovir Chemical compound NC=1C=CN(C[C@@H](CO)OCP(O)(O)=O)C(=O)N=1 VWFCHDSQECPREK-LURJTMIESA-N 0.000 abstract 1
- 230000000840 anti-viral effect Effects 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 239000002773 nucleotide Substances 0.000 abstract 1
- 125000003729 nucleotide group Chemical class 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6509—Six-membered rings
- C07F9/6512—Six-membered rings having the nitrogen atoms in positions 1 and 3
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US56620090A | 1990-08-10 | 1990-08-10 | |
| PCT/US1991/005578 WO1992002511A1 (en) | 1990-08-10 | 1991-08-06 | Novel process for the preparation of nucleotides |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI930552A0 true FI930552A0 (fi) | 1993-02-09 |
| FI930552A7 FI930552A7 (fi) | 1993-02-22 |
| FI930552L FI930552L (fi) | 1993-02-22 |
Family
ID=24261919
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI930552A FI930552L (fi) | 1990-08-10 | 1991-08-06 | Nytt foerfarande foer framstaellning av nukleotider |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US5476938A (fi) |
| EP (1) | EP0574386B1 (fi) |
| JP (1) | JP3116079B2 (fi) |
| KR (1) | KR100221981B1 (fi) |
| AT (1) | ATE194142T1 (fi) |
| AU (1) | AU653552B2 (fi) |
| CA (1) | CA2088363C (fi) |
| DE (1) | DE69132276T2 (fi) |
| ES (1) | ES2149157T3 (fi) |
| FI (1) | FI930552L (fi) |
| WO (1) | WO1992002511A1 (fi) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CS387190A3 (en) * | 1990-08-06 | 1992-03-18 | Ustav Organicke Chemie A Bioch | (2r)-2-/di(2-propyl)phosphonylmethoxy/-3-p-toluenesulfonyloxy -1- trimethylacetoxypropane and process for preparing thereof |
| KR100221981B1 (ko) * | 1990-08-10 | 1999-09-15 | 안토닌 포레이트 | 뉴클레오티드의 신규 제조방법 |
| ATE167679T1 (de) * | 1990-09-14 | 1998-07-15 | Acad Of Science Czech Republic | Wirkstoffvorläufer von phosphonaten |
| US6057305A (en) | 1992-08-05 | 2000-05-02 | Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic | Antiretroviral enantiomeric nucleotide analogs |
| US6448373B1 (en) * | 1994-01-11 | 2002-09-10 | Isis Pharmaceuticals, Inc. | Phosphate linked oligomers formed of monomeric diols and processes for preparing same |
| NZ535408A (en) | 2000-07-21 | 2006-09-29 | Gilead Sciences Inc | Method for selecting prodrugs of phosphonate nucleotide analogues |
| WO2004064845A1 (en) * | 2003-01-14 | 2004-08-05 | Gilead Sciences, Inc. | Compositions and methods for combination antiviral therapy |
| NZ544988A (en) * | 2003-07-30 | 2009-11-27 | Gilead Sciences Inc | Nucleobase phosphonate analogs for antiviral treatment |
| US20070003608A1 (en) * | 2005-04-08 | 2007-01-04 | Almond Merrick R | Compounds, compositions and methods for the treatment of viral infections and other medical disorders |
| US8642577B2 (en) | 2005-04-08 | 2014-02-04 | Chimerix, Inc. | Compounds, compositions and methods for the treatment of poxvirus infections |
| TWI375560B (en) * | 2005-06-13 | 2012-11-01 | Gilead Sciences Inc | Composition comprising dry granulated emtricitabine and tenofovir df and method for making the same |
| TWI471145B (zh) | 2005-06-13 | 2015-02-01 | Bristol Myers Squibb & Gilead Sciences Llc | 單一式藥學劑量型 |
| ES2534589T3 (es) | 2007-04-13 | 2015-04-24 | Southern Research Institute | Clomipramina como agente antiangiogénico |
| JP5562255B2 (ja) | 2008-01-25 | 2014-07-30 | キメリクス，インコーポレイテッド | ウイルス感染を治療する方法 |
| US8614200B2 (en) | 2009-07-21 | 2013-12-24 | Chimerix, Inc. | Compounds, compositions and methods for treating ocular conditions |
| ES2629165T3 (es) | 2010-02-12 | 2017-08-07 | Chimerix, Inc. | Métodos de tratamiento de una infección vírica |
| WO2011139709A2 (en) | 2010-04-26 | 2011-11-10 | Chimerix, Inc. | Methods of treating retroviral infections and related dosage regimes |
| US8569321B2 (en) * | 2010-08-31 | 2013-10-29 | Chimerix, Inc. | Phosphonate ester derivatives and methods of synthesis thereof |
| CN103338754A (zh) | 2010-12-10 | 2013-10-02 | 西格玛制药实验有限责任公司 | 口服活性核苷酸类似物或口服活性核苷酸类似物前药的高度稳定组合物 |
| ES2874774T3 (es) | 2011-12-22 | 2021-11-05 | Geron Corp | Análogos de guanina como sustratos de telomerasa y afectores de la longitud de los telómeros |
| DK2999476T3 (en) | 2013-11-15 | 2018-09-03 | Chimerix Inc | MORPHIC FORMS OF HEXADECYLOXYPROPYL PHOSPHONATE TESTERS |
| CN103951703A (zh) * | 2014-04-28 | 2014-07-30 | 中国人民解放军军事医学科学院微生物流行病研究所 | 制备膦酯衍生物的方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CS233665B1 (en) * | 1983-01-06 | 1985-03-14 | Antonin Holy | Processing of isomere o-phosphonylmethylderivative of anantiomere racemic vicinal diene |
| JPH0625061B2 (ja) * | 1984-07-03 | 1994-04-06 | ザ ウエルカム フアウンデ−シヨン リミテツド | 抗ウイルス性化合物 |
| CS263951B1 (en) * | 1985-04-25 | 1989-05-12 | Antonin Holy | 9-(phosponylmethoxyalkyl)adenines and method of their preparation |
| IL82998A0 (en) * | 1986-07-07 | 1987-12-20 | Koller Werner | Dental sleeve,its production and its use for producing a ceramic crown |
| CS264222B1 (en) * | 1986-07-18 | 1989-06-13 | Holy Antonin | N-phosphonylmethoxyalkylderivatives of bases of pytimidine and purine and method of use them |
| KR100221981B1 (ko) * | 1990-08-10 | 1999-09-15 | 안토닌 포레이트 | 뉴클레오티드의 신규 제조방법 |
-
1991
- 1991-08-06 KR KR1019930700374A patent/KR100221981B1/ko not_active Expired - Lifetime
- 1991-08-06 EP EP91915336A patent/EP0574386B1/en not_active Expired - Lifetime
- 1991-08-06 DE DE69132276T patent/DE69132276T2/de not_active Expired - Lifetime
- 1991-08-06 FI FI930552A patent/FI930552L/fi unknown
- 1991-08-06 ES ES91915336T patent/ES2149157T3/es not_active Expired - Lifetime
- 1991-08-06 AT AT91915336T patent/ATE194142T1/de not_active IP Right Cessation
- 1991-08-06 CA CA002088363A patent/CA2088363C/en not_active Expired - Lifetime
- 1991-08-06 WO PCT/US1991/005578 patent/WO1992002511A1/en not_active Ceased
- 1991-08-06 JP JP03514505A patent/JP3116079B2/ja not_active Expired - Lifetime
- 1991-08-06 AU AU84928/91A patent/AU653552B2/en not_active Expired
-
1992
- 1992-01-21 US US07/822,271 patent/US5476938A/en not_active Expired - Lifetime
-
1995
- 1995-06-07 US US08/482,036 patent/US5591852A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| ES2149157T3 (es) | 2000-11-01 |
| DE69132276D1 (de) | 2000-08-03 |
| US5476938A (en) | 1995-12-19 |
| KR930702349A (ko) | 1993-09-08 |
| DE69132276T2 (de) | 2001-03-01 |
| EP0574386B1 (en) | 2000-06-28 |
| JPH06503807A (ja) | 1994-04-28 |
| CA2088363A1 (en) | 1992-02-11 |
| ATE194142T1 (de) | 2000-07-15 |
| EP0574386A1 (en) | 1993-12-22 |
| FI930552A7 (fi) | 1993-02-22 |
| JP3116079B2 (ja) | 2000-12-11 |
| US5591852A (en) | 1997-01-07 |
| AU8492891A (en) | 1992-03-02 |
| EP0574386A4 (en) | 1993-10-27 |
| CA2088363C (en) | 2002-05-28 |
| WO1992002511A1 (en) | 1992-02-20 |
| FI930552L (fi) | 1993-02-22 |
| KR100221981B1 (ko) | 1999-09-15 |
| AU653552B2 (en) | 1994-10-06 |
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