FI930262L - Kinuklidinderivat - Google Patents

Kinuklidinderivat Download PDF

Info

Publication number
FI930262L
FI930262L FI930262A FI930262A FI930262L FI 930262 L FI930262 L FI 930262L FI 930262 A FI930262 A FI 930262A FI 930262 A FI930262 A FI 930262A FI 930262 L FI930262 L FI 930262L
Authority
FI
Finland
Prior art keywords
kinucliden
derivatives
kinucliden derivatives
Prior art date
Application number
FI930262A
Other languages
English (en)
Other versions
FI114473B (fi
FI930262A0 (fi
Inventor
Iii John A Lowe
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of FI930262A0 publication Critical patent/FI930262A0/fi
Publication of FI930262L publication Critical patent/FI930262L/fi
Application granted granted Critical
Publication of FI114473B publication Critical patent/FI114473B/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Soft Magnetic Materials (AREA)
  • Paper (AREA)
  • Control Of Electric Motors In General (AREA)
FI930262A 1990-07-23 1993-01-22 Menetelmä terapeuttisesti käyttökelpoisten kinuklidiinijohdannaisten valmistamiseksi FI114473B (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US55744290A 1990-07-23 1990-07-23
US55744290 1990-07-23
US9103369 1991-05-14
PCT/US1991/003369 WO1992001688A1 (en) 1990-07-23 1991-05-14 Quinuclidine derivatives

Publications (3)

Publication Number Publication Date
FI930262A0 FI930262A0 (fi) 1993-01-22
FI930262L true FI930262L (fi) 1993-01-22
FI114473B FI114473B (fi) 2004-10-29

Family

ID=24225412

Family Applications (1)

Application Number Title Priority Date Filing Date
FI930262A FI114473B (fi) 1990-07-23 1993-01-22 Menetelmä terapeuttisesti käyttökelpoisten kinuklidiinijohdannaisten valmistamiseksi

Country Status (25)

Country Link
US (5) US5422354A (fi)
EP (1) EP0540526B1 (fi)
JP (1) JP2514137B2 (fi)
CN (1) CN1058405A (fi)
AT (1) ATE116317T1 (fi)
AU (1) AU660416B2 (fi)
BR (1) BR9106665A (fi)
CA (1) CA2086434C (fi)
DE (1) DE69106365T2 (fi)
DK (1) DK0540526T3 (fi)
ES (1) ES2065691T3 (fi)
FI (1) FI114473B (fi)
GR (1) GR3015144T3 (fi)
HU (1) HUT62584A (fi)
IE (1) IE65000B1 (fi)
IL (1) IL98860A (fi)
MX (1) MX9100308A (fi)
MY (1) MY107157A (fi)
NO (1) NO302172B1 (fi)
NZ (1) NZ239063A (fi)
PL (1) PL167568B1 (fi)
PT (1) PT98393B (fi)
WO (1) WO1992001688A1 (fi)
YU (1) YU128091A (fi)
ZA (1) ZA915727B (fi)

Families Citing this family (76)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69106365T2 (de) * 1990-07-23 1995-05-04 Pfizer Chinuclidinderivate.
US5716965A (en) * 1991-05-22 1998-02-10 Pfizer Inc. Substituted 3-aminoquinuclidines
BR9206161A (pt) * 1991-06-20 1995-10-31 Pfizer Derivados fluoroalcoxibenzilamino de heterociclos contendo nitrogénio
TW202432B (fi) * 1991-06-21 1993-03-21 Pfizer
FI941212L (fi) * 1991-09-26 1994-03-15 Pfizer Fuusioituneet trisykliset, typpeä sisältävät heterosykliset yhdisteet
FI942187L (fi) * 1991-11-12 1994-05-11 Pfizer Asyklisiä etyleenidiamiinijohdannaisia aine P-reseptoriantagonisteina
CA2134964C (en) * 1992-05-18 1997-12-30 Manoj C. Desai Bridged aza-bicyclic derivatives as substance p antagonists
US5688804A (en) * 1992-08-04 1997-11-18 Pfizer Inc. 3-Benzylamino-2-phenyl-piperidine derivatives as substance P receptor antagonists
EP1114823A3 (en) * 1992-08-19 2001-07-18 Pfizer Inc. Substituted benzylamino nitrogen containing non-aromatic heterocycles
CA2150123C (en) * 1992-12-10 2004-12-07 Harry R. Howard Aminomethylene substituted non-aromatic heterocycles
US5830854A (en) * 1992-12-14 1998-11-03 Merck Sharp & Dohme, Limited Method of treating cystic fibrosis using a tachykinin receptor antagonist
US5340826A (en) * 1993-02-04 1994-08-23 Pfizer Inc. Pharmaceutical agents for treatment of urinary incontinence
US5393762A (en) * 1993-06-04 1995-02-28 Pfizer Inc. Pharmaceutical agents for treatment of emesis
EP0655246A1 (en) * 1993-11-30 1995-05-31 Pfizer Inc. Substance P antagonists for the treatment of disorders caused by helicobacter pylori or other spiral urease-positive gram-negative bacteria
FR2725900B1 (fr) * 1994-10-21 1997-07-18 Sanofi Sa Utilisation d'antagonistes des recepteurs nk1 pour la preparation de medicaments a action cardioregulatrice
IL116249A (en) * 1994-12-12 2003-07-06 Pfizer Nk-1 receptor antagonists for the treatment of neuronal damage and stroke
GB9502582D0 (en) * 1995-02-10 1995-03-29 Smithkline Beecham Plc Novel process
GB9510459D0 (en) 1995-05-24 1995-07-19 Zeneca Ltd Bicyclic amines
CA2251851A1 (en) * 1996-05-13 1997-11-20 Roger Salmon Bicyclic amines as insecticides
US6518423B1 (en) 1996-08-09 2003-02-11 Eisai Co., Ltd. Benzopiperidine derivatives
GB9623944D0 (en) * 1996-11-15 1997-01-08 Zeneca Ltd Bicyclic amine derivatives
GB9624114D0 (en) * 1996-11-20 1997-01-08 Zeneca Ltd Pesticidal bicyclic amine derivatives
GB9624611D0 (en) * 1996-11-26 1997-01-15 Zeneca Ltd Bicyclic amine compounds
TR199901704T2 (xx) 1996-11-26 1999-12-21 Zeneca Limited 8-Azabisiklo$3.2.1]oktan-, 8-azabisiklo$3.2.1]okt-6-en-,9-azabisiklo$3.3.1] nonan-,9-aza-3-oksabisiklo$3.3.1]nonan-ve 9-aza-3-tiabisiklo$3.3.1]nonan t�revleri, bunlar�n haz�rlanmas� ve insektisidler olarak kullan�mlar�.
AU7723300A (en) 1999-09-27 2001-04-30 Georgetown University Novel tropane analogs
JP2001172178A (ja) * 1999-10-25 2001-06-26 Pfizer Prod Inc 偏頭痛治療用のｎｋ−１レセプターアンタゴニスト及びエレトリプタン
US7163949B1 (en) 1999-11-03 2007-01-16 Amr Technology, Inc. 4-phenyl substituted tetrahydroisoquinolines and use thereof
KR100885986B1 (ko) 1999-11-03 2009-03-03 에이엠알 테크놀로지, 인크. 노르에피네프린, 도파민 및 세로토닌의 재흡수를 방지하기위한 아릴 및 헤테로아릴 치환된테트라하이드로이소퀴놀린 및 이들의 용도
CA2415532C (en) 2000-07-11 2010-05-11 Albany Molecular Research, Inc. Novel 4-phenyl substituted tetrahydroisoquinolines therapeutic use thereof
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KR101389246B1 (ko) 2004-07-15 2014-04-24 브리스톨-마이어스스퀴브컴파니 아릴- 및 헤테로아릴-치환된 테트라히드로이소퀴놀린, 및 이것의 노르에피네프린, 도파민 및 세로토닌의 재흡수를 차단하기 위한 용도
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US8293900B2 (en) 2005-09-29 2012-10-23 Merck Sharp & Dohme Corp Acylated spiropiperidine derivatives as melanocortin-4 receptor modulators
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US20110218176A1 (en) 2006-11-01 2011-09-08 Barbara Brooke Jennings-Spring Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development
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US9156812B2 (en) 2008-06-04 2015-10-13 Bristol-Myers Squibb Company Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine
UA105182C2 (ru) 2008-07-03 2014-04-25 Ньюрексон, Інк. Бензоксазины, бензотиазины и родственные соединения, которые имеют ингибирующую nos активность
US8691825B2 (en) 2009-04-01 2014-04-08 Merck Sharp & Dohme Corp. Inhibitors of AKT activity
CN102638982B (zh) 2009-05-12 2015-07-08 百时美施贵宝公司 (S)-7-([1,2,4]三唑并[1,5-a]吡啶-6-基)-4-(3,4-二氯苯基)-1,2,3,4-四氢异喹啉的晶型及其用途
KR101830447B1 (ko) 2009-05-12 2018-02-20 알바니 몰레큘라 리써치, 인크. 7-(［1,2,4］트리아졸로［1,5-α］피리딘-6-일)-4-(3,4-디클로로페닐)-1,2,3,4-테트라하이드로이소퀴놀린 및 이의 용도
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US3560510A (en) * 1969-03-05 1971-02-02 Aldrich Chem Co Inc 2-benzhydrylquinuclidines
GB1527489A (en) * 1976-08-05 1978-10-04 Andreu Sa Dr Amine compound
US4246201A (en) * 1979-06-11 1981-01-20 Alfa Farmaceutici, S.P.A. Substituted N-(3-phenylthiopropyl)-3,3-diphenyl-propylamines possessing pharmacological activity
WO1990005525A1 (en) * 1988-11-23 1990-05-31 Pfizer Inc. Quinuclidine derivatives as substance p antagonists
UA41251C2 (uk) * 1990-01-04 2001-09-17 Пфайзер, Інк. Гідровані азотвмісні гетероциклічні сполуки, похідні піперидину, фармацевтична композиція та спосіб пригнічення активності речовини р в організмі
EP0532527B1 (en) * 1990-06-01 1994-11-09 Pfizer Inc. 3-amino-2-aryl quinuclidines, process for their preparation and pharmaceutical compositions containing them
DE69106365T2 (de) * 1990-07-23 1995-05-04 Pfizer Chinuclidinderivate.

Also Published As

Publication number Publication date
DE69106365D1 (de) 1995-02-09
EP0540526B1 (en) 1994-12-28
PT98393A (pt) 1992-05-29
ZA915727B (en) 1993-02-24
JP2514137B2 (ja) 1996-07-10
US5698568A (en) 1997-12-16
PT98393B (pt) 1999-01-29
NZ239063A (en) 1995-09-26
US5821248A (en) 1998-10-13
NO302172B1 (no) 1998-02-02
US5854256A (en) 1998-12-29
FI114473B (fi) 2004-10-29
IL98860A0 (en) 1992-07-15
HUT62584A (en) 1993-05-28
AU660416B2 (en) 1995-06-29
IL98860A (en) 1995-11-27
AU7894891A (en) 1992-02-18
WO1992001688A1 (en) 1992-02-06
BR9106665A (pt) 1993-06-08
FI930262A0 (fi) 1993-01-22
NO930222D0 (no) 1993-01-22
CA2086434C (en) 1998-09-22
MX9100308A (es) 1992-02-28
EP0540526A1 (en) 1993-05-12
GR3015144T3 (en) 1995-05-31
PL167568B1 (pl) 1995-09-30
DE69106365T2 (de) 1995-05-04
YU128091A (sh) 1994-01-20
ATE116317T1 (de) 1995-01-15
IE65000B1 (en) 1995-10-04
US5641786A (en) 1997-06-24
NO930222L (no) 1993-01-22
JPH05507687A (ja) 1993-11-04
IE912560A1 (en) 1992-01-29
ES2065691T3 (es) 1995-02-16
MY107157A (en) 1995-09-30
CN1058405A (zh) 1992-02-05
CA2086434A1 (en) 1992-01-24
US5422354A (en) 1995-06-06
DK0540526T3 (da) 1995-04-18
HU9300188D0 (en) 1993-04-28

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