FI93016B - Syntetiska receptoranaloger - Google Patents
Syntetiska receptoranaloger Download PDFInfo
- Publication number
- FI93016B FI93016B FI910653A FI910653A FI93016B FI 93016 B FI93016 B FI 93016B FI 910653 A FI910653 A FI 910653A FI 910653 A FI910653 A FI 910653A FI 93016 B FI93016 B FI 93016B
- Authority
- FI
- Finland
- Prior art keywords
- cha
- alkyl
- galabiosis
- formula
- compound
- Prior art date
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- 108010031480 Artificial Receptors Proteins 0.000 title description 3
- 241000894006 Bacteria Species 0.000 claims abstract description 29
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- 150000001875 compounds Chemical class 0.000 claims description 107
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- 125000000400 lauroyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 239000000787 lecithin Substances 0.000 description 1
- 235000010445 lecithin Nutrition 0.000 description 1
- ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 description 1
- 239000001095 magnesium carbonate Substances 0.000 description 1
- 229910000021 magnesium carbonate Inorganic materials 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 229910021645 metal ion Inorganic materials 0.000 description 1
- 239000002480 mineral oil Substances 0.000 description 1
- 235000010446 mineral oil Nutrition 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 210000000214 mouth Anatomy 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 239000007922 nasal spray Substances 0.000 description 1
- 229940097496 nasal spray Drugs 0.000 description 1
- 238000006386 neutralization reaction Methods 0.000 description 1
- 210000001331 nose Anatomy 0.000 description 1
- 238000000655 nuclear magnetic resonance spectrum Methods 0.000 description 1
- 230000000269 nucleophilic effect Effects 0.000 description 1
- 125000005064 octadecenyl group Chemical group C(=CCCCCCCCCCCCCCCCC)* 0.000 description 1
- QYSGYZVSCZSLHT-UHFFFAOYSA-N octafluoropropane Chemical compound FC(F)(F)C(F)(F)C(F)(F)F QYSGYZVSCZSLHT-UHFFFAOYSA-N 0.000 description 1
- TVMXDCGIABBOFY-UHFFFAOYSA-N octane Chemical compound CCCCCCCC TVMXDCGIABBOFY-UHFFFAOYSA-N 0.000 description 1
- 125000002801 octanoyl group Chemical group C(CCCCCCC)(=O)* 0.000 description 1
- 125000002347 octyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 239000000668 oral spray Substances 0.000 description 1
- 229940041678 oral spray Drugs 0.000 description 1
- 239000012044 organic layer Substances 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 125000004430 oxygen atom Chemical group O* 0.000 description 1
- 239000006174 pH buffer Substances 0.000 description 1
- 125000000913 palmityl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 230000007918 pathogenicity Effects 0.000 description 1
- 229940124531 pharmaceutical excipient Drugs 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 229940127557 pharmaceutical product Drugs 0.000 description 1
- 210000003800 pharynx Anatomy 0.000 description 1
- 125000000612 phthaloyl group Chemical group C(C=1C(C(=O)*)=CC=CC1)(=O)* 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 239000013612 plasmid Substances 0.000 description 1
- 239000003880 polar aprotic solvent Substances 0.000 description 1
- 229920001281 polyalkylene Polymers 0.000 description 1
- 229920000656 polylysine Polymers 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 239000003380 propellant Substances 0.000 description 1
- 125000001501 propionyl group Chemical group O=C([*])C([H])([H])C([H])([H])[H] 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 239000003586 protic polar solvent Substances 0.000 description 1
- LVTJOONKWUXEFR-FZRMHRINSA-N protoneodioscin Natural products O(C[C@@H](CC[C@]1(O)[C@H](C)[C@@H]2[C@]3(C)[C@H]([C@H]4[C@@H]([C@]5(C)C(=CC4)C[C@@H](O[C@@H]4[C@H](O[C@H]6[C@@H](O)[C@@H](O)[C@@H](O)[C@H](C)O6)[C@@H](O)[C@H](O[C@H]6[C@@H](O)[C@@H](O)[C@@H](O)[C@H](C)O6)[C@H](CO)O4)CC5)CC3)C[C@@H]2O1)C)[C@H]1[C@H](O)[C@H](O)[C@H](O)[C@@H](CO)O1 LVTJOONKWUXEFR-FZRMHRINSA-N 0.000 description 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
- 125000000246 pyrimidin-2-yl group Chemical group [H]C1=NC(*)=NC([H])=C1[H] 0.000 description 1
- 125000004528 pyrimidin-5-yl group Chemical group N1=CN=CC(=C1)* 0.000 description 1
- 210000002345 respiratory system Anatomy 0.000 description 1
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 239000001632 sodium acetate Substances 0.000 description 1
- 235000017281 sodium acetate Nutrition 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000012439 solid excipient Substances 0.000 description 1
- 239000008247 solid mixture Substances 0.000 description 1
- 229940035044 sorbitan monolaurate Drugs 0.000 description 1
- 125000006850 spacer group Chemical group 0.000 description 1
- 230000005477 standard model Effects 0.000 description 1
- 125000004079 stearyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 238000010254 subcutaneous injection Methods 0.000 description 1
- 239000007929 subcutaneous injection Substances 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- GFYHSKONPJXCDE-UHFFFAOYSA-N sym-collidine Natural products CC1=CN=C(C)C(C)=C1 GFYHSKONPJXCDE-UHFFFAOYSA-N 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 125000004853 tetrahydropyridinyl group Chemical group N1(CCCC=C1)* 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 230000002485 urinary effect Effects 0.000 description 1
- 210000001635 urinary tract Anatomy 0.000 description 1
- 208000019206 urinary tract infection Diseases 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
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- 229910052727 yttrium Inorganic materials 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/14—Acyclic radicals, not substituted by cyclic structures attached to a sulfur, selenium or tellurium atom of a saccharide radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H23/00—Compounds containing boron, silicon, or a metal, e.g. chelates, vitamin B12
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56911—Bacteria
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- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Microbiology (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Prostheses (AREA)
Claims (11)
1. Förfarande för framställning av en farmaceutiskt verksam förening med den allmänna formeln I eller dess dimera förening i vilken formel Ri är Ci-C2«-alkyl; C2-C2.*-alkenyl; C2-C2«-alkynyl; tri(Ci-C<i-alkyl)silyletyl; aryl, som valbart är substituerad med hydroxi, amino, Ci-Ca-alkyl, Ci-CU-alkoxi, nitro, halogen eller fenoxi; mono- eller di-halogen-Ci-C-t-alkyl; fenyl-Ci-C^-alkyl; en grupp med formeln II eller Ha R3-(CH2)n-S(0)m-CH2CH2- (II) (R3- (CH2 ) n—S (O)m—CH2) 2CH—CH2— (Ha) där R3 är H, karboxi, karboxi-Ci-CU-alkyl, hydroxi, amino eller en bärare, n är ett helt tai inom omrädet 1-24 och m är 0 eller 2; en grupp med formeln III eller lila Phe-S(O)m-CH2CH2- (III) (Phe-S(0)m-CH2)2CH-CH2- (lila) där m har den ovan definierade betydelsen och varje Phe är en fenylgrupp, som valbart är monosubstituerad med hydroxi, amino, Ci-CU-alkyl, Ci-C*-alkoxi, nitro, halogen eller fenoxi, en grupp med formeln IV R*CH*CH(CH2Rs)CH2- (IV) där R« och Rs oberoende av varandra är halogen, en grupp Q-(CH2)»-, där Q är en bärare och n har ovan definierade betydelse; och 93016 60 Ra är en mono- eller disackaridgrupp som är bunden via en glykosidbindning; Ci-Cie-alkyl; Ca-Cis-alkenyl; Ca-Ci*-alky-nyl; Ci-Cie-alkyloximetyl; Ci-Cie-alkanoyl; a-hydroxi-Ci-Cie-alkanoyl; naftyl-, heterocyklyl- eller fenyl-Ci-Ce-alkoxi, där naftyl-, heterocyklyl- eller fenylgruppen kan vara substitue-rad med hydroxi, amino, Ci-C^-alkyl, Ci-C*-alkoxi, nitro, halogen eller fenoxi; tri (Ci-C4-alkyl Jsilyletyl; tri(Ci-C*-alkyl)silyl; tri(Ci-C4-alkyl)silyletoximetyl; halogen; CO-hyd-roxi-Ci-C^-alkyl; tetrahydropyranyl; bensyloximetyl; Cs-Ce-cykloalkyl; en monoterpenylgrupp; bensoyl som valbart är mono-substituerad med hydroxi, amino, Ci-C^-alkyl, Ci-C4-alkoxi, nitro, halogen eller fenoxi; aylresten av en naturligt före-kommande aminosyra; eller en grupp med formeln V Re-C(O)-N(Rt)-CH(Re)-CHa- (V) där Re är Ci-C4-alkyl; eller fenyl, som valbart är monosubsti-tuerad med hydroxi, amino, Ci-C^-alkyl, Ci-C4-alkoxi, nitro, halogen eller fenoxi; Rt är H eller Ci-C^-alkyl och Ra är H, Ci-C-4-alkyl eller hydroxi-C1-C4-alkyl, Z är -O-, -S-, -SO2- eller -CH2-, X är -O-, -S-, -SO2-, -CHa- eller -NR3-, där R3 är H eller har en av betydelserna definierade för Ra ovan, och R3 och Ri är valbart sammanbundna tili en ring, och Y är -O- eller -NR3-, där R3 är H eller har en av betydelserna definierade för Ra, och R3 och Ra är valbart sammanbundna tili en ring, kännetecknatav att • · . a) en förening med formeln I T<°<!vH0Z> m där alla symboler betecknar samma som ovan utom att en eller flere fria hydroxigrupper är försedda med skyddsgrupp, bringas i en reaktion som avlägsnar skyddsgruppen, eller 61 9301 6 b) för framställning av en dimer förening med formeln VI MO c* *° Oh i vilken formel R» och Ra' oberoende av varandra är CH3O-, CH3CH2O- eller (CHa)aCHO- och p är ett helt tai inom omrädet 1-12, fördelaktigt 3, 6 eller 9, en förening med formeln VI, där alla symboler betecknar samma som ovan utom att en eller flere fria hydroxigrupper är försedda med skyddsgrupp, bringas i en reaktion som avlägsnar skyddsgruppen.
2. Förfarande enligt patentkravet 1, kännetecknat av att man framställer en förening med formeln I, där Z är -0-.
3. Förfarande enligt patentkravet 1 eller 2, k ä n n e -tecknatav att man framställer en förening med formeln I, där Y är -0-.
4. Förfarande enligt nägot av patentkraven 1-3, kännetecknat av att man framställer en förening med formeln I, där X är -O- eller -S-.
5. Förfarande enligt patentkravet 1, kännetecknat av att man framställer en förening med formeln I, där Ra och Y tillsammans är (Ci-Ce-alkyl)2N-, där tvä Ci-Ce-alkylgrupper valbart är sammanbundna tili en ring säsom tetrahydropyridi-nyl.
6. Förfarande enligt nagot av patentkraven 1-4, k ä n n e -tecknatav att man framställer en förening med formeln 62 «016 I, där Ri är Ci-Ca4-alkyl; tri(Ci-C4-alkyl)silyletyl; aryl, som valbart är substituerad med amino eller nitro; en grupp med formeln II eller Ha, där R3 är H, karboxi, karboxi-Ci-C4-alkyl eller en bärare, och n och m är samma som ovan definiera-des; en grupp enligt formeln III eller lila, där m är samma som ovan definierades och varje fenylgrupp är valbart mono-substituerad med amino eller nitro; eller en grupp Q-CCHa)^-, där Q är en bärare och n är samma som ovan definierades.
7. Förfarande enligt nägot av patentkraven 1-4 eller 6, kännetecknatav att man framställer en förening med formeln I, där Ra är en mono- eller disackaridgrupp som är bunden via en glykosidbindning; Ci-Cie-alkyl; Ci-Cie-alkoxi-metyl; tetrahydropyranyl; eller bensyloximetyl.
8. Förfarande enligt nägot av patentkraven 1-4, 6 eller 7, kännetecknat av att man framställer en förening med formeln I, där Ra är en 2-acetamido-2-deoxi-0-D-galaktopyrano-sylrest; en 2-deoxi-2-ftalamido-0-D-galaktopyranosylrest; Ci-Ce-alkyl; Cx-Ce-alkyloximetyl; tetrahydropyranyl; eller bensyloximetyl.
9. Förfarande enligt patentkravet 1, kännetecknat av att man framställer en förening med formeln I, där -XRi är -S-CHaCHs, -O-CHaCH[CHaSOa(CHa)3CH3]2, -S-CHaCH[CHaSOa(CHa)3- CH3]2 ja -CHa-CHaCH[CHaSOa(CHa)3CH3]a.
10. En diagnostisk anordning eller reagensförpackning, k ä n - · netecknadav att den innefattar minst en förening med formeln I, som definierats i nägot av patentkraven 1-9, i väsentligen immobiliserad form. II. Förfarande för detektering av närvaron av bakterier i ett prov, kännetecknat av att provet bringas i kontakt med en förening enligt formeln I, som definierats i nägot av patentkraven 1-9, varefter bakterier som häftar vid föreningen med formeln I detekteras. li
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK455088A DK455088D0 (da) | 1988-08-12 | 1988-08-12 | Syntetiske receptoranaloger |
| DK455088 | 1988-08-12 | ||
| DK8900192 | 1989-08-11 | ||
| PCT/DK1989/000192 WO1990001488A1 (en) | 1988-08-12 | 1989-08-11 | Synthetic receptor analogues |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI910653A0 FI910653A0 (sv) | 1991-02-11 |
| FI93016B true FI93016B (sv) | 1994-10-31 |
| FI93016C FI93016C (sv) | 1995-02-10 |
Family
ID=8134551
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI910653A FI93016C (sv) | 1988-08-12 | 1991-02-11 | Syntetiska receptoranaloger |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US5474986A (sv) |
| EP (1) | EP0428605B1 (sv) |
| JP (1) | JPH04506509A (sv) |
| KR (1) | KR900701807A (sv) |
| AT (1) | ATE113056T1 (sv) |
| AU (1) | AU634976B2 (sv) |
| CA (1) | CA1332234C (sv) |
| DE (1) | DE68918944T2 (sv) |
| DK (1) | DK455088D0 (sv) |
| FI (1) | FI93016C (sv) |
| IL (1) | IL91269A (sv) |
| WO (1) | WO1990001488A1 (sv) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4119472A1 (de) * | 1991-06-13 | 1992-12-17 | Merck Patent Gmbh | Verfahren zur stereoselektiven herstellung von gal-(alpha)(1-3)/gal-(beta)(1-4)/glcnac-trisacchariden und von neuen (beta)(1-3)-verknuepften oligolactosaminen ueber neue partiell alkylierte glykale |
| US5409902A (en) * | 1991-12-31 | 1995-04-25 | Lever Brothers Company | Oral hygiene compositions containing glyceroglycolipids as antiplaque compounds |
| EP0601417A3 (de) * | 1992-12-11 | 1998-07-01 | Hoechst Aktiengesellschaft | Physiologisch verträglicher und physiologisch abbaubarer, Kohlenhydratrezeptorblocker auf Polymerbasis, ein Verfahren zu seiner Herstellung und seine Verwendung |
| TW307775B (en) * | 1994-02-15 | 1997-06-11 | Novartis Erfind Verwalt Gmbh | Unsaturated carbohydrate derivatives, polymers thereof and their use |
| US6596707B2 (en) * | 2001-05-24 | 2003-07-22 | Abbott Laboratories | Monovalent saccharides and uses thereof |
| US7790010B2 (en) * | 2002-12-20 | 2010-09-07 | University Of Maryland, College Park | Spatially selective deposition of polysaccharide layer onto patterned template |
| JP5236189B2 (ja) * | 2003-12-05 | 2013-07-17 | チルドレンズ ホスピタル メディカル センター | オリゴ糖組成物および感染症の治療における該組成物の使用 |
| JP5766947B2 (ja) | 2007-09-07 | 2015-08-19 | チルドレンズ ホスピタル メディカル センター | 臨床サンプルにおける分泌性のルイス抗原およびシアル化抗原のレベルの疾患リスクの予測指標としての使用 |
| DK2451462T3 (en) | 2009-07-06 | 2017-12-11 | Children's Hospital Medical Center | Inhibition of inflammation with milk oligosaccharides |
| JP6187893B2 (ja) * | 2011-07-08 | 2017-08-30 | 群栄化学工業株式会社 | 保湿剤の製造方法 |
| WO2014130789A1 (en) | 2013-02-21 | 2014-08-28 | Children's Hospital Medical Center | Use of glycans and glycosyltransferases for diagnosing/monitoring inflammatory bowel disease |
| US10857167B2 (en) | 2015-04-28 | 2020-12-08 | Children's Hospital Medical Center | Use of oligosaccharide compositions to enhance weight gain |
| CN111566117A (zh) | 2017-12-29 | 2020-08-21 | 糖模拟物有限公司 | E-选择蛋白和半乳凝素-3的异双功能抑制剂 |
| AU2019416330A1 (en) | 2018-12-27 | 2021-07-01 | Glycomimetics, Inc. | Galectin-3 inhibiting c-glycosides |
| WO2020139962A1 (en) | 2018-12-27 | 2020-07-02 | Glycomimetics, Inc. | Heterobifunctional inhibitors of e-selectin and galectin-3 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE8001748L (sv) * | 1980-03-05 | 1981-09-06 | Kaellenius Gunilla | Kompositioner for terapeutisk eller diagnostisk anvendning jemte forfarande for terapeutik |
| EP0089940A1 (en) * | 1982-03-23 | 1983-09-28 | BioCarp AB | Compositions for therapeutic or diagnostic use containing oligosaccharides |
| SE8203925D0 (sv) * | 1982-06-23 | 1982-06-23 | Svenska Sockerfabriks Ab | New and novel glycosides, glycoconjugates and processes for their preparation |
| SE8304007D0 (sv) * | 1983-07-15 | 1983-07-15 | Karlsson Karl Anders | Forening och komposition for terapeutisk eller diagnostisk anvendning samt forfarande for terapeutisk behandling |
| SE8406626D0 (sv) * | 1984-12-27 | 1984-12-27 | Bio Carb Ab | Forening och komposition for terapeutisk eller diagnostisk anvendning jemte anvendning av sadan forening och komposition for terapeutisk behandling och isolering av shigatoxin |
| DK17685D0 (da) * | 1985-01-14 | 1985-01-14 | Hans Goeran Magnusson | Glycosidderivater |
-
1988
- 1988-08-12 DK DK455088A patent/DK455088D0/da not_active Application Discontinuation
-
1989
- 1989-08-09 IL IL9126989A patent/IL91269A/en not_active IP Right Cessation
- 1989-08-11 EP EP89909545A patent/EP0428605B1/en not_active Expired - Lifetime
- 1989-08-11 DE DE68918944T patent/DE68918944T2/de not_active Expired - Fee Related
- 1989-08-11 CA CA000608146A patent/CA1332234C/en not_active Expired - Fee Related
- 1989-08-11 JP JP1508951A patent/JPH04506509A/ja active Pending
- 1989-08-11 US US07/689,077 patent/US5474986A/en not_active Expired - Fee Related
- 1989-08-11 AT AT89909545T patent/ATE113056T1/de not_active IP Right Cessation
- 1989-08-11 AU AU40749/89A patent/AU634976B2/en not_active Ceased
- 1989-08-11 WO PCT/DK1989/000192 patent/WO1990001488A1/en active IP Right Grant
- 1989-08-11 KR KR1019900700766A patent/KR900701807A/ko not_active Application Discontinuation
-
1991
- 1991-02-11 FI FI910653A patent/FI93016C/sv not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DE68918944T2 (de) | 1995-05-11 |
| DK455088D0 (da) | 1988-08-12 |
| DE68918944D1 (de) | 1994-11-24 |
| KR900701807A (ko) | 1990-12-04 |
| US5474986A (en) | 1995-12-12 |
| WO1990001488A1 (en) | 1990-02-22 |
| IL91269A (en) | 1994-11-11 |
| FI910653A0 (sv) | 1991-02-11 |
| AU4074989A (en) | 1990-03-05 |
| FI93016C (sv) | 1995-02-10 |
| CA1332234C (en) | 1994-10-04 |
| EP0428605A1 (en) | 1991-05-29 |
| ATE113056T1 (de) | 1994-11-15 |
| EP0428605B1 (en) | 1994-10-19 |
| AU634976B2 (en) | 1993-03-11 |
| JPH04506509A (ja) | 1992-11-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| BB | Publication of examined application | ||
| MM | Patent lapsed |