FI924847A7 - 2-aminometyyli-kromaanit - Google Patents

2-aminometyyli-kromaanit Download PDF

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Publication number
FI924847A7
FI924847A7 FI924847A FI924847A FI924847A7 FI 924847 A7 FI924847 A7 FI 924847A7 FI 924847 A FI924847 A FI 924847A FI 924847 A FI924847 A FI 924847A FI 924847 A7 FI924847 A7 FI 924847A7
Authority
FI
Finland
Prior art keywords
chromans
aminomethyl
Prior art date
Application number
FI924847A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI924847A0 (fi
FI924847L (fi
Inventor
Hans-Georg Heine
Thomas Glaser
Vry Jean Marie Viktor De
Wolfgang Dompert
Henning Sommermeyer
Rudolf Schohe-Loop
Bodo Junge
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of FI924847A0 publication Critical patent/FI924847A0/fi
Publication of FI924847L publication Critical patent/FI924847L/fi
Publication of FI924847A7 publication Critical patent/FI924847A7/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/64—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with oxygen atoms directly attached in position 8
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cosmetics (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
FI924847A 1991-10-28 1992-10-26 2-aminometyyli-kromaanit FI924847A7 (fi)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4135474A DE4135474A1 (de) 1991-10-28 1991-10-28 2-aminomethyl-chromane

Publications (3)

Publication Number Publication Date
FI924847A0 FI924847A0 (fi) 1992-10-26
FI924847L FI924847L (fi) 1993-04-29
FI924847A7 true FI924847A7 (fi) 1993-04-29

Family

ID=6443566

Family Applications (1)

Application Number Title Priority Date Filing Date
FI924847A FI924847A7 (fi) 1991-10-28 1992-10-26 2-aminometyyli-kromaanit

Country Status (17)

Country Link
US (3) US5318988A (en:Method)
EP (1) EP0540914B1 (en:Method)
JP (1) JP3299321B2 (en:Method)
KR (1) KR930007930A (en:Method)
AT (1) ATE180777T1 (en:Method)
AU (1) AU2626492A (en:Method)
CA (1) CA2081300A1 (en:Method)
CZ (1) CZ322592A3 (en:Method)
DE (2) DE4135474A1 (en:Method)
ES (1) ES2132105T3 (en:Method)
FI (1) FI924847A7 (en:Method)
HU (1) HUT62875A (en:Method)
IL (1) IL103545A0 (en:Method)
MX (1) MX9205681A (en:Method)
NO (1) NO923975L (en:Method)
TW (1) TW207537B (en:Method)
ZA (1) ZA928291B (en:Method)

Families Citing this family (76)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4135474A1 (de) * 1991-10-28 1993-04-29 Bayer Ag 2-aminomethyl-chromane
GB9303340D0 (en) * 1993-02-19 1993-04-07 Smithkline Beecham Plc Pharmaceuticals
SI0707007T1 (en) * 1994-10-14 2002-04-30 Merck Patent Gmbh (R)-(-)-2-(5-(4-fluorophenyl)-3-pyridylmethylaminomethyl)chromane as CNS active agent
US5541199A (en) * 1995-06-02 1996-07-30 American Home Products Corporation Chroman-2-ylmethylamino derivatives
DE19522088A1 (de) * 1995-06-19 1997-01-02 Bayer Ag Benzisothiazolyl-substituierte Aminomethylchromane
US5670667A (en) * 1995-07-25 1997-09-23 American Home Products Corporation Chroman-2-ylmethylamino derivatives
US5663194A (en) * 1995-07-25 1997-09-02 Mewshaw; Richard E. Chroman-2-ylmethylamino derivatives
US5684039A (en) * 1995-07-25 1997-11-04 American Home Products Corporation Chroman-2-ylmethylamino derivatives
US5756532A (en) * 1995-11-06 1998-05-26 American Home Products Corporation Aminomethyl-2 3 8 9-tetrahydro-7H-1 4-dioxino 2 3-E!-indol-8-ones and derivatives
IL119483A (en) * 1995-11-06 1999-06-20 American Home Prod 2-(Aminomethyl)-3,4,7,9- tetrahydro- 2H-pyrano-2[3,3-e]indol-8-ones their derivatives and pharmaceutical compositions containing them
US5869490A (en) * 1996-10-15 1999-02-09 American Home Products Corporation Azaheterocyclymethyl derivatives of 2,3,8,9-tetrahydro-7h-1,4-dioxino (2,3-e) indol-8-one
EP0932609B1 (en) * 1996-10-15 2003-05-14 Wyeth AZAHETEROCYCLYMETHYL DERIVATIVES OF 2,3,8,9-TETRAHYDRO-7H-1,4-DIOXINO 2,3-e]INDOL-8-ONE
US5750556A (en) * 1996-10-30 1998-05-12 American Home Products Corporation 2-(aminomethyl)-3,4,7,9-tetrahydro-2H-pyrano- 2,3-E!indol-8-ones and derivatives
UA58470C2 (uk) 1997-07-31 2003-08-15 Брістол-Майєрс Сквібб Фарма Компані Спосіб одержання циклопропілацетилену та проміжна сполука для його здійснення
FR2769629B1 (fr) * 1997-10-09 1999-11-12 Synthelabo Derives de 8-azabicyclo[3.2.1]octane-3-methanamine, leur preparation et leur application en therapeutique
UA58476C2 (uk) 1997-10-09 2003-08-15 Санофі-Сентелябо Похідні 8-азабіцикло[3.2.1]октан-3-метанаміну, фармацевтична композиція та лікарський засіб
DE19751949A1 (de) * 1997-11-24 1999-05-27 Bayer Ag Verwendung von substituierten Aminomethyl-Chromanen zur Verhinderung der neuronalen Degeneration und zur Förderung der neuronalen Regeneration
DE19754573A1 (de) * 1997-12-09 1999-06-10 Bayer Ag Pharmazeutische Zusammensetzung zur Behandlung von Schlaganfall und Schädel-Hirn-Trauma
US6235957B1 (en) 1998-06-29 2001-05-22 Dupont Pharmaceuticals Company Process for the preparation of cyclopropylacetylene
WO2000018706A1 (en) 1998-10-01 2000-04-06 Du Pont Pharmaceuticals Company Process for the preparation of cyclopropylacetylene
US6288297B1 (en) 1998-10-01 2001-09-11 Dupont Pharmaceuticals Company Process for the preparation of cyclopropylacetylene
DE19858341A1 (de) * 1998-12-17 2000-06-21 Merck Patent Gmbh Chromanderivate
UA73981C2 (en) 2000-03-10 2005-10-17 Merck Patent Gmbh (r)-(-)-2-[5-(4-fluorophenyl)-3-pyridylmethylaminomethyl]-chromane for treatment of extrapyramidal movement disorders (variants), pharmaceutical composition and kit
US20030207890A1 (en) 2001-02-23 2003-11-06 Collier Robert J Compounds with 5-ht1a activity useful for treating disorders of the outer retina
US6458802B1 (en) 2001-03-14 2002-10-01 Wyeth Antidepressant azaheterocyclymethyl derivatives of 2,3-dihydro-1,4-dioxino [2,3-f]quinoline
US6803368B2 (en) 2001-04-25 2004-10-12 Wyeth Antipsychotic aminomethyl derivatives of 7,8-dihydro-3H-6,9-dioxa-1,3-diaza-cyclopenta[a]naphthalene
DE10120619A1 (de) * 2001-04-26 2002-10-31 Merck Patent Gmbh 2-(5-(4-Fluorphenyl)-3-pyridylmethylaminomethyl-chroman
US7008944B2 (en) * 2001-04-26 2006-03-07 Wyeth Antidepressant azaheterocyclylmethyl derivatives of 2,3-dihydro-1,4-Dioxino[2,3-f]quinoxaline
US6800642B2 (en) 2001-04-26 2004-10-05 Wyeth Antipsychotic aminomethyl derivatives of 7,8-dihydro-2,6,9-trioxa-3-aza-cyclopenta[a]naphthalene
US6800641B2 (en) 2001-04-26 2004-10-05 Wyeth Antipsychotic aminomethyl derivatives of 7,8-dihydro-3H-6,9-dioxa-2,3-diaza-cyclopenta[a]naphthalene
US6800648B2 (en) 2001-04-26 2004-10-05 Wyeth Antipsychotic aminomethyl derivatives of 7,8-dihydro-3H-1,6,9-trioxa-3-AZA-cyclopenta[a]naphthalen-2-one
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US6656947B2 (en) 2001-04-26 2003-12-02 Wyeth Antidepressant azaheterocyclylmethyl derivatives of 2,3-dihydro-1,4-dioxino[2,3-f]quinazoline
US6780860B2 (en) 2001-04-26 2004-08-24 Wyeth Azabicyclylmethyl derivatives of 7,8-dihydro-1,6,9-trioxa-3-aza-cyclopenta[a]naphthalene as 5-ht1a antagonists
US6593350B2 (en) 2001-04-26 2003-07-15 Wyeth Antidepressant indoletetrahydropyridine derivatives of 2,3-dihydro-7H-[1,4]dioxino[2,3-e]indole
US6927226B2 (en) * 2001-04-26 2005-08-09 Wyeth Antidepressant azaheterocyclymethyl derivatives of 7,8-dihydro-3H-6,9-dioxa-1,3-diazacyclopenta[a]naphthalene
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US6821981B2 (en) 2001-04-26 2004-11-23 Wyeth Azaheterocyclylmethyl derivatives of 2,3-dihydro-1,4-dioxino[2,3-f]-quinoline as 5-HT1A antagonists
US6861434B2 (en) 2001-04-26 2005-03-01 Wyeth Antipsychotic aminomethyl derivatives of 1,3,7,8-tetrahydro-6,9-dioxa-1,3-diaza-cyclopenta[a]-naphthalen-2-one
US6861427B2 (en) * 2001-04-26 2005-03-01 Wyeth Azabicyclylmethyl derivatives of 2,3-dihydro-1,4-dioxino[2,3-f]quinoline as 5-HT1A antagonists
CN1267434C (zh) 2001-04-26 2006-08-02 惠氏公司 抗抑郁的(SSSRI)7,8－二氢－3H－6,9－二氧杂－1,3－二氮杂环戊二烯并[a]萘的氮杂环基甲基衍生物
US6627639B2 (en) 2001-04-26 2003-09-30 Wyeth Uses for indoletetrahydropyridine derivatives of 2,3-dihydro-7H-[1,4]dioxino-[2,3-e]indole
US6706736B2 (en) 2001-04-26 2004-03-16 Wyeth Antidepressant azaheterocyclylmethyl derivatives of oxaheterocycle-fused-[1,4]-benzodioxans
US6906206B2 (en) * 2001-04-30 2005-06-14 Wyeth Antidepressant azaheterocyclylmethyl derivatives of 1,4,5-trioxa-phenanthrene
US6555560B2 (en) 2001-04-30 2003-04-29 Wyeth Antidepressant azaheterocyclylmethyl derivatives of 1,4,5-trioxa-phenanthrene
US6617334B2 (en) 2001-04-30 2003-09-09 Wyeth Antidepressant azaheterocyclylmethyl derivatives of 7,8-dihydro-1,6,9-trioxa-3-aza-cyclopenta[a]naphthalene
ATE277934T1 (de) 2001-04-30 2004-10-15 Wyeth Corp Antidepressive azaheterocyclylmethylderivate von 7,8-dihydro-1,6,9-trioxa-3- azacyclopenta(a)naphthalin
US6815448B2 (en) 2001-05-07 2004-11-09 Wyeth Azaheterocyclylmethyl derivatives of 7,8-dihydro-1,6,9-trioxa-3-aza-cyclopenta[a]naphthalene as 5-HT1A antagonists
AU2002309769B2 (en) * 2001-05-17 2008-04-17 Wyeth Processes for the synthesis of derivatives of 2,3-dihydro-1,4-dioxino-[2,3-f] quinoline
US6541502B1 (en) 2001-07-20 2003-04-01 Wyeth 2-(aminomethyl)-tetrahydro-9-oxa-1,3-diaza-cyclopenta[a]-naphthalenyl derivatives with antipsychotic activity
US6541501B2 (en) 2001-07-20 2003-04-01 Wyeth 2-(aminomethyl)-tetrahydro-9-oxa-1,3-diaza-cyclopenta[a]-naphthalenyl derivatives with antipsychotic activity
US6903110B2 (en) * 2001-07-25 2005-06-07 Wyeth Antidepressant azaheterocyclylmethyl derivatives of 7,8-dihydro-6H-5-oxa-1-aza-phenanthrene
US7872030B2 (en) 2001-07-26 2011-01-18 Merck Patent Gmbh Use of 2-[5-(4-fluorophenyl)-3-pyridylmethylaminomethyl]-chromane and its physiologically acceptable salts
AU2002331229B2 (en) * 2001-09-19 2008-05-15 Merck Patent Gmbh Novel use of substituted aminomethyl chromans
BR0213094A (pt) * 2001-10-04 2004-10-13 Wyeth Corp Derivados de cromano como ligandos de 5-hidroxi-triptamina-6
WO2003029239A1 (en) 2001-10-04 2003-04-10 Wyeth Chroman and benzofuran derivatives as 5-hydroxytryptamine-6 ligands
BR0213127A (pt) 2001-10-05 2004-09-21 Wyeth Corp Processo para a sìntese estéreo-seletiva de 2-hidroximetil-cromanos
EP1432694A1 (en) 2001-10-05 2004-06-30 Wyeth Stereospecific process for the synthesis of 2-yl chroman derivatives
EP1524267A1 (en) * 2003-10-15 2005-04-20 Newron Pharmaceuticals S.p.A. Substituted benzylaminoalkylene heterocycles
AU2004286855B2 (en) 2003-10-29 2011-04-21 Wyeth Sustained release pharmaceutical compositions comprising aplindore and derivatives thereof
TW200811182A (en) 2006-05-25 2008-03-01 Wyeth Corp Oxindoledioxans, synthesis thereof, and intermediates thereto
CL2007003043A1 (es) * 2006-10-24 2008-05-30 Wyeth Corp Compuestos derivados de cromano; composicion farmaceutica que los comprende; y uso para el tratamiento de un trastorno psicotico, bipolar, depresivo y ansiedad entre otros.
AR063372A1 (es) * 2006-10-25 2009-01-21 Wyeth Corp Derivados de cromano, su sintesis e intermediarios
JP5514804B2 (ja) * 2008-04-29 2014-06-04 エヌエスエイビー、フィリアル アヴ ノイロサーチ スウェーデン エービー、スヴェーリエ ドーパミン神経伝達のモジュレーター
JP2011519839A (ja) * 2008-04-29 2011-07-14 エヌエスエイビー、フィリアル アヴ ノイロサーチ スウェーデン エービー、スヴェーリエ ドーパミン神経伝達のモジュレーター
WO2009133110A1 (en) * 2008-04-29 2009-11-05 Nsab, Filial Af Neurosearch Sweden Ab, Sverige Modulators of dopamine neurotransmission
BR112012004668A2 (pt) * 2009-09-02 2019-09-24 Du Pont "composição e processo"
US20110218319A1 (en) * 2009-09-02 2011-09-08 E. I. Du Pont De Nemours And Company Polyaramid films comprising fluorovinylether functionalized aromatic moieties
IN2012DN01776A (en:Method) * 2009-09-02 2015-06-05 Du Pont
WO2011028766A2 (en) * 2009-09-02 2011-03-10 E. I. Du Pont De Nemours And Company Fluorinated 4-oxo-chroman-carboxylates
CN102597060B (zh) * 2009-09-02 2014-05-07 纳幕尔杜邦公司 包含氟乙烯基醚官能化芳族部分的芳族聚酰胺
US8304513B2 (en) * 2009-09-02 2012-11-06 E I Du Pont De Nemours And Company Polyesters comprising fluorovinylether functionalized aromatic moieties
AP2013007331A0 (en) 2011-06-24 2013-12-31 Amgen Inc TRPM8 antagonists and their use in treatments
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US8952009B2 (en) 2012-08-06 2015-02-10 Amgen Inc. Chroman derivatives as TRPM8 inhibitors
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Family Cites Families (8)

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EP0396620B1 (en) * 1988-01-15 1993-08-11 Abbott Laboratories Aminomethyl-chroman and -thiochroman compounds
CA1337432C (en) * 1988-03-23 1995-10-24 Raymond M. Xhonneux Method of lowering the blood pressure
DE3901814A1 (de) * 1988-07-28 1990-02-01 Bayer Ag Substituierte aminomethylzetraline sowie ihre heterocyclischen analoga
CA2002649C (en) * 1988-11-14 2000-06-06 Margaret Petty Cardioprotective tocopherol analogs
US5229398A (en) * 1990-02-27 1993-07-20 Adir Et Compagnie Aminomethylpiperidine compounds
US5126367A (en) * 1991-06-21 1992-06-30 American Home Products Corporation Psychotropic benzodioxan derivatives
DE4135474A1 (de) * 1991-10-28 1993-04-29 Bayer Ag 2-aminomethyl-chromane

Also Published As

Publication number Publication date
FI924847A0 (fi) 1992-10-26
EP0540914A1 (de) 1993-05-12
JP3299321B2 (ja) 2002-07-08
DE4135474A1 (de) 1993-04-29
NO923975L (no) 1993-04-29
JPH05194473A (ja) 1993-08-03
US5318988A (en) 1994-06-07
ES2132105T3 (es) 1999-08-16
NO923975D0 (no) 1992-10-13
CA2081300A1 (en) 1993-04-29
ZA928291B (en) 1993-05-06
IL103545A0 (en) 1993-03-15
MX9205681A (es) 1993-04-01
KR930007930A (ko) 1993-05-20
ATE180777T1 (de) 1999-06-15
US5468882A (en) 1995-11-21
DE59209704D1 (de) 1999-07-08
US5962513A (en) 1999-10-05
EP0540914B1 (de) 1999-06-02
AU2626492A (en) 1993-04-29
HU9203383D0 (en) 1993-01-28
FI924847L (fi) 1993-04-29
TW207537B (en:Method) 1993-06-11
CZ322592A3 (en) 1993-05-12
HUT62875A (en) 1993-06-28

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