FI91400C - Förfarande för framställning av kinolinkarboxylsyraderivat - Google Patents
Förfarande för framställning av kinolinkarboxylsyraderivat Download PDFInfo
- Publication number
- FI91400C FI91400C FI890723A FI890723A FI91400C FI 91400 C FI91400 C FI 91400C FI 890723 A FI890723 A FI 890723A FI 890723 A FI890723 A FI 890723A FI 91400 C FI91400 C FI 91400C
- Authority
- FI
- Finland
- Prior art keywords
- formula
- compound
- acid
- process according
- carboxylic acid
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
- C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Quinoline Compounds (AREA)
Claims (7)
1. F6rfarande fttr framstållning av kinolinkar-boxylsyraderivat med formeln I och farmaceutiskt godtagba-5 ra salter dårav, 0 COOH \ I I (I) 10 i vilken formel R1 år fenyl, som kan vara substituerad med en eller två 15 halogenatomer, och R2 år piperazinyl eller 4-metyl-piperazinyl; kånnetecknat dårav, att en fiirening med formeln R\ /R 20 Fxx^ ° dår R1 betecknar samma som ovan och R år en alifatisk acyl-oxigrupp med 2-6 kolatomer eller en aromatisk acyloxi-grupp med 7-11 kolatomer, omsåtts med en amin med for-30 meln r5^p (III) 35 13 91400 dar R5 Sr vate eller metyl, eller ett salt darav, och den erhållna foreningen med formeln R\ 5 o'x£Kb jii (IV) YTT 10 ii dar R, R1 och R2 betecknar samma som ovan, hydrolyseras efter Isolering eller utan isolering och, om så Onskas, omvandlas en erhållen forening med formeln (I) till ett 15 salt eller frigOrs foreningen från ett salt darav.
2. FOrfarande enligt patentkravet 1, kanne-t e c k n a t darav, att en forening med formeln (II) omsatte med en amin med formeln (III) i narvaro av ett organiskt lOsningsmedel, fOretradesvis en syraamid, sulfoxid, 20 ett keton, en alkohol, eter eller ester.
3. FOrfarande enligt patentkravet 2, kanne-t e c k n a t darav, att som organiskt lOsningsmedel an-vands dimetylsulfoxid.
4. FOrfarande enligt patentkravet 1, kanne- 25 tecknat darav, att reaktionen av fOreningarna med formlerne (II) och (III) utfOrs i narvaro av ett syrabin-dande medel.
5. FOrfarande enligt patentkravet 4, kanne-tecknat darav, att som syrabindande medel anvands 30 en amin eller ett Overskott av en forening med formeln (HD.
6. FOrfarande enligt patentkravet 1, kanne-tecknat darav, att hydrolysen utfOrs i ett alkaliskt medium.
7. FOrfarande enligt patentkravet 6, kanne- tecknat darav, att en alkalimetallhydroxid, en jordalkalimetallhydroxid eller en organisk bas, fOretradesvis en vattenlOsning av trietylamin anvands.
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HU285887A HU200175B (en) | 1987-06-24 | 1987-06-24 | Process for producing quinolinecarboxylic acid derivatives |
HU285887 | 1987-06-24 | ||
HU314687 | 1987-07-10 | ||
HU873146A HU199822B (en) | 1987-07-10 | 1987-07-10 | Process for production of derivatives of quinoline carbonic acid |
HU8800036 | 1988-05-20 | ||
PCT/HU1988/000036 WO1988010253A1 (en) | 1987-06-24 | 1988-05-20 | Process for the preparation of quinoline carboxylic acid derivatives |
Publications (4)
Publication Number | Publication Date |
---|---|
FI890723A FI890723A (sv) | 1989-02-15 |
FI890723A0 FI890723A0 (sv) | 1989-02-15 |
FI91400B FI91400B (sv) | 1994-03-15 |
FI91400C true FI91400C (sv) | 1994-06-27 |
Family
ID=26317564
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI890723A FI91400C (sv) | 1987-06-24 | 1989-02-15 | Förfarande för framställning av kinolinkarboxylsyraderivat |
Country Status (11)
Country | Link |
---|---|
EP (1) | EP0329719A1 (sv) |
JP (1) | JP2693988B2 (sv) |
KR (1) | KR970005911B1 (sv) |
CN (1) | CN1025028C (sv) |
CA (1) | CA1325010C (sv) |
CS (1) | CS274677B2 (sv) |
DK (1) | DK84089D0 (sv) |
ES (1) | ES2006994A6 (sv) |
FI (1) | FI91400C (sv) |
WO (1) | WO1988010253A1 (sv) |
YU (1) | YU46570B (sv) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4562852A (en) * | 1984-08-20 | 1986-01-07 | Britt Franklin J | Safety valve |
US4606367A (en) * | 1985-04-04 | 1986-08-19 | Britt Franklin J | Apparatus and method for relieving pressure within a high pressure tank |
HU198709B (en) * | 1987-04-08 | 1989-11-28 | Chinoin Gyogyszer Es Vegyeszet | Process for producing quinoline-carboxylic acid derivatives |
JP3055757B2 (ja) * | 1990-09-11 | 2000-06-26 | シェリング・コーポレーション | アルブテロール、およびその中間体であるアセタール、ヘミアセタールおよびアリールグリオキサール水化物の製造方法 |
JP3165742B2 (ja) * | 1991-07-16 | 2001-05-14 | 中外製薬株式会社 | キノロンカルボン酸誘導体の製造方法 |
US5869661A (en) * | 1991-07-16 | 1999-02-09 | Chugai Seiyaku Kabushiki Kaisha | Method of producing a quinolonecarboxylic acid derivative |
ES2049636B1 (es) * | 1992-04-15 | 1994-12-16 | Genesis Para La Investigacion | Procedimiento para la preparacion de derivados de acidos quinolincarboxilicos. |
ES2077490B1 (es) * | 1992-11-18 | 1996-10-16 | Marga Investigacion | Esteres trimetilsililicos y solvatos de quelatos de acidos quinolin-3-carboxilicos. preparacion y aplicacion al proceso de quinolonas. |
ES2092963B1 (es) * | 1995-04-12 | 1997-12-16 | Sint Quimica Sa | Procedimiento para la preparacion del acido 1-ciclopropil-6-fluoro-1, 4-dihidro-7-(1s,4s)-5-metil-2,5-diazabiciclo(2.2.1) hept-2-il)-4-oxo-3-quinolincarboxilico y sus sales. |
ES2095809B1 (es) * | 1995-07-27 | 1997-12-16 | Sint Quimica Sa | Procedimiento para la preparacion de acidos naftiridin carboxilicos y sus sales. |
FR2916446B1 (fr) | 2007-05-24 | 2009-08-21 | Biocodex Sa | Nouveau procede de synthese de fluoroquinolones |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS59122470A (ja) * | 1982-12-27 | 1984-07-14 | Dai Ichi Seiyaku Co Ltd | キノリン−3−カルボン酸誘導体の製造法 |
NZ208470A (en) * | 1983-07-18 | 1988-06-30 | Abbott Lab | 6-fluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid derivatives and antibacterial compositions containing such |
-
1988
- 1988-05-20 JP JP63504328A patent/JP2693988B2/ja not_active Expired - Lifetime
- 1988-05-20 WO PCT/HU1988/000036 patent/WO1988010253A1/en not_active Application Discontinuation
- 1988-05-20 EP EP88904603A patent/EP0329719A1/en not_active Ceased
- 1988-05-20 KR KR1019890700325A patent/KR970005911B1/ko not_active IP Right Cessation
- 1988-06-14 CS CS412388A patent/CS274677B2/cs unknown
- 1988-06-21 ES ES8801926A patent/ES2006994A6/es not_active Expired
- 1988-06-23 CA CA000570183A patent/CA1325010C/en not_active Expired - Fee Related
- 1988-06-23 YU YU121788A patent/YU46570B/sh unknown
- 1988-06-24 CN CN88103892A patent/CN1025028C/zh not_active Expired - Fee Related
-
1989
- 1989-02-15 FI FI890723A patent/FI91400C/sv not_active IP Right Cessation
- 1989-02-23 DK DK084089A patent/DK84089D0/da not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
CS412388A2 (en) | 1990-11-14 |
KR970005911B1 (ko) | 1997-04-22 |
JPH02500366A (ja) | 1990-02-08 |
CN1025028C (zh) | 1994-06-15 |
YU121788A (en) | 1989-12-31 |
FI91400B (sv) | 1994-03-15 |
FI890723A (sv) | 1989-02-15 |
DK84089A (da) | 1989-02-23 |
KR890701564A (ko) | 1989-12-21 |
JP2693988B2 (ja) | 1997-12-24 |
CN1032166A (zh) | 1989-04-05 |
CA1325010C (en) | 1993-12-07 |
CS274677B2 (en) | 1991-09-15 |
FI890723A0 (sv) | 1989-02-15 |
ES2006994A6 (es) | 1989-05-16 |
WO1988010253A1 (en) | 1988-12-29 |
YU46570B (sh) | 1993-11-16 |
EP0329719A1 (en) | 1989-08-30 |
DK84089D0 (da) | 1989-02-23 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
BB | Publication of examined application | ||
MM | Patent lapsed |
Owner name: CHINOIN GYOGUSZER ES VEGYESZETI TERMEKEK |