FI912280A0 - Kiral syntes av 1-aryl-3-aminopropan-1 -oler. - Google Patents

Kiral syntes av 1-aryl-3-aminopropan-1 -oler.

Info

Publication number
FI912280A0
FI912280A0 FI912280A FI912280A FI912280A0 FI 912280 A0 FI912280 A0 FI 912280A0 FI 912280 A FI912280 A FI 912280A FI 912280 A FI912280 A FI 912280A FI 912280 A0 FI912280 A0 FI 912280A0
Authority
FI
Finland
Prior art keywords
syntes
kiral
oler
aminopropan
aryl
Prior art date
Application number
FI912280A
Other languages
English (en)
Other versions
FI912280A (fi
Inventor
Michael Alexander Staszak
Gilbert Stanley Staten
Leland Otto Weigel
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of FI912280A0 publication Critical patent/FI912280A0/fi
Publication of FI912280A publication Critical patent/FI912280A/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C215/22—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
    • C07C215/28—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FI912280A 1990-05-17 1991-05-10 Kiral syntes av 1-aryl-3-aminopropan-1 -oler. FI912280A (fi)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US52451290A 1990-05-17 1990-05-17

Publications (2)

Publication Number Publication Date
FI912280A0 true FI912280A0 (fi) 1991-05-10
FI912280A FI912280A (fi) 1991-11-18

Family

ID=24089523

Family Applications (1)

Application Number Title Priority Date Filing Date
FI912280A FI912280A (fi) 1990-05-17 1991-05-10 Kiral syntes av 1-aryl-3-aminopropan-1 -oler.

Country Status (8)

Country Link
EP (1) EP0457559A3 (fi)
JP (1) JPH04226948A (fi)
KR (1) KR910019960A (fi)
CA (1) CA2042346A1 (fi)
FI (1) FI912280A (fi)
HU (1) HUT57760A (fi)
IE (1) IE911677A1 (fi)
IL (1) IL98108A0 (fi)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0571685A1 (en) * 1992-05-27 1993-12-01 Novo Nordisk A/S Aryloxyheteroarylpropylamines, their preparation and use
US5362886A (en) * 1993-10-12 1994-11-08 Eli Lilly And Company Asymmetric synthesis
US6090950A (en) * 1996-08-23 2000-07-18 Zeeland Chemicals, Inc. Chiral hydride complexes
TW514634B (en) * 1997-10-14 2002-12-21 Lilly Co Eli Process to make chiral compounds
US6008412A (en) * 1997-10-14 1999-12-28 Eli Lilly And Company Process to make chiral compounds
US5936124A (en) * 1998-06-22 1999-08-10 Sepacor Inc. Fluoxetine process from benzoylpropionic acid
US6025517A (en) * 1998-08-03 2000-02-15 Sepracor Inc. Fluoxetine process from benzoylacetonitrile
DE10207586A1 (de) * 2002-02-22 2003-09-11 Degussa Herstellung von N-Methyl-3-hydroxy-3-(2-thienyl)propanamin über neue carbamatgruppenhaltige Thiophenderivate als Zwischenprodukte
US7659409B2 (en) 2002-03-19 2010-02-09 Mitsubishi Chemical Corporation 3-Hydroxy-3-(2-thienyl) propionamides and production method thereof, and production method of 3-amino-1-(2-thienyl)-1-propanols using the same
EP1486493A4 (en) * 2002-03-19 2007-04-04 Mitsubishi Chem Corp 3-HYDROXY-3- (2-THIENYL) PROPIONIC ACID AMID COMPOUND, METHOD FOR THE PRODUCTION THEREOF AND METHOD FOR PRODUCING A 3-AMINO-1- (2-THIENYL) -1-PROPANOL COMPOUND THEREFOR
US20060167278A1 (en) * 2002-05-20 2006-07-27 Mitsubishi Rayon Co. Ltd. Propanolamine derivatives, process for preparation of 3-n-methylamino-1-(2-thienyl)-1-propanols and process for preparation of propanolamine derivatives
DE60329640D1 (de) * 2002-07-09 2009-11-19 Lonza Ag Verfahren zur Herstellung von N-Monoalkyl-Beta-Aminoalkoholen
DK1852415T3 (da) * 2002-07-09 2010-01-25 Lonza Ag Fremgangsmåde til fremstilling af N-monosubstituerede beta-aminoalkoholer
DE10235206A1 (de) * 2002-08-01 2004-02-19 Basf Ag Verfahren zur Herstellung von (S)-3-Methylmino-1-(thien-2-yl)propan-1-ol
JP4589724B2 (ja) * 2002-08-27 2010-12-01 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング アミノアルコールのエナンチオ選択的水素化法
GB0221438D0 (en) * 2002-09-16 2002-10-23 Avecia Ltd Processes and compounds
US6846957B2 (en) 2002-11-22 2005-01-25 Board Of Regents, The University Of Texas System Synthesis of 3-aminomethyl-1-propanol, a fluoxetine precursor
GB0229583D0 (en) 2002-12-19 2003-01-22 Cipla Ltd A process for preparing duloxetine and intermediates for use therein
DE10302595A1 (de) 2003-01-22 2004-07-29 Basf Ag 3-Methylamino-1-(2-thienyl)-1-proganon, seine Herstellung und Verwendung
DE10345772A1 (de) 2003-10-01 2005-04-21 Basf Ag Verfahren zur Herstellung von 3-Methylamino-1-(thien-2-yl)-propan-1-ol
DE102004004719A1 (de) 2004-01-29 2005-08-18 Basf Ag Verfahren zur Herstellung von enantiomerenreinen Aminoalkoholen
EP1566383A1 (en) * 2004-02-19 2005-08-24 Lonza AG Process for the preparation of enantiomerically pure 1-substituted-3-aminoalcohols
PT1720852E (pt) * 2004-02-19 2012-10-22 Lonza Ag Processo para a preparação de 3-aminoálcoois 1- substituídos enantiometricamente puros
CN1300137C (zh) * 2004-03-31 2007-02-14 上海医药工业研究院 (s)－(+)－n,n－二甲基－3－(1－萘氧基)－3－(2－噻吩基)丙胺的制备方法
DE102004022686A1 (de) 2004-05-05 2005-11-24 Basf Ag Verfahren zur Herstellung optisch aktiver Alkohole
WO2006071868A2 (en) * 2004-12-23 2006-07-06 Teva Pharmaceutical Industries Ltd. Process for preparing pharmaceutically acceptable salts of duloxetine and intermediates thereof
WO2006087166A1 (en) 2005-02-21 2006-08-24 Lonza Ag Process for the preparation of enantiomerically pure 1-substituted-3-aminoalcohols
EP1856087A1 (en) 2005-03-08 2007-11-21 Teva Pharmaceutical Industries Limited Crystal forms of (s)-(+)-n,n-dimethyl-3-(1-naphthalenyloxy)-3-(2-thienyl) propanamine oxalate and the preparation thereof
EP1858874A1 (en) 2005-03-14 2007-11-28 Teva Pharmaceutical Industries Ltd. (s)-n,n-dimethyl-3-(1-naphthalenyloxy)-3-(2-thienyl) propanamine-di-p-toluoyl-l-tartarate and methods of preparation thereof
EP1838692A2 (en) 2005-09-22 2007-10-03 Teva Pharmaceutical Industries Ltd Dnt-maleate and methods of preparation thereof
WO2007067581A1 (en) 2005-12-05 2007-06-14 Teva Pharmaceutical Industries Ltd. 2-(n-methyl-propanamine)-3-(2-naphthol) thiophene, an impurity of duloxetine hydrochloride
DE102005062662A1 (de) 2005-12-23 2007-06-28 Basf Ag Verfahren zur Herstellung optisch aktiver Alkohole
DE102005062661A1 (de) 2005-12-23 2007-08-16 Basf Ag Verfahren zur Herstellung von optisch aktivem (1S)-3-Chlor-(-thien-2-yl)-propan-1-ol
US8362279B2 (en) 2006-01-06 2013-01-29 Msn Laboratories Limited Process for pure duloxetine hydrochloride
MX2007011676A (es) * 2006-01-23 2007-11-15 Teva Pharma Dnt-bencensulfonato y metodos de preparacion de el.
EP1856089A1 (en) * 2006-01-23 2007-11-21 Teva Pharmaceutical Industries Limited Dnt-succinate and methods of preparation thereof
MX2007011611A (es) * 2006-01-23 2007-10-18 Teva Pharma Fumarato de dnt y metodos de preparacion de ellos.
WO2007095200A2 (en) * 2006-02-13 2007-08-23 Teva Pharmaceutical Industries Ltd. A process for the preparation of (s)-(+)-n,n-dimethyl-3-(1-naphthalenyloxy)-3-(2-thienyl)propanamine, a duloxetine intermediate
EP1888554A2 (en) 2006-02-21 2008-02-20 Teva Pharmaceutical Industries Ltd Process for the preparation of (s)-(-)-n,n-dimethyl-3-(2-thienyl)-3-hydroxypropanamine, a duloxetine intermediate
HU228458B1 (en) * 2006-03-13 2013-03-28 Egis Gyogyszergyar Nyrt Duloxetine salts for producing pharmaceutical compositions
WO2008004191A2 (en) 2006-07-03 2008-01-10 Ranbaxy Laboratories Limited Process for the preparation of enantiomerically pure salts of n-methyl-3- ( 1-naphthaleneoxy) -3- (2-thienyl) propanamine
ATE552250T1 (de) 2006-12-22 2012-04-15 Synthon Bv Verfahren zur herstellung von duloxetin und verwandten verbindungen
WO2009128057A2 (en) 2008-04-18 2009-10-22 UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN et al Psycho-pharmaceuticals
HU230480B1 (hu) * 2008-07-25 2016-07-28 Egis Gyógyszergyár Nyilvánosan Működő Részvénytársaság Eljárás N-metil-ariloxi-propánamin származékok előállítására
WO2010025287A2 (en) 2008-08-27 2010-03-04 Codexis, Inc. Ketoreductase polypeptides for the production of 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine
US8426178B2 (en) 2008-08-27 2013-04-23 Codexis, Inc. Ketoreductase polypeptides for the production of a 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine
WO2010079404A2 (en) * 2009-01-06 2010-07-15 Alembic Limited An improved process for the preparation of duloxetine and salts thereof
CN102822161A (zh) * 2010-03-24 2012-12-12 住友精化株式会社 制造光学活性n-单烷基-3-羟基-3-芳基丙胺化合物的方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR880007433A (ko) * 1986-12-22 1988-08-27 메리 앤 터커 3-아릴옥시-3-치환된 프로판아민
DK630987D0 (da) * 1987-12-01 1987-12-01 Ferrosan As Aryloxyphenylpropylaminer, deres fremstilling og anvendelse
CA1337128C (en) * 1988-04-08 1995-09-26 David Wayne Robertson Propanamine derivatives

Also Published As

Publication number Publication date
KR910019960A (ko) 1991-12-19
IL98108A0 (en) 1992-06-21
EP0457559A2 (en) 1991-11-21
JPH04226948A (ja) 1992-08-17
IE911677A1 (en) 1991-11-20
HUT57760A (en) 1991-12-30
CA2042346A1 (en) 1991-11-18
HU911648D0 (en) 1991-11-28
EP0457559A3 (en) 1993-05-12
FI912280A (fi) 1991-11-18

Similar Documents

Publication Publication Date Title
FI912280A0 (fi) Kiral syntes av 1-aryl-3-aminopropan-1 -oler.
FI900779A (fi) Hydrometallurgiskt foerfarande foer behandling av zinksulfidhaltiga raoaemnen.
FI911505A (fi) Foerfarande foer oligomerisering av olefiner foer framstaellning av basraoaemnen foer smoerjmedel.
FI901135A (fi) Foerfarande foer framstaellning av vaextoljeprodukt.
FI900134A (fi) Foerfarande foer identifiering av plantor.
FI900995A (fi) Tillslutningsmekanism foer suganordningen av en tandvaordsmaskin.
FI912385A (fi) Foerfarande foer framstaellning av semisekvenserade polyamidimider.
FI900939A (fi) Foerfarande foer maerkning av traestycken.
FI900107A (fi) Foerfarande foer framstaellning av oxalsyra.
FI901377A0 (fi) Blaosanordning foer vindspridning av spaonor.
FI914527A0 (fi) Foerfarande foer framstaellning av polyketoner.
FI901059A0 (fi) Vinkelkonstruktion av eldstad.
FI901210A (fi) Foerfarande foer framstaellning av wobblerkropp.
FI901456A0 (fi) Stroemfoerdelningsanordning foer framstaellning av flerskiktsskiva.
FI901161A0 (fi) Reaktionsprodukter av alkenylbaernstenssyraimid.
FI900208A0 (fi) Vridanordning foer vridning av en fordonsstol.
FI901430A (fi) Fotsnara foer faongande av djur.
FI901073A0 (fi) Centralvaermeanordning bestaoende av vaermeskaop.
FI901061A0 (fi) Energilucka foer utsidan av foenster.
FI900106A0 (fi) Foerfarande foer framstaellning av syraamid.
FI900977A0 (fi) Pulverkomposition foer bildande av munvatten.
FI900245A0 (fi) Foerfarande foer byggande av traefartyg.
FI900850A0 (fi) Foerfarande foer snabb uppladdning av en ackumulator.
FI900829A0 (fi) Datorbaserat foerfarande foer rangering av taog.
FI900830A0 (fi) Foerfarande foer aotervinning av returprodukter.