IL98108A0 - Chiral synthesis of 1-aryl-3-aminopropan-1-ols - Google Patents
Chiral synthesis of 1-aryl-3-aminopropan-1-olsInfo
- Publication number
- IL98108A0 IL98108A0 IL98108A IL9810891A IL98108A0 IL 98108 A0 IL98108 A0 IL 98108A0 IL 98108 A IL98108 A IL 98108A IL 9810891 A IL9810891 A IL 9810891A IL 98108 A0 IL98108 A0 IL 98108A0
- Authority
- IL
- Israel
- Prior art keywords
- aminopropan
- ols
- aryl
- chiral synthesis
- chiral
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C215/22—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
- C07C215/28—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Furan Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US52451290A | 1990-05-17 | 1990-05-17 |
Publications (1)
Publication Number | Publication Date |
---|---|
IL98108A0 true IL98108A0 (en) | 1992-06-21 |
Family
ID=24089523
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL98108A IL98108A0 (en) | 1990-05-17 | 1991-05-10 | Chiral synthesis of 1-aryl-3-aminopropan-1-ols |
Country Status (8)
Country | Link |
---|---|
EP (1) | EP0457559A3 (xx) |
JP (1) | JPH04226948A (xx) |
KR (1) | KR910019960A (xx) |
CA (1) | CA2042346A1 (xx) |
FI (1) | FI912280A (xx) |
HU (1) | HUT57760A (xx) |
IE (1) | IE911677A1 (xx) |
IL (1) | IL98108A0 (xx) |
Families Citing this family (48)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0571685A1 (en) * | 1992-05-27 | 1993-12-01 | Novo Nordisk A/S | Aryloxyheteroarylpropylamines, their preparation and use |
US5362886A (en) * | 1993-10-12 | 1994-11-08 | Eli Lilly And Company | Asymmetric synthesis |
US6090950A (en) * | 1996-08-23 | 2000-07-18 | Zeeland Chemicals, Inc. | Chiral hydride complexes |
US6008412A (en) * | 1997-10-14 | 1999-12-28 | Eli Lilly And Company | Process to make chiral compounds |
TW514634B (en) * | 1997-10-14 | 2002-12-21 | Lilly Co Eli | Process to make chiral compounds |
US5936124A (en) * | 1998-06-22 | 1999-08-10 | Sepacor Inc. | Fluoxetine process from benzoylpropionic acid |
US6025517A (en) * | 1998-08-03 | 2000-02-15 | Sepracor Inc. | Fluoxetine process from benzoylacetonitrile |
DE10207586A1 (de) * | 2002-02-22 | 2003-09-11 | Degussa | Herstellung von N-Methyl-3-hydroxy-3-(2-thienyl)propanamin über neue carbamatgruppenhaltige Thiophenderivate als Zwischenprodukte |
US7659409B2 (en) | 2002-03-19 | 2010-02-09 | Mitsubishi Chemical Corporation | 3-Hydroxy-3-(2-thienyl) propionamides and production method thereof, and production method of 3-amino-1-(2-thienyl)-1-propanols using the same |
AU2003221028A1 (en) * | 2002-03-19 | 2003-09-29 | Mitsubishi Chemical Corporation | 3-hydroxy-3-(2-thienyl)propionamide compound, process for producing the same, and process for producing 3-amino-1-(2-thienyl)-1-propanol compound therefrom |
WO2003097632A1 (fr) * | 2002-05-20 | 2003-11-27 | Mitsubishi Rayon Co., Ltd. | Derives de propanolamine, procede de preparation de 3-n-methylamino-1-(2-thienyl)-1-propanols et procede de preparation de derives de propanolamine |
WO2004005239A1 (en) * | 2002-07-09 | 2004-01-15 | Lonza Ag | PROCESS FOR THE PREPARATION OF N-MONOSUBSTITUTED β-AMINO ALCOHOLS |
DK1852415T3 (da) * | 2002-07-09 | 2010-01-25 | Lonza Ag | Fremgangsmåde til fremstilling af N-monosubstituerede beta-aminoalkoholer |
DE10235206A1 (de) * | 2002-08-01 | 2004-02-19 | Basf Ag | Verfahren zur Herstellung von (S)-3-Methylmino-1-(thien-2-yl)propan-1-ol |
KR101017884B1 (ko) * | 2002-08-27 | 2011-03-04 | 메르크 파텐트 게엠베하 | 아미노 알콜의 거울상이성질 선택성 수소화 반응을 위한 제조방법 |
GB0221438D0 (en) * | 2002-09-16 | 2002-10-23 | Avecia Ltd | Processes and compounds |
US6846957B2 (en) | 2002-11-22 | 2005-01-25 | Board Of Regents, The University Of Texas System | Synthesis of 3-aminomethyl-1-propanol, a fluoxetine precursor |
GB0229583D0 (en) * | 2002-12-19 | 2003-01-22 | Cipla Ltd | A process for preparing duloxetine and intermediates for use therein |
DE10302595A1 (de) * | 2003-01-22 | 2004-07-29 | Basf Ag | 3-Methylamino-1-(2-thienyl)-1-proganon, seine Herstellung und Verwendung |
DE10345772A1 (de) | 2003-10-01 | 2005-04-21 | Basf Ag | Verfahren zur Herstellung von 3-Methylamino-1-(thien-2-yl)-propan-1-ol |
DE102004004719A1 (de) | 2004-01-29 | 2005-08-18 | Basf Ag | Verfahren zur Herstellung von enantiomerenreinen Aminoalkoholen |
EP1566383A1 (en) * | 2004-02-19 | 2005-08-24 | Lonza AG | Process for the preparation of enantiomerically pure 1-substituted-3-aminoalcohols |
BRPI0506796A (pt) * | 2004-02-19 | 2007-05-22 | Lonza Ag | processo para a preparação de 1-substituìdos-3-aminoálcoois enantiomericamentente puros |
CN1300137C (zh) * | 2004-03-31 | 2007-02-14 | 上海医药工业研究院 | (s)-(+)-n,n-二甲基-3-(1-萘氧基)-3-(2-噻吩基)丙胺的制备方法 |
DE102004022686A1 (de) | 2004-05-05 | 2005-11-24 | Basf Ag | Verfahren zur Herstellung optisch aktiver Alkohole |
JP2007523213A (ja) * | 2004-12-23 | 2007-08-16 | テバ ファーマシューティカル インダストリーズ リミティド | 医薬的に許容できるデュロキセチンの塩及びその中間体の調製方法 |
EP1868983A1 (en) | 2005-02-21 | 2007-12-26 | Lonza Ag | Process for the preparation of enantiomerically pure 1-substituted-3-aminoalcohols |
MX2007010931A (es) | 2005-03-08 | 2007-10-16 | Teva Pharma | Formas cristalinas de (s)-(+)-n,n-dimetil-3-(1-naftaleniloxi)-3-(2 -tienil)propanamina oxalato y la preparacion ellas. |
EP1874754A1 (en) | 2005-03-14 | 2008-01-09 | Teva Pharmaceutical Industries Ltd | Pure duloxetine hydrochloride |
US7842717B2 (en) | 2005-09-22 | 2010-11-30 | Teva Pharmaceutical Industries Ltd. | DNT-maleate and methods of preparation thereof |
US7759500B2 (en) | 2005-12-05 | 2010-07-20 | Teva Pharmaceutical Industries Ltd. | 2-(N-methyl-propanamine)-3-(2-naphthol)thiophene, an impurity of duloxetine hydrochloride |
DE102005062662A1 (de) | 2005-12-23 | 2007-06-28 | Basf Ag | Verfahren zur Herstellung optisch aktiver Alkohole |
DE102005062661A1 (de) | 2005-12-23 | 2007-08-16 | Basf Ag | Verfahren zur Herstellung von optisch aktivem (1S)-3-Chlor-(-thien-2-yl)-propan-1-ol |
WO2007077580A2 (en) | 2006-01-06 | 2007-07-12 | Msn Laboratories Limited | Improved process for pure duloxetine hydrochloride |
MX2007011727A (es) * | 2006-01-23 | 2007-11-15 | Teva Pharma | Dnt-succinato y metodos de preparacion de el. |
EP1856088A1 (en) * | 2006-01-23 | 2007-11-21 | Teva Pharmaceutical Industries Ltd | Dnt-benzenesulfonate and methods of preparation thereof |
MX2007011611A (es) * | 2006-01-23 | 2007-10-18 | Teva Pharma | Fumarato de dnt y metodos de preparacion de ellos. |
EP1976845A2 (en) * | 2006-02-13 | 2008-10-08 | Teva Pharmaceutical Industries Ltd | A process for the preparation of (s)-(+)-n,n-dimethyl-3-(1-naphthalenyloxy)-3-(2-thienyl)propanamine, a duloxetine intermediate |
US7560573B2 (en) | 2006-02-21 | 2009-07-14 | Teva Pharmaceutical Industries Ltd | Process for the preparation of (S)-(-)-N,N-dimethyl-3-(2-thienyl)-3-hydroxypropananine, a duloxetine intermediate |
HU228458B1 (en) * | 2006-03-13 | 2013-03-28 | Egis Gyogyszergyar Nyrt | Duloxetine salts for producing pharmaceutical compositions |
CN101484435A (zh) | 2006-07-03 | 2009-07-15 | 兰贝克赛实验室有限公司 | 制备n-甲基-3-(1-萘氧基)-3-(2-噻吩基)丙胺及其纯对应异构体盐的方法 |
EP2114912B1 (en) | 2006-12-22 | 2012-04-04 | Synthon B.V. | Process for making duloxetine and related compounds |
EP2291181B9 (en) | 2008-04-18 | 2013-09-11 | University College Dublin National University Of Ireland, Dublin | Captodiamine for the treatment of depression symptoms |
HU230480B1 (hu) * | 2008-07-25 | 2016-07-28 | Egis Gyógyszergyár Nyilvánosan Működő Részvénytársaság | Eljárás N-metil-ariloxi-propánamin származékok előállítására |
WO2010025238A2 (en) | 2008-08-27 | 2010-03-04 | Codexis, Inc. | Ketoreductase polypeptides for the production of a 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine |
US8288141B2 (en) | 2008-08-27 | 2012-10-16 | Codexis, Inc. | Ketoreductase polypeptides for the production of 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine |
CA2758736A1 (en) * | 2009-01-06 | 2010-07-15 | Alembic Pharmaceuticals Limited | An improved process for the reparation of duloxetine and salts thereof |
JPWO2011118625A1 (ja) | 2010-03-24 | 2013-07-04 | 住友精化株式会社 | 光学活性なn−モノアルキル−3−ヒドロキシ−3−アリールプロピルアミン化合物の製造方法 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR880007433A (ko) * | 1986-12-22 | 1988-08-27 | 메리 앤 터커 | 3-아릴옥시-3-치환된 프로판아민 |
DK630987D0 (da) * | 1987-12-01 | 1987-12-01 | Ferrosan As | Aryloxyphenylpropylaminer, deres fremstilling og anvendelse |
CA1337128C (en) * | 1988-04-08 | 1995-09-26 | David Wayne Robertson | Propanamine derivatives |
-
1991
- 1991-05-10 CA CA002042346A patent/CA2042346A1/en not_active Abandoned
- 1991-05-10 FI FI912280A patent/FI912280A/fi unknown
- 1991-05-10 IL IL98108A patent/IL98108A0/xx unknown
- 1991-05-15 EP EP19910304345 patent/EP0457559A3/en not_active Withdrawn
- 1991-05-16 HU HU911648A patent/HUT57760A/hu unknown
- 1991-05-16 IE IE167791A patent/IE911677A1/en unknown
- 1991-05-17 KR KR1019910008023A patent/KR910019960A/ko not_active Application Discontinuation
- 1991-05-17 JP JP3113034A patent/JPH04226948A/ja not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
EP0457559A3 (en) | 1993-05-12 |
HU911648D0 (en) | 1991-11-28 |
KR910019960A (ko) | 1991-12-19 |
JPH04226948A (ja) | 1992-08-17 |
FI912280A0 (fi) | 1991-05-10 |
HUT57760A (en) | 1991-12-30 |
IE911677A1 (en) | 1991-11-20 |
EP0457559A2 (en) | 1991-11-21 |
FI912280A (fi) | 1991-11-18 |
CA2042346A1 (en) | 1991-11-18 |
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