FI904851A0 - Radiomaerkta antikoagulantpeptider. - Google Patents

Radiomaerkta antikoagulantpeptider.

Info

Publication number
FI904851A0
FI904851A0 FI904851A FI904851A FI904851A0 FI 904851 A0 FI904851 A0 FI 904851A0 FI 904851 A FI904851 A FI 904851A FI 904851 A FI904851 A FI 904851A FI 904851 A0 FI904851 A0 FI 904851A0
Authority
FI
Finland
Prior art keywords
anticoagulant
radiomaerkta
peptidider
iodinated
usage
Prior art date
Application number
FI904851A
Other languages
English (en)
Finnish (fi)
Inventor
John Leonard Krstenansky
Simon Jen Tan Mao
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Publication of FI904851A0 publication Critical patent/FI904851A0/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/81—Protease inhibitors
    • G01N2333/815—Protease inhibitors from leeches, e.g. hirudin, eglin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
FI904851A 1989-10-03 1990-10-02 Radiomaerkta antikoagulantpeptider. FI904851A0 (fi)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US41633589A 1989-10-03 1989-10-03

Publications (1)

Publication Number Publication Date
FI904851A0 true FI904851A0 (fi) 1990-10-02

Family

ID=23649537

Family Applications (1)

Application Number Title Priority Date Filing Date
FI904851A FI904851A0 (fi) 1989-10-03 1990-10-02 Radiomaerkta antikoagulantpeptider.

Country Status (18)

Country Link
US (1) US5279812A (de)
EP (1) EP0421366B1 (de)
JP (1) JP2899390B2 (de)
KR (1) KR0168644B1 (de)
CN (1) CN1050721A (de)
AT (1) ATE125269T1 (de)
AU (1) AU631681B2 (de)
CA (1) CA2026377A1 (de)
DE (1) DE69021000T2 (de)
ES (1) ES2076999T3 (de)
FI (1) FI904851A0 (de)
HU (1) HU207525B (de)
IE (1) IE903531A1 (de)
IL (1) IL95864A0 (de)
NO (1) NO904291L (de)
NZ (1) NZ235499A (de)
PT (1) PT95485A (de)
ZA (1) ZA907743B (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5395609A (en) * 1989-06-19 1995-03-07 Antisoma Limited Synthetic peptides for use in tumor detection
GB8914020D0 (en) * 1989-06-19 1989-08-09 Antisoma Ltd Synthetic peptides for use in thrombus detection
EP0540574B1 (de) * 1990-07-24 1996-09-11 Merrell Pharmaceuticals Inc. Antigerinnungspeptide
ZA915658B (en) * 1990-07-24 1992-05-27 Merrell Dow Pharma Analogs of hirudin having antiplatelet activity
US5574012A (en) * 1990-07-24 1996-11-12 Merrell Pharmaceuticals Inc. Analogs of hirudin having anti-platelet activity
WO1993004082A1 (en) * 1991-08-20 1993-03-04 Baxter International Inc. Analogs of hirudin
US5371184A (en) * 1992-02-05 1994-12-06 Mallinckrodt Medical, Inc. Radiolabelled peptide compounds
JPH08504166A (ja) * 1992-02-05 1996-05-07 マリンクロッド・メディカル・インコーポレイテッド 放射標識ペプチド化合物
US5750088A (en) 1993-03-30 1998-05-12 The Dupont Merck Pharmaceutical Company Stable hydrazones linked to a peptide moiety as reagents for the preparation of radiopharmaceuticals
US5879657A (en) * 1993-03-30 1999-03-09 The Dupont Merck Pharmaceutical Company Radiolabeled platelet GPIIb/IIIa receptor antagonists as imaging agents for the diagnosis of thromboembolic disorders
ATE246203T1 (de) * 1993-06-11 2003-08-15 Merrell Pharma Inc Trifunktionelle antithrombin-und antiplättchenpeptide
US5457177A (en) * 1993-06-16 1995-10-10 Merck & Co., Inc. Thrombin receptor radioligands
US5780509A (en) * 1994-05-24 1998-07-14 Muromachi Kagaku Kogyo Kaisha, Ltd. Compound bearing two, 2,6-diiodophenol-4-YL groups and diagnostic drug for iodine allergy
US5808146A (en) * 1995-11-09 1998-09-15 Emory University Amino acid analogs for tumor imaging
US6808698B1 (en) 1999-03-26 2004-10-26 Bristol-Myers Squibb Pharma Company Method for localization of blood clots
US6254852B1 (en) 1999-07-16 2001-07-03 Dupont Pharmaceuticals Company Porous inorganic targeted ultrasound contrast agents
US6685914B1 (en) * 1999-09-13 2004-02-03 Bristol-Myers Squibb Pharma Company Macrocyclic chelants for metallopharmaceuticals
US7544715B2 (en) * 2002-04-30 2009-06-09 Emory University Tumor imaging compounds
US7317104B2 (en) 2003-06-13 2008-01-08 Bristol-Myers Squibb Pharma Company Chelants and macrocyclic metal complex radiopharmaceuticals thereof
US7319149B2 (en) * 2003-06-13 2008-01-15 Bristol-Myers Squibb Pharma Company Chelants and macrocyclic metal complex radiopharmaceuticals thereof
CN100402092C (zh) * 2005-06-07 2008-07-16 西安交通大学 血栓诊断和/或治疗用含气干粉活性剂及其制备工艺
JP5349960B2 (ja) * 2005-06-23 2013-11-20 エモリー ユニバーシティー 腫瘍画像化のためのアミノ酸類似体の立体選択的合成
JP2009505947A (ja) * 2005-06-23 2009-02-12 エモリー・ユニバーシティ 画像化剤
US8246752B2 (en) 2008-01-25 2012-08-21 Clear Catheter Systems, Inc. Methods and devices to clear obstructions from medical tubes
CN110437307B (zh) * 2019-07-26 2020-11-13 暨南大学 一类具抗血栓和脑神经细胞保护作用的水蛭多肽及其应用

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5850213B2 (ja) * 1977-06-20 1983-11-09 株式会社第一ラジオアイソト−プ研究所 カルチトニンの定量法
DE3040824A1 (de) * 1980-10-30 1982-08-19 Dr. Karl Thomae Gmbh, 7950 Biberach Neues dekapeptid, verfahren zu seiner herstellung und verwendung
US4455290A (en) * 1981-04-02 1984-06-19 Research Corporation Inhibition of fibrin polymerization by a peptide isolated from fibrin Fragment D1
US4585740A (en) * 1983-05-03 1986-04-29 The Whittier Institute For Diabetes And Endocrinology Prolactin immunoassay using synthetic peptide
FR2550204B1 (fr) * 1983-08-05 1987-11-13 Toyo Jozo Kk Derives peptidiques de (nle8,nle1b, tyr34)-h-pth
DE3445532A1 (de) * 1984-12-13 1986-06-19 Plantorgan Werk Heinrich G.E. Christensen, KG, 2903 Bad Zwischenahn Hirudin-pa, desulfatohirudine-pa, verfahren zur herstellung und pharmazeutische mittel, die diese wirkstoffe enthalten
DE3689525D1 (de) * 1985-07-17 1994-02-24 Hoechst Ag Neue Polypeptide mit blutgerinnungshemmender Wirkung, Verfahren zu deren Herstellung bzw. Gewinnung, deren Verwendung und diese enthaltende Mittel.
CA1341032C (en) * 1987-01-23 2000-06-20 John L. Krstenansky Anticoagulant peptides
CA1328540C (en) * 1987-05-21 1994-04-12 John L. Krstenansky Cyclic anticoagulant peptides
ZA883443B (en) * 1987-05-21 1988-11-16 Merrell Dow Pharmaceuticals Inc. Cyclic anticoagulant peptides
EP0333356A3 (de) * 1988-03-04 1990-12-19 Biogen, Inc. Hirudin-Peptide
ES2052062T3 (es) * 1988-06-11 1994-07-01 Ciba Geigy Ag Nuevos polipeptidos con actividad anticoagulante.
US5192747A (en) * 1989-10-03 1993-03-09 Merrell Dow Pharmaceuticals Inc. Anticoagulant peptides

Also Published As

Publication number Publication date
US5279812A (en) 1994-01-18
DE69021000T2 (de) 1996-04-04
CA2026377A1 (en) 1991-04-04
EP0421366B1 (de) 1995-07-19
JPH03120296A (ja) 1991-05-22
JP2899390B2 (ja) 1999-06-02
AU631681B2 (en) 1992-12-03
KR0168644B1 (ko) 1999-01-15
IE903531A1 (en) 1991-04-10
ATE125269T1 (de) 1995-08-15
HUT55801A (en) 1991-06-28
AU6368990A (en) 1991-04-11
DE69021000D1 (de) 1995-08-24
ZA907743B (en) 1991-07-31
EP0421366A1 (de) 1991-04-10
CN1050721A (zh) 1991-04-17
NO904291D0 (no) 1990-10-02
IL95864A0 (en) 1991-07-18
HU207525B (en) 1993-04-28
KR910007959A (ko) 1991-05-30
NO904291L (no) 1991-04-04
ES2076999T3 (es) 1995-11-16
NZ235499A (en) 1993-04-28
HU906271D0 (en) 1991-03-28
PT95485A (pt) 1991-06-25

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Legal Events

Date Code Title Description
FD Application lapsed
MM Patent lapsed

Owner name: MERRELL DOW PHARMACEUTICALS INC.