FI904588A0 - Nmda antagonister. - Google Patents

Nmda antagonister.

Info

Publication number
FI904588A0
FI904588A0 FI904588A FI904588A FI904588A0 FI 904588 A0 FI904588 A0 FI 904588A0 FI 904588 A FI904588 A FI 904588A FI 904588 A FI904588 A FI 904588A FI 904588 A0 FI904588 A0 FI 904588A0
Authority
FI
Finland
Prior art keywords
antagonister
nmda
nmda antagonister
Prior art date
Application number
FI904588A
Other languages
English (en)
Other versions
FI102613B (fi
FI102613B1 (fi
Inventor
Jeffrey Paul Whitten
Bruce Michael Baron
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/553,431 external-priority patent/US5095009A/en
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Publication of FI904588A0 publication Critical patent/FI904588A0/fi
Application granted granted Critical
Publication of FI102613B publication Critical patent/FI102613B/fi
Publication of FI102613B1 publication Critical patent/FI102613B1/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6527—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07F9/653—Five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
    • C07F9/3804—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se) not used, see subgroups
    • C07F9/3808—Acyclic saturated acids which can have further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6509—Six-membered rings
    • C07F9/650952—Six-membered rings having the nitrogen atoms in the positions 1 and 4
FI904588A 1989-09-19 1990-09-18 Menetelmä NMDA-antagonistien valmistamiseksi FI102613B1 (fi)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US40947889A 1989-09-19 1989-09-19
US40947889 1989-09-19
US50833390A 1990-04-11 1990-04-11
US50833390 1990-04-11
US55343190 1990-07-20
US07/553,431 US5095009A (en) 1990-04-11 1990-07-20 NMDA antagonists

Publications (3)

Publication Number Publication Date
FI904588A0 true FI904588A0 (fi) 1990-09-18
FI102613B FI102613B (fi) 1999-01-15
FI102613B1 FI102613B1 (fi) 1999-01-15

Family

ID=27410806

Family Applications (1)

Application Number Title Priority Date Filing Date
FI904588A FI102613B1 (fi) 1989-09-19 1990-09-18 Menetelmä NMDA-antagonistien valmistamiseksi

Country Status (20)

Country Link
EP (1) EP0418863B1 (fi)
JP (1) JP2934295B2 (fi)
KR (2) KR100191116B1 (fi)
CN (1) CN1027694C (fi)
AR (2) AR247889A1 (fi)
AT (1) ATE116653T1 (fi)
AU (1) AU632362B2 (fi)
CA (1) CA2025326C (fi)
DE (1) DE69015745T2 (fi)
DK (1) DK0418863T3 (fi)
ES (1) ES2069644T3 (fi)
FI (1) FI102613B1 (fi)
GR (1) GR3015656T3 (fi)
HU (1) HU207523B (fi)
IE (1) IE65118B1 (fi)
IL (1) IL95718A (fi)
MX (1) MX9203696A (fi)
NO (1) NO178375C (fi)
NZ (1) NZ235322A (fi)
PT (1) PT95344B (fi)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3168563B2 (ja) * 1991-11-15 2001-05-21 メレルダウファーマス−ティカルズ インコーポレイテッド ホスネートｎｍｄａ拮抗剤の調製用ｎ−トリチルアスパラギン酸誘導体類
US5554773A (en) * 1991-11-15 1996-09-10 Merrell Pharmaceuticals Inc. N-trityl protected aspartic acid derivatives for the preparation of phosphonate NMDA antagonists
GB9325368D0 (en) * 1993-12-10 1994-02-16 Univ Bristol Organic compounds
EP0684238A3 (en) * 1994-04-27 1997-01-15 Hoffmann La Roche Process for the preparation of dicarboxamides.
EP3427729A1 (en) 2017-07-13 2019-01-16 Paris Sciences et Lettres - Quartier Latin Probenecid for use in treating epileptic diseases, disorders or conditions

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3970684A (en) * 1973-07-06 1976-07-20 Syntex (U.S.A.) Inc. Polyunsaturated prostaglandin derivatives
CA1248531A (en) * 1984-04-17 1989-01-10 Jeffrey C. Watkins 4-substituted piperazine-2-carboxylic acids

Also Published As

Publication number Publication date
DE69015745D1 (de) 1995-02-16
ES2069644T3 (es) 1995-05-16
KR100191116B1 (ko) 1999-06-15
AR248028A1 (es) 1995-05-31
KR910006311A (ko) 1991-04-29
EP0418863A2 (en) 1991-03-27
MX9203696A (es) 1992-09-01
AU632362B2 (en) 1992-12-24
GR3015656T3 (en) 1995-07-31
CA2025326C (en) 2001-04-24
EP0418863B1 (en) 1995-01-04
ATE116653T1 (de) 1995-01-15
DK0418863T3 (da) 1995-03-20
CN1050387A (zh) 1991-04-03
AU6247490A (en) 1991-03-28
HUT54699A (en) 1991-03-28
FI102613B (fi) 1999-01-15
HU207523B (en) 1993-04-28
NO178375B (no) 1995-12-04
IL95718A (en) 1998-03-10
KR100196265B1 (ko) 1999-06-15
PT95344B (pt) 1998-02-27
PT95344A (pt) 1991-06-25
CA2025326A1 (en) 1991-03-20
NO904061D0 (no) 1990-09-18
NO178375C (no) 1996-03-13
AR247889A1 (es) 1995-04-28
IE903380A1 (en) 1991-04-10
IE65118B1 (en) 1995-10-04
DE69015745T2 (de) 1995-05-11
JP2934295B2 (ja) 1999-08-16
NO904061L (no) 1991-03-20
JPH03130295A (ja) 1991-06-04
EP0418863A3 (en) 1991-06-12
NZ235322A (en) 1993-02-25
FI102613B1 (fi) 1999-01-15
CN1027694C (zh) 1995-02-22

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Legal Events

Date Code Title Description
FG Patent granted

Owner name: MERRELL DOW PHARMACEUTICALS INC.

MM Patent lapsed

Owner name: MERRELL DOW PHARMACEUTICALS INC.