FI904207A0 - Fettsyra-laekemedelkonjugat foer tillfoering av laekemedel genom blodhjaernbarriaeren. - Google Patents

Fettsyra-laekemedelkonjugat foer tillfoering av laekemedel genom blodhjaernbarriaeren.

Info

Publication number
FI904207A0
FI904207A0 FI904207A FI904207A FI904207A0 FI 904207 A0 FI904207 A0 FI 904207A0 FI 904207 A FI904207 A FI 904207A FI 904207 A FI904207 A FI 904207A FI 904207 A0 FI904207 A0 FI 904207A0
Authority
FI
Finland
Prior art keywords
drug
prodrug
carrier
stomach
tillfoering
Prior art date
Application number
FI904207A
Other languages
English (en)
Inventor
Victor E Shashoua
Original Assignee
Victor E Shashoua
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Victor E Shashoua filed Critical Victor E Shashoua
Publication of FI904207A0 publication Critical patent/FI904207A0/fi

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
FI904207A 1988-02-26 1990-08-24 Fettsyra-laekemedelkonjugat foer tillfoering av laekemedel genom blodhjaernbarriaeren. FI904207A0 (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/160,667 US4939174A (en) 1988-02-26 1988-02-26 Appetite suppression with dopamine-fatty acid conjugates
PCT/US1989/000757 WO1989007938A1 (en) 1988-02-26 1989-02-24 Fatty acid-drug conjugate for delivery of the drug across the blood-brain barrier

Publications (1)

Publication Number Publication Date
FI904207A0 true FI904207A0 (fi) 1990-08-24

Family

ID=22577881

Family Applications (1)

Application Number Title Priority Date Filing Date
FI904207A FI904207A0 (fi) 1988-02-26 1990-08-24 Fettsyra-laekemedelkonjugat foer tillfoering av laekemedel genom blodhjaernbarriaeren.

Country Status (10)

Country Link
US (1) US4939174A (fi)
EP (1) EP0401301B1 (fi)
JP (1) JP2959784B2 (fi)
KR (1) KR100228456B1 (fi)
AT (1) ATE176152T1 (fi)
AU (1) AU635203B2 (fi)
DE (1) DE68928920T2 (fi)
DK (1) DK526189A (fi)
FI (1) FI904207A0 (fi)
WO (1) WO1989007938A1 (fi)

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WO1992020362A1 (en) * 1991-05-14 1992-11-26 Shashoua Victor E Nerve growth peptides and uses therefor
FR2712888B1 (fr) * 1993-11-23 1996-02-09 Bioeurope Utilisation de alpha-D-alkylglucopyranosides et esters de ceux-ci pour la préparation de prodrogues capables de traverser la barrière hématoencéphalique, prodrogues obtenues et précurseurs de celles-ci.
DE4437502A1 (de) * 1993-12-02 1995-06-08 Basf Ag Hirudin-Konjugate aus Hirudin und lipophilen Verbindungen
WO1995022963A1 (en) * 1994-02-28 1995-08-31 Medinova Medical Consulting Gmbh Drug targeting system, method for preparing same and its use
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NZ298712A (en) * 1995-01-16 1998-12-23 Commw Scient Ind Res Org Fatty acid acyl group conjugates as therapeutic compounds
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US6576636B2 (en) * 1996-05-22 2003-06-10 Protarga, Inc. Method of treating a liver disorder with fatty acid-antiviral agent conjugates
US5919815A (en) * 1996-05-22 1999-07-06 Neuromedica, Inc. Taxane compounds and compositions
ES2151277T3 (es) * 1996-05-22 2000-12-16 Protarga Inc Composiciones que comprenden conjugados de acido cis-docosahexaenoico y taxotere.
US5795909A (en) * 1996-05-22 1998-08-18 Neuromedica, Inc. DHA-pharmaceutical agent conjugates of taxanes
US6589994B1 (en) 1996-08-30 2003-07-08 Nps Pharmaceuticals, Inc. Treating a variety of pathological conditions, including spasticity and convulsions, by effecting a modulation of CNS activity with isovaleramide, isovaleric acid, or a related compound
US5977174A (en) * 1997-11-26 1999-11-02 Neuromedica, Inc. Cholinergic compositions and uses thereof
US6153653A (en) * 1997-11-26 2000-11-28 Protarga, Inc. Choline compositions and uses thereof
US6197764B1 (en) * 1997-11-26 2001-03-06 Protarga, Inc. Clozapine compositions and uses thereof
US5955459A (en) * 1997-11-26 1999-09-21 Neuromedica, Inc. Fatty acid-antipsychotic compositions and uses thereof
US6225444B1 (en) 1998-02-10 2001-05-01 Protarga, Inc. Neuroprotective peptides and uses thereof
IL125731A (en) * 1998-08-11 2004-06-20 Zvi Yehuda Acylates which are products of neurotransmitters and essential fatty acids, pharmaceutical compositions containing them, use of such acylates in the manufacture of medicaments, and method for treating nervous diseases in non-human animals
US6703381B1 (en) 1998-08-14 2004-03-09 Nobex Corporation Methods for delivery therapeutic compounds across the blood-brain barrier
US7235583B1 (en) 1999-03-09 2007-06-26 Luitpold Pharmaceuticals, Inc., Fatty acid-anticancer conjugates and uses thereof
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WO2002076402A2 (en) * 2001-03-23 2002-10-03 Protarga, Inc. Fatty amine drug conjugates
JP4634694B2 (ja) * 2001-03-23 2011-02-16 ルイトポルド・ファーマシューティカルズ・インコーポレーテッド 脂肪アルコール薬物複合体
EP1487460A2 (en) 2002-02-28 2004-12-22 A & D Bioscience, Inc. Glycuronamides, glycosides and orthoester glycosides of fluoxetine, analogs and uses thereof
AU2003220222A1 (en) 2002-03-13 2003-09-29 Signum Biosciences, Inc. Modulation of protein methylation and phosphoprotein phosphate
WO2003079980A2 (en) * 2002-03-19 2003-10-02 A & D Bioscience, Inc. Caboxylic acid glycuronides, glycosamides and glycosides of quinolones, penicillins, analogs, and uses thereof
US20050255038A1 (en) * 2002-04-12 2005-11-17 A And D Bioscience, Inc. Conjugates comprising cancer cell specific ligands, a sugar and diagnostic agents and uses thereof
WO2003094842A2 (en) * 2002-05-07 2003-11-20 A & D Bioscience, Inc. Conjugates comprising central nervous system active drug
US20050215487A1 (en) * 2002-06-27 2005-09-29 Holick Michael F Conjugates comprising an nsaid and a sugar and uses thereof
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WO2005089515A2 (en) * 2004-03-18 2005-09-29 The Brigham And Women's Hospital, Inc. Methods for the treatment of synucleinopathies
US20050272068A1 (en) * 2004-03-18 2005-12-08 The Brigham And Women's Hospital, Inc. UCH-L1 expression and cancer therapy
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US7989499B2 (en) * 2005-02-09 2011-08-02 Mitotek, Llc Compositions and methods for inhibiting an isoform of human manganese superoxide dismutase
US20060194821A1 (en) * 2005-02-18 2006-08-31 The Brigham And Women's Hospital, Inc. Compounds inhibiting the aggregation of superoxide dismutase-1
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US8232402B2 (en) * 2008-03-12 2012-07-31 Link Medicine Corporation Quinolinone farnesyl transferase inhibitors for the treatment of synucleinopathies and other indications
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BRPI0920927A2 (pt) * 2008-11-13 2019-09-24 Link Medicine Corp derivados de azaquinolinona e usos dos mesmos
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JP2013513588A (ja) 2009-12-11 2013-04-22 ジーンコード エーエス Ｇｄｎｆファミリーリガンド（ｇｆｌ）のミメティックまたはｒｅｔシグナル経路活性化因子を用いた、神経系細胞の生存を容易にするための方法
FR2964866B1 (fr) * 2010-09-22 2013-03-29 Oreal Utilisation comme antipelliculaire de derives ortho-diphenol, nouveaux composes et composition cosmetique les comprenant
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IT7927748A0 (it) * 1979-11-30 1979-11-30 Simes Derivati dell'acido 6,6'-diapopsi psicarotenedioico e relativi procedimenti di preparazione.
JPS58177953A (ja) * 1982-04-13 1983-10-18 Eisai Co Ltd ポリプレニルカルボン酸アミドおよびその製造方法
US4550109A (en) * 1984-05-31 1985-10-29 The Board Of Regents, The University Of Texas System Lipoidal biopterin compounds

Also Published As

Publication number Publication date
JPH03503893A (ja) 1991-08-29
DE68928920T2 (de) 1999-07-22
ATE176152T1 (de) 1999-02-15
AU3354689A (en) 1989-09-22
US4939174A (en) 1990-07-03
EP0401301B1 (en) 1999-01-27
AU635203B2 (en) 1993-03-18
DK526189A (da) 1989-12-12
WO1989007938A1 (en) 1989-09-08
EP0401301A4 (en) 1991-09-04
KR900700092A (ko) 1990-08-11
EP0401301A1 (en) 1990-12-12
DK526189D0 (da) 1989-10-24
KR100228456B1 (ko) 1999-11-01
JP2959784B2 (ja) 1999-10-06
DE68928920D1 (de) 1999-03-11

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Legal Events

Date Code Title Description
FD Application lapsed
FD Application lapsed

Owner name: SHASHOUA, VICTOR, E.