FI903819A0 - 1,3-dihydro-1-(pyridinylamino)-2h-indol- 2-oner, foerfarande foer framstaellning av dem och anvaendning av dem som laekemedel. - Google Patents

1,3-dihydro-1-(pyridinylamino)-2h-indol- 2-oner, foerfarande foer framstaellning av dem och anvaendning av dem som laekemedel.

Info

Publication number
FI903819A0
FI903819A0 FI903819A FI903819A FI903819A0 FI 903819 A0 FI903819 A0 FI 903819A0 FI 903819 A FI903819 A FI 903819A FI 903819 A FI903819 A FI 903819A FI 903819 A0 FI903819 A0 FI 903819A0
Authority
FI
Finland
Prior art keywords
dem
pyridinylamino
indol
dihydro
oner
Prior art date
Application number
FI903819A
Other languages
English (en)
Finnish (fi)
Inventor
Richard Charles Effland
David Gordon Wettlaufer
Original Assignee
Hoechst Roussel Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Roussel Pharma filed Critical Hoechst Roussel Pharma
Publication of FI903819A0 publication Critical patent/FI903819A0/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/96—Spiro-condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
FI903819A 1989-08-02 1990-07-31 1,3-dihydro-1-(pyridinylamino)-2h-indol- 2-oner, foerfarande foer framstaellning av dem och anvaendning av dem som laekemedel. FI903819A0 (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/388,437 US5006537A (en) 1989-08-02 1989-08-02 1,3-dihydro-1-(pyridinylamino)-2H-indol-2-ones
US07/535,640 US5053511A (en) 1989-08-02 1990-06-11 1,3-dihydro-1-(pyridinylamino)-2h-indol-2-ones

Publications (1)

Publication Number Publication Date
FI903819A0 true FI903819A0 (fi) 1990-07-31

Family

ID=27012314

Family Applications (1)

Application Number Title Priority Date Filing Date
FI903819A FI903819A0 (fi) 1989-08-02 1990-07-31 1,3-dihydro-1-(pyridinylamino)-2h-indol- 2-oner, foerfarande foer framstaellning av dem och anvaendning av dem som laekemedel.

Country Status (18)

Country Link
US (2) US5006537A (de)
EP (1) EP0415102B1 (de)
JP (1) JPH0674265B2 (de)
KR (2) KR0169108B1 (de)
AT (1) ATE118001T1 (de)
AU (2) AU628202B2 (de)
CA (1) CA2022486C (de)
DE (1) DE69016530T2 (de)
DK (1) DK0415102T3 (de)
ES (1) ES2068293T3 (de)
FI (1) FI903819A0 (de)
GR (1) GR3015227T3 (de)
IE (1) IE67045B1 (de)
IL (1) IL95252A0 (de)
NO (1) NO903389L (de)
NZ (1) NZ234725A (de)
PT (1) PT94879B (de)
ZA (1) ZA906050B (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4868190A (en) * 1988-12-27 1989-09-19 Hoechst-Roussel Pharmaceuticals, Inc. N-pyridinyl-9H-carbazol-9-amines
US5006537A (en) * 1989-08-02 1991-04-09 Hoechst-Roussel Pharmaceuticals, Inc. 1,3-dihydro-1-(pyridinylamino)-2H-indol-2-ones
US5296488A (en) * 1989-08-02 1994-03-22 Hoechst-Roussel Pharmaceuticals Inc. Method of using 2,3-dihydro-1-(pyridinylamino)-indoles as anticonvulsants and for the enhancement of memory
US4914102A (en) * 1989-09-28 1990-04-03 Hoechst Roussel Pharmaceuticals, Inc. N-aminocarbamates related to physostigmine, pharmacentical compositions and use
US5076835A (en) * 1990-05-31 1991-12-31 America Cyanamid Company Aryloxyspiroalkylindolinone herbicides
US5102891A (en) * 1990-07-23 1992-04-07 Hoechst-Roussel Pharmaceuticals Inc. 1-(substituted pyridinylamino)-1H-indol-5-yl substituted carbamates
US5264442A (en) * 1990-08-13 1993-11-23 Hoechst-Roussel Pharmaceuticals Incorporated Carbamoyl-1-(pyridinylalkyl)-1H-indoles, indolines and related analogs
US5214038A (en) * 1991-04-15 1993-05-25 Hoechst-Roussel Pharmaceuticals Inc. 1-(pyrido[3,4-b]-1,4-oxazinyl-4-yl)-1H-indoles and intermediates for the preparation thereof
US5185350A (en) * 1991-09-23 1993-02-09 Hoechst-Roussel Pharmaceuticals Incorporated Substituted pyridinylamino-1h-indoles,1h-indazoles,2h-indazoles, benzo (b)thiophenes and 1,2-benzisothiazoles
US5246947A (en) * 1991-09-23 1993-09-21 Hoechst-Roussel Pharmaceuticals Incorporated Substituted pyridinylamino-1,2-benzisothiazoles and their use for treating depression
EP0623127B1 (de) * 1992-01-16 1997-04-02 The Du Pont Merck Pharmaceutical Company Verbindungen,die neurotransmitter freisetzen,um die lernfähigkeit zu erhöhen
RU2051151C1 (ru) * 1992-01-16 1995-12-27 Дзе Дюпон Мерк Фармасьютикал Компани Азотсодержащие гетероциклические производные флуорена
US5278162A (en) * 1992-09-18 1994-01-11 The Du Pont Merck Pharmaceutical Company 3,3'-disubstituted-1,3-dihydro-2H-pyrrolo[2,3-b]heterocyclic-2-one useful in the treatment of cognitive disorders of man
US5296478A (en) * 1992-10-07 1994-03-22 The Dupont Merck Pharmaceutical Co. 1-substituted oxindoles as cognition enhancers
FR2708606B1 (fr) * 1993-07-30 1995-10-27 Sanofi Sa Dérivés du N-phénylalkylindol-2-one, leur préparation, les compositions pharmaceutiques en contenant.
JP3004728B2 (ja) * 1994-04-29 2000-01-31 ファイザー インク． 神経伝達物質放出増強薬としての新規な非環式および環式アミド類
HUP9802413A3 (en) * 1995-07-27 2002-02-28 Aventis Pharmaceuticals Inc Br Use of n-(pyrrol-1-yl)pyridinamines as anticonvulsant agents and for the preparation of a pharmaceutical composition for the treatment of convulsions
US6100276A (en) * 1996-04-12 2000-08-08 Aventis Pharmaceuticals Inc. Isatin derivatives as acetylcholinesterase inhibitors and analgesics
IL126308A0 (en) * 1996-04-12 1999-05-09 Hoechst Marion Roussel Inc Isatin derivatives as acetylcholinesterase inhibitors and analgesics
DK0950056T3 (da) * 1996-12-27 2003-01-27 Aventis Pharma Inc N-(pyridinylamino)isoindoliner og beslægtede forbindelser
KR100507145B1 (ko) * 2002-06-20 2005-08-09 현대자동차주식회사 차량의 전원제어장치

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4260767A (en) * 1979-12-26 1981-04-07 American Cyanamid Company 2-Pyridylhydrazides
US4569942A (en) * 1984-05-04 1986-02-11 Pfizer Inc. N,3-Disubstituted 2-oxindole-1-carboxamides as analgesic and antiinflammatory agents
EP0287982B1 (de) * 1987-04-24 1994-12-07 Hoechst-Roussel Pharmaceuticals Incorporated N-(Pyridinyl)-1H-indol-1-amine, Verfahren zu deren Herstellung und ihre Verwendung als Arzneimittel
US4983615A (en) * 1989-06-28 1991-01-08 Hoechst-Roussel Pharmaceuticals Inc. Heteroarylamino- and heteroaryloxypyridinamine compounds which are useful in treating skin disorders
US5006537A (en) * 1989-08-02 1991-04-09 Hoechst-Roussel Pharmaceuticals, Inc. 1,3-dihydro-1-(pyridinylamino)-2H-indol-2-ones

Also Published As

Publication number Publication date
EP0415102A1 (de) 1991-03-06
IL95252A0 (en) 1991-06-10
NO903389D0 (no) 1990-08-01
KR910004599A (ko) 1991-03-29
US5006537A (en) 1991-04-09
NO903389L (no) 1991-02-04
AU641595B2 (en) 1993-09-23
ZA906050B (en) 1991-05-29
GR3015227T3 (en) 1995-05-31
JPH03118377A (ja) 1991-05-20
IE67045B1 (en) 1996-02-21
ATE118001T1 (de) 1995-02-15
DK0415102T3 (da) 1995-06-19
DE69016530T2 (de) 1995-07-06
AU6000490A (en) 1991-02-07
KR0175639B1 (en) 1999-10-01
CA2022486A1 (en) 1991-02-03
AU1963092A (en) 1992-10-01
JPH0674265B2 (ja) 1994-09-21
DE69016530D1 (de) 1995-03-16
PT94879B (pt) 1997-08-29
PT94879A (pt) 1991-04-18
CA2022486C (en) 2001-04-03
ES2068293T3 (es) 1995-04-16
IE902787A1 (en) 1991-02-27
US5053511A (en) 1991-10-01
AU628202B2 (en) 1992-09-10
KR0169108B1 (ko) 1999-01-15
NZ234725A (en) 1992-12-23
EP0415102B1 (de) 1995-02-01

Similar Documents

Publication Publication Date Title
FI903819A0 (fi) 1,3-dihydro-1-(pyridinylamino)-2h-indol- 2-oner, foerfarande foer framstaellning av dem och anvaendning av dem som laekemedel.
IL95568A0 (en) N-substituted-4-pyrimidinamines and pyrimidinidiamines,process for their preparation and pharmaceutical compositions containing them
FI903818A0 (fi) 1-(pyridinylamino)-2-pyrrolidoner, foerfarande foer deras framstaellning och deras anvaendning som laekemedel.
AU628201B2 (en) 2,3-dihydro-1-(pyridinylamino)-indoles, a process for their preparation and their use as medicaments
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Legal Events

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Owner name: HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED