FI89909B - Foerfarande foer framstaellning av nya terapeutiskt anvaendbara sulfonamidderivat och mellanprodukter - Google Patents
Foerfarande foer framstaellning av nya terapeutiskt anvaendbara sulfonamidderivat och mellanprodukter Download PDFInfo
- Publication number
- FI89909B FI89909B FI884070A FI884070A FI89909B FI 89909 B FI89909 B FI 89909B FI 884070 A FI884070 A FI 884070A FI 884070 A FI884070 A FI 884070A FI 89909 B FI89909 B FI 89909B
- Authority
- FI
- Finland
- Prior art keywords
- formula
- give
- vacuo
- evaporated
- preparation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
- C07D211/28—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms to which a second hetero atom is attached
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Heart & Thoracic Surgery (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hydrogenated Pyridines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Medicines Containing Plant Substances (AREA)
- Peptides Or Proteins (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Claims (3)
1. Förfarande för framställning av nya terapeu-tiskt användbara sulfonamidderivat med formeln I och far- 5 maceutiskt godtagbara salter därav, Π ^^A^NCH2CH2Y>*JS0?R (I)
10 XJ - W H - RS0»N 7 i "H i vilken formel symbolerna R, som är lika, betecknar C1.4-15 alkyl, X är CH2 eller O och Y är O eller en direkt bind-ning, kännetecknat därav, att en förening med formeln H_,N C 25 där X och Y betecknar samma som ovan, omsätts med anting-en (a) en C1.4-alkansulfonylklorid eller -bromid eller (b) en C1.4-alkansulfonsyraanhydrid, varefter, om sä önskas, en erhällen förening med formeln I omvandlas tili ett 30 farmaceutiskt godtagbart sait.
2. Förfarande enligt patentkravet 1, känne-t e c k n a t därav, att en förening med formeln III omsätts med en C1.4-alkansulfonylklorid i närvaro av en sy-raacceptor. 35 1: 29 0 9 9 0 9
3. Förening raed formeln f-\ 5 f~ Z (II) z"^ där X är CH2 eller O, Y är O eller en direkt bindning och 10 symbolerna Z, som är lika, betecknar nitro eller amino.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB8720910 | 1987-09-05 | ||
| GB878720910A GB8720910D0 (en) | 1987-09-05 | 1987-09-05 | Antiarrhythmic agents |
| CA000567186A CA1291164C (en) | 1987-09-05 | 1988-05-19 | Indane sulfonamide antiarrythmic agents |
| CA567186 | 1988-05-19 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| FI884070A0 FI884070A0 (fi) | 1988-09-02 |
| FI884070A FI884070A (fi) | 1989-03-06 |
| FI89909B true FI89909B (fi) | 1993-08-31 |
| FI89909C FI89909C (sv) | 1993-12-10 |
Family
ID=25671902
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI884070A FI89909C (sv) | 1987-09-05 | 1988-09-02 | Förfarande för framställning av nya terapeutiskt användbara sulfonamid derivat och mellanprodukter |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP0307121B1 (sv) |
| JP (1) | JP2653850B2 (sv) |
| AT (1) | ATE73773T1 (sv) |
| CA (2) | CA1291164C (sv) |
| DD (1) | DD281596A5 (sv) |
| DE (1) | DE3869289D1 (sv) |
| DK (1) | DK488588A (sv) |
| ES (1) | ES2032972T3 (sv) |
| FI (1) | FI89909C (sv) |
| GB (1) | GB8720910D0 (sv) |
| GR (1) | GR3004627T3 (sv) |
| IE (1) | IE61505B1 (sv) |
| PT (1) | PT88406B (sv) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4906634A (en) * | 1988-03-08 | 1990-03-06 | Schering A.G. | Novel N-[4-(aminosubstituted)phenyl]methanesulfonamides and their use as cardiovascular agents |
| US5215989A (en) * | 1989-12-08 | 1993-06-01 | Merck & Co., Inc. | Nitrogen-containing heterocyclic compounds as class III antiarrhythmic agents |
| US5032604A (en) * | 1989-12-08 | 1991-07-16 | Merck & Co., Inc. | Class III antiarrhythmic agents |
| US5032598A (en) * | 1989-12-08 | 1991-07-16 | Merck & Co., Inc. | Nitrogens containing heterocyclic compounds as class III antiarrhythmic agents |
| US5112824A (en) * | 1989-12-08 | 1992-05-12 | Merck & Co., Inc. | Benzofuran compounds as class III antiarrhythmic agents |
| AU653837B2 (en) * | 1991-04-17 | 1994-10-13 | Pharmacia & Upjohn Company | Substituted phenylazacycloalkanes as CNS agents |
| US5382587A (en) * | 1993-06-30 | 1995-01-17 | Merck & Co., Inc. | Spirocycles |
| DE4335718A1 (de) * | 1993-10-20 | 1995-04-27 | Merck Patent Gmbh | Cyclische Aminderivate |
| US5403846A (en) * | 1993-11-22 | 1995-04-04 | Merck & Co., Inc. | Spirocycles |
| US5439914A (en) * | 1994-02-18 | 1995-08-08 | Merck & Co., Inc. | Spirocycles |
| US7812035B2 (en) | 2001-12-11 | 2010-10-12 | Sepracor Inc. | 4-substituted piperidines, and methods of use thereof |
| GB2543296A (en) * | 2015-10-13 | 2017-04-19 | Indivior Uk Ltd | Dopamine D3 receptor antagonists having a morpholine moiety |
| CN118251382A (zh) * | 2021-11-08 | 2024-06-25 | 豪夫迈·罗氏有限公司 | 芳硝基化合物的催化氢化 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0068669A1 (en) * | 1981-06-20 | 1983-01-05 | Beecham Group Plc | Secondary phenylethanol amines, processes for their preparation and their pharmaceutical application |
| DE3476386D1 (de) * | 1983-11-02 | 1989-03-02 | Beecham Group Plc | Morpholine derivatives |
| EP0164865B1 (en) * | 1984-05-04 | 1988-12-21 | The Upjohn Company | N-(aminoalkylphenyl)sulfonamides their preparation and therapeutic use |
-
1987
- 1987-09-05 GB GB878720910A patent/GB8720910D0/en active Pending
-
1988
- 1988-05-19 CA CA000567186A patent/CA1291164C/en not_active Expired - Lifetime
- 1988-06-02 DD DD88316361A patent/DD281596A5/de not_active IP Right Cessation
- 1988-08-26 AT AT88307956T patent/ATE73773T1/de not_active IP Right Cessation
- 1988-08-26 DE DE8888307956T patent/DE3869289D1/de not_active Expired - Lifetime
- 1988-08-26 ES ES198888307956T patent/ES2032972T3/es not_active Expired - Lifetime
- 1988-08-26 EP EP88307956A patent/EP0307121B1/en not_active Expired - Lifetime
- 1988-09-02 DK DK488588A patent/DK488588A/da not_active Application Discontinuation
- 1988-09-02 IE IE266588A patent/IE61505B1/en not_active IP Right Cessation
- 1988-09-02 CA CA000576405A patent/CA1320726C/en not_active Expired - Fee Related
- 1988-09-02 PT PT88406A patent/PT88406B/pt not_active IP Right Cessation
- 1988-09-02 FI FI884070A patent/FI89909C/sv not_active IP Right Cessation
- 1988-09-05 JP JP63222190A patent/JP2653850B2/ja not_active Expired - Lifetime
-
1992
- 1992-05-18 GR GR920400955T patent/GR3004627T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES2032972T3 (es) | 1993-03-01 |
| JP2653850B2 (ja) | 1997-09-17 |
| FI89909C (sv) | 1993-12-10 |
| DD281596A5 (de) | 1990-08-15 |
| IE61505B1 (en) | 1994-11-02 |
| DE3869289D1 (de) | 1992-04-23 |
| FI884070A (fi) | 1989-03-06 |
| CA1291164C (en) | 1991-10-22 |
| GR3004627T3 (sv) | 1993-04-28 |
| GB8720910D0 (en) | 1987-10-14 |
| EP0307121B1 (en) | 1992-03-18 |
| PT88406B (pt) | 1992-10-30 |
| DK488588D0 (da) | 1988-09-02 |
| JPS6471856A (en) | 1989-03-16 |
| PT88406A (pt) | 1989-07-31 |
| CA1320726C (en) | 1993-07-27 |
| IE882665L (en) | 1989-03-05 |
| EP0307121A1 (en) | 1989-03-15 |
| ATE73773T1 (de) | 1992-04-15 |
| DK488588A (da) | 1989-03-06 |
| FI884070A0 (fi) | 1988-09-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| BB | Publication of examined application | ||
| MM | Patent lapsed |
Owner name: PFIZER LIMITED |