FI89173C - Analogimetod foer tillverkning av terapeutiskt anvaendbara polysvavelsyraestrar av bis-aldonamider och deras derivat - Google Patents
Analogimetod foer tillverkning av terapeutiskt anvaendbara polysvavelsyraestrar av bis-aldonamider och deras derivat Download PDFInfo
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- FI89173C FI89173C FI884697A FI884697A FI89173C FI 89173 C FI89173 C FI 89173C FI 884697 A FI884697 A FI 884697A FI 884697 A FI884697 A FI 884697A FI 89173 C FI89173 C FI 89173C
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- radical
- analogy method
- radicals
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- NAQMVNRVTILPCV-UHFFFAOYSA-N hexane-1,6-diamine Chemical compound NCCCCCCN NAQMVNRVTILPCV-UHFFFAOYSA-N 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 235000001050 hortel pimenta Nutrition 0.000 description 1
- 239000003906 humectant Substances 0.000 description 1
- IKDUDTNKRLTJSI-UHFFFAOYSA-N hydrazine monohydrate Substances O.NN IKDUDTNKRLTJSI-UHFFFAOYSA-N 0.000 description 1
- 150000004678 hydrides Chemical class 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 description 1
- 150000004679 hydroxides Chemical class 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 238000011065 in-situ storage Methods 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 238000004255 ion exchange chromatography Methods 0.000 description 1
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 1
- 229910052744 lithium Inorganic materials 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 239000003055 low molecular weight heparin Substances 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 239000001525 mentha piperita l. herb oil Substances 0.000 description 1
- 239000003094 microcapsule Substances 0.000 description 1
- 235000019813 microcrystalline cellulose Nutrition 0.000 description 1
- 239000008108 microcrystalline cellulose Substances 0.000 description 1
- 229940016286 microcrystalline cellulose Drugs 0.000 description 1
- CQDGTJPVBWZJAZ-UHFFFAOYSA-N monoethyl carbonate Chemical compound CCOC(O)=O CQDGTJPVBWZJAZ-UHFFFAOYSA-N 0.000 description 1
- IGSFQSTYARRVAJ-UHFFFAOYSA-N n'-benzylmethanediamine Chemical compound NCNCC1=CC=CC=C1 IGSFQSTYARRVAJ-UHFFFAOYSA-N 0.000 description 1
- DIAIBWNEUYXDNL-UHFFFAOYSA-N n,n-dihexylhexan-1-amine Chemical compound CCCCCCN(CCCCCC)CCCCCC DIAIBWNEUYXDNL-UHFFFAOYSA-N 0.000 description 1
- OOHAUGDGCWURIT-UHFFFAOYSA-N n,n-dipentylpentan-1-amine Chemical compound CCCCCN(CCCCC)CCCCC OOHAUGDGCWURIT-UHFFFAOYSA-N 0.000 description 1
- YBXBWBBVLXZQBJ-UHFFFAOYSA-N n-[2-(5-hydroxy-2-methyl-1h-indol-3-yl)ethyl]-2-methoxyacetamide Chemical compound C1=C(O)C=C2C(CCNC(=O)COC)=C(C)NC2=C1 YBXBWBBVLXZQBJ-UHFFFAOYSA-N 0.000 description 1
- 125000001280 n-hexyl group Chemical group C(CCCCC)* 0.000 description 1
- 125000000740 n-pentyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 125000004957 naphthylene group Chemical group 0.000 description 1
- 125000001971 neopentyl group Chemical group [H]C([*])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 239000004006 olive oil Substances 0.000 description 1
- 235000008390 olive oil Nutrition 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 125000000913 palmityl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 239000012188 paraffin wax Substances 0.000 description 1
- 238000007911 parenteral administration Methods 0.000 description 1
- JIIGCFAEDFDFJH-UHFFFAOYSA-N pentanide Chemical compound CCCC[CH2-] JIIGCFAEDFDFJH-UHFFFAOYSA-N 0.000 description 1
- 210000001539 phagocyte Anatomy 0.000 description 1
- 125000005562 phenanthrylene group Chemical group 0.000 description 1
- WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 description 1
- 125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- ZNZJJSYHZBXQSM-UHFFFAOYSA-N propane-2,2-diamine Chemical compound CC(C)(N)N ZNZJJSYHZBXQSM-UHFFFAOYSA-N 0.000 description 1
- 239000003380 propellant Substances 0.000 description 1
- WGYKZJWCGVVSQN-UHFFFAOYSA-N propylamine Chemical group CCCN WGYKZJWCGVVSQN-UHFFFAOYSA-N 0.000 description 1
- 125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 description 1
- DUPBILVWMPJNKH-UHFFFAOYSA-N pyridine;sulfur dioxide Chemical compound O=S=O.C1=CC=NC=C1 DUPBILVWMPJNKH-UHFFFAOYSA-N 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 230000035484 reaction time Effects 0.000 description 1
- 239000003642 reactive oxygen metabolite Substances 0.000 description 1
- 239000012266 salt solution Substances 0.000 description 1
- 238000013207 serial dilution Methods 0.000 description 1
- UQDJGEHQDNVPGU-UHFFFAOYSA-N serine phosphoethanolamine Chemical compound [NH3+]CCOP([O-])(=O)OCC([NH3+])C([O-])=O UQDJGEHQDNVPGU-UHFFFAOYSA-N 0.000 description 1
- 239000008159 sesame oil Substances 0.000 description 1
- 235000011803 sesame oil Nutrition 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
- 229910052814 silicon oxide Inorganic materials 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 208000010110 spontaneous platelet aggregation Diseases 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 238000005670 sulfation reaction Methods 0.000 description 1
- 229910021653 sulphate ion Inorganic materials 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- FAGUFWYHJQFNRV-UHFFFAOYSA-N tetraethylenepentamine Chemical compound NCCNCCNCCNCCN FAGUFWYHJQFNRV-UHFFFAOYSA-N 0.000 description 1
- 125000003698 tetramethyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 229960004072 thrombin Drugs 0.000 description 1
- 210000001541 thymus gland Anatomy 0.000 description 1
- 239000000196 tragacanth Substances 0.000 description 1
- 235000010487 tragacanth Nutrition 0.000 description 1
- 229940116362 tragacanth Drugs 0.000 description 1
- YFTHZRPMJXBUME-UHFFFAOYSA-N tripropylamine Chemical compound CCCN(CCC)CCC YFTHZRPMJXBUME-UHFFFAOYSA-N 0.000 description 1
- 235000019871 vegetable fat Nutrition 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 239000011787 zinc oxide Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Crystallography & Structural Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Genetics & Genomics (AREA)
- Public Health (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Pain & Pain Management (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Saccharide Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Furan Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19873734815 DE3734815A1 (de) | 1987-10-14 | 1987-10-14 | Polyschwefelsaeureester von bis-aldonsaeureamiden und deren derivaten, verfahren zu ihrer herstellung und arzneimittel |
| DE3734815 | 1987-10-14 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| FI884697A0 FI884697A0 (fi) | 1988-10-12 |
| FI884697L FI884697L (fi) | 1989-04-15 |
| FI89173B FI89173B (fi) | 1993-05-14 |
| FI89173C true FI89173C (fi) | 1993-08-25 |
Family
ID=6338337
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI884697A FI89173C (fi) | 1987-10-14 | 1988-10-12 | Analogimetod foer tillverkning av terapeutiskt anvaendbara polysvavelsyraestrar av bis-aldonamider och deras derivat |
Country Status (13)
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3734853A1 (de) * | 1987-10-14 | 1989-04-27 | Luitpold Werk Chem Pharm | Bis-aldonsaeureamide und verfahren zu ihrer herstellung |
| IT1237518B (it) * | 1989-11-24 | 1993-06-08 | Renato Conti | Eparine supersolfatate |
| DE69100275T2 (de) * | 1990-04-23 | 1993-12-02 | Akzo Nv | Eine Trisaccharideinheit enthaltende Kohlenhydratderivate. |
| US5386018A (en) * | 1991-12-31 | 1995-01-31 | Lever Brothers Company, Division Of Conopco, Inc. | Process of preparing N-substituted aldonamides |
| US5589588A (en) * | 1993-03-30 | 1996-12-31 | Reliable Biopharmaceutical Corporation | Sulfated acid amides having anticoagulant properties |
| US5714598A (en) * | 1993-03-30 | 1998-02-03 | Reliable Biopharmaceutical Corporation | Sulfated acid amides having anticoagulant properties |
| ES2147216T3 (es) * | 1993-09-01 | 2000-09-01 | Akzo Nobel Nv | Bisconjugados que comprenden dos sacaridos y un grupo de union. |
| TW308598B (enrdf_load_html_response) * | 1994-01-14 | 1997-06-21 | Hoffmann La Roche | |
| ZA9586B (en) * | 1994-01-14 | 1995-07-20 | Hoffmann La Roche | New sulfuric acid esters of sugar alochols |
| US5565432A (en) * | 1994-11-07 | 1996-10-15 | American Home Products Corporation | Smooth muscle cell proliferation inhibitors |
| US5773420A (en) * | 1994-11-07 | 1998-06-30 | American Home Products Corporation | Acylated benzylglycosides as inhibitors of smooth muscle cell proliferation |
| US5498775A (en) * | 1994-11-07 | 1996-03-12 | American Home Products Corporation | Polyanionic benzylglycosides as inhibitors of smooth muscle cell proliferation |
| US5686603A (en) * | 1995-05-04 | 1997-11-11 | Lever Brothers Company, Division Of Conopco, Inc. | Sulfated polyhydroxy compounds as anionic surfactants and a process for their manufacture |
| TR199600329A2 (tr) * | 1995-05-05 | 1997-03-21 | Hoffmann La Roche | Seker alkollerin yeni sülfürik asit esterleri. |
| CA2174582A1 (en) * | 1995-05-05 | 1996-11-06 | Alexander Chucholowski | Sulphuric acid esters of amino-sugars |
| US5849709A (en) * | 1995-05-10 | 1998-12-15 | Glycomed Incorporated | Saccharopeptides and derivatives thereof |
| US7132402B2 (en) | 1998-11-24 | 2006-11-07 | Wyeth | Acylated benzylmaltosides as inhibitors of smooth muscle cell proliferation |
| US6258784B1 (en) | 1998-11-24 | 2001-07-10 | American Home Products Corp. | Acetal benzylmaltosides as inhibitors of smooth muscle cell proliferation |
| US6451767B1 (en) | 1998-11-24 | 2002-09-17 | Wyeth | Benzylmaltotriosides as inhibitors of smooth muscle cell proliferation |
| US7081448B2 (en) * | 1998-11-24 | 2006-07-25 | Wyeth | Benzyllactobionamides as inhibitors of smooth muscle cell proliferation |
| US6362170B1 (en) | 1998-11-24 | 2002-03-26 | American Home Products Corporation | Benzylglycosylamides as inhibitors of smooth muscle cell proliferation |
| AU5706699A (en) * | 1998-11-24 | 2000-06-13 | American Home Products Corporation | Benzyllactobionamides as inhibitors of smooth muscle cell proliferation |
| US6340670B1 (en) | 1998-11-24 | 2002-01-22 | American Home Products Corporation | Acetal benzylmaltosides as inhibitors of smooth muscle cell proliferation |
| US6664243B1 (en) * | 1998-11-24 | 2003-12-16 | Wyeth | Benzyllactobionamides as inhibitors of smooth muscle cell proliferation |
| US6187755B1 (en) | 1998-11-24 | 2001-02-13 | American Home Products Corporation | Benzylmaltosides as inhibitors of smooth muscle cell proliferation |
| US6339064B1 (en) | 1998-11-24 | 2002-01-15 | American Home Products Corporation | Benzylglycosylamides as inhibitors of smooth muscle cell proliferation |
| US6291434B1 (en) | 1998-11-24 | 2001-09-18 | American Home Products Corp. | Benzylmaltotriosides as inhibitors of smooth muscle cell proliferation |
| US7902158B2 (en) * | 2004-08-05 | 2011-03-08 | Ivax Drug Research Ltd. | Polysulfated glycosides and salts thereof |
| GB0622688D0 (en) * | 2006-11-14 | 2006-12-27 | Diosamine Dev Corp | Novel compounds |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2752334A (en) * | 1952-03-01 | 1956-06-26 | Nat Dairy Res Lab Inc | Nu-substituted lactobionamides |
| DE1124938B (de) * | 1959-02-05 | 1962-03-08 | Akad Wissenschaften Ddr | Verfahren zur Herstellung von nichtionogenen Polyoxycarbonsaeureamiden |
| US4098995A (en) * | 1976-07-12 | 1978-07-04 | American Cyanamid Company | Polygalactosido-sucrose poly(h-)sulfate salts |
| US4229446A (en) * | 1979-03-13 | 1980-10-21 | Kyowa Hakko Kogyo Co., Ltd. | Aluminum acetylsalicylate glutaminate |
| US4357326A (en) * | 1981-08-28 | 1982-11-02 | American Cyanamid Company | Multi-glucopyranosyl-fructofuranosyl-galactopyranosyl-glucopyranoside sulfate salts and methods of use |
| DE3204373A1 (de) * | 1982-02-09 | 1983-08-18 | Luitpold-Werk, Chemisch-pharmazeutische Fabrik GmbH & Co, 8000 München | Thiazaspiranderivate, verfahren zu ihrer herstellung und arzneimittel |
| JPS6261965A (ja) * | 1985-09-11 | 1987-03-18 | Kao Corp | ビス（２−グルコンアミドアルキル）ジスルフイド |
| DE3734853A1 (de) * | 1987-10-14 | 1989-04-27 | Luitpold Werk Chem Pharm | Bis-aldonsaeureamide und verfahren zu ihrer herstellung |
-
1987
- 1987-10-14 DE DE19873734815 patent/DE3734815A1/de active Granted
-
1988
- 1988-10-05 IL IL87936A patent/IL87936A/xx not_active IP Right Cessation
- 1988-10-12 US US07/256,624 patent/US5008247A/en not_active Expired - Fee Related
- 1988-10-12 FI FI884697A patent/FI89173C/fi not_active IP Right Cessation
- 1988-10-12 AU AU23686/88A patent/AU596755B2/en not_active Ceased
- 1988-10-13 ZA ZA887641A patent/ZA887641B/xx unknown
- 1988-10-13 IE IE310388A patent/IE63947B1/en not_active IP Right Cessation
- 1988-10-14 ES ES88117115T patent/ES2061592T3/es not_active Expired - Lifetime
- 1988-10-14 AT AT88117115T patent/ATE101159T1/de not_active IP Right Cessation
- 1988-10-14 DK DK572788A patent/DK162393C/da not_active IP Right Cessation
- 1988-10-14 DE DE88117115T patent/DE3887618D1/de not_active Expired - Fee Related
- 1988-10-14 JP JP63257376A patent/JPH064667B2/ja not_active Expired - Lifetime
- 1988-10-14 EP EP88117115A patent/EP0312086B1/de not_active Expired - Lifetime
-
1991
- 1991-12-20 CS CS913957A patent/CS395791A3/cs unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL87936A (en) | 1993-01-31 |
| FI884697A0 (fi) | 1988-10-12 |
| US5008247A (en) | 1991-04-16 |
| DK162393B (da) | 1991-10-21 |
| DE3734815A1 (de) | 1989-04-27 |
| EP0312086B1 (de) | 1994-02-02 |
| FI884697L (fi) | 1989-04-15 |
| EP0312086A2 (de) | 1989-04-19 |
| IE883103L (en) | 1989-04-14 |
| IE63947B1 (en) | 1995-06-28 |
| ZA887641B (en) | 1989-07-26 |
| JPH064667B2 (ja) | 1994-01-19 |
| DE3887618D1 (de) | 1994-03-17 |
| DK162393C (da) | 1992-03-09 |
| ATE101159T1 (de) | 1994-02-15 |
| DK572788D0 (da) | 1988-10-14 |
| IL87936A0 (en) | 1989-03-31 |
| DK572788A (da) | 1989-04-15 |
| AU2368688A (en) | 1989-04-20 |
| JPH01143890A (ja) | 1989-06-06 |
| EP0312086A3 (de) | 1991-07-03 |
| CS395791A3 (en) | 1992-09-16 |
| AU596755B2 (en) | 1990-05-10 |
| ES2061592T3 (es) | 1994-12-16 |
| FI89173B (fi) | 1993-05-14 |
| DE3734815C2 (enrdf_load_html_response) | 1990-12-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM | Patent lapsed |
Owner name: LUITPOLD PHARMA GMBH |