FI88509C - 9-alfa,11-beta-nitro-substituerade och 11-beta-nitro-substituerade estraner - Google Patents

9-alfa,11-beta-nitro-substituerade och 11-beta-nitro-substituerade estraner

Info

Publication number
FI88509C
FI88509C FI870808A FI870808A FI88509C FI 88509 C FI88509 C FI 88509C FI 870808 A FI870808 A FI 870808A FI 870808 A FI870808 A FI 870808A FI 88509 C FI88509 C FI 88509C
Authority
FI
Finland
Prior art keywords
beta
nitro
substituents
alpha
estraner
Prior art date
Application number
FI870808A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI870808A0 (fi
FI870808A (fi
FI88509B (fi
Inventor
David Franklin Crowe
Masato Tanabe
Richard H Peters
Original Assignee
Stanford Res Inst Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Stanford Res Inst Int filed Critical Stanford Res Inst Int
Publication of FI870808A0 publication Critical patent/FI870808A0/fi
Publication of FI870808A publication Critical patent/FI870808A/fi
Publication of FI88509B publication Critical patent/FI88509B/fi
Application granted granted Critical
Publication of FI88509C publication Critical patent/FI88509C/fi

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0059—Estrane derivatives substituted in position 17 by a keto group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0062—Estrane derivatives substituted in position 17 alfa not substituted in position 17 beta
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0066—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0081—Substituted in position 17 alfa and 17 beta
    • C07J1/0088—Substituted in position 17 alfa and 17 beta the substituent in position 17 alfa being an unsaturated hydrocarbon group
    • C07J1/0096—Alkynyl derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0072—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the A ring of the steroid being aromatic

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Steroid Compounds (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Diaphragms For Electromechanical Transducers (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Silicon Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Liquid Crystal Substances (AREA)
  • Compounds Of Unknown Constitution (AREA)
FI870808A 1985-06-25 1987-02-25 9-alfa,11-beta-nitro-substituerade och 11-beta-nitro-substituerade estraner FI88509C (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US06/748,489 US4705783A (en) 1985-06-25 1985-06-25 9α, 11β-substituted and 11β-substituted estranes
US74848985 1985-06-25
PCT/US1986/001358 WO1987000175A1 (en) 1985-06-25 1986-06-24 9alpha, 11beta-SUBSTITUTED AND 11beta-SUBSTITUTED ESTRANES
US8601358 1986-06-24

Publications (4)

Publication Number Publication Date
FI870808A0 FI870808A0 (fi) 1987-02-25
FI870808A FI870808A (fi) 1987-02-25
FI88509B FI88509B (fi) 1993-02-15
FI88509C true FI88509C (fi) 1993-05-25

Family

ID=25009663

Family Applications (1)

Application Number Title Priority Date Filing Date
FI870808A FI88509C (fi) 1985-06-25 1987-02-25 9-alfa,11-beta-nitro-substituerade och 11-beta-nitro-substituerade estraner

Country Status (9)

Country Link
US (3) US4705783A (no)
EP (1) EP0227813B1 (no)
JP (1) JPH0816117B2 (no)
AT (1) ATE68001T1 (no)
DE (1) DE3681786D1 (no)
DK (1) DK98087A (no)
FI (1) FI88509C (no)
NO (1) NO870759D0 (no)
WO (1) WO1987000175A1 (no)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5352809A (en) * 1986-10-10 1994-10-04 Gist-Brocades N.V. 9-alpha-hydroxy steroids, process for their preparation, process for the preparation of the corresponding 9(11)-dehydro derivatives and pharmaceutical preparations containing such steroids
US5137882A (en) * 1990-06-11 1992-08-11 Holt Dennis A Steroidal 3-acetic acid derivatives as 5-alpha-reductase inhibitors
US5554603A (en) * 1993-09-17 1996-09-10 The United States Of America As Represented By The Department Of Health And Human Services Orally active derivatives of 1,3,5(10)-estratriene
US5922349A (en) * 1995-09-28 1999-07-13 Schering Aktiengesellschaft Hormone replacement therapy method and hormone dispenser
US6083528A (en) * 1995-09-28 2000-07-04 Schering Aktiengesellschaft Hormone replacement therapy method and hormone dispenser
US6551611B2 (en) 1995-09-28 2003-04-22 Schering Aktiengesellschaft Hormone replacement therapy method
US6054446A (en) * 1997-12-24 2000-04-25 Sri International Anti-estrogenic steroids, and associated pharmaceutical compositions and methods of use
US6548491B2 (en) 1997-12-24 2003-04-15 Sri International Anti-estrogenic steroids, and associated pharmaceutical compositions and methods of use
US6503896B1 (en) 1997-12-24 2003-01-07 Sri International Anti-estrogenic steroids, and associated pharmaceutical compositions and methods of use
DE19906159A1 (de) * 1999-02-09 2000-08-10 Schering Ag 16-Hydroxyestratriene als selektiv wirksame Estrogene
US20050282791A1 (en) * 1999-11-02 2005-12-22 Alexander Hillisch 18-nor steroids as selectively active estrogens
JP2003513102A (ja) * 1999-11-02 2003-04-08 シエーリング アクチエンゲゼルシャフト 選択的な作用を有するエストロゲンとしての１８−ノル−ステロイド
US6958327B1 (en) 1999-11-02 2005-10-25 Schering, Ag 18 Norsteroids as selectively active estrogens
WO2001098322A1 (en) * 2000-06-22 2001-12-27 Northeastern University Novel steroidal antiestrogens and antiandrogens and uses thereof
US8173628B2 (en) * 2000-06-22 2012-05-08 Northeastern University Steroidal antiestrogens and antiandrogens and uses thereof
AU2001296872A1 (en) * 2000-09-14 2002-03-26 Accelerated Pharmaceuticals, Inc. Method of making 7alpha-methyl-11beta-methoxy estradiol and related compounds with estrogenic activity
DE10233723A1 (de) * 2002-07-24 2004-02-12 Schering Ag Mikrobiologische Verfahren zur Herstellung von 7α-substituierten 11α-Hydroxysteroiden, daraus herstellbare 7α,17α-substituierte 11β-Halogensteroide, deren Herstellungsverfahren und Verwendung sowie pharmazeutische Präparate, die diese Verbindungen enthalten, sowie daraus herstellbare 7α-substituierte Estra-1,3,5(10)-triene
EP1603933A2 (en) * 2003-03-13 2005-12-14 Nitromed, Inc. Nitrosated and nitrosylated compounds, compositions and methods of use

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1074493A (en) * 1963-06-12 1967-07-05 Roussel Uclaf Novel estrane derivatives and processes for preparing them
BE649225A (no) * 1963-06-12
FR5519M (no) * 1966-06-07 1967-11-06
US3411567A (en) * 1966-06-13 1968-11-19 United Eng Foundry Co Mold supporting structure for casting machine
FR6854M (no) * 1967-12-15 1969-04-08
US3980681A (en) * 1969-11-21 1976-09-14 Peter Job Sykes Process for the preparation of 11-β-nitro-oxysteroids
US3755574A (en) * 1971-01-21 1973-08-28 Roussel Uclaf Estrogenic compositions comprising 11beta-alkoxy-gona-1,3,5(10)-trienes
US3906096A (en) * 1971-11-23 1975-09-16 Roussel Uclaf Novel 11{62 -alkoxy steroids
US3755301A (en) * 1972-06-23 1973-08-28 Searle & Co Manufacture of 11-alkyl steroids
NL7405626A (nl) * 1974-04-26 1975-10-28 Akzo Nv Nieuwe 11-gesubstitueerde steroiden van de oestraanreeks.
NL7613248A (nl) * 1976-11-26 1978-05-30 Akzo Nv Werkwijze voor het bereiden van nieuwe steroid- esters.
DE3248434A1 (de) * 1982-12-23 1984-06-28 Schering AG, 1000 Berlin und 4709 Bergkamen Verfahren zur herstellung von 3,11(alpha)-dihydroxy-1,3,5(10)-oestratrien-derivaten

Also Published As

Publication number Publication date
US4705783A (en) 1987-11-10
EP0227813B1 (en) 1991-10-02
DK98087D0 (da) 1987-02-25
ATE68001T1 (de) 1991-10-15
USRE34136E (en) 1992-12-01
FI870808A0 (fi) 1987-02-25
JPS63500101A (ja) 1988-01-14
FI870808A (fi) 1987-02-25
EP0227813A1 (en) 1987-07-08
FI88509B (fi) 1993-02-15
DE3681786D1 (de) 1991-11-07
DK98087A (da) 1987-02-25
JPH0816117B2 (ja) 1996-02-21
US4859370A (en) 1989-08-22
NO870759L (no) 1987-02-24
NO870759D0 (no) 1987-02-24
WO1987000175A1 (en) 1987-01-15

Similar Documents

Publication Publication Date Title
FI88509C (fi) 9-alfa,11-beta-nitro-substituerade och 11-beta-nitro-substituerade estraner
DE3664938D1 (en) Reflecting textile material, process for its manufacture and its use
NO890873L (no) Mikrobiologisk fremgangsmaate for innspleising av genetiskmateriale i plantezygoter.
ATE111452T1 (de) Tetrahydronaphthalin- und indanderivate, deren herstellung und verwendung für pharmazeutische präparate.
EP0252286A3 (en) Pharmaceutical preparations for topical use, process for their manufacture and their use
DK381485D0 (da) 1,2-benzisothiazol-3-yl-piperazinderivater og fremgangsmaade til fremstilling deraf
NO903898D0 (no) Fremgangsmaate for igjenplugging av en sone i en broenn.
NO860362L (no) Keramiske komposittgjenstander og fremgangsmaater for fremstilling derav.
NO904585D0 (no) Syntetiske plantegener og fremgangsmaate for fremstilling derav.
HUT47103A (en) Process for producing 1,4-benzoxazine derivatives and pharmaceutical compositions comprising the same
DE69004501D1 (de) Materialbehandlungsverfahren.
PH24599A (en) Amonoycyllabdanes, pharmaceutical compositions and a process for the preparations thereof
DE3870316D1 (de) Photoinitiator und photopolymerisierbare zusammensetzung damit.
FI894546A (fi) Menetelmä uusien 2'-halogeenimetylideeni-, 2'-etenylideeni- ja 2'-etynyyliadenosiinijohdannaisten valmistamiseksi
EP0247446A3 (en) Nitromodified chromatographic support materials, process for their manufacture and their use
FI102169B1 (fi) 3-aminopyrrolit, menetelmä niiden valmistamiseksi ja niiden käyttö lääkeaineina
DE69018583D1 (de) Propargylverbindungen und deren Herstellung.
DE3586952D1 (de) Fibrinophiler urokinase-komplex und dessen herstellung.
GB2182926B (en) Nitro anthracyclines, process for their preparation and use thereof
DK155702C (da) Datamatstyret toerfodringsanlaeg, navnlig til anvendelse i svinestalde
ZA878324B (en) New 2,6-diamino-3-halobenzylpyridines and processes for their manufacture as well as their use in pharmaceuticals
DE3661072D1 (en) 16-oxa-bicycloû13.1.0¨-hexadec-7-ene, process for its production and its use as a perfume
DE3675631D1 (de) In-vitro-kulturverfahren.
DE3560004D1 (en) Substituted salicylamides, process for their production and their use as pharmaceutical preparations
ZA802139B (en) Novel flavone derivatives,process therefor and pharmaceutical agents

Legal Events

Date Code Title Description
BB Publication of examined application
MM Patent lapsed
MM Patent lapsed

Owner name: SRI INTERNATIONAL