FI884889A - Foerfarande foer framstaellning av en sammansaettning av amfotericin b och kolesterolsulfat. - Google Patents

Foerfarande foer framstaellning av en sammansaettning av amfotericin b och kolesterolsulfat. Download PDF

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Publication number
FI884889A
FI884889A FI884889A FI884889A FI884889A FI 884889 A FI884889 A FI 884889A FI 884889 A FI884889 A FI 884889A FI 884889 A FI884889 A FI 884889A FI 884889 A FI884889 A FI 884889A
Authority
FI
Finland
Prior art keywords
amphotericin
kolesterolsulfat
amfotericin
sammansaettning
och
Prior art date
Application number
FI884889A
Other languages
English (en)
Other versions
FI884889A0 (fi
Inventor
Robert M Abra
Original Assignee
Liposome Technology Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Liposome Technology Inc filed Critical Liposome Technology Inc
Publication of FI884889A0 publication Critical patent/FI884889A0/fi
Publication of FI884889A publication Critical patent/FI884889A/fi

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/28—Steroids, e.g. cholesterol, bile acids or glycyrrhetinic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/5123—Organic compounds, e.g. fats, sugars
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nanotechnology (AREA)
  • Molecular Biology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Biomedical Technology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)
FI884889A 1987-02-27 1988-10-21 Foerfarande foer framstaellning av en sammansaettning av amfotericin b och kolesterolsulfat. FI884889A (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/019,575 US4822777A (en) 1987-02-27 1987-02-27 Amphotericin B/cholesterol sulfate composition
PCT/US1988/000599 WO1988006450A1 (en) 1987-02-27 1988-02-26 Amphotericin b/cholesterol sulfate composition and method

Publications (2)

Publication Number Publication Date
FI884889A0 FI884889A0 (fi) 1988-10-21
FI884889A true FI884889A (fi) 1988-10-21

Family

ID=21793937

Family Applications (1)

Application Number Title Priority Date Filing Date
FI884889A FI884889A (fi) 1987-02-27 1988-10-21 Foerfarande foer framstaellning av en sammansaettning av amfotericin b och kolesterolsulfat.

Country Status (12)

Country Link
US (1) US4822777A (fi)
EP (1) EP0303683B1 (fi)
JP (1) JPH0610134B2 (fi)
AT (1) ATE88348T1 (fi)
AU (1) AU599779B2 (fi)
CA (1) CA1336890C (fi)
DE (1) DE3880397T2 (fi)
DK (1) DK174871B1 (fi)
FI (1) FI884889A (fi)
HK (1) HK80596A (fi)
NO (1) NO884741L (fi)
WO (1) WO1988006450A1 (fi)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0825869B2 (ja) * 1987-02-09 1996-03-13 株式会社ビタミン研究所 抗腫瘍剤包埋リポソ−ム製剤
US5032582A (en) * 1987-02-27 1991-07-16 Liposome Technology, Inc. Method for treating fungal infections with amphotericin B/cholesterol sulfate composition
US6406713B1 (en) 1987-03-05 2002-06-18 The Liposome Company, Inc. Methods of preparing low-toxicity drug-lipid complexes
US5616334A (en) * 1987-03-05 1997-04-01 The Liposome Company, Inc. Low toxicity drug-lipid systems
US5194266A (en) * 1989-08-08 1993-03-16 Liposome Technology, Inc. Amphotericin B/cholesterol sulfate composition and method
US5776904A (en) * 1990-11-16 1998-07-07 Nippon Shinyaku Co., Ltd. Dispersion preparation
CA2113272A1 (en) * 1991-08-14 1993-03-04 Francis J. Martin Hiv-treatment method with low-toxicity amphotericin b
US5264220A (en) * 1991-11-12 1993-11-23 Long David M Jr Method of extending the vascular dwell-time of particulate therapeutic and particulate diagnostic agents
AU5171293A (en) * 1992-10-14 1994-05-09 Regents Of The University Of Colorado, The Ion-pairing of drugs for improved efficacy and delivery
IT1283149B1 (it) * 1996-07-12 1998-04-07 Prodotti Antibiotici Spa Complessi di n'-dimetilaminoacetilpartricina a dimetilaminoetilamide, o suoi sali, e colesterol 3-solfato
US6613352B2 (en) 1999-04-13 2003-09-02 Universite De Montreal Low-rigidity liposomal formulation
US8404217B2 (en) 2000-05-10 2013-03-26 Novartis Ag Formulation for pulmonary administration of antifungal agents, and associated methods of manufacture and use
AU2002245181B2 (en) 2000-12-21 2006-06-29 Nektar Therapeutics Pulmonary delivery of polyene antifungal agents
TWI297335B (en) 2001-07-10 2008-06-01 Synta Pharmaceuticals Corp Taxol enhancer compounds
TWI332943B (en) * 2001-07-10 2010-11-11 Synta Pharmaceuticals Corp Taxol enhancer compounds
TWI252847B (en) * 2001-07-10 2006-04-11 Synta Pharmaceuticals Corp Synthesis of taxol enhancers
TWI330079B (en) * 2003-01-15 2010-09-11 Synta Pharmaceuticals Corp Treatment for cancers
TWI249408B (en) * 2003-12-10 2006-02-21 Ind Tech Res Inst New antifungal formulation and manufacturing method thereof
JP5362986B2 (ja) * 2004-06-23 2013-12-11 シンタ ファーマスーティカルズ コーポレイション 癌治療のためのビス（チオ‐ヒドラジドアミド）塩
BRPI0610219A2 (pt) * 2005-04-15 2010-06-08 Synta Pharmaceuticals Corp métodos de tratamento de um ser humano com cáncer e composição de farmacêutica
WO2007021881A1 (en) 2005-08-16 2007-02-22 Synta Pharmaceuticals Corp. Bis(thio-hydrazide amide) formulation
KR20090045354A (ko) 2006-08-21 2009-05-07 신타 파마슈티칼스 코프. 증식성 장애를 치료하기 위한 화합물
AU2007290490B2 (en) * 2006-08-31 2011-09-08 Synta Pharmaceuticals Corp. Combination with bis(thiohydrazide amides) for treating cancer
TW200829543A (en) * 2006-09-15 2008-07-16 Synta Pharmaceuticals Corp Purification of bis(thiohydrazide amides)
US20100068251A1 (en) * 2006-10-10 2010-03-18 Jina Pharmaceuticals, Inc. Aqueous Systems For The Preparation Of Lipid Based Pharmaceutical Compounds; Compositions, Methods, And Uses Thereof
DE102015102210A1 (de) 2015-02-16 2016-08-18 Heraeus Medical Gmbh Antimykotischer polymerisierbarer Knochenzement und ein Verfahren zu seiner Herstellung
CA3053566A1 (en) * 2017-02-21 2018-08-30 Ico Therapeutics Inc. Solid oral formulations of amphotericin b
CN110305926B (zh) * 2019-05-27 2021-02-26 浙江工业大学 一种基于两性霉素b代谢途径的发酵方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4002741A (en) * 1974-04-24 1977-01-11 Valter Osvaldovich Kulbakh Meglumine complex fungicidal polyene macrolide antibiotic compositions and treatment method
US4468513A (en) * 1980-09-22 1984-08-28 Eli Lilly And Company 2'-N-Acylated and 2'-N-alkylated derivatives of 4-O-substituted-2-deoxystreptamine aminoglycosides
PT78628B (en) * 1984-05-02 1986-06-18 Liposome Co Inc Pharmaceutical composition with reduced toxicity
US4707470A (en) * 1985-05-17 1987-11-17 Smithkline Beckman Corporation Polyene antibiotic emulsion formulation

Also Published As

Publication number Publication date
AU599779B2 (en) 1990-07-26
JPH0610134B2 (ja) 1994-02-09
DE3880397D1 (de) 1993-05-27
DE3880397T2 (de) 1993-07-29
DK598388D0 (da) 1988-10-27
US4822777A (en) 1989-04-18
HK80596A (en) 1996-05-17
EP0303683A1 (en) 1989-02-22
DK598388A (da) 1988-10-27
AU1482688A (en) 1988-09-26
CA1336890C (en) 1995-09-05
NO884741D0 (no) 1988-10-25
EP0303683B1 (en) 1993-04-21
WO1988006450A1 (en) 1988-09-07
DK174871B1 (da) 2004-01-12
JPH01502270A (ja) 1989-08-10
ATE88348T1 (de) 1993-05-15
EP0303683A4 (en) 1989-12-28
NO884741L (no) 1988-10-25
FI884889A0 (fi) 1988-10-21

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Legal Events

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FD Application lapsed
FD Application lapsed

Owner name: LIPOSOME TECHNOLOGY, INC.