DK598388D0 - Amphotericin-b/cholesterolsulfatsammensaetning og fremgangsmaade til fremstilling af samme - Google Patents

Amphotericin-b/cholesterolsulfatsammensaetning og fremgangsmaade til fremstilling af samme

Info

Publication number
DK598388D0
DK598388D0 DK598388A DK598388A DK598388D0 DK 598388 D0 DK598388 D0 DK 598388D0 DK 598388 A DK598388 A DK 598388A DK 598388 A DK598388 A DK 598388A DK 598388 D0 DK598388 D0 DK 598388D0
Authority
DK
Denmark
Prior art keywords
amphotericin
composition
preparing
same
molar ratio
Prior art date
Application number
DK598388A
Other languages
English (en)
Other versions
DK598388A (da
DK174871B1 (da
Inventor
Robert Abra
Original Assignee
Liposome Technology Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Liposome Technology Inc filed Critical Liposome Technology Inc
Publication of DK598388D0 publication Critical patent/DK598388D0/da
Publication of DK598388A publication Critical patent/DK598388A/da
Application granted granted Critical
Publication of DK174871B1 publication Critical patent/DK174871B1/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/28—Steroids, e.g. cholesterol, bile acids or glycyrrhetinic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/5123—Organic compounds, e.g. fats, sugars
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nanotechnology (AREA)
  • Molecular Biology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Biomedical Technology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)
DK198805983A 1987-02-27 1988-10-27 Amphotericin-B/cholesterolsulfat-sammensætning og fremgangsmåde til fremstilling af samme DK174871B1 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US1957587 1987-02-27
US07/019,575 US4822777A (en) 1987-02-27 1987-02-27 Amphotericin B/cholesterol sulfate composition
PCT/US1988/000599 WO1988006450A1 (en) 1987-02-27 1988-02-26 Amphotericin b/cholesterol sulfate composition and method
US8800599 1988-02-26

Publications (3)

Publication Number Publication Date
DK598388D0 true DK598388D0 (da) 1988-10-27
DK598388A DK598388A (da) 1988-10-27
DK174871B1 DK174871B1 (da) 2004-01-12

Family

ID=21793937

Family Applications (1)

Application Number Title Priority Date Filing Date
DK198805983A DK174871B1 (da) 1987-02-27 1988-10-27 Amphotericin-B/cholesterolsulfat-sammensætning og fremgangsmåde til fremstilling af samme

Country Status (12)

Country Link
US (1) US4822777A (da)
EP (1) EP0303683B1 (da)
JP (1) JPH0610134B2 (da)
AT (1) ATE88348T1 (da)
AU (1) AU599779B2 (da)
CA (1) CA1336890C (da)
DE (1) DE3880397T2 (da)
DK (1) DK174871B1 (da)
FI (1) FI884889A (da)
HK (1) HK80596A (da)
NO (1) NO884741L (da)
WO (1) WO1988006450A1 (da)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0825869B2 (ja) * 1987-02-09 1996-03-13 株式会社ビタミン研究所 抗腫瘍剤包埋リポソ−ム製剤
US5032582A (en) * 1987-02-27 1991-07-16 Liposome Technology, Inc. Method for treating fungal infections with amphotericin B/cholesterol sulfate composition
US6406713B1 (en) 1987-03-05 2002-06-18 The Liposome Company, Inc. Methods of preparing low-toxicity drug-lipid complexes
US5616334A (en) * 1987-03-05 1997-04-01 The Liposome Company, Inc. Low toxicity drug-lipid systems
US5194266A (en) * 1989-08-08 1993-03-16 Liposome Technology, Inc. Amphotericin B/cholesterol sulfate composition and method
US5776904A (en) * 1990-11-16 1998-07-07 Nippon Shinyaku Co., Ltd. Dispersion preparation
CA2113272A1 (en) * 1991-08-14 1993-03-04 Francis J. Martin Hiv-treatment method with low-toxicity amphotericin b
US5264220A (en) * 1991-11-12 1993-11-23 Long David M Jr Method of extending the vascular dwell-time of particulate therapeutic and particulate diagnostic agents
AU5171293A (en) * 1992-10-14 1994-05-09 Regents Of The University Of Colorado, The Ion-pairing of drugs for improved efficacy and delivery
IT1283149B1 (it) * 1996-07-12 1998-04-07 Prodotti Antibiotici Spa Complessi di n'-dimetilaminoacetilpartricina a dimetilaminoetilamide, o suoi sali, e colesterol 3-solfato
US6613352B2 (en) 1999-04-13 2003-09-02 Universite De Montreal Low-rigidity liposomal formulation
US8404217B2 (en) 2000-05-10 2013-03-26 Novartis Ag Formulation for pulmonary administration of antifungal agents, and associated methods of manufacture and use
AU2002245181B2 (en) 2000-12-21 2006-06-29 Nektar Therapeutics Pulmonary delivery of polyene antifungal agents
TWI297335B (en) 2001-07-10 2008-06-01 Synta Pharmaceuticals Corp Taxol enhancer compounds
TWI332943B (en) * 2001-07-10 2010-11-11 Synta Pharmaceuticals Corp Taxol enhancer compounds
TWI252847B (en) * 2001-07-10 2006-04-11 Synta Pharmaceuticals Corp Synthesis of taxol enhancers
TWI330079B (en) * 2003-01-15 2010-09-11 Synta Pharmaceuticals Corp Treatment for cancers
TWI249408B (en) * 2003-12-10 2006-02-21 Ind Tech Res Inst New antifungal formulation and manufacturing method thereof
JP5362986B2 (ja) * 2004-06-23 2013-12-11 シンタ ファーマスーティカルズ コーポレイション 癌治療のためのビス（チオ‐ヒドラジドアミド）塩
BRPI0610219A2 (pt) * 2005-04-15 2010-06-08 Synta Pharmaceuticals Corp métodos de tratamento de um ser humano com cáncer e composição de farmacêutica
WO2007021881A1 (en) 2005-08-16 2007-02-22 Synta Pharmaceuticals Corp. Bis(thio-hydrazide amide) formulation
KR20090045354A (ko) 2006-08-21 2009-05-07 신타 파마슈티칼스 코프. 증식성 장애를 치료하기 위한 화합물
AU2007290490B2 (en) * 2006-08-31 2011-09-08 Synta Pharmaceuticals Corp. Combination with bis(thiohydrazide amides) for treating cancer
TW200829543A (en) * 2006-09-15 2008-07-16 Synta Pharmaceuticals Corp Purification of bis(thiohydrazide amides)
US20100068251A1 (en) * 2006-10-10 2010-03-18 Jina Pharmaceuticals, Inc. Aqueous Systems For The Preparation Of Lipid Based Pharmaceutical Compounds; Compositions, Methods, And Uses Thereof
DE102015102210A1 (de) 2015-02-16 2016-08-18 Heraeus Medical Gmbh Antimykotischer polymerisierbarer Knochenzement und ein Verfahren zu seiner Herstellung
CA3053566A1 (en) * 2017-02-21 2018-08-30 Ico Therapeutics Inc. Solid oral formulations of amphotericin b
CN110305926B (zh) * 2019-05-27 2021-02-26 浙江工业大学 一种基于两性霉素b代谢途径的发酵方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4002741A (en) * 1974-04-24 1977-01-11 Valter Osvaldovich Kulbakh Meglumine complex fungicidal polyene macrolide antibiotic compositions and treatment method
US4468513A (en) * 1980-09-22 1984-08-28 Eli Lilly And Company 2'-N-Acylated and 2'-N-alkylated derivatives of 4-O-substituted-2-deoxystreptamine aminoglycosides
PT78628B (en) * 1984-05-02 1986-06-18 Liposome Co Inc Pharmaceutical composition with reduced toxicity
US4707470A (en) * 1985-05-17 1987-11-17 Smithkline Beckman Corporation Polyene antibiotic emulsion formulation

Also Published As

Publication number Publication date
AU599779B2 (en) 1990-07-26
JPH0610134B2 (ja) 1994-02-09
DE3880397D1 (de) 1993-05-27
DE3880397T2 (de) 1993-07-29
US4822777A (en) 1989-04-18
HK80596A (en) 1996-05-17
EP0303683A1 (en) 1989-02-22
DK598388A (da) 1988-10-27
AU1482688A (en) 1988-09-26
CA1336890C (en) 1995-09-05
NO884741D0 (no) 1988-10-25
EP0303683B1 (en) 1993-04-21
WO1988006450A1 (en) 1988-09-07
DK174871B1 (da) 2004-01-12
JPH01502270A (ja) 1989-08-10
ATE88348T1 (de) 1993-05-15
EP0303683A4 (en) 1989-12-28
NO884741L (no) 1988-10-25
FI884889A0 (fi) 1988-10-21
FI884889A (fi) 1988-10-21

Similar Documents

Publication Publication Date Title
DK598388D0 (da) Amphotericin-b/cholesterolsulfatsammensaetning og fremgangsmaade til fremstilling af samme
CA2320488A1 (en) Strategically modified hepatitis b core proteins and their derivatives
AU555952B2 (en) Collagen implant containing active ingredient for implantation in bones
CS590188A2 (en) Method of erythropoietin's stabilized preparation production
DK0556256T3 (da) Aerosolmedikamenter
EP0824152A3 (en) Microbial production of vitamin B12 and production and use of compositions comprising high concentrations of vitamin B12 activity
IL98258A0 (en) Composition for treating impotence containing doxazosin,amlodipine,or u.k.52,046
HUT61196A (en) Process for producing pharmaceutical composition which may be dropped in the eye
ES2141486T3 (es) Fertilizante y procedimiento de preparacion del mismo.
FI930266A (fi) Vateriitti ja menetelmä sen valmistamiseksi
CA2014721A1 (en) Concentrated aqueous solution of glutaraldehyde and 1,2-benzisothiazolin-3-one
WO2002003974A3 (en) Composition comprising folic acid and zinc for improving male fertility
CA2349967A1 (en) Polyhydric alcohol anti-dust agent for inorganic materials
SE8700137D0 (sv) Diuretisk komposition
PH31320A (en) Fenbendazole formulations.
YU45988B (sh) Postupak za izradu čvrste kompozicije za oralnu upotrebu na bazi nifedipina sa kontrolisanim otpuštanjem aktivne supstance
NZ229276A (en) Micronised 4-androstene-3,17-diones
CA2216583A1 (en) Levobupivacaine and its use as an anaesthetic in pregnant women
GR860329B (en) Reagent for the dosage of antibodies against bacteric toxines by hemaglutination method for preparation and application thereof
EP0349589A4 (en) PHARMACOLOGICALLY ACTIVE CHOLINERGE PREPARATIONS AND METHOD FOR THE PRODUCTION AND THEIR USE FOR TREATING DISEASES.
IE800344L (en) Anti-perspirant compositions
HUT33951A (en) Pesticide composition and process for producing tetrahydo-thio-pirane-3,5-dione-4-carboxamide derivatives utilizable as active agents
CA2120353A1 (en) Cell cycle controlling compositions and methods of using same
EP0010515A3 (en) (n-methylcarbamoyl-phenoxy)-(n'.n".n"-trialkyl urea)-n.n'-sulfide derivatives, process for their preparation, compositions containing these derivatives as active components and their use in combating insects; (n-methyl-carbamoylhalogenide)-(n'.n".n'"-trialkyl urea)-n.n' sulfides and process for their preparation
EP0379266A3 (en) Production method for anhydrous gypsum

Legal Events

Date Code Title Description
PBP Patent lapsed

Country of ref document: DK