FI882001A - Menetelmä terapeuttisesti käyttökelpoisten substituoitujen 2-(2-aminoetoksimetyyli)-4-(2-kloorifenyyli)-3-etoksikarbonyyli-5-metoksikarbonyyli-6-metyyli-1,4-dihydropyridiinien valmistamiseksi - Google Patents

Menetelmä terapeuttisesti käyttökelpoisten substituoitujen 2-(2-aminoetoksimetyyli)-4-(2-kloorifenyyli)-3-etoksikarbonyyli-5-metoksikarbonyyli-6-metyyli-1,4-dihydropyridiinien valmistamiseksi Download PDF

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Publication number
FI882001A
FI882001A FI882001A FI882001A FI882001A FI 882001 A FI882001 A FI 882001A FI 882001 A FI882001 A FI 882001A FI 882001 A FI882001 A FI 882001A FI 882001 A FI882001 A FI 882001A
Authority
FI
Finland
Prior art keywords
aminoethoxymethyl
dihydropyridines
ethoxycarbonyl
methoxycarbonyl
chlorophenyl
Prior art date
Application number
FI882001A
Other languages
English (en)
Swedish (sv)
Other versions
FI882001A0 (fi
FI90415C (fi
FI90415B (fi
Inventor
Simon Fraser Campbell
Michael John Humphrey
Alan Stobie
Original Assignee
Pfizer Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Ltd filed Critical Pfizer Ltd
Publication of FI882001A0 publication Critical patent/FI882001A0/fi
Publication of FI882001A publication Critical patent/FI882001A/fi
Application granted granted Critical
Publication of FI90415B publication Critical patent/FI90415B/fi
Publication of FI90415C publication Critical patent/FI90415C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Dental Preparations (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Plural Heterocyclic Compounds (AREA)
FI882001A 1987-05-02 1988-04-28 Menetelmä terapeuttisesti käyttökelpoisten substituoitujen 2-(2-aminoetoksimetyyli)-4-(2-kloorifenyyli)-3-etoksikarbonyyli-5-metoksikarbonyyli-6-metyyli-1,4-dihydropyridiinien valmistamiseksi FI90415C (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB878710493A GB8710493D0 (en) 1987-05-02 1987-05-02 Dihydropyridines
GB8710493 1987-05-02

Publications (4)

Publication Number Publication Date
FI882001A0 FI882001A0 (fi) 1988-04-28
FI882001A true FI882001A (fi) 1988-11-03
FI90415B FI90415B (fi) 1993-10-29
FI90415C FI90415C (fi) 1994-02-10

Family

ID=10616773

Family Applications (1)

Application Number Title Priority Date Filing Date
FI882001A FI90415C (fi) 1987-05-02 1988-04-28 Menetelmä terapeuttisesti käyttökelpoisten substituoitujen 2-(2-aminoetoksimetyyli)-4-(2-kloorifenyyli)-3-etoksikarbonyyli-5-metoksikarbonyyli-6-metyyli-1,4-dihydropyridiinien valmistamiseksi

Country Status (13)

Country Link
US (1) US4806557A (fi)
EP (1) EP0290211B1 (fi)
JP (1) JPS63297365A (fi)
AT (1) ATE66915T1 (fi)
CA (1) CA1326672C (fi)
DE (1) DE3864573D1 (fi)
DK (1) DK172094B1 (fi)
ES (1) ES2031595T3 (fi)
FI (1) FI90415C (fi)
GB (1) GB8710493D0 (fi)
GR (1) GR3002767T3 (fi)
IE (1) IE60055B1 (fi)
PT (1) PT87361B (fi)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5270323A (en) * 1990-05-31 1993-12-14 Pfizer Inc. Method of treating impotence
US6057344A (en) * 1991-11-26 2000-05-02 Sepracor, Inc. Methods for treating hypertension, and angina using optically pure (-) amlodipine
CA2377278C (en) * 1999-06-25 2010-03-23 Vertex Pharmaceuticals Incorporated Prodrugs of carbamate inhibitors of impdh
GB0008332D0 (en) * 2000-04-04 2000-05-24 Pfizer Ltd Treament
US6521647B2 (en) 2000-04-04 2003-02-18 Pfizer Inc. Treatment of renal disorders
MXPA03005882A (es) 2000-12-29 2005-04-19 Pfizer Ltd Derivado amida de amlodipina.
US7335380B2 (en) 2000-12-29 2008-02-26 Synthon Ip Inc. Amlodipine free base
US6653481B2 (en) 2000-12-29 2003-11-25 Synthon Bv Process for making amlodipine
AT5874U1 (de) 2000-12-29 2003-01-27 Bioorg Bv Pharmazeutische zubereitungen enthaltend amlodipinmaleat
GB2371862B (en) 2000-12-29 2004-07-14 Bioorg Bv Reference standards for determining the purity or stability of amlodipine maleate and processes therefor
EP1309557B9 (en) 2000-12-29 2006-11-15 Pfizer Limited Amlodipine hemimaleate
WO2002053541A1 (en) 2000-12-29 2002-07-11 Pfizer Limited Amide derivative of amlodipine
BR0116557A (pt) 2000-12-29 2003-10-28 Pfizer Ltd Processo, processo para fabricação de um sal de maleato de amlodipina substancialmente livre de aspartato de amlodipina, processo para purificação, maleato de amlodipina, composição farmacêutica para tratar ou prevenir angina ou hipertenção, método para tratar hipertenção, angina ou ataque cardìaco, benzeno sulfonato de amlodipina, hidrocloreto de amlodipina e uso de maleato de amlodipina substancialmente livre de aspartato de amlodipina
EP1309556B1 (en) 2000-12-29 2004-11-24 Pfizer Limited Amlodipine fumarate
GB2372036B (en) 2000-12-29 2004-05-19 Bioorg Bv Aspartate derivative of amlodipine
US6699892B2 (en) 2002-06-04 2004-03-02 Yung Shin Pharmaceutical Industrial Co., Ltd. Pharmaceutically acceptable salt of amlodipine and method of preparing the same
KR100496436B1 (ko) * 2002-07-30 2005-06-20 씨제이 주식회사 암로디핀의 유기산염
KR20040011751A (ko) * 2002-07-30 2004-02-11 씨제이 주식회사 암로디핀의 유기산염
KR100538641B1 (ko) * 2002-07-30 2005-12-22 씨제이 주식회사 암로디핀의 유기산염
KR100462304B1 (ko) * 2002-07-30 2004-12-17 씨제이 주식회사 암로디핀의 유기산염
KR100467669B1 (ko) * 2002-08-21 2005-01-24 씨제이 주식회사 암로디핀의 유기산염
US20130053411A1 (en) 2010-05-03 2013-02-28 Tsh Biopharm Corporation Ltd. Pharmaceutical composition and method for treating hypertension

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1552911A (en) * 1975-07-02 1979-09-19 Fujisawa Pharmaceutical Co 1,4 dihydropyridine derivatives and the preparation thereof
US4447613A (en) * 1979-08-24 1984-05-08 Zoecon Corporation Pyridyl esters and thiolesters of aminoalkanoic acids
CS228917B2 (en) * 1981-03-14 1984-05-14 Pfizer Method of preparing substituted derivatives of 1,4-dihydropyridine
DK161312C (da) * 1982-03-11 1991-12-09 Pfizer Analogifremgangsmaade til fremstilling af 2-aminoalkoxymethyl-4-phenyl-6-methyl-1,4-dihydropyridin-3,5-dicarboxylsyreestere eller syreadditionssalte deraf samt phthalimidoderivater til anvendelse som udgangsmateriale ved fremgangsmaaden
GB8306666D0 (en) * 1983-03-10 1983-04-13 Pfizer Ltd Therapeutic agents
US4568677A (en) * 1983-07-23 1986-02-04 Pfizer Inc. 2-(4-Pyrimidone alkoxyalkyl) dihydropyridine anti-ischaemic and antihypertensive agents

Also Published As

Publication number Publication date
US4806557A (en) 1989-02-21
GR3002767T3 (en) 1993-01-25
IE881283L (en) 1988-11-02
DK234388A (da) 1989-01-19
ATE66915T1 (de) 1991-09-15
FI882001A0 (fi) 1988-04-28
GB8710493D0 (en) 1987-06-03
PT87361B (pt) 1992-08-31
FI90415C (fi) 1994-02-10
PT87361A (pt) 1989-05-31
JPH0581588B2 (fi) 1993-11-15
FI90415B (fi) 1993-10-29
ES2031595T3 (es) 1992-12-16
DK234388D0 (da) 1988-04-28
DK172094B1 (da) 1997-10-20
JPS63297365A (ja) 1988-12-05
EP0290211A1 (en) 1988-11-09
IE60055B1 (en) 1994-05-18
EP0290211B1 (en) 1991-09-04
CA1326672C (en) 1994-02-01
DE3864573D1 (en) 1991-10-10

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Owner name: PFIZER LIMITED