FI881825A0 - Framstaellning av nya heterobicykliska kinolonderivat. - Google Patents
Framstaellning av nya heterobicykliska kinolonderivat.Info
- Publication number
- FI881825A0 FI881825A0 FI881825A FI881825A FI881825A0 FI 881825 A0 FI881825 A0 FI 881825A0 FI 881825 A FI881825 A FI 881825A FI 881825 A FI881825 A FI 881825A FI 881825 A0 FI881825 A0 FI 881825A0
- Authority
- FI
- Finland
- Prior art keywords
- kinolonderivat
- heterobicycliska
- nya
- framstaellning
- nya heterobicycliska
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Quinoline Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB878709448A GB8709448D0 (en) | 1987-04-21 | 1987-04-21 | Heterobicyclic quinoline derivatives |
Publications (2)
Publication Number | Publication Date |
---|---|
FI881825A0 true FI881825A0 (fi) | 1988-04-19 |
FI881825A FI881825A (fi) | 1988-10-22 |
Family
ID=10616116
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI881825A FI881825A (fi) | 1987-04-21 | 1988-04-19 | Framstaellning av nya heterobicykliska kinolonderivat. |
Country Status (7)
Country | Link |
---|---|
US (1) | US4898872A (fi) |
EP (1) | EP0290153A1 (fi) |
JP (1) | JPS63280078A (fi) |
DK (1) | DK214088A (fi) |
FI (1) | FI881825A (fi) |
GB (1) | GB8709448D0 (fi) |
PT (1) | PT87273A (fi) |
Families Citing this family (55)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3932953A1 (de) * | 1989-10-03 | 1991-04-11 | Boehringer Mannheim Gmbh | Neue 2-bicyclo-benzimidazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
WO1991012251A1 (en) * | 1990-02-19 | 1991-08-22 | Chugai Seiyaku Kabushiki Kaisha | Novel fused heterocyclic compound and antiasthmatic agent prepared therefrom |
US6162804A (en) * | 1997-09-26 | 2000-12-19 | Merck & Co., Inc. | Tyrosine kinase inhibitors |
US6465484B1 (en) | 1997-09-26 | 2002-10-15 | Merck & Co., Inc. | Angiogenesis inhibitors |
EP1091939A1 (en) * | 1998-06-30 | 2001-04-18 | Du Pont Pharmaceuticals Company | Substituted quinolin-2(1h)-ones useful as hiv reverse transcriptase inhibitors |
US6127382A (en) * | 1999-08-16 | 2000-10-03 | Allergan Sales, Inc. | Amines substituted with a tetrahydroquinolinyl group an aryl or heteroaryl group and an alkyl group, having retinoid-like biological activity |
US6613917B1 (en) * | 2000-03-23 | 2003-09-02 | Allergan, Inc. | Amines substituted with a dihydronaphthalenyl, chromenyl, or thiochromenyl group, an aryl or heteroaryl group and an alkyl group, having retinoid-like biological activity |
US6528649B2 (en) | 2000-05-30 | 2003-03-04 | Neurogen Corporation | Imidazoloisoquinolines |
ATE448226T1 (de) | 2000-09-01 | 2009-11-15 | Novartis Vaccines & Diagnostic | Aza heterocyclische derivate und ihre therapeutische verwendung |
PT1650203E (pt) | 2000-09-11 | 2008-05-13 | Novartis Vaccines & Diagnostic | Processo de preparação de derivados de benzimidazol-2-ilquinolinona |
US7825132B2 (en) | 2002-08-23 | 2010-11-02 | Novartis Vaccines And Diagnostics, Inc. | Inhibition of FGFR3 and treatment of multiple myeloma |
BR0313743A (pt) | 2002-08-23 | 2005-07-05 | Chiron Corp | Benzimidazol quinolinonas e usos destas |
AU2003290699B2 (en) | 2002-11-13 | 2009-08-27 | Novartis Vaccines And Diagnostics, Inc. | Methods of treating cancer and related methods |
EP1602648B1 (en) * | 2003-03-13 | 2013-04-17 | Idemitsu Kosan Co., Ltd. | Nitrogen-containing heterocycle derivative and organic electroluminescent element using the same |
RU2377988C2 (ru) | 2004-02-20 | 2010-01-10 | Новартис Вэксинес Энд Дайэгностикс, Инк. | Модуляция воспалительных и метастатических процессов |
US7772271B2 (en) | 2004-07-14 | 2010-08-10 | Ptc Therapeutics, Inc. | Methods for treating hepatitis C |
US7868037B2 (en) | 2004-07-14 | 2011-01-11 | Ptc Therapeutics, Inc. | Methods for treating hepatitis C |
US7781478B2 (en) | 2004-07-14 | 2010-08-24 | Ptc Therapeutics, Inc. | Methods for treating hepatitis C |
NZ553329A (en) | 2004-07-22 | 2010-09-30 | Ptc Therapeutics Inc | Thienopyridines for treating hepatitis C |
CN101083985A (zh) * | 2004-09-21 | 2007-12-05 | 幸讬制药公司 | 用于炎症及免疫相关用途的化合物 |
ES2440799T3 (es) | 2005-05-13 | 2014-01-30 | Novartis Ag | Métodos para tratar cáncer resistente a los fármacos |
JP5545925B2 (ja) | 2005-05-17 | 2014-07-09 | ノバルティス アーゲー | ヘテロ環化合物の合成方法 |
CA2609353C (en) | 2005-05-23 | 2015-04-28 | Novartis Ag | Crystalline and other forms of 4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1h-benzimidazol-2-yl]-1h-quinolin-2-one lactic acid salts |
RU2478635C2 (ru) | 2006-10-19 | 2013-04-10 | СИГНАЛ ФАРМАСЬЮТИКАЛЗ, ЭлЭлСи | Гетероарильные соединения, содержащие их композиции и способы лечения с применением этих соединений |
DE102008022221A1 (de) * | 2008-05-06 | 2009-11-12 | Universität des Saarlandes | Inhibitoren der humanen Aldosteronsynthase CYP11B2 |
EP2307400B1 (en) | 2008-05-30 | 2014-04-23 | Amgen, Inc | Inhibitors of pi3 kinase |
EP2348018A4 (en) | 2008-09-25 | 2012-04-25 | Kyorin Seiyaku Kk | HETEROCYCLIC BIARYLIC DERIVATIVE AND PDE INHIBITOR COMPRISING THE SAME AS ACTIVE INGREDIENT |
WO2010041711A1 (ja) | 2008-10-09 | 2010-04-15 | 杏林製薬株式会社 | イソキノリン誘導体及びそれらを有効成分とするpde阻害剤 |
US8110578B2 (en) | 2008-10-27 | 2012-02-07 | Signal Pharmaceuticals, Llc | Pyrazino[2,3-b]pyrazine mTOR kinase inhibitors for oncology indications and diseases associated with the mTOR/PI3K/Akt pathway |
WO2011021678A1 (ja) * | 2009-08-21 | 2011-02-24 | 武田薬品工業株式会社 | 縮合複素環化合物 |
MX341704B (es) | 2009-10-26 | 2016-08-31 | Signal Pharm Llc | Métodos de síntesis y purificación de compuestos de heteroarilo. |
US9353081B2 (en) | 2011-09-23 | 2016-05-31 | Hoffmann-La Roche Inc. | Bicyclic dihydroquinoline-2-one derivatives |
MY183661A (en) | 2011-10-19 | 2021-03-05 | Signal Pharm Llc | Treatment of cancer with tor kinase inhibitors |
WO2013082344A1 (en) | 2011-12-02 | 2013-06-06 | Signal Pharmaceuticals, Llc | Pharmaceutical compositions of 7-(6-(2-hydroxypropan-2-yl)pyridin-3-yl)-1-((trans)-4-methoxycyclohexyl)-3,4-dihydropyrazino [2,3-b]pyrazin-2(1h)-one, a solid form thereof and methods of their use |
ES2742398T3 (es) | 2012-02-24 | 2020-02-14 | Signal Pharm Llc | Métodos para tratar el cáncer de pulmón no microcítico usando una terapia de combinación de inhibidores de TOR quinasa |
AU2013203714B2 (en) | 2012-10-18 | 2015-12-03 | Signal Pharmaceuticals, Llc | Inhibition of phosphorylation of PRAS40, GSK3-beta or P70S6K1 as a marker for TOR kinase inhibitory activity |
AU2014207641A1 (en) | 2013-01-16 | 2015-08-06 | Signal Pharmaceuticals, Llc | Substituted Pyrrolopyrimidine Compounds, compositions thereof, and methods of treatment therewith |
MX2015014455A (es) | 2013-04-17 | 2016-07-21 | Signal Pharm Llc | Terapia de combinacion que comprende un inhibidor de tor cinasa y n-(3-(5-fluoro-2-(4-(2-metoxietoxi)fenilamino)pirimidin-4-ilamino )fenil)acrilamida para tratar cancer. |
US9474757B2 (en) | 2013-04-17 | 2016-10-25 | Signal Pharmaceuticals, Llc | Methods for treating cancer using TOR kinase inhibitor combination therapy |
MX2015014590A (es) | 2013-04-17 | 2016-03-03 | Signal Pharm Llc | Tratamiento de cancer con dihidropirazino-pirazinas. |
NZ631082A (en) | 2013-04-17 | 2017-06-30 | Signal Pharm Llc | Methods for treating cancer using tor kinase inhibitor combination therapy |
BR112015026238A8 (pt) | 2013-04-17 | 2019-12-24 | Signal Pharm Llc | composto dihidropirazino-pirazina, composição farmacêutica que o compreende, uso do composto, métodos para inibir ou medir a fosforilação e para inibir a atividade da proteína quinase, bem como kit |
BR112015026257B1 (pt) | 2013-04-17 | 2022-12-20 | Signal Pharmaceuticals, Llc | Uso de um composto dihidropirazino-pirazina e enzalutamida, composição farmacêutica que os compreende, e kit |
AU2014254050B2 (en) | 2013-04-17 | 2018-10-04 | Signal Pharmaceuticals, Llc | Pharmaceutical formulations, processes, solid forms and methods of use relating to 1-ethyl-7-(2-methyl-6-(1h-1,2,4-triazol-3-yl) pyridin-3-yl) -3,4-dihydropyrazino[2,3-b]pyrazin-2(1h)-one |
JPWO2014174745A1 (ja) * | 2013-04-26 | 2017-02-23 | 国立大学法人京都大学 | Eg5阻害剤 |
CA2912627C (en) | 2013-05-29 | 2022-03-15 | Signal Pharmaceuticals, Llc | Pharmaceutical compositions of 7-(6-(2-hydroxypropan-2-yl)pyridin-3-yl)-1-((trans)-4-methoxycyclohexyl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1h)-one, a solid form thereof and methods of their use |
WO2015160882A1 (en) | 2014-04-16 | 2015-10-22 | Signal Pharmaceuticals, Llc | SOLID FORMS COMPRISING 7-(6-(2-HYDROXYPROPAN-2YL) PYRIDIN-3-YL)-1-(TRANS)-4-METHOXYCYCLOHEXYL)-3, 4-DIHYDROPYRAZINO[2,3-b] PYRAZIN-2(1H)-ONE, AND A COFORMER, COMPOSITIONS AND METHODS OF USE THEREOF |
NZ714742A (en) | 2014-04-16 | 2017-04-28 | Signal Pharm Llc | Solid forms of 1-ethyl-7-(2-methyl-6-(1h-1,2,4-triazol-3-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1h)-one, compositions thereof and methods of their use |
ES2823756T3 (es) | 2014-04-16 | 2021-05-10 | Signal Pharm Llc | Métodos para tratar el cáncer usando terapia de combinación de inhibidores de quinasa TOR |
WO2015160880A1 (en) | 2014-04-16 | 2015-10-22 | Signal Pharmaceuticals, Llc | SOLID FORMS COMPRISING 1-ETHYL-7-(2-METHYL-6-(1H-1,2,4-TRIAZOL-3-YL) PYRIDIN-3-YL)-3,4-DIHYDROPYRAZINO(2,3-b)PYRAZIN-2(1H)-ONE, AND A COFORMER, COMPOSITIONS AND METHODS OF USE THEREOF |
NZ629796A (en) | 2014-07-14 | 2015-12-24 | Signal Pharm Llc | Amorphous form of 4-((4-(cyclopentyloxy)-5-(2-methylbenzo[d]oxazol-6-yl)-7h-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-3-methoxy-n-methylbenzamide, compositions thereof and methods of their use |
JP2017520603A (ja) | 2014-07-14 | 2017-07-27 | シグナル ファーマシューティカルズ,エルエルシー | 置換ピロロピリミジン化合物を使用するがんの治療方法及びその組成物 |
WO2016055926A1 (en) | 2014-10-10 | 2016-04-14 | Sabic Global Technologies B.V. | Polyetherimide varnish compositions, methods of manufacture, and articles prepared therefrom |
KR20200019229A (ko) | 2017-06-22 | 2020-02-21 | 셀진 코포레이션 | B형 간염 바이러스 감염을 특징으로 하는 간세포 암종의 치료 |
WO2019043208A1 (en) * | 2017-09-04 | 2019-03-07 | F. Hoffmann-La Roche Ag | DIHYDROQUINOLINONES |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1164459A (en) * | 1980-11-11 | 1984-03-27 | Yung-Hsiung Yang | Process for preparing (imidazo¬1,2-a|pyridine- 2-yl)-carbostyril or -3,4-dihydrocarbostyryl derivatives |
JPS5782390A (en) * | 1980-11-11 | 1982-05-22 | Otsuka Pharmaceut Co Ltd | Carbostyril derivative |
FI77852C (fi) * | 1981-02-17 | 1989-05-10 | Otsuka Pharma Co Ltd | Foerfarande foer framstaellning av nya, saosom hjaertmediciner anvaendbara substituerade amid- och (maettad heterocykel)karbonylkarbostyrilderivat. |
US4710507A (en) * | 1983-12-22 | 1987-12-01 | Pfizer Inc. | Quinolone inotropic agents |
ES8608874A1 (es) * | 1984-05-29 | 1986-09-01 | Pfizer | Un procedimiento para la preparacion de una 2-(1h)-quinolona |
GB8502267D0 (en) * | 1985-01-30 | 1985-02-27 | Pfizer Ltd | Quinolone inotropic agents |
JPH0662608B2 (ja) * | 1985-08-26 | 1994-08-17 | 大塚製薬株式会社 | カルボスチリル誘導体 |
GB8529362D0 (en) * | 1985-11-28 | 1986-01-02 | Pfizer Ltd | Quinolone cardiac stimulants |
JPS63301821A (ja) * | 1986-03-05 | 1988-12-08 | Otsuka Pharmaceut Co Ltd | 抗不整脈剤 |
JPH07121937B2 (ja) * | 1987-03-18 | 1995-12-25 | 大塚製薬株式会社 | カルボスチリル誘導体 |
-
1987
- 1987-04-21 GB GB878709448A patent/GB8709448D0/en active Pending
-
1988
- 1988-04-15 EP EP88303410A patent/EP0290153A1/en not_active Withdrawn
- 1988-04-19 FI FI881825A patent/FI881825A/fi not_active Application Discontinuation
- 1988-04-19 PT PT87273A patent/PT87273A/pt not_active Application Discontinuation
- 1988-04-20 DK DK214088A patent/DK214088A/da not_active Application Discontinuation
- 1988-04-21 JP JP63099280A patent/JPS63280078A/ja active Pending
- 1988-04-21 US US07/184,462 patent/US4898872A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
DK214088D0 (da) | 1988-04-20 |
EP0290153A1 (en) | 1988-11-09 |
US4898872A (en) | 1990-02-06 |
DK214088A (da) | 1988-12-07 |
GB8709448D0 (en) | 1987-05-28 |
JPS63280078A (ja) | 1988-11-17 |
PT87273A (pt) | 1988-05-01 |
FI881825A (fi) | 1988-10-22 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
FI881825A0 (fi) | Framstaellning av nya heterobicykliska kinolonderivat. | |
FI880173A0 (fi) | Nya peptidasinhibitorer. | |
FI881650A (fi) | Foerfarande foer framstaellning av nya acylderivat. | |
FI880469A0 (fi) | Nya polyaminderivat. | |
FI884305A (fi) | Nya amidinotricyklderivat. | |
FI884627A (fi) | Foerfarande foer framstaellning av nya terapeutiskt anvaendbara dideoxicytidinderivat. | |
FI884363A0 (fi) | Nya aluminium-magnesium -hydroxifoereningar. | |
FI881571A (fi) | Nya ribofuransyraderivator. | |
FI881639A (fi) | Foerfarande foer framstaellning av nya substituerade anilidderivat. | |
FI884304A (fi) | Nya amidinoderivat. | |
FI882640A0 (fi) | Nya heterocykliska pesticida foereningar. | |
FI881641A (fi) | Foerfarande foer framstaellning av nya acylderivat. | |
FI884752A0 (fi) | Foerfarande foer framstaellning av nya kinolinderivat. | |
FI883146A0 (fi) | Nya foereningar. | |
FI884106A0 (fi) | Foerfarande foer framstaellning av nya antibakteriella 4-oxo-3-kinolinkarboxylsyror. | |
FI871320A0 (fi) | Nya langmuir-blodgettmembranstrukturer. | |
FI886065A (fi) | Foerfarande foer framstaellning av nya terapeutiskt anvaendbara dioxazocinderivat. | |
FI884535A0 (fi) | Foerfarande foer framstaellning av nya kinolinium- och isokinoliniumderivat. | |
FI881921A (fi) | Foerfarande foer framstaellning av nya terapeutiskt anvaendbara kinolintioetrar. | |
FI880536A0 (fi) | Foerfarande foer framstaellning av nya 1-detia-2-tiakefalosporinderivat. | |
FI913098A0 (fi) | Foerfarande foer framstaellning av nya terapeutiskt anvaendbara tricykliska triatsolpyrimidinderivat. | |
FI885047A0 (fi) | Framstaellningsfoerfarande av nya oktahydroindenofuranderivat. | |
FI914338A0 (fi) | Foerfarande foer framstaellning av nya terapeutiskt anvaendbara kastanosperminglykosider. | |
FI875426A0 (fi) | Foerfarande foer framstaellning av nya antibakteriella guanidinderivat av kinolonkarboxylsyror. | |
FI873336A0 (fi) | Nya makromolekyler. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA | Application withdrawn |
Owner name: PFIZER LIMITED |