FI872299A - Heterocykliska analoger av mevalonolaktoner och deras derivat, foerfaranden foer deras framstaellning och deras anvaendning som farmaceutiska medel. - Google Patents
Heterocykliska analoger av mevalonolaktoner och deras derivat, foerfaranden foer deras framstaellning och deras anvaendning som farmaceutiska medel. Download PDFInfo
- Publication number
- FI872299A FI872299A FI872299A FI872299A FI872299A FI 872299 A FI872299 A FI 872299A FI 872299 A FI872299 A FI 872299A FI 872299 A FI872299 A FI 872299A FI 872299 A FI872299 A FI 872299A
- Authority
- FI
- Finland
- Prior art keywords
- deras
- och
- pharmaceutiska
- mevalonolaktoner
- heterocyclis
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/337—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US79119885A | 1985-10-25 | 1985-10-25 | |
US81666486A | 1986-01-07 | 1986-01-07 | |
PCT/EP1986/000598 WO1987002662A2 (en) | 1985-10-25 | 1986-10-21 | Heterocyclic analogs of mevalonolactone and derivatives thereof, processes for their production and their use as pharmaceuticals |
Publications (2)
Publication Number | Publication Date |
---|---|
FI872299A0 FI872299A0 (fi) | 1987-05-25 |
FI872299A true FI872299A (fi) | 1987-05-25 |
Family
ID=27121116
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI872299A FI872299A (fi) | 1985-10-25 | 1987-05-25 | Heterocykliska analoger av mevalonolaktoner och deras derivat, foerfaranden foer deras framstaellning och deras anvaendning som farmaceutiska medel. |
Country Status (12)
Country | Link |
---|---|
EP (1) | EP0221025A1 (de) |
KR (1) | KR900001212B1 (de) |
AU (1) | AU598775B2 (de) |
CA (1) | CA1278794C (de) |
DK (1) | DK321887A (de) |
FI (1) | FI872299A (de) |
HU (1) | HUT48208A (de) |
IL (1) | IL80403A (de) |
NZ (1) | NZ218045A (de) |
PL (1) | PL154130B1 (de) |
PT (1) | PT83610B (de) |
WO (1) | WO1987002662A2 (de) |
Families Citing this family (96)
Publication number | Priority date | Publication date | Assignee | Title |
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US4647576A (en) * | 1984-09-24 | 1987-03-03 | Warner-Lambert Company | Trans-6-[2-(substitutedpyrrol-1-yl)alkyl]-pyran-2-one inhibitors of cholesterol synthesis |
NO881411L (no) * | 1987-04-14 | 1988-10-17 | Bayer Ag | Substituerte pyrroler. |
US5091378A (en) * | 1987-05-22 | 1992-02-25 | E. R. Squibb & Sons, Inc. | Phosphorus-containing HMG-CoA reductase inhibitors, new intermediates and method |
DE3722806A1 (de) * | 1987-07-10 | 1989-01-19 | Hoechst Ag | 7-(1h-pyrrol-3-yl)-substituierte 3,5-dihydroxy-hept-6-ensaeuren, 7-(1h-pyrrol-3-yl)-substituierte 3,5-dihydroxy-heptansaeuren, ihre entsprechenden (delta)-lactone und salze, verfahren zu ihrer herstellung ihre verwendung als arzneimittel, pharmazeutische praeparate und zwischenprodukte |
DE3817808A1 (de) * | 1987-07-21 | 1989-02-02 | Bayer Ag | Verfahren zur herstellung von 2-substituierten pyrrolen |
US4822799A (en) * | 1988-01-27 | 1989-04-18 | Sandoz Pharm. Corp. | Pyrazolopyridine analogs of mevalonolactone and derivatives thereof useful for inhibiting cholesterol biosynthesis in mammals |
NO890988L (no) * | 1988-03-24 | 1989-09-25 | Bayer Ag | Disubstituerte pyrroler. |
EP0339342A1 (de) * | 1988-04-23 | 1989-11-02 | Bayer Ag | N-Substituierte N-Amino-pyrrole |
EP0352575A3 (de) * | 1988-07-28 | 1991-08-21 | Bayer Ag | Substituierte anellierte Pyrrole |
DE3826814A1 (de) * | 1988-08-06 | 1990-02-08 | Hoechst Ag | Neue 6-fluor-3,5-dihydroxycarbonsaeuren und deren derivate, verfahren zu ihrer herstellung, ihre verwendung als arzneimittel, pharmazeutische praeparate und zwischenprodukte |
US5506219A (en) * | 1988-08-29 | 1996-04-09 | E. R. Squibb & Sons, Inc. | Pyridine anchors for HMG-CoA reductase inhibitors |
DE3832570A1 (de) * | 1988-09-24 | 1990-03-29 | Hoechst Ag | 7-substituierte derivate der 3,5-dihydroxyhept-6-insaeure, verfahren zur ihrer herstellung, ihre verwendung als arzneimittel, sowie zwischenprodukte |
AU628862B2 (en) * | 1988-10-03 | 1992-09-24 | Glaxo Group Limited | Substituted n-vinyl imidazole derivatives |
FI94339C (fi) | 1989-07-21 | 1995-08-25 | Warner Lambert Co | Menetelmä farmaseuttisesti käyttökelpoisen /R-(R*,R*)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi |
JPH03184961A (ja) * | 1989-10-10 | 1991-08-12 | Glaxo Group Ltd | 化合物 |
IT1237792B (it) * | 1989-12-21 | 1993-06-17 | Zambon Spa | Composti attivi come inibitori dell'enzima hmg-coa reduttasi |
US5049577A (en) * | 1990-01-29 | 1991-09-17 | E. R. Squibb & Sons, Inc. | 2-pyrrolidone substituted dihydroxy alkanoic, alkenoic and alkynoic acids, compositions and HMG-CoA reductase inhibition therewith |
US5049578A (en) * | 1990-03-09 | 1991-09-17 | E. R. Squibb & Sons, Inc. | 1-aroyl or 1-acyl-2-2pyrrolidinyl-3,5-dihydroxy alkanoic and alkenoic acids, salts, esters and lactones |
US5128366A (en) * | 1990-07-05 | 1992-07-07 | Shinogi & Co., Ltd. | Pyrrole derivatives |
WO1992019240A1 (en) * | 1991-05-01 | 1992-11-12 | University Of New Mexico | Treatment of aberrant cellular states with biomodulators |
WO1992019239A1 (en) * | 1991-05-01 | 1992-11-12 | University Of New Mexico | Treatment of aberrant cellular states with biomodulators |
US20010006644A1 (en) | 1997-07-31 | 2001-07-05 | David J. Bova | Combinations of hmg-coa reductase inhibitors and nicotinic acid and methods for treating hyperlipidemia once a day at night |
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US3168527A (en) * | 1962-06-14 | 1965-02-02 | Parke Davis & Co | 1-aryl-5-(p-fluorophenyl)-pyrrole-2-propionic acid compounds |
US3168532A (en) * | 1963-06-12 | 1965-02-02 | Parke Davis & Co | 1, 5-diarylpyrrole-2-propionic acid compounds |
US3462451A (en) * | 1966-04-25 | 1969-08-19 | Upjohn Co | 2,3-bis(alkoxyphenyl)pyrroles |
DE2261965A1 (de) * | 1971-12-23 | 1973-06-28 | Continental Pharma | Derivate der pyrrolessigsaeure und deren salze sowie von pyrrolacetonitril, verfahren zur herstellung dieser verbindungen, diese verbindungen enthaltende pharmazeutische produkte und verwendung dieser verbindungen und produkte |
US4035394A (en) * | 1976-02-24 | 1977-07-12 | Morton-Norwich Products, Inc. | 5-Phenyl-2-furanyl-oxo or-hydroxy alkanoic acids and ethyl esters as gastric acid antisecretory agents |
HU187137B (en) * | 1982-06-22 | 1985-11-28 | Richter Gedeon Vegyeszet | Process for producing esters of 1-alkyl- orl,4-dialkyl-1h-pyrrol-acetic acid |
WO1984002131A1 (en) * | 1982-11-22 | 1984-06-07 | Sandoz Ag | Analogs of mevalolactone and derivatives thereof, processes for their production, pharmaceutical compositions containing them and their use as pharmaceuticals |
ATE23326T1 (de) * | 1983-01-24 | 1986-11-15 | Sandoz Ag | Mevalonslakton-analoge und ihre derivate, verfahren zu ihrer herstellung, diese enthaltende pharmazeutische zusammensetzungen sowie deren verwendung als heilmittel. |
DE3309355A1 (de) * | 1983-03-16 | 1984-09-27 | Basf Ag, 6700 Ludwigshafen | Verfahren zur herstellung von pyrrolen |
DE3407510A1 (de) * | 1984-03-01 | 1985-09-05 | A. Nattermann & Cie GmbH, 5000 Köln | (omega)-aryl-alkylthienylalk(a,e)nsaeuren und ihre derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate |
DE3582674D1 (de) * | 1984-06-22 | 1991-05-29 | Sandoz Ag | Pyrazolanaloge von mevalonolakton und abkoemmlinge davon, verfahren zu deren herstellung und deren verwendung. |
DE3581638D1 (de) * | 1984-12-04 | 1991-03-07 | Sandoz Ag | Inden-analoga von mevalonolakton und ihre derivate. |
-
1986
- 1986-10-21 KR KR1019870700553A patent/KR900001212B1/ko not_active IP Right Cessation
- 1986-10-21 HU HU865313A patent/HUT48208A/hu unknown
- 1986-10-21 WO PCT/EP1986/000598 patent/WO1987002662A2/en active Application Filing
- 1986-10-21 AU AU65994/86A patent/AU598775B2/en not_active Ceased
- 1986-10-21 EP EP86810470A patent/EP0221025A1/de not_active Withdrawn
- 1986-10-23 IL IL80403A patent/IL80403A/xx unknown
- 1986-10-23 NZ NZ218045A patent/NZ218045A/xx unknown
- 1986-10-23 PT PT83610A patent/PT83610B/pt not_active IP Right Cessation
- 1986-10-24 PL PL1986262032A patent/PL154130B1/pl unknown
- 1986-10-24 CA CA000521333A patent/CA1278794C/en not_active Expired - Lifetime
-
1987
- 1987-05-25 FI FI872299A patent/FI872299A/fi not_active Application Discontinuation
- 1987-06-24 DK DK321887A patent/DK321887A/da not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
HUT48208A (en) | 1989-05-29 |
IL80403A0 (en) | 1987-01-30 |
FI872299A0 (fi) | 1987-05-25 |
KR870700602A (ko) | 1987-12-30 |
IL80403A (en) | 1990-09-17 |
NZ218045A (en) | 1990-03-27 |
EP0221025A1 (de) | 1987-05-06 |
KR900001212B1 (ko) | 1990-02-28 |
WO1987002662A3 (en) | 1987-12-17 |
AU598775B2 (en) | 1990-07-05 |
DK321887D0 (da) | 1987-06-24 |
CA1278794C (en) | 1991-01-08 |
PL262032A1 (en) | 1988-07-21 |
AU6599486A (en) | 1987-05-19 |
PT83610B (pt) | 1989-05-31 |
DK321887A (da) | 1987-06-24 |
WO1987002662A2 (en) | 1987-05-07 |
PL154130B1 (en) | 1991-07-31 |
PT83610A (en) | 1986-11-01 |
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Legal Events
Date | Code | Title | Description |
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FD | Application lapsed |
Owner name: SANDOZ AG |