HUT48208A - Process for producing heterocyclic analogues of mevalolactone derivatives and pharmaceutical compositions comprising such compounds - Google Patents
Process for producing heterocyclic analogues of mevalolactone derivatives and pharmaceutical compositions comprising such compoundsInfo
- Publication number
- HUT48208A HUT48208A HU865313A HU531386A HUT48208A HU T48208 A HUT48208 A HU T48208A HU 865313 A HU865313 A HU 865313A HU 531386 A HU531386 A HU 531386A HU T48208 A HUT48208 A HU T48208A
- Authority
- HU
- Hungary
- Prior art keywords
- mevalolactone
- derivatives
- compounds
- pharmaceutical compositions
- heterocyclic analogues
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/337—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US79119885A | 1985-10-25 | 1985-10-25 | |
US81666486A | 1986-01-07 | 1986-01-07 | |
PCT/EP1986/000598 WO1987002662A2 (en) | 1985-10-25 | 1986-10-21 | Heterocyclic analogs of mevalonolactone and derivatives thereof, processes for their production and their use as pharmaceuticals |
Publications (1)
Publication Number | Publication Date |
---|---|
HUT48208A true HUT48208A (en) | 1989-05-29 |
Family
ID=27121116
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU865313A HUT48208A (en) | 1985-10-25 | 1986-10-21 | Process for producing heterocyclic analogues of mevalolactone derivatives and pharmaceutical compositions comprising such compounds |
Country Status (12)
Country | Link |
---|---|
EP (1) | EP0221025A1 (hu) |
KR (1) | KR900001212B1 (hu) |
AU (1) | AU598775B2 (hu) |
CA (1) | CA1278794C (hu) |
DK (1) | DK321887A (hu) |
FI (1) | FI872299A0 (hu) |
HU (1) | HUT48208A (hu) |
IL (1) | IL80403A (hu) |
NZ (1) | NZ218045A (hu) |
PL (1) | PL154130B1 (hu) |
PT (1) | PT83610B (hu) |
WO (1) | WO1987002662A2 (hu) |
Families Citing this family (96)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4647576A (en) * | 1984-09-24 | 1987-03-03 | Warner-Lambert Company | Trans-6-[2-(substitutedpyrrol-1-yl)alkyl]-pyran-2-one inhibitors of cholesterol synthesis |
NO881411L (no) * | 1987-04-14 | 1988-10-17 | Bayer Ag | Substituerte pyrroler. |
US5091378A (en) * | 1987-05-22 | 1992-02-25 | E. R. Squibb & Sons, Inc. | Phosphorus-containing HMG-CoA reductase inhibitors, new intermediates and method |
DE3722806A1 (de) * | 1987-07-10 | 1989-01-19 | Hoechst Ag | 7-(1h-pyrrol-3-yl)-substituierte 3,5-dihydroxy-hept-6-ensaeuren, 7-(1h-pyrrol-3-yl)-substituierte 3,5-dihydroxy-heptansaeuren, ihre entsprechenden (delta)-lactone und salze, verfahren zu ihrer herstellung ihre verwendung als arzneimittel, pharmazeutische praeparate und zwischenprodukte |
DE3817808A1 (de) * | 1987-07-21 | 1989-02-02 | Bayer Ag | Verfahren zur herstellung von 2-substituierten pyrrolen |
US4822799A (en) * | 1988-01-27 | 1989-04-18 | Sandoz Pharm. Corp. | Pyrazolopyridine analogs of mevalonolactone and derivatives thereof useful for inhibiting cholesterol biosynthesis in mammals |
NO890988L (no) * | 1988-03-24 | 1989-09-25 | Bayer Ag | Disubstituerte pyrroler. |
EP0339342A1 (de) * | 1988-04-23 | 1989-11-02 | Bayer Ag | N-Substituierte N-Amino-pyrrole |
EP0352575A3 (de) * | 1988-07-28 | 1991-08-21 | Bayer Ag | Substituierte anellierte Pyrrole |
DE3826814A1 (de) * | 1988-08-06 | 1990-02-08 | Hoechst Ag | Neue 6-fluor-3,5-dihydroxycarbonsaeuren und deren derivate, verfahren zu ihrer herstellung, ihre verwendung als arzneimittel, pharmazeutische praeparate und zwischenprodukte |
US5506219A (en) * | 1988-08-29 | 1996-04-09 | E. R. Squibb & Sons, Inc. | Pyridine anchors for HMG-CoA reductase inhibitors |
DE3832570A1 (de) * | 1988-09-24 | 1990-03-29 | Hoechst Ag | 7-substituierte derivate der 3,5-dihydroxyhept-6-insaeure, verfahren zur ihrer herstellung, ihre verwendung als arzneimittel, sowie zwischenprodukte |
DK483689A (da) * | 1988-10-03 | 1990-04-04 | Glaxo Group Ltd | Imidazolderivater |
FI94339C (fi) | 1989-07-21 | 1995-08-25 | Warner Lambert Co | Menetelmä farmaseuttisesti käyttökelpoisen /R-(R*,R*)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi |
CA2027179A1 (en) * | 1989-10-10 | 1991-04-11 | Barry C. Ross | Chemical compounds |
IT1237792B (it) * | 1989-12-21 | 1993-06-17 | Zambon Spa | Composti attivi come inibitori dell'enzima hmg-coa reduttasi |
US5049577A (en) * | 1990-01-29 | 1991-09-17 | E. R. Squibb & Sons, Inc. | 2-pyrrolidone substituted dihydroxy alkanoic, alkenoic and alkynoic acids, compositions and HMG-CoA reductase inhibition therewith |
US5049578A (en) * | 1990-03-09 | 1991-09-17 | E. R. Squibb & Sons, Inc. | 1-aroyl or 1-acyl-2-2pyrrolidinyl-3,5-dihydroxy alkanoic and alkenoic acids, salts, esters and lactones |
US5128366A (en) * | 1990-07-05 | 1992-07-07 | Shinogi & Co., Ltd. | Pyrrole derivatives |
WO1992019239A1 (en) * | 1991-05-01 | 1992-11-12 | University Of New Mexico | Treatment of aberrant cellular states with biomodulators |
WO1992019240A1 (en) * | 1991-05-01 | 1992-11-12 | University Of New Mexico | Treatment of aberrant cellular states with biomodulators |
US20010006644A1 (en) | 1997-07-31 | 2001-07-05 | David J. Bova | Combinations of hmg-coa reductase inhibitors and nicotinic acid and methods for treating hyperlipidemia once a day at night |
CA2384782A1 (en) | 1999-09-14 | 2001-03-22 | Merck Frosst Canada & Co. | Carboxylic acids and acylsulfonamides, compositions containing such compounds and methods of treatment |
DE60008399T2 (de) | 1999-09-14 | 2004-12-09 | Merck Frosst Canada & Co, Kirkland | Carbonsäuren und acylsulfonamide, solche verbindungen enthaltende zubereitungen und behandlungsmethoden |
US7276249B2 (en) | 2002-05-24 | 2007-10-02 | Elan Pharma International, Ltd. | Nanoparticulate fibrate formulations |
AU2002254567B2 (en) | 2001-04-11 | 2007-10-11 | Bristol-Myers Squibb Company | Amino acid complexes of C-aryl glucosides for treatment of diabetes and method |
US7238671B2 (en) | 2001-10-18 | 2007-07-03 | Bristol-Myers Squibb Company | Human glucagon-like-peptide-1 mimics and their use in the treatment of diabetes and related conditions |
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US6806381B2 (en) | 2001-11-02 | 2004-10-19 | Bristol-Myers Squibb Company | Process for the preparation of aniline-derived thyroid receptor ligands |
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US7250444B2 (en) | 2003-08-11 | 2007-07-31 | Pfizer Inc. | Pyrrole-based HMG-CoA reductase inhibitors |
US7829552B2 (en) | 2003-11-19 | 2010-11-09 | Metabasis Therapeutics, Inc. | Phosphorus-containing thyromimetics |
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US7145040B2 (en) | 2004-07-02 | 2006-12-05 | Bristol-Myers Squibb Co. | Process for the preparation of amino acids useful in the preparation of peptide receptor modulators |
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US7517991B2 (en) | 2004-10-12 | 2009-04-14 | Bristol-Myers Squibb Company | N-sulfonylpiperidine cannabinoid receptor 1 antagonists |
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US20090011994A1 (en) | 2007-07-06 | 2009-01-08 | Bristol-Myers Squibb Company | Non-basic melanin concentrating hormone receptor-1 antagonists and methods |
WO2009018065A2 (en) | 2007-07-27 | 2009-02-05 | Bristol-Myers Squibb Company | Novel glucokinase activators and methods of using same |
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US20100256153A1 (en) | 2009-03-27 | 2010-10-07 | Bristol-Myers Squibb Company | Methods for preventing or reducing risk of mortality |
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Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3168527A (en) * | 1962-06-14 | 1965-02-02 | Parke Davis & Co | 1-aryl-5-(p-fluorophenyl)-pyrrole-2-propionic acid compounds |
US3168532A (en) * | 1963-06-12 | 1965-02-02 | Parke Davis & Co | 1, 5-diarylpyrrole-2-propionic acid compounds |
US3462451A (en) * | 1966-04-25 | 1969-08-19 | Upjohn Co | 2,3-bis(alkoxyphenyl)pyrroles |
DE2261965A1 (de) * | 1971-12-23 | 1973-06-28 | Continental Pharma | Derivate der pyrrolessigsaeure und deren salze sowie von pyrrolacetonitril, verfahren zur herstellung dieser verbindungen, diese verbindungen enthaltende pharmazeutische produkte und verwendung dieser verbindungen und produkte |
US4035394A (en) * | 1976-02-24 | 1977-07-12 | Morton-Norwich Products, Inc. | 5-Phenyl-2-furanyl-oxo or-hydroxy alkanoic acids and ethyl esters as gastric acid antisecretory agents |
HU187137B (en) * | 1982-06-22 | 1985-11-28 | Richter Gedeon Vegyeszet | Process for producing esters of 1-alkyl- orl,4-dialkyl-1h-pyrrol-acetic acid |
AU570021B2 (en) * | 1982-11-22 | 1988-03-03 | Novartis Ag | Analogs of mevalolactone |
IE840153L (en) * | 1983-01-24 | 1984-07-24 | Sandoz Ltd | Mevalonolactone analogues and related hydroxy acids for¹control of blood cholesterol levels. |
DE3309355A1 (de) * | 1983-03-16 | 1984-09-27 | Basf Ag, 6700 Ludwigshafen | Verfahren zur herstellung von pyrrolen |
DE3407510A1 (de) * | 1984-03-01 | 1985-09-05 | A. Nattermann & Cie GmbH, 5000 Köln | (omega)-aryl-alkylthienylalk(a,e)nsaeuren und ihre derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate |
WO1986000307A2 (en) * | 1984-06-22 | 1986-01-16 | Sandoz Ag | Pyrazole analogs of mevalonolactone and derivatives thereof, processes for their production and their use |
KR910003427B1 (ko) * | 1984-12-04 | 1991-05-31 | 산도즈 파마슈티칼스 코포레이션 | 메발로노락톤의 인덴동족체 및 이들의 유도체의 제법 |
-
1986
- 1986-10-21 HU HU865313A patent/HUT48208A/hu unknown
- 1986-10-21 KR KR1019870700553A patent/KR900001212B1/ko not_active IP Right Cessation
- 1986-10-21 EP EP86810470A patent/EP0221025A1/en not_active Withdrawn
- 1986-10-21 WO PCT/EP1986/000598 patent/WO1987002662A2/en active Application Filing
- 1986-10-21 AU AU65994/86A patent/AU598775B2/en not_active Ceased
- 1986-10-23 IL IL80403A patent/IL80403A/xx unknown
- 1986-10-23 NZ NZ218045A patent/NZ218045A/xx unknown
- 1986-10-23 PT PT83610A patent/PT83610B/pt not_active IP Right Cessation
- 1986-10-24 CA CA000521333A patent/CA1278794C/en not_active Expired - Lifetime
- 1986-10-24 PL PL1986262032A patent/PL154130B1/pl unknown
-
1987
- 1987-05-25 FI FI872299A patent/FI872299A0/fi not_active Application Discontinuation
- 1987-06-24 DK DK321887A patent/DK321887A/da not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
AU6599486A (en) | 1987-05-19 |
DK321887D0 (da) | 1987-06-24 |
PT83610A (en) | 1986-11-01 |
KR900001212B1 (ko) | 1990-02-28 |
KR870700602A (ko) | 1987-12-30 |
IL80403A (en) | 1990-09-17 |
PT83610B (pt) | 1989-05-31 |
EP0221025A1 (en) | 1987-05-06 |
NZ218045A (en) | 1990-03-27 |
DK321887A (da) | 1987-06-24 |
FI872299A (fi) | 1987-05-25 |
IL80403A0 (en) | 1987-01-30 |
WO1987002662A3 (en) | 1987-12-17 |
AU598775B2 (en) | 1990-07-05 |
CA1278794C (en) | 1991-01-08 |
PL262032A1 (en) | 1988-07-21 |
WO1987002662A2 (en) | 1987-05-07 |
FI872299A0 (fi) | 1987-05-25 |
PL154130B1 (en) | 1991-07-31 |
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