FI86727B - Foerfarande foer framstaellning av terapeutiskt anvaendbara 2-fenyl- eller halogenfenyl-7,8,9,10 -tetrahydropyrido/e//1,2,4/triazolo/1,5-c/-pyrimidoner. - Google Patents

Foerfarande foer framstaellning av terapeutiskt anvaendbara 2-fenyl- eller halogenfenyl-7,8,9,10 -tetrahydropyrido/e//1,2,4/triazolo/1,5-c/-pyrimidoner. Download PDF

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Publication number
FI86727B
FI86727B FI882081A FI882081A FI86727B FI 86727 B FI86727 B FI 86727B FI 882081 A FI882081 A FI 882081A FI 882081 A FI882081 A FI 882081A FI 86727 B FI86727 B FI 86727B
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FI
Finland
Prior art keywords
compound
triazolo
compounds
formula
tetrahydropyrido
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Application number
FI882081A
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English (en)
Finnish (fi)
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FI882081A0 (fi
FI882081A (fi
FI86727C (sv
Inventor
John E Francis
Karl O Gelotte
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Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Priority claimed from US07/020,055 external-priority patent/US4831013A/en
Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag
Publication of FI882081A0 publication Critical patent/FI882081A0/fi
Publication of FI882081A publication Critical patent/FI882081A/fi
Publication of FI86727B publication Critical patent/FI86727B/fi
Application granted granted Critical
Publication of FI86727C publication Critical patent/FI86727C/sv

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/02—Heterocyclic radicals containing only nitrogen as ring hetero atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pulmonology (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Phenolic Resins Or Amino Resins (AREA)

Claims (3)

1. Förfarande för framställning av 2-fenyl- eller halofenyl-tetrahydro-pyrido[e][1,2,4]triazolo[1,5-c]pyrimidoner, vilka Sr lämpliga som bensodiazepinreceptoragonister/antagonister och vilka har formeln Ia /R’ r'N^yVn L ’ 1 o*) H 25 86727 i vilken R Sr a-metylbensyl, karbamoyl, fenylsulfonyl, kar-boximetyl, lägalkoxikarbonylmetyl, karbamoylmetyl, cyanome-tyl, pyridylmetyl eller tetrazolylmetyl och R^ betecknar fe-nyl eller halofenyl, tautomerer och farmaceutiskt godtagbara salter dSrav, kännetecknat därav, att en före-ning med formeln X %^vCN kAz (x) i vilken R' Sr vSte, lägalkoxikarbonyl eller R, som betecknar detsamma som ovan, och Z Sr -NCH(=0)-lägalkyl, omsSttes med en hydra2id med formeln XI 0=C-Rx NH (χΙ) / h2n i vilken R! betecknar detsamma som ovan, och, vid behov, en erhällen förening, i vilken R' betecknar lägalkoxikarbo-nyl, hydrolyseras och a) en erhällen förening alkyleras eller b) en erhällen förening acyleras eller c) en erhällen förening sulfoneras eller d) en erhällen förening alkyleras och hydrolyseras eller e) en erhällen förening alkyleras, hydrolyseras och ami-deras eller f) en erhällen förening karbamoyleras eller 26 86727 g) en erhällen förening alkyleras och den erhällna resten R omvandlas tili en tetrazolylring, och/eller ett sait överföres i en fri förening eller i ett annat sait och/eller en erhällen fri förening, vilken har en saltbildande grupp, överföres i ett farmaceutiskt godtagbart sait.
2. Förfarande enligt patentkravet 1, känneteck-n a t därav, att man framställer 2-(2-fluorfenyl)-9-(3-pikolyl)-7,8,9,10-tetrahydropyrido-[3,4-e][1,2,4]triazolo[1,5-c]pyrimidin-5(6H)on eller farmaceutiskt godtagbara salter därav.
3. Förfarande enligt patentkravet l, känneteck-n a t därav, att man framställer 9-etoxikarbonylmetyl-2-(2-fluorfenyl)-7,8,9,10-tetrahyd-ropyridof 3,4-e][1,2,4]triazolo[1,5-c]pyrimidin-5(6H)on och farmaceutiskt godtagbara salter därav.
FI882081A 1986-09-30 1988-05-04 Förfarande för framställning av terapeutiskt användbara 2-fenyl- eller halogenfenyl-7,8,9,10-tetrahydropyrido/e//1,2,4/triazolo/1,5-c/-pyrim idoner FI86727C (sv)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US91317386A 1986-09-30 1986-09-30
US91317386 1986-09-30
US2005587 1987-02-27
US07/020,055 US4831013A (en) 1986-03-20 1987-02-27 2-substituted-e-fused-[1,2,4]triazolo[1,5-c]pyrimidines, pharmaceutical compositions, and uses thereof
PCT/EP1987/000547 WO1988002370A1 (en) 1986-09-30 1987-09-25 2-substituted-e-fused-[1,2,4]triazolo[1,5-c]pyrimidines pharmaceutical compositions and uses thereof
EP8700547 1987-09-25
CN89106168 1989-08-03
CN89106168A CN1049120A (zh) 1986-09-30 1989-08-03 制取合成材料的方法

Publications (4)

Publication Number Publication Date
FI882081A0 FI882081A0 (fi) 1988-05-04
FI882081A FI882081A (fi) 1988-05-04
FI86727B true FI86727B (fi) 1992-06-30
FI86727C FI86727C (sv) 1992-10-12

Family

ID=36741346

Family Applications (1)

Application Number Title Priority Date Filing Date
FI882081A FI86727C (sv) 1986-09-30 1988-05-04 Förfarande för framställning av terapeutiskt användbara 2-fenyl- eller halogenfenyl-7,8,9,10-tetrahydropyrido/e//1,2,4/triazolo/1,5-c/-pyrim idoner

Country Status (13)

Country Link
EP (1) EP0263071B1 (sv)
JP (1) JPH06104666B2 (sv)
CN (1) CN1049120A (sv)
AT (1) ATE79380T1 (sv)
AU (1) AU612331B2 (sv)
CA (1) CA1317590C (sv)
DE (1) DE3781080T2 (sv)
DK (1) DK289888A (sv)
ES (1) ES2051772T3 (sv)
FI (1) FI86727C (sv)
GR (1) GR3006247T3 (sv)
IE (1) IE59815B1 (sv)
WO (1) WO1988002370A1 (sv)

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CA1331178C (en) * 1988-02-05 1994-08-02 James J. Wade Triazolo ¬1,5-c| pyrimido ¬1,4| azines as bronchodilators
US5173492A (en) * 1989-09-14 1992-12-22 Kyowa Hakko Kogyo Co., Ltd. s-Triazolo(3,4-I)purine derivatives
CA2029651C (en) * 1989-11-17 2000-06-06 David D. Davey Tricyclic pteridinones and a process for their preparation
US5095015A (en) * 1990-07-24 1992-03-10 Neurogen Corporation Certain azacycloalkyl imidazopyrimidines; a new class of gaba brain receptor ligands
US5185446A (en) * 1990-09-04 1993-02-09 Neurogen Corporation Certain cycloalkyl imidazopyrimidines; a new class of gaba brainreceptor ligands
US5206222A (en) * 1991-05-22 1993-04-27 Vanderbilt University Methods for the reduction of myocardial reperfusion injury
GB9111130D0 (en) * 1991-05-23 1991-07-17 Ici Plc Azole derivatives
GB9111131D0 (en) * 1991-05-23 1991-07-17 Ici Plc Heterocyclic compounds
GB9125002D0 (en) * 1991-11-25 1992-01-22 Ici Plc Azole derivatives
IT1264901B1 (it) * 1993-06-29 1996-10-17 Schering Plough S P A Analoghi eterociclici di 1,2,4-triazolo(15-c)pirimidine ad attivita' antagonista per il recettore a2 dell'adenosina
ATE208199T1 (de) * 1993-07-27 2001-11-15 Kyowa Hakko Kogyo Kk Arzneimittel gegen parkinsonsche krankheit
US5677309A (en) * 1996-03-22 1997-10-14 Neurogen Corporation 1,2,4-triazolo 4,3-c! quinazolin-3-ones and 1,2,4-triazolo 4,3-c!quinazolin-3-thiones; a new class of GABA brain receptor ligands
US5955465A (en) * 1996-03-22 1999-09-21 Neurogen Corporation 1,2,4-triazolo 4,3-c!quinazolin-3-ones and 1,2,4-triazolo 4,3-c!quinazolin-3-thiones
CN1060698C (zh) * 1996-04-26 2001-01-17 清华大学 可完成多种快速原型制造工艺的多功能设备
CN1061279C (zh) * 1996-06-21 2001-01-31 李琎 制造铁铝或铁三铝金属间化合物零件的方法
JP4195729B2 (ja) 1997-03-24 2008-12-10 協和醗酵工業株式会社 ［１，２，４］トリアゾロ［１，５−ｃ］ピリミジン誘導体
CA2326716C (en) * 1998-04-03 2006-12-12 Otsuka Pharmaceutical Factory, Inc. Triazolopurine derivative, pharmaceutical composition containing the derivative, adenosine a3 receptor ligand, and remedy for asthma
DE19826843A1 (de) * 1998-06-16 1999-12-23 Boehringer Ingelheim Pharma Neue Imidazotriazolopyrimidine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
US6448253B1 (en) * 1998-09-16 2002-09-10 King Pharmaceuticals Research And Development, Inc. Adenosine A3 receptor modulators
ATE265459T1 (de) 1999-09-28 2004-05-15 Otsuka Pharma Co Ltd Triazolpurin-derivate, medikamentzusammensetzungen, die diese enthalten und mittel, die affinität zum adenosin a3 rezeptor zeigen
KR100687954B1 (ko) * 2001-10-15 2007-02-27 쉐링 코포레이션 아데노신 Ａ2ａ 수용체 길항제로서의이미다조（4,3-ｅ）-1,2,4-트리아졸로（1,5-ｃ） 피리미딘
US7196106B2 (en) 2002-11-05 2007-03-27 Merck & Co., Inc Cyanothiophene derivatives, compositions containing such compounds and methods of use
AU2004244906A1 (en) * 2003-06-10 2004-12-16 Kyowa Hakko Kirin Co., Ltd. A method of treating an anxiety disorder
WO2014101113A1 (en) * 2012-12-28 2014-07-03 Merck Sharp & Dohme Corp. Piperazine-substituted 7-methoxy-[1,2,4]triazolo[1,5-c]quinazolin-5-amine compounds with a2a antagonist properties
GB2575490A (en) * 2018-07-12 2020-01-15 Recordati Ind Chimica E Farmaceutica Spa P2X3 receptor antagonists
JP7280883B2 (ja) * 2018-08-30 2023-05-24 テラ・ストーン株式会社 キサンチンオキシダーゼを阻害するためのヒドラジノプリン化合物及びトリアゾロプリン化合物
CN113692306A (zh) * 2019-04-03 2021-11-23 泰拉强石株式会社 基于胸腺嘧啶核酸碱基的三唑并嘧啶类及其制造方法
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CN116380599B (zh) * 2023-06-06 2023-08-11 江苏省沙钢钢铁研究院有限公司 一种大尺寸非金属夹杂物的制备方法及其应用

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DE3677445D1 (de) * 1985-09-30 1991-03-14 Ciba Geigy Ag 2-substituierte-e-kondensierte(1,5-c)-pyrimidine, pharmazeutische zubereitungen und ihre verwendung.

Also Published As

Publication number Publication date
DE3781080T2 (de) 1992-12-24
AU8027187A (en) 1988-04-21
EP0263071A1 (en) 1988-04-06
EP0263071B1 (en) 1992-08-12
FI882081A0 (fi) 1988-05-04
JPH06104666B2 (ja) 1994-12-21
WO1988002370A1 (en) 1988-04-07
JPH01500996A (ja) 1989-04-06
CA1317590C (en) 1993-05-11
AU612331B2 (en) 1991-07-11
ES2051772T3 (es) 1994-07-01
IE59815B1 (en) 1994-04-06
DK289888D0 (da) 1988-05-27
FI882081A (fi) 1988-05-04
CN1049120A (zh) 1991-02-13
IE872615L (en) 1988-03-30
GR3006247T3 (sv) 1993-06-21
ATE79380T1 (de) 1992-08-15
FI86727C (sv) 1992-10-12
DE3781080D1 (de) 1992-09-17
DK289888A (da) 1988-05-27

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