FI851876L - (r)-alfa-etyl-2-oxo-1 pyrrolidinacetamid. - Google Patents
(r)-alfa-etyl-2-oxo-1 pyrrolidinacetamid.Info
- Publication number
- FI851876L FI851876L FI851876A FI851876A FI851876L FI 851876 L FI851876 L FI 851876L FI 851876 A FI851876 A FI 851876A FI 851876 A FI851876 A FI 851876A FI 851876 L FI851876 L FI 851876L
- Authority
- FI
- Finland
- Prior art keywords
- radical
- oxo
- alpha
- ethyl
- pyrrolidinacetamide
- Prior art date
Links
- LBTUTDYXOOUODJ-UHFFFAOYSA-N 2-pyrrolidin-1-ylacetamide Chemical compound NC(=O)CN1CCCC1 LBTUTDYXOOUODJ-UHFFFAOYSA-N 0.000 title 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 abstract 2
- HNNJFUDLLWOVKZ-GSVOUGTGSA-N (2r)-2-aminobutanamide Chemical compound CC[C@@H](N)C(N)=O HNNJFUDLLWOVKZ-GSVOUGTGSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 229910021529 ammonia Inorganic materials 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- HPHUVLMMVZITSG-ZCFIWIBFSA-N levetiracetam Chemical compound CC[C@H](C(N)=O)N1CCCC1=O HPHUVLMMVZITSG-ZCFIWIBFSA-N 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000001988 toxicity Effects 0.000 abstract 1
- 231100000419 toxicity Toxicity 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
- C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB848412358A GB8412358D0 (en) | 1984-05-15 | 1984-05-15 | Pharmaceutical composition |
GB8412358 | 1984-05-15 |
Publications (4)
Publication Number | Publication Date |
---|---|
FI851876A0 FI851876A0 (fi) | 1985-05-13 |
FI851876L true FI851876L (fi) | 1985-11-16 |
FI80674B FI80674B (fi) | 1990-03-30 |
FI80674C FI80674C (fi) | 1990-07-10 |
Family
ID=10560975
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI851876A FI80674C (fi) | 1984-05-15 | 1985-05-13 | Foerfarande foer framstaellning av terapeutiskt aktivt (r)-alfa-etyl-2-oxo-1-pyrrolidinacetamid. |
Country Status (23)
Country | Link |
---|---|
US (2) | US4696942A (fi) |
EP (1) | EP0165919B1 (fi) |
JP (1) | JPS60255764A (fi) |
AT (1) | ATE45348T1 (fi) |
AU (1) | AU574175B2 (fi) |
BG (2) | BG50272A3 (fi) |
CA (1) | CA1237138A (fi) |
CY (1) | CY1568A (fi) |
DE (1) | DE3572168D1 (fi) |
DK (1) | DK163500C (fi) |
ES (2) | ES8703419A1 (fi) |
FI (1) | FI80674C (fi) |
GB (1) | GB8412358D0 (fi) |
GR (1) | GR851156B (fi) |
HK (1) | HK62692A (fi) |
IE (1) | IE58393B1 (fi) |
IL (1) | IL75180A (fi) |
NO (1) | NO164535C (fi) |
PL (2) | PL147387B1 (fi) |
PT (1) | PT80461B (fi) |
SG (1) | SG80190G (fi) |
SU (3) | SU1417799A3 (fi) |
ZA (1) | ZA853636B (fi) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8412357D0 (en) * | 1984-05-15 | 1984-06-20 | Ucb Sa | Pharmaceutical composition |
DE3420193A1 (de) * | 1984-05-30 | 1985-12-05 | Boehringer Ingelheim KG, 6507 Ingelheim | Neue substituierte pyrrolidinone, verfahren zu ihrer herstellung und arzneimittel |
GB8827389D0 (en) * | 1988-11-23 | 1988-12-29 | Ucb Sa | Process for preparation of(s)alpha-ethyl-2-oxo-1-pyrrolidineacetamide |
US6124473A (en) * | 1998-05-08 | 2000-09-26 | Ucb, S.A. | Process for preparing (s)- and (R)-α-ethyl-2-oxo-1-pyrrolidineacetamide |
GB0004297D0 (en) * | 2000-02-23 | 2000-04-12 | Ucb Sa | 2-oxo-1 pyrrolidine derivatives process for preparing them and their uses |
DE60134337D1 (de) * | 2000-11-21 | 2008-07-17 | Ucb Pharma Sa | N-alkylierte gaba verbindungen, verfahren zu deren |
WO2002076451A1 (en) * | 2001-03-22 | 2002-10-03 | Ucb, S.A. | Use of certain substituted pyrrolidones such as piracetam in the treatment of viral and other diseases |
DE60229267D1 (de) | 2001-08-10 | 2008-11-20 | Ucb Pharma Sa | Oxopyrrolidin verbindungen, verfahren zur herstellung dieser verbindungen und deren verwendung zur herstellung von levetiracetam und analogen |
EP1706376B1 (en) | 2003-12-02 | 2009-03-04 | UCB Pharma, S.A. | Imidazole derivatives, processes for preparing them and their uses |
CA2488325C (en) * | 2004-11-22 | 2010-08-24 | Apotex Pharmachem Inc. | Improved process for the preparation of (s)-alpha-ethyl-2-oxo-1-pyrrolidineacetamide and (r)-alpha-ethyl-2-oxo-1-pyrrolidineacetamide |
EP1891042B1 (en) | 2005-06-01 | 2013-10-02 | UCB Pharma, S.A. | 2-oxo-1-pyrrolidine derivatives, processes for preparing them and their therapeutic use on the central nervous system |
AU2009303834B2 (en) | 2008-10-16 | 2016-08-11 | The Johns Hopkins University | Methods and compositions for improving cognitive function |
KR20120102058A (ko) | 2009-10-23 | 2012-09-17 | 유씨비 파마, 에스.에이. | 2-옥소-1-피롤리디닐 이미다조티아디아졸 유도체 |
CA2789014C (en) * | 2010-02-09 | 2019-01-15 | Michela Gallagher | Methods and compositions for improving cognitive function |
SI2699581T1 (sl) | 2011-04-18 | 2016-02-29 | Ucb Biopharma Sprl | Derivati 2-okso-1-imidazolidinil imidazotiadiazola |
CN102633675A (zh) * | 2012-04-10 | 2012-08-15 | 南京大学 | 一种dl-2-氨基丁酰胺制备方法 |
EP3610890A1 (en) | 2012-11-14 | 2020-02-19 | The Johns Hopkins University | Methods and compositions for treating schizophrenia |
US10806717B2 (en) | 2013-03-15 | 2020-10-20 | The Johns Hopkins University | Methods and compositions for improving cognitive function |
AU2014228512A1 (en) | 2013-03-15 | 2015-10-01 | Agenebio, Inc. | Methods and compositions for improving cognitive function |
KR20220039824A (ko) | 2014-01-21 | 2022-03-29 | 얀센 파마슈티카 엔.브이. | 대사 조절형 글루탐산 작동성 수용체 제2아형의 양성 알로스테릭 조절제 또는 오르토스테릭 작동제를 포함하는 조합 및 그 용도 |
IL279202B2 (en) | 2014-01-21 | 2023-09-01 | Janssen Pharmaceutica Nv | Combinations containing positive allosteric modulators or orthosteric agonists of metabotropic glutamatergic subtype 2 receptor and their use |
JP6899043B2 (ja) | 2015-05-22 | 2021-07-07 | エージンバイオ, インコーポレイテッド | レベチラセタムの持続放出性医薬組成物 |
SG11202105863PA (en) | 2018-12-04 | 2021-07-29 | Metys Pharmaceuticals AG | Synergistic compositions comprising (r)-2-(2-oxopyrrolidin-1-yl)butanamide and (s)-2-(2-oxopyrrolidin-1-yl)butanamide in a non-racemic ratio |
US11384050B1 (en) | 2021-02-03 | 2022-07-12 | Vitaworks Ip, Llc | Method for preparing levetiracetam and intermediates thereof |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1309692A (en) * | 1970-02-13 | 1973-03-14 | Ucb Sa | N-substituted lactams |
GB1583871A (en) * | 1976-10-19 | 1981-02-04 | Ucb Sa | Anti-aggregants |
FR2418790A1 (fr) * | 1978-03-02 | 1979-09-28 | Philagro Sa | Nouveaux derives de pyrrolidinone-2 et compositions herbicides les contenant |
AU579863B2 (en) * | 1984-05-16 | 1988-12-15 | Williams, David Andrew | A parking control apparatus |
-
1984
- 1984-05-15 GB GB848412358A patent/GB8412358D0/en active Pending
-
1985
- 1985-05-13 GR GR851156A patent/GR851156B/el unknown
- 1985-05-13 FI FI851876A patent/FI80674C/fi not_active IP Right Cessation
- 1985-05-13 IL IL75180A patent/IL75180A/xx unknown
- 1985-05-14 IE IE119285A patent/IE58393B1/en not_active IP Right Cessation
- 1985-05-14 PT PT80461A patent/PT80461B/pt not_active IP Right Cessation
- 1985-05-14 EP EP85870068A patent/EP0165919B1/fr not_active Expired
- 1985-05-14 PL PL1985257386A patent/PL147387B1/pl unknown
- 1985-05-14 AU AU42529/85A patent/AU574175B2/en not_active Ceased
- 1985-05-14 DE DE8585870068T patent/DE3572168D1/de not_active Expired
- 1985-05-14 US US06/733,791 patent/US4696942A/en not_active Expired - Lifetime
- 1985-05-14 JP JP60102530A patent/JPS60255764A/ja active Pending
- 1985-05-14 BG BG70237A patent/BG50272A3/xx unknown
- 1985-05-14 ES ES543125A patent/ES8703419A1/es not_active Expired
- 1985-05-14 BG BG94053A patent/BG60030A3/xx unknown
- 1985-05-14 DK DK212885A patent/DK163500C/da not_active IP Right Cessation
- 1985-05-14 SU SU3892951A patent/SU1417799A3/ru active
- 1985-05-14 PL PL1985253373A patent/PL144345B1/pl unknown
- 1985-05-14 ZA ZA853636A patent/ZA853636B/xx unknown
- 1985-05-14 AT AT85870068T patent/ATE45348T1/de not_active IP Right Cessation
- 1985-05-14 NO NO851934A patent/NO164535C/no not_active IP Right Cessation
- 1985-05-14 CA CA000481511A patent/CA1237138A/en not_active Expired
- 1985-10-25 SU SU853968801A patent/SU1320207A1/ru active
-
1986
- 1986-01-29 ES ES551366A patent/ES8706114A1/es not_active Expired
- 1986-08-13 SU SU4027936A patent/SU1428194A3/ru active
-
1987
- 1987-03-12 US US07/025,278 patent/US4837224A/en not_active Expired - Lifetime
-
1990
- 1990-10-02 SG SG801/90A patent/SG80190G/en unknown
-
1991
- 1991-12-20 CY CY1568A patent/CY1568A/xx unknown
-
1992
- 1992-08-20 HK HK626/92A patent/HK62692A/xx not_active IP Right Cessation
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE45348T1 (de) | (r)-alpha-ethyl-2-oxo-1-pyrrolidinacetamid. | |
DE3572348D1 (de) | (s)-alpha-ethyl-2-oxo-1-pyrrolidinacetamide |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM | Patent lapsed |
Owner name: UCB S.A. |