ATE45348T1 - (r)-alpha-ethyl-2-oxo-1-pyrrolidinacetamid. - Google Patents
(r)-alpha-ethyl-2-oxo-1-pyrrolidinacetamid.Info
- Publication number
- ATE45348T1 ATE45348T1 AT85870068T AT85870068T ATE45348T1 AT E45348 T1 ATE45348 T1 AT E45348T1 AT 85870068 T AT85870068 T AT 85870068T AT 85870068 T AT85870068 T AT 85870068T AT E45348 T1 ATE45348 T1 AT E45348T1
- Authority
- AT
- Austria
- Prior art keywords
- radical
- oxo
- alpha
- ethyl
- pyrrolidineacetamide
- Prior art date
Links
- HPHUVLMMVZITSG-ZCFIWIBFSA-N levetiracetam Chemical compound CC[C@H](C(N)=O)N1CCCC1=O HPHUVLMMVZITSG-ZCFIWIBFSA-N 0.000 title abstract 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 abstract 2
- HNNJFUDLLWOVKZ-GSVOUGTGSA-N (2r)-2-aminobutanamide Chemical compound CC[C@@H](N)C(N)=O HNNJFUDLLWOVKZ-GSVOUGTGSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 229910021529 ammonia Inorganic materials 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000001988 toxicity Effects 0.000 abstract 1
- 231100000419 toxicity Toxicity 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
- C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Detergent Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Cephalosporin Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB848412358A GB8412358D0 (en) | 1984-05-15 | 1984-05-15 | Pharmaceutical composition |
| EP85870068A EP0165919B1 (de) | 1984-05-15 | 1985-05-14 | (R)-Alpha-ethyl-2-oxo-1-pyrrolidinacetamid |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE45348T1 true ATE45348T1 (de) | 1989-08-15 |
Family
ID=10560975
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT85870068T ATE45348T1 (de) | 1984-05-15 | 1985-05-14 | (r)-alpha-ethyl-2-oxo-1-pyrrolidinacetamid. |
Country Status (23)
| Country | Link |
|---|---|
| US (2) | US4696942A (de) |
| EP (1) | EP0165919B1 (de) |
| JP (1) | JPS60255764A (de) |
| AT (1) | ATE45348T1 (de) |
| AU (1) | AU574175B2 (de) |
| BG (2) | BG50272A3 (de) |
| CA (1) | CA1237138A (de) |
| CY (1) | CY1568A (de) |
| DE (1) | DE3572168D1 (de) |
| DK (1) | DK163500C (de) |
| ES (2) | ES8703419A1 (de) |
| FI (1) | FI80674C (de) |
| GB (1) | GB8412358D0 (de) |
| GR (1) | GR851156B (de) |
| HK (1) | HK62692A (de) |
| IE (1) | IE58393B1 (de) |
| IL (1) | IL75180A (de) |
| NO (1) | NO164535C (de) |
| PL (2) | PL144345B1 (de) |
| PT (1) | PT80461B (de) |
| SG (1) | SG80190G (de) |
| SU (3) | SU1417799A3 (de) |
| ZA (1) | ZA853636B (de) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8412357D0 (en) * | 1984-05-15 | 1984-06-20 | Ucb Sa | Pharmaceutical composition |
| DE3420193A1 (de) * | 1984-05-30 | 1985-12-05 | Boehringer Ingelheim KG, 6507 Ingelheim | Neue substituierte pyrrolidinone, verfahren zu ihrer herstellung und arzneimittel |
| GB8827389D0 (en) * | 1988-11-23 | 1988-12-29 | Ucb Sa | Process for preparation of(s)alpha-ethyl-2-oxo-1-pyrrolidineacetamide |
| US6124473A (en) * | 1998-05-08 | 2000-09-26 | Ucb, S.A. | Process for preparing (s)- and (R)-α-ethyl-2-oxo-1-pyrrolidineacetamide |
| GB0004297D0 (en) * | 2000-02-23 | 2000-04-12 | Ucb Sa | 2-oxo-1 pyrrolidine derivatives process for preparing them and their uses |
| AU2002224847A1 (en) * | 2000-11-21 | 2002-06-03 | U C B, S.A. | N-alkylated gaba compounds, processes for their preparation and their use as medicaments |
| DE60204224T2 (de) * | 2001-03-22 | 2006-02-02 | Ucb S.A. | Verwendung bestimmter substituierter pyrrolidone wie z.b. piracetam bei der behandlung von viralen und anderen erkrankungen |
| IL160045A0 (en) * | 2001-08-10 | 2004-06-20 | Ucb Sa | Oxopyrrolidine compounds, preparation of said compounds and their use in the manufacturing of levetiracetam and analogues |
| ATE424384T1 (de) | 2003-12-02 | 2009-03-15 | Ucb Pharma Sa | Imidazolderivate, verfahren zu deren herstellung und deren anwendungen |
| CA2488325C (en) * | 2004-11-22 | 2010-08-24 | Apotex Pharmachem Inc. | Improved process for the preparation of (s)-alpha-ethyl-2-oxo-1-pyrrolidineacetamide and (r)-alpha-ethyl-2-oxo-1-pyrrolidineacetamide |
| WO2006128693A2 (en) | 2005-06-01 | 2006-12-07 | Ucb Pharma, S.A. | 2 -oxo-i -pyrrolidine derivatives/ processes for preparing them and their therapeutic use on the central nervous system |
| WO2010044878A1 (en) | 2008-10-16 | 2010-04-22 | The Johns Hopkins University | Methods and compositions for improving cognitive function |
| RS54595B1 (sr) | 2009-10-23 | 2016-08-31 | Ucb Biopharma Sprl. | Derivati 2-okso-1-pirolidinil imidazotiadiazola |
| CA2789014C (en) * | 2010-02-09 | 2019-01-15 | Michela Gallagher | Methods and compositions for improving cognitive function |
| JP5969003B2 (ja) | 2011-04-18 | 2016-08-10 | ユセベ ファルマ ソシエテ アノニム | ２−オキソ−１−イミダゾリジニルイミダゾチアジアゾール誘導体 |
| CN102633675A (zh) * | 2012-04-10 | 2012-08-15 | 南京大学 | 一种dl-2-氨基丁酰胺制备方法 |
| US20140206667A1 (en) | 2012-11-14 | 2014-07-24 | Michela Gallagher | Methods and compositions for treating schizophrenia |
| EP2968237A4 (de) | 2013-03-15 | 2016-08-31 | Univ Johns Hopkins | Verfahren und zusammensetzungen zur verbesserung der kognitiven funktion |
| ES2881081T3 (es) | 2013-03-15 | 2021-11-26 | Agenebio Inc | Procedimientos y composiciones para mejorar la función cognitiva |
| PH12019500127B1 (en) | 2014-01-21 | 2022-05-04 | Janssen Pharmaceutica Nv | Combinations comprising positive allosteric modulators or orthosteric agonists of metabotropic glutamatergic receptor subtype 2 and their use |
| SMT201900545T1 (it) | 2014-01-21 | 2019-11-13 | Janssen Pharmaceutica Nv | Combinazioni comprendenti modulatori allosterici positivi o agonisti ortosterici del recettore glutammatergico metabotropico sottotipo 2 e loro utilizzo |
| CA2986598C (en) | 2015-05-22 | 2023-09-26 | Agenebio, Inc. | Extended release pharmaceutical compositions of levetiracetam |
| EP3890833B1 (de) | 2018-12-04 | 2023-06-07 | Metys Pharmaceuticals AG | Synergistische zusammensetzungen mit (r)-2-(2-oxopyrrolidin-1-yl)butanamid und (s)-2-(2-oxopyrrolidin-1-yl)butanamid in einem nicht-racemischen verhältnis |
| US11384050B1 (en) | 2021-02-03 | 2022-07-12 | Vitaworks Ip, Llc | Method for preparing levetiracetam and intermediates thereof |
| US12528770B2 (en) | 2023-06-12 | 2026-01-20 | Suzhou Brighthope Pharmatech Co., Ltd. | Process for the production of levetiracetam and intermediates thereof |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1309692A (en) * | 1970-02-13 | 1973-03-14 | Ucb Sa | N-substituted lactams |
| GB1583871A (en) * | 1976-10-19 | 1981-02-04 | Ucb Sa | Anti-aggregants |
| FR2418790A1 (fr) * | 1978-03-02 | 1979-09-28 | Philagro Sa | Nouveaux derives de pyrrolidinone-2 et compositions herbicides les contenant |
| AU579863B2 (en) * | 1984-05-16 | 1988-12-15 | Williams, David Andrew | A parking control apparatus |
-
1984
- 1984-05-15 GB GB848412358A patent/GB8412358D0/en active Pending
-
1985
- 1985-05-13 IL IL75180A patent/IL75180A/xx unknown
- 1985-05-13 FI FI851876A patent/FI80674C/fi not_active IP Right Cessation
- 1985-05-13 GR GR851156A patent/GR851156B/el unknown
- 1985-05-14 PL PL1985253373A patent/PL144345B1/pl unknown
- 1985-05-14 US US06/733,791 patent/US4696942A/en not_active Expired - Lifetime
- 1985-05-14 SU SU3892951A patent/SU1417799A3/ru active
- 1985-05-14 BG BG070237A patent/BG50272A3/xx unknown
- 1985-05-14 IE IE119285A patent/IE58393B1/en not_active IP Right Cessation
- 1985-05-14 ZA ZA853636A patent/ZA853636B/xx unknown
- 1985-05-14 PT PT80461A patent/PT80461B/pt not_active IP Right Cessation
- 1985-05-14 NO NO851934A patent/NO164535C/no not_active IP Right Cessation
- 1985-05-14 BG BG094053A patent/BG60030B2/bg unknown
- 1985-05-14 CA CA000481511A patent/CA1237138A/en not_active Expired
- 1985-05-14 EP EP85870068A patent/EP0165919B1/de not_active Expired
- 1985-05-14 AT AT85870068T patent/ATE45348T1/de not_active IP Right Cessation
- 1985-05-14 AU AU42529/85A patent/AU574175B2/en not_active Ceased
- 1985-05-14 JP JP60102530A patent/JPS60255764A/ja active Pending
- 1985-05-14 DK DK212885A patent/DK163500C/da not_active IP Right Cessation
- 1985-05-14 ES ES543125A patent/ES8703419A1/es not_active Expired
- 1985-05-14 PL PL1985257386A patent/PL147387B1/pl unknown
- 1985-05-14 DE DE8585870068T patent/DE3572168D1/de not_active Expired
- 1985-10-25 SU SU853968801A patent/SU1320207A1/ru active
-
1986
- 1986-01-29 ES ES551366A patent/ES8706114A1/es not_active Expired
- 1986-08-13 SU SU4027936A patent/SU1428194A3/ru active
-
1987
- 1987-03-12 US US07/025,278 patent/US4837224A/en not_active Expired - Lifetime
-
1990
- 1990-10-02 SG SG801/90A patent/SG80190G/en unknown
-
1991
- 1991-12-20 CY CY1568A patent/CY1568A/xx unknown
-
1992
- 1992-08-20 HK HK626/92A patent/HK62692A/xx not_active IP Right Cessation
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE3572168D1 (de) | (r)-alpha-ethyl-2-oxo-1-pyrrolidinacetamide | |
| DE3572348D1 (de) | (s)-alpha-ethyl-2-oxo-1-pyrrolidinacetamide |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |