FI84783B - Foerfarande foer framstaellning av ett farmaceutiskt preparat i enhetsdosform. - Google Patents

Foerfarande foer framstaellning av ett farmaceutiskt preparat i enhetsdosform. Download PDF

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Publication number
FI84783B
FI84783B FI852236A FI852236A FI84783B FI 84783 B FI84783 B FI 84783B FI 852236 A FI852236 A FI 852236A FI 852236 A FI852236 A FI 852236A FI 84783 B FI84783 B FI 84783B
Authority
FI
Finland
Prior art keywords
coated
particles
water
drug
parts
Prior art date
Application number
FI852236A
Other languages
English (en)
Finnish (fi)
Other versions
FI84783C (sv
FI852236A0 (fi
FI852236L (fi
Inventor
Paul Jonathan Harrison
John Richard Langridge
Christopher John Potter
Original Assignee
Sterwin Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sterwin Ag filed Critical Sterwin Ag
Publication of FI852236A0 publication Critical patent/FI852236A0/fi
Publication of FI852236L publication Critical patent/FI852236L/fi
Publication of FI84783B publication Critical patent/FI84783B/fi
Application granted granted Critical
Publication of FI84783C publication Critical patent/FI84783C/sv

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
    • A61K9/1676—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids

Landscapes

  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Control Of El Displays (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Steroid Compounds (AREA)
  • Compounds Of Unknown Constitution (AREA)

Claims (5)

1. Förfarande för framställning av ett farma-ceutiskt preparat i enhetsdosform, vilket innehäller ett 5 fast steroidläkemedel, vars löslighet i vatten vid om-givningens temperatur är mindre än 1 viktdel per 5000 viktdelar, företrädesvis mindre än 1 viktdel per 10000 viktdelar, kännetecknat därav, att pärlor bil-das genom att belägga kärnmaterialpartiklar, vilka omfat-10 tar organiska eller oorganiska nonpareils, vars storlek enligt British standard är 10 - 60 mesh, med finfördelade avskilda partiklar av nämnda steroidförening tillsammans med ett vattenhaltigt förtunningsmedel och ett vat-tenlösligt bindemedel, som väljs frän en grupp polymera 15 cellulosabindemedel, socker erhället frän sockersirap, vattenlösliga polysackarider, polyvinylpyrrolidon, kopoly-merer av vinylpyrrolidon, liksom sädana som bildats med vinylacetat, och blandningar därav, varpä de belagda pärl-orna torkas och enhetsdoser av nämnda pärlor packas i be-20 hällare av ett material, som löses upp i magsaften.
2. Förfarande enligt patentkravet 1, kännetecknat därav, att nämnda material, som löses upp i magsaften, har formen av en gelatinkapsel.
3. Förfarande enligt patentkravet 1 eller 2, k ä n-25 netecknat därav, att bindemedlet är hydroxipro- pylmetylcellulosa, polyvinylpyrrolidon, vinylpyrrolidon-vinylacetatkopolymer eller en blandning därav.
4. Förfarande enligt nägot av de föregäende patent-kraven, kännetecknat därav, att en suspension, 30 som innehäller de finfördelade läkemedelspartiklarna, bil-das i en vattenlösning av nämnda bindemedel, nonpareils som utgör nämnda partikelformade kärnmaterial beläggs med denna suspension och de säledes bildade belagda pärlorna torkas. 35
5. Förfarande enligt patentkravet 4, känne tecknat därav, att ett farmakologiskt godtagbarbe-fuktningsmedel inkluderas i nämnda vattenlösning.
FI852236A 1984-06-04 1985-06-04 Förfarande för framställning av ett farmaceutiskt preparat i enhetsdos form FI84783C (sv)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB848414221A GB8414221D0 (en) 1984-06-04 1984-06-04 Unit dosage form
GB8414221 1984-06-04

Publications (4)

Publication Number Publication Date
FI852236A0 FI852236A0 (fi) 1985-06-04
FI852236L FI852236L (fi) 1985-12-05
FI84783B true FI84783B (fi) 1991-10-15
FI84783C FI84783C (sv) 1992-01-27

Family

ID=10561913

Family Applications (1)

Application Number Title Priority Date Filing Date
FI852236A FI84783C (sv) 1984-06-04 1985-06-04 Förfarande för framställning av ett farmaceutiskt preparat i enhetsdos form

Country Status (20)

Country Link
US (1) US4717569A (sv)
EP (1) EP0164967B1 (sv)
JP (1) JPS611613A (sv)
KR (1) KR860000067A (sv)
AT (1) ATE56357T1 (sv)
AU (1) AU578474B2 (sv)
CA (1) CA1242646A (sv)
DE (1) DE3579631D1 (sv)
DK (1) DK164355C (sv)
ES (1) ES8608865A1 (sv)
FI (1) FI84783C (sv)
GB (1) GB8414221D0 (sv)
GR (1) GR851355B (sv)
IL (1) IL75372A (sv)
MX (1) MX161943A (sv)
NO (1) NO166918C (sv)
NZ (1) NZ212255A (sv)
PH (1) PH22173A (sv)
PT (1) PT80584B (sv)
ZA (1) ZA854115B (sv)

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DE3440288C2 (de) * 1984-11-05 1987-03-12 Gergely, Gerhard, Dr.-Ing., Wien Pharmazeutische Zubereitung mit einem Gehalt an Ibuprofen sowie Verfahren zu ihrer Herstellung
GB2176999B (en) * 1985-06-22 1989-07-12 Stanley Stewart Davis Sustained release medicament
US4833133A (en) * 1986-05-22 1989-05-23 Sterling Drug Inc. Method of regulating fertility in cattle using epostane
US4870068A (en) * 1986-05-22 1989-09-26 Sterling Drug Inc. Method of regulating fertility in swine using epostane
JP2680614B2 (ja) * 1988-08-01 1997-11-19 日清製粉株式会社 ダナゾール組成物
JP2773895B2 (ja) * 1989-04-25 1998-07-09 東京田辺製薬株式会社 ダナゾール組成物
EP0452862B1 (en) * 1990-04-18 1995-07-19 Asahi Kasei Kogyo Kabushiki Kaisha Spherical seed cores, spherical granules and process for production thereof
JP2542122B2 (ja) * 1990-04-18 1996-10-09 旭化成工業株式会社 球状核、球形顆粒およびその製造方法
US5223268A (en) * 1991-05-16 1993-06-29 Sterling Drug, Inc. Low solubility drug-coated bead compositions
US5547948A (en) * 1995-01-17 1996-08-20 American Home Products Corporation Controlled release of steroids from sugar coatings
US5573783A (en) * 1995-02-13 1996-11-12 Nano Systems L.L.C. Redispersible nanoparticulate film matrices with protective overcoats
FR2758459B1 (fr) * 1997-01-17 1999-05-07 Pharma Pass Composition pharmaceutique de fenofibrate presentant une biodisponibilite elevee et son procede de preparation
US6248363B1 (en) * 1999-11-23 2001-06-19 Lipocine, Inc. Solid carriers for improved delivery of active ingredients in pharmaceutical compositions
US20030236236A1 (en) * 1999-06-30 2003-12-25 Feng-Jing Chen Pharmaceutical compositions and dosage forms for administration of hydrophobic drugs
US7863331B2 (en) * 1999-07-09 2011-01-04 Ethypharm Pharmaceutical composition containing fenofibrate and method for the preparation thereof
FR2795961B1 (fr) 1999-07-09 2004-05-28 Ethypharm Lab Prod Ethiques Composition pharmaceutique contenant du fenofibrate micronise, un tensioactif et un derive cellulosique liant et procede de preparation
US20030180352A1 (en) * 1999-11-23 2003-09-25 Patel Mahesh V. Solid carriers for improved delivery of active ingredients in pharmaceutical compositions
JP3386052B2 (ja) * 2001-02-13 2003-03-10 トヨタ自動車株式会社 ポンプ装置
GB2375958B (en) * 2001-04-09 2005-03-02 George Margetts The use of steroids to lower the levels of cortisol
US8101209B2 (en) * 2001-10-09 2012-01-24 Flamel Technologies Microparticulate oral galenical form for the delayed and controlled release of pharmaceutical active principles
FR2842736B1 (fr) * 2002-07-26 2005-07-22 Flamel Tech Sa Formulation pharmaceutique orale sous forme d'une pluralite de microcapsules permettant la liberation prolongee de principe(s) actif(s) peu soluble(s)
GB2400554B (en) * 2003-04-16 2007-04-18 George Margetts Treatment of angiotensin II-induced cardiovascular disease
AU2004275816A1 (en) * 2003-09-26 2005-04-07 Alza Corporation Controlled release formulations of opioid and nonopioid analgesics
KR20060092255A (ko) * 2003-09-26 2006-08-22 알자 코포레이션 고도의 약물적재를 제공하는 약물코팅제 및 그의 제조방법
MXPA06003452A (es) * 2003-09-26 2006-08-31 Johnson & Johnson Formulaciones de liberacion controlada que exhiben una velocidad de liberacion ascendente.
MXPA06003453A (es) * 2003-09-26 2006-08-31 Johnson & Johnson Barra de empuje oros para el suministro controlado de agentes activos.
US20060003002A1 (en) * 2003-11-03 2006-01-05 Lipocine, Inc. Pharmaceutical compositions with synchronized solubilizer release
US8541026B2 (en) 2004-09-24 2013-09-24 Abbvie Inc. Sustained release formulations of opioid and nonopioid analgesics
FR2885526B1 (fr) * 2005-05-13 2007-07-27 Flamel Technologies Sa Medicament oral a base d'inhibiteur de pompe a protons
US20070036859A1 (en) * 2005-08-11 2007-02-15 Perry Ronald L Sustained release antihistamine and decongestant composition
US20080096819A1 (en) * 2006-05-02 2008-04-24 Allozyne, Inc. Amino acid substituted molecules
EP2581450B1 (en) * 2006-05-02 2018-08-15 MedImmune Limited Non-natural amino acid substituted polypeptides
CA2707840A1 (en) * 2007-08-20 2009-02-26 Allozyne, Inc. Amino acid substituted molecules
US8861813B2 (en) * 2008-03-13 2014-10-14 Mallinckrodt Llc Multi-function, foot-activated controller for imaging system
CA2736899C (en) 2008-09-25 2016-08-30 Isp Investments Inc. Smooth, high solids tablet coating composition
US11304960B2 (en) 2009-01-08 2022-04-19 Chandrashekar Giliyar Steroidal compositions
US9358241B2 (en) 2010-11-30 2016-06-07 Lipocine Inc. High-strength testosterone undecanoate compositions
US20180153904A1 (en) 2010-11-30 2018-06-07 Lipocine Inc. High-strength testosterone undecanoate compositions
US9034858B2 (en) 2010-11-30 2015-05-19 Lipocine Inc. High-strength testosterone undecanoate compositions
US20120148675A1 (en) 2010-12-10 2012-06-14 Basawaraj Chickmath Testosterone undecanoate compositions
CN103313703A (zh) * 2010-12-27 2013-09-18 富田制药株式会社 制剂用崩解型核粒子
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WO2016033549A2 (en) 2014-08-28 2016-03-03 Lipocine Inc. (17-ß)-3-OXOANDROST-4-EN-17-YL TRIDECANOATE COMPOSITIONS AND METHODS OF THEIR PREPARATION AND USE
EP3544614A4 (en) 2016-11-28 2020-08-05 Lipocine Inc. ORAL TESTOSTERONE UNDECANOATE THERAPY

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GB765086A (en) * 1954-11-19 1957-01-02 Smith Kline & French Internat Anticholinergic preparation
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Also Published As

Publication number Publication date
JPS611613A (ja) 1986-01-07
DK247485D0 (da) 1985-06-03
EP0164967A2 (en) 1985-12-18
EP0164967A3 (en) 1986-12-30
DK164355B (da) 1992-06-15
DK164355C (da) 1992-11-02
PH22173A (en) 1988-06-28
DE3579631D1 (de) 1990-10-18
AU4323785A (en) 1985-12-12
ATE56357T1 (de) 1990-09-15
IL75372A (en) 1989-08-15
IL75372A0 (en) 1985-09-29
EP0164967B1 (en) 1990-09-12
ES8608865A1 (es) 1986-07-16
GB8414221D0 (en) 1984-07-11
FI84783C (sv) 1992-01-27
MX161943A (es) 1991-03-08
PT80584B (pt) 1987-09-18
DK247485A (da) 1985-12-05
ES543828A0 (es) 1986-07-16
NO166918C (no) 1991-09-18
FI852236A0 (fi) 1985-06-04
ZA854115B (en) 1986-01-29
US4717569A (en) 1988-01-05
FI852236L (fi) 1985-12-05
AU578474B2 (en) 1988-10-27
GR851355B (sv) 1985-11-25
CA1242646A (en) 1988-10-04
KR860000067A (ko) 1986-01-25
NO852226L (no) 1985-12-05
NZ212255A (en) 1988-06-30
PT80584A (en) 1985-07-01
NO166918B (no) 1991-06-10

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MM Patent lapsed
MM Patent lapsed

Owner name: STERWIN AKTIENGESELLSCHAFT