FI84604B - Foerfarande foer framstaellning av antipsykotiskt 8-/4-/4-(1-oxo-1,2-bensisotiazol-3-yl)-1-piperazinyl/butyl/ -8-azaspiro/4,5/dekan-7,9-dion eller salt daerav. - Google Patents
Foerfarande foer framstaellning av antipsykotiskt 8-/4-/4-(1-oxo-1,2-bensisotiazol-3-yl)-1-piperazinyl/butyl/ -8-azaspiro/4,5/dekan-7,9-dion eller salt daerav. Download PDFInfo
- Publication number
- FI84604B FI84604B FI861668A FI861668A FI84604B FI 84604 B FI84604 B FI 84604B FI 861668 A FI861668 A FI 861668A FI 861668 A FI861668 A FI 861668A FI 84604 B FI84604 B FI 84604B
- Authority
- FI
- Finland
- Prior art keywords
- compound
- formula
- bmy
- salt
- azaspiro
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Psychiatry (AREA)
- Anesthesiology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Claims (2)
1. Förfarande för framställning av antipsykotiskt 8-[4-[4-( 1-oxo-l, 2-bensisotiazol-3-yl)-1-piperazinyl]bu- 5 tyl]-8-azaspiro[4.5]dekan-7,9-dion med formeln I 10 m 15 eller ett farmaceutiskt godtagbart syraadditiossalt därav, kännetecknat därav, att en förening med formeln Q k S~)-N \-(CH)-NχΊ · Hei N»' N_I 2 ‘ )_Λ-> V 25 omsätts med en blandnlng av mlneralsyror vid en temperatur som är lägre än 5 eC och, ifall önskvärt, bildas ett farmaceutiskt godtagbart sait genom att omsätta den säsom 30 produkt erhälinä basen med en önskad organisk eller oorga-nisk syra.
2. Förfarande enligt patentkravet 1, kännetecknat därav, att blandningen av mlneralsyror om-fattar salpetersyra och svavelsyra.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US72644985 | 1985-04-24 | ||
| US06/726,449 US4656173A (en) | 1985-04-24 | 1985-04-24 | Antipsychotic benzisothiazole S-oxide compound |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| FI861668A0 FI861668A0 (fi) | 1986-04-21 |
| FI861668A FI861668A (fi) | 1986-10-25 |
| FI84604B true FI84604B (fi) | 1991-09-13 |
| FI84604C FI84604C (sv) | 1991-12-27 |
Family
ID=24918649
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI861668A FI84604C (sv) | 1985-04-24 | 1986-04-21 | Förfarande för framställning av antipsykotiskt 8-/4-/4-(1-oxo-1,2-bens isotiazol-3-yl)-1-piperazinyl/butyl/-8-azaspiro/4,5/dekan-7,9-dion ell er salt därav |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US4656173A (sv) |
| JP (1) | JPH0764842B2 (sv) |
| KR (1) | KR900000372B1 (sv) |
| CN (1) | CN1017528B (sv) |
| AT (1) | AT394719B (sv) |
| AU (1) | AU592787B2 (sv) |
| BE (1) | BE904662A (sv) |
| CA (1) | CA1247102A (sv) |
| CH (1) | CH666034A5 (sv) |
| DE (1) | DE3613739C2 (sv) |
| DK (1) | DK187686A (sv) |
| EG (1) | EG18002A (sv) |
| ES (1) | ES8708228A1 (sv) |
| FI (1) | FI84604C (sv) |
| FR (1) | FR2581064B1 (sv) |
| GB (1) | GB2174393B (sv) |
| GR (1) | GR861063B (sv) |
| HU (1) | HU195654B (sv) |
| IE (1) | IE59182B1 (sv) |
| IT (1) | IT1208600B (sv) |
| LU (1) | LU86405A1 (sv) |
| MY (1) | MY102041A (sv) |
| NL (1) | NL8601043A (sv) |
| PT (1) | PT82450B (sv) |
| SE (1) | SE462163B (sv) |
| ZA (1) | ZA861531B (sv) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4780466A (en) * | 1988-03-17 | 1988-10-25 | Hoechst-Roussel Pharmaceuticals, Inc. | Arylpiperazinylalkoxy derivatives of cyclic imides |
| EP0350145A3 (en) * | 1988-04-28 | 1990-07-04 | Yamanouchi Pharmaceutical Co. Ltd. | Pyridylthiazolidine carboxamide derivatives and their intermediates and production of both |
| HUT61760A (en) * | 1988-09-16 | 1993-03-01 | Pfizer | Process for producing bridged, bicyclic imides comprising 4-/4-(3-benzisothiazolyl)-1-piperazinyl/-butyl group and pharmaceutical compositions comprising such compounds |
| US4956368A (en) * | 1989-07-24 | 1990-09-11 | Bristol-Myers Company | Metabolites and prodrug formulations of 8-[4-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]butyl]-8-azaspiro[4.5]decane-7,9-dione |
| US4968792A (en) * | 1989-09-25 | 1990-11-06 | American Home Products Corporation | Psychotropic benzisothiazole derivatives |
| US5162321A (en) * | 1989-12-20 | 1992-11-10 | Adir Et Compagnie | 1-naphthyl piperazines useful as 5-HT1A receptor ligands |
| JP2800953B2 (ja) * | 1990-07-06 | 1998-09-21 | 住友製薬株式会社 | 新規なイミド誘導体 |
| EP2919788A4 (en) | 2012-11-14 | 2016-05-25 | Univ Johns Hopkins | METHODS AND COMPOSITIONS FOR THE TREATMENT OF SCHIZOPHRENIA |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE759371A (fr) * | 1969-11-24 | 1971-05-24 | Bristol Myers Co | Azaspirodecanediones heterocycliques et procedes pour leur preparation |
| US3976776A (en) * | 1972-12-06 | 1976-08-24 | Mead Johnson & Company | Tranquilizer process employing N-(heteroarcyclic)piperazinylalkylazaspiroalkanediones |
| CH582699A5 (sv) * | 1973-03-26 | 1976-12-15 | Sandoz Ag | |
| AT342057B (de) * | 1974-04-25 | 1978-03-10 | Thomae Gmbh Dr K | Verfahren zur herstellung von neuen 3-piperazino-isochinolinen und deren salzen |
| FI753625A (sv) * | 1975-01-06 | 1976-07-07 | Spofa Vereinigte Pharma Werke | |
| JPS51144735A (en) * | 1975-06-06 | 1976-12-13 | Nippon Nohyaku Co Ltd | A remedy for hepatic failure |
| US4411901A (en) * | 1981-12-23 | 1983-10-25 | Mead Johnson & Company | Benzisothiazole and benzisoxazole piperazine derivatives |
| US4452799A (en) * | 1981-12-23 | 1984-06-05 | Mead Johnson & Company | Benzisothiazole and benzisoxazole piperazine derivatives |
| US4524206A (en) * | 1983-09-12 | 1985-06-18 | Mead Johnson & Company | 1-Heteroaryl-4-(2,5-pyrrolidinedion-1-yl)alkyl)piperazine derivatives |
-
1985
- 1985-04-24 US US06/726,449 patent/US4656173A/en not_active Expired - Lifetime
-
1986
- 1986-02-21 CA CA000502439A patent/CA1247102A/en not_active Expired
- 1986-02-28 ZA ZA861531A patent/ZA861531B/xx unknown
- 1986-04-02 KR KR1019860002515A patent/KR900000372B1/ko not_active IP Right Cessation
- 1986-04-15 AU AU56121/86A patent/AU592787B2/en not_active Ceased
- 1986-04-20 EG EG232/86A patent/EG18002A/xx active
- 1986-04-21 FI FI861668A patent/FI84604C/sv not_active IP Right Cessation
- 1986-04-22 FR FR8605789A patent/FR2581064B1/fr not_active Expired
- 1986-04-22 GR GR861063A patent/GR861063B/el unknown
- 1986-04-23 LU LU86405A patent/LU86405A1/fr unknown
- 1986-04-23 ES ES554284A patent/ES8708228A1/es not_active Expired
- 1986-04-23 CN CN86102742A patent/CN1017528B/zh not_active Expired
- 1986-04-23 CH CH1685/86A patent/CH666034A5/de not_active IP Right Cessation
- 1986-04-23 NL NL8601043A patent/NL8601043A/nl active Search and Examination
- 1986-04-23 PT PT82450A patent/PT82450B/pt not_active IP Right Cessation
- 1986-04-23 BE BE0/216581A patent/BE904662A/fr not_active IP Right Cessation
- 1986-04-23 DE DE3613739A patent/DE3613739C2/de not_active Expired - Fee Related
- 1986-04-23 GB GB08609932A patent/GB2174393B/en not_active Expired
- 1986-04-23 SE SE8601883A patent/SE462163B/sv not_active IP Right Cessation
- 1986-04-23 IE IE108386A patent/IE59182B1/en not_active IP Right Cessation
- 1986-04-23 DK DK187686A patent/DK187686A/da not_active Application Discontinuation
- 1986-04-23 IT IT8620187A patent/IT1208600B/it active
- 1986-04-24 AT AT0110486A patent/AT394719B/de not_active IP Right Cessation
- 1986-04-24 JP JP61095859A patent/JPH0764842B2/ja not_active Expired - Lifetime
- 1986-04-24 HU HU861704A patent/HU195654B/hu not_active IP Right Cessation
-
1987
- 1987-09-28 MY MYPI87002086A patent/MY102041A/en unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM | Patent lapsed |
Owner name: BRISTOL-MYERS SQUIBB COMPANY |