FI84481C - Förfarande för framställning av nya antihypertensiva 7-amino-1,2,3,4,6 ,7,8,12b-oktahydro-6-oxopyrido/2,1-a//2/-bensazepin-4-karboxylsyraderi vat - Google Patents
Förfarande för framställning av nya antihypertensiva 7-amino-1,2,3,4,6 ,7,8,12b-oktahydro-6-oxopyrido/2,1-a//2/-bensazepin-4-karboxylsyraderi vat Download PDFInfo
- Publication number
- FI84481C FI84481C FI872613A FI872613A FI84481C FI 84481 C FI84481 C FI 84481C FI 872613 A FI872613 A FI 872613A FI 872613 A FI872613 A FI 872613A FI 84481 C FI84481 C FI 84481C
- Authority
- FI
- Finland
- Prior art keywords
- alkyl
- amino
- oxopyrido
- mmol
- acid
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
- C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Indole Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Hydrogenated Pyridines (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Claims (2)
1. Förfarande för framställning av terapeutiskt användbara 7-amino-l,2,3,4,6,7,8,l2b-oktahydro-6-oxopyri-5 do[2,1-a][2]bensazepin-4-karboxylsyraderivat med formeln (II) och farmaceutiskt godtagbara salter därav,
10 R'iOOC \ CH, i j—n j (ii< b^hn/ li Y>
0 COOR' 15. vilken formel R' är väte, C1.6-alkyl eller difenylmetyl; R'x är väte eller C1.6-alkyl; och R’2 är väte eller fenyl-C^-alkyl, kännetecknat därav, att en fuslonerad laktam 20 med formeln (XXII)
25. I ^^2 N J (XXII) H J T u COOR' 30 omsätts med ett reagens med formeln (A) C0oR'-I 2 1 R'2Ch (A) 5s°2CF3 35 24 84481 där R* och R' x är annat än väte, i närvaro av en bas, och ifali önskvärt, avlägsnas en eller bäda av estergrup-perna R' och R'
2. Förfarande enligt patentkravet 1, k ä n n e -5 tecknat därav, att man framställer [4a,7a(R*),126]- 7-[[1-(etoxikarbony1)-3-fenylpropy1]amino]-l,2,3,4,6,7, 12b-oktahydro-6-oxopyrido[2,1-a][2]bensazepin-4-karboxyl-syra.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US87375486A | 1986-06-13 | 1986-06-13 | |
| US87375486 | 1986-06-13 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| FI872613A0 FI872613A0 (fi) | 1987-06-11 |
| FI872613A FI872613A (fi) | 1987-12-14 |
| FI84481B FI84481B (fi) | 1991-08-30 |
| FI84481C true FI84481C (sv) | 1991-12-10 |
Family
ID=25362243
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI872613A FI84481C (sv) | 1986-06-13 | 1987-06-11 | Förfarande för framställning av nya antihypertensiva 7-amino-1,2,3,4,6 ,7,8,12b-oktahydro-6-oxopyrido/2,1-a//2/-bensazepin-4-karboxylsyraderi vat |
Country Status (9)
| Country | Link |
|---|---|
| CN (1) | CN1020612C (sv) |
| AT (1) | ATE81511T1 (sv) |
| DE (1) | DE3782190T2 (sv) |
| FI (1) | FI84481C (sv) |
| HU (2) | HU201326B (sv) |
| IL (1) | IL82850A (sv) |
| NO (1) | NO168584C (sv) |
| NZ (1) | NZ220649A (sv) |
| PT (1) | PT85070B (sv) |
-
1987
- 1987-06-10 NZ NZ220649A patent/NZ220649A/xx unknown
- 1987-06-11 IL IL82850A patent/IL82850A/xx not_active IP Right Cessation
- 1987-06-11 AT AT87108410T patent/ATE81511T1/de not_active IP Right Cessation
- 1987-06-11 FI FI872613A patent/FI84481C/sv not_active IP Right Cessation
- 1987-06-11 DE DE8787108410T patent/DE3782190T2/de not_active Expired - Lifetime
- 1987-06-11 PT PT85070A patent/PT85070B/pt unknown
- 1987-06-12 HU HU8990A patent/HU201326B/hu not_active IP Right Cessation
- 1987-06-12 HU HU872684A patent/HU197328B/hu not_active IP Right Cessation
- 1987-06-12 NO NO872461A patent/NO168584C/no not_active IP Right Cessation
- 1987-06-12 CN CN87104166A patent/CN1020612C/zh not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| IL82850A0 (en) | 1987-12-20 |
| NO168584B (no) | 1991-12-02 |
| DE3782190T2 (de) | 1993-02-25 |
| FI872613A (fi) | 1987-12-14 |
| NO168584C (no) | 1992-03-11 |
| DE3782190D1 (de) | 1992-11-19 |
| NZ220649A (en) | 1990-09-26 |
| NO872461D0 (no) | 1987-06-12 |
| HU201326B (en) | 1990-10-28 |
| IL82850A (en) | 1991-03-10 |
| FI84481B (fi) | 1991-08-30 |
| HU197328B (en) | 1989-03-28 |
| ATE81511T1 (de) | 1992-10-15 |
| NO872461L (no) | 1987-12-14 |
| HUT44518A (en) | 1988-03-28 |
| CN1020612C (zh) | 1993-05-12 |
| PT85070B (pt) | 1990-03-08 |
| PT85070A (en) | 1987-07-01 |
| CN87104166A (zh) | 1988-01-20 |
| FI872613A0 (fi) | 1987-06-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| BB | Publication of examined application | ||
| FG | Patent granted |
Owner name: MERRELL DOW PHARMACEUTICALS INC. |
|
| PC | Transfer of assignment of patent |
Owner name: AVENTIS INC. Free format text: AVENTIS INC. |
|
| MA | Patent expired |