FI84481C - Förfarande för framställning av nya antihypertensiva 7-amino-1,2,3,4,6 ,7,8,12b-oktahydro-6-oxopyrido/2,1-a//2/-bensazepin-4-karboxylsyraderi vat - Google Patents
Förfarande för framställning av nya antihypertensiva 7-amino-1,2,3,4,6 ,7,8,12b-oktahydro-6-oxopyrido/2,1-a//2/-bensazepin-4-karboxylsyraderi vat Download PDFInfo
- Publication number
- FI84481C FI84481C FI872613A FI872613A FI84481C FI 84481 C FI84481 C FI 84481C FI 872613 A FI872613 A FI 872613A FI 872613 A FI872613 A FI 872613A FI 84481 C FI84481 C FI 84481C
- Authority
- FI
- Finland
- Prior art keywords
- alkyl
- amino
- oxopyrido
- mmol
- acid
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
- C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Indole Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Hydrogenated Pyridines (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Claims (2)
1. Förfarande för framställning av terapeutiskt användbara 7-amino-l,2,3,4,6,7,8,l2b-oktahydro-6-oxopyri-5 do[2,1-a][2]bensazepin-4-karboxylsyraderivat med formeln (II) och farmaceutiskt godtagbara salter därav,
10 R'iOOC \ CH, i j—n j (ii< b^hn/ li Y>
0 COOR' 15. vilken formel R' är väte, C1.6-alkyl eller difenylmetyl; R'x är väte eller C1.6-alkyl; och R’2 är väte eller fenyl-C^-alkyl, kännetecknat därav, att en fuslonerad laktam 20 med formeln (XXII)
25. I ^^2 N J (XXII) H J T u COOR' 30 omsätts med ett reagens med formeln (A) C0oR'-I 2 1 R'2Ch (A) 5s°2CF3 35 24 84481 där R* och R' x är annat än väte, i närvaro av en bas, och ifali önskvärt, avlägsnas en eller bäda av estergrup-perna R' och R'
2. Förfarande enligt patentkravet 1, k ä n n e -5 tecknat därav, att man framställer [4a,7a(R*),126]- 7-[[1-(etoxikarbony1)-3-fenylpropy1]amino]-l,2,3,4,6,7, 12b-oktahydro-6-oxopyrido[2,1-a][2]bensazepin-4-karboxyl-syra.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US87375486A | 1986-06-13 | 1986-06-13 | |
US87375486 | 1986-06-13 |
Publications (4)
Publication Number | Publication Date |
---|---|
FI872613A0 FI872613A0 (fi) | 1987-06-11 |
FI872613A FI872613A (fi) | 1987-12-14 |
FI84481B FI84481B (fi) | 1991-08-30 |
FI84481C true FI84481C (sv) | 1991-12-10 |
Family
ID=25362243
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI872613A FI84481C (sv) | 1986-06-13 | 1987-06-11 | Förfarande för framställning av nya antihypertensiva 7-amino-1,2,3,4,6 ,7,8,12b-oktahydro-6-oxopyrido/2,1-a//2/-bensazepin-4-karboxylsyraderi vat |
Country Status (9)
Country | Link |
---|---|
CN (1) | CN1020612C (sv) |
AT (1) | ATE81511T1 (sv) |
DE (1) | DE3782190T2 (sv) |
FI (1) | FI84481C (sv) |
HU (2) | HU201326B (sv) |
IL (1) | IL82850A (sv) |
NO (1) | NO168584C (sv) |
NZ (1) | NZ220649A (sv) |
PT (1) | PT85070B (sv) |
-
1987
- 1987-06-10 NZ NZ220649A patent/NZ220649A/xx unknown
- 1987-06-11 IL IL82850A patent/IL82850A/xx not_active IP Right Cessation
- 1987-06-11 AT AT87108410T patent/ATE81511T1/de not_active IP Right Cessation
- 1987-06-11 FI FI872613A patent/FI84481C/sv not_active IP Right Cessation
- 1987-06-11 DE DE8787108410T patent/DE3782190T2/de not_active Expired - Lifetime
- 1987-06-11 PT PT85070A patent/PT85070B/pt unknown
- 1987-06-12 HU HU8990A patent/HU201326B/hu not_active IP Right Cessation
- 1987-06-12 HU HU872684A patent/HU197328B/hu not_active IP Right Cessation
- 1987-06-12 NO NO872461A patent/NO168584C/no not_active IP Right Cessation
- 1987-06-12 CN CN87104166A patent/CN1020612C/zh not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
IL82850A0 (en) | 1987-12-20 |
NO168584B (no) | 1991-12-02 |
DE3782190T2 (de) | 1993-02-25 |
FI872613A (fi) | 1987-12-14 |
NO168584C (no) | 1992-03-11 |
DE3782190D1 (de) | 1992-11-19 |
NZ220649A (en) | 1990-09-26 |
NO872461D0 (no) | 1987-06-12 |
HU201326B (en) | 1990-10-28 |
IL82850A (en) | 1991-03-10 |
FI84481B (fi) | 1991-08-30 |
HU197328B (en) | 1989-03-28 |
ATE81511T1 (de) | 1992-10-15 |
NO872461L (no) | 1987-12-14 |
HUT44518A (en) | 1988-03-28 |
CN1020612C (zh) | 1993-05-12 |
PT85070B (pt) | 1990-03-08 |
PT85070A (en) | 1987-07-01 |
CN87104166A (zh) | 1988-01-20 |
FI872613A0 (fi) | 1987-06-11 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US4350704A (en) | Substituted acyl derivatives of octahydro-1H-indole-2-carboxylic acids | |
US4885283A (en) | Phosphinic acid derivatives | |
FI76074C (sv) | Förfarande för framställning av antihypertensiva 3-amino-/1/bensazepin -2-on-1-alkansyror | |
EP0249223B1 (en) | Novel antihypertensive agent | |
US4973585A (en) | Tricyclic lactams active as antihypertensive agents | |
EP0037231A2 (en) | Substituted acyl derivatives of octahydro-1H-indole-2-carboxylic acids | |
JPH09505601A (ja) | インドリル基含有化合物類および成長ホルモン放出を促進するためのそれらの使用 | |
JPH05255279A (ja) | コレシストキニン拮抗薬 | |
US4425355A (en) | Substituted acyl derivatives of chair form of octahydro-1H-indole-2-carboxylic acids | |
EP0728746B1 (en) | Azepinone compounds useful in the inhibition of ACE and NEP | |
WO1997038705A1 (en) | N-formyl hydroxylamine containing compounds useful as ace inhibitors and/or nep inhibitors | |
FR2502149A1 (fr) | Nouveaux amido-aminoacides, compositions pharmaceutiques les contenant et procede de preparation de ces amido-aminoacides | |
EP0166357A2 (en) | Benzofused lactams and pharmaceutical compositions containing them | |
EP0187037A2 (en) | Piperidine derivatives, their production and use | |
FI84481C (sv) | Förfarande för framställning av nya antihypertensiva 7-amino-1,2,3,4,6 ,7,8,12b-oktahydro-6-oxopyrido/2,1-a//2/-bensazepin-4-karboxylsyraderi vat | |
KR890004365B1 (ko) | 디플루오로사이클로스타틴 함유 폴리펩티드 유도체의 제조방법 | |
US20020061840A1 (en) | Tripeptide compounds useful as selective inhibitors of aminopeptidase A and corresponding pharmaceutical compositions | |
FR2468589A1 (fr) | Derives aminoacyles de mercaptoacyl amino-acides, a action antihypertensive | |
US4503043A (en) | Substituted acyl derivatives of octahydro-1H-isoindole-1-carboxylic acids | |
JPS6115874A (ja) | 抗高血圧剤及びコレシストキニンきつ抗物質として有用なベンゼン環の縮合したラクタム | |
FI76560B (fi) | Foerfarande foer framstaellning av farmaceutiskt anvaendbar 1-/2-/(1-karbetoxi-3-fenylpropyl)amino/-1- oxopropyl/-oktahydro-1h-indol-2-karboxylsyra. | |
US6777550B1 (en) | N-formyl hydroxylamine containing compounds useful as ACE inhibitors and/or NEP inhibitors | |
JPH0694477B2 (ja) | 燐含有レニン阻害剤 | |
HU225916B1 (en) | Thiazolo[3,2-a]azepine derivatives, process for the preparation thereof and pharmaceutical compositions containing them | |
CS237325B2 (cs) | Způsob přípravy knrbexyalkylciipeptidů |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
BB | Publication of examined application | ||
FG | Patent granted |
Owner name: MERRELL DOW PHARMACEUTICALS INC. |
|
PC | Transfer of assignment of patent |
Owner name: AVENTIS INC. Free format text: AVENTIS INC. |
|
MA | Patent expired |