FI84481C - Förfarande för framställning av nya antihypertensiva 7-amino-1,2,3,4,6 ,7,8,12b-oktahydro-6-oxopyrido/2,1-a//2/-bensazepin-4-karboxylsyraderi vat - Google Patents

Förfarande för framställning av nya antihypertensiva 7-amino-1,2,3,4,6 ,7,8,12b-oktahydro-6-oxopyrido/2,1-a//2/-bensazepin-4-karboxylsyraderi vat Download PDF

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Publication number
FI84481C
FI84481C FI872613A FI872613A FI84481C FI 84481 C FI84481 C FI 84481C FI 872613 A FI872613 A FI 872613A FI 872613 A FI872613 A FI 872613A FI 84481 C FI84481 C FI 84481C
Authority
FI
Finland
Prior art keywords
alkyl
amino
oxopyrido
mmol
acid
Prior art date
Application number
FI872613A
Other languages
English (en)
Finnish (fi)
Other versions
FI872613A (fi
FI84481B (fi
FI872613A0 (fi
Inventor
Gary A Flynn
Douglas W Beight
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Publication of FI872613A0 publication Critical patent/FI872613A0/fi
Publication of FI872613A publication Critical patent/FI872613A/fi
Application granted granted Critical
Publication of FI84481B publication Critical patent/FI84481B/fi
Publication of FI84481C publication Critical patent/FI84481C/sv

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Claims (2)

1. Förfarande för framställning av terapeutiskt användbara 7-amino-l,2,3,4,6,7,8,l2b-oktahydro-6-oxopyri-5 do[2,1-a][2]bensazepin-4-karboxylsyraderivat med formeln (II) och farmaceutiskt godtagbara salter därav,
10 R'iOOC \ CH, i j—n j (ii< b^hn/ li Y>
0 COOR' 15. vilken formel R' är väte, C1.6-alkyl eller difenylmetyl; R'x är väte eller C1.6-alkyl; och R’2 är väte eller fenyl-C^-alkyl, kännetecknat därav, att en fuslonerad laktam 20 med formeln (XXII)
25. I ^^2 N J (XXII) H J T u COOR' 30 omsätts med ett reagens med formeln (A) C0oR'-I 2 1 R'2Ch (A) 5s°2CF3 35 24 84481 där R* och R' x är annat än väte, i närvaro av en bas, och ifali önskvärt, avlägsnas en eller bäda av estergrup-perna R' och R'
2. Förfarande enligt patentkravet 1, k ä n n e -5 tecknat därav, att man framställer [4a,7a(R*),126]- 7-[[1-(etoxikarbony1)-3-fenylpropy1]amino]-l,2,3,4,6,7, 12b-oktahydro-6-oxopyrido[2,1-a][2]bensazepin-4-karboxyl-syra.
FI872613A 1986-06-13 1987-06-11 Förfarande för framställning av nya antihypertensiva 7-amino-1,2,3,4,6 ,7,8,12b-oktahydro-6-oxopyrido/2,1-a//2/-bensazepin-4-karboxylsyraderi vat FI84481C (sv)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US87375486A 1986-06-13 1986-06-13
US87375486 1986-06-13

Publications (4)

Publication Number Publication Date
FI872613A0 FI872613A0 (fi) 1987-06-11
FI872613A FI872613A (fi) 1987-12-14
FI84481B FI84481B (fi) 1991-08-30
FI84481C true FI84481C (sv) 1991-12-10

Family

ID=25362243

Family Applications (1)

Application Number Title Priority Date Filing Date
FI872613A FI84481C (sv) 1986-06-13 1987-06-11 Förfarande för framställning av nya antihypertensiva 7-amino-1,2,3,4,6 ,7,8,12b-oktahydro-6-oxopyrido/2,1-a//2/-bensazepin-4-karboxylsyraderi vat

Country Status (9)

Country Link
CN (1) CN1020612C (sv)
AT (1) ATE81511T1 (sv)
DE (1) DE3782190T2 (sv)
FI (1) FI84481C (sv)
HU (2) HU201326B (sv)
IL (1) IL82850A (sv)
NO (1) NO168584C (sv)
NZ (1) NZ220649A (sv)
PT (1) PT85070B (sv)

Also Published As

Publication number Publication date
IL82850A0 (en) 1987-12-20
NO168584B (no) 1991-12-02
DE3782190T2 (de) 1993-02-25
FI872613A (fi) 1987-12-14
NO168584C (no) 1992-03-11
DE3782190D1 (de) 1992-11-19
NZ220649A (en) 1990-09-26
NO872461D0 (no) 1987-06-12
HU201326B (en) 1990-10-28
IL82850A (en) 1991-03-10
FI84481B (fi) 1991-08-30
HU197328B (en) 1989-03-28
ATE81511T1 (de) 1992-10-15
NO872461L (no) 1987-12-14
HUT44518A (en) 1988-03-28
CN1020612C (zh) 1993-05-12
PT85070B (pt) 1990-03-08
PT85070A (en) 1987-07-01
CN87104166A (zh) 1988-01-20
FI872613A0 (fi) 1987-06-11

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Legal Events

Date Code Title Description
BB Publication of examined application
FG Patent granted

Owner name: MERRELL DOW PHARMACEUTICALS INC.

PC Transfer of assignment of patent

Owner name: AVENTIS INC.

Free format text: AVENTIS INC.

MA Patent expired