FI844751A0 - Substituerade trans -1,2-diamino-cyklohexyl-amidfoereningar. - Google Patents
Substituerade trans -1,2-diamino-cyklohexyl-amidfoereningar.Info
- Publication number
- FI844751A0 FI844751A0 FI844751A FI844751A FI844751A0 FI 844751 A0 FI844751 A0 FI 844751A0 FI 844751 A FI844751 A FI 844751A FI 844751 A FI844751 A FI 844751A FI 844751 A0 FI844751 A0 FI 844751A0
- Authority
- FI
- Finland
- Prior art keywords
- amidfoereningar
- substituerade
- diamino
- cyclohexyl
- trans
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/82—Carbazoles; Hydrogenated carbazoles
- C07D209/86—Carbazoles; Hydrogenated carbazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D333/60—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D333/64—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US55873183A | 1983-12-06 | 1983-12-06 | |
| US55873183 | 1983-12-06 | ||
| US06/669,922 US4656182A (en) | 1983-12-06 | 1984-11-13 | Substituted trans-1,2-diaminocyclohexyl amide compounds |
| US66992284 | 1984-11-13 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| FI844751A0 true FI844751A0 (fi) | 1984-12-03 |
| FI844751L FI844751L (fi) | 1985-06-07 |
| FI80031B FI80031B (fi) | 1989-12-29 |
| FI80031C FI80031C (fi) | 1990-04-10 |
Family
ID=27071828
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI844751A FI80031C (fi) | 1983-12-06 | 1984-12-03 | Foerfarande foer framstaellning av saosom laekemedel anvaendbara substituerade trans-1,2-diaminocyklohexylamidfoereningar. |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US4656182A (fi) |
| EP (1) | EP0147085B1 (fi) |
| KR (1) | KR880002532B1 (fi) |
| AU (1) | AU565236B2 (fi) |
| CA (1) | CA1234808A (fi) |
| DE (1) | DE3481614D1 (fi) |
| DK (1) | DK576184A (fi) |
| ES (1) | ES538243A0 (fi) |
| FI (1) | FI80031C (fi) |
| GR (1) | GR81174B (fi) |
| HU (1) | HU200162B (fi) |
| IE (1) | IE57673B1 (fi) |
| IL (1) | IL73632A (fi) |
| NO (1) | NO165838C (fi) |
| NZ (1) | NZ210440A (fi) |
| OA (1) | OA07885A (fi) |
| PH (1) | PH21740A (fi) |
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5010085A (en) * | 1986-09-10 | 1991-04-23 | E. I. Du Pont De Nemours And Company | Benzo-fused cycloalkane and oxa- and thia-cycloalkane trans-1,2-diamine derivatives |
| ZA876778B (en) * | 1986-09-10 | 1989-05-30 | Du Pont | Benzo-fused cycloalkane and oxa-and thia-,cycloalkane trans-1,2-diamine derivatives |
| US4876269A (en) * | 1986-09-10 | 1989-10-24 | E. I. Du Pont De Nemours And Company | Benoz-fused cycloalkane trans-1,2-diamine derivatives |
| FR2608598B1 (fr) * | 1986-12-23 | 1989-04-14 | Roussel Uclaf | Nouveaux derives de l'indane, leur procede de preparation et les nouveaux intermediaires ainsi obtenus, leur application comme medicaments et les compositions les renfermant |
| GB8803259D0 (en) * | 1988-02-12 | 1988-03-09 | Zambeletti Spa L | Compounds |
| US4855316A (en) * | 1988-02-18 | 1989-08-08 | Warner-Lambert Company | 1,2-diamino-4,5-dimethoxycyclohexyl amide analgesic compounds |
| FR2627491B1 (fr) * | 1988-02-18 | 1992-01-24 | Roussel Uclaf | Nouveaux derives du benzocyclohexane et du benzocycloheptane ainsi que leurs sels, leur procede de preparation et les nouveaux intermediaires ainsi obtenus, leur application comme medicaments et les compositions les renfermant |
| US5051428A (en) * | 1988-12-06 | 1991-09-24 | Warner-Lambert Company | 2-amino-4 or 5-methoxycyclohexyl amides useful as analgesics |
| US4906655A (en) * | 1989-01-24 | 1990-03-06 | Warner-Lambert Company | Novel 1,2-cyclohexylaminoaryl amides useful as analgesic agents |
| EP0552386A1 (en) * | 1992-01-13 | 1993-07-28 | Warner-Lambert Company | 2-Amino-3 or 6-methoxycyclohexyl amide derivatives |
| AU668932B2 (en) * | 1992-03-26 | 1996-05-23 | University Of British Columbia, The | Method of blocking sodium channels or neuronal tissue |
| US5506257A (en) * | 1992-03-26 | 1996-04-09 | University Of British Columbia | Aminocyclohexylamides for antiarrhythmic and anaesthetic uses |
| ATE211135T1 (de) * | 1993-09-24 | 2002-01-15 | Univ British Columbia | Aminocyclohexylester und ihre anwendung |
| US6239154B1 (en) | 1996-03-08 | 2001-05-29 | Adolor Corporation | Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith |
| US6057323A (en) * | 1996-03-08 | 2000-05-02 | Adolor Corporation | Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith |
| US5688955A (en) * | 1996-03-08 | 1997-11-18 | Adolor Corporation | Kappa agonist compounds and pharmaceutical formulations thereof |
| US5646151A (en) * | 1996-03-08 | 1997-07-08 | Adolor Corporation | Kappa agonist compounds and pharmaceutical formulations thereof |
| US6750216B2 (en) | 1996-03-08 | 2004-06-15 | Adolor Corporation | Kappa agonist compounds and pharmaceutical formulations thereof |
| US5763445A (en) * | 1996-03-08 | 1998-06-09 | Adolor Corporation | Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith |
| US6303611B1 (en) | 1996-03-08 | 2001-10-16 | Adolor Corporation | Kappa agonist compounds and pharmaceutical formulations thereof |
| USRE38133E1 (en) * | 1996-03-08 | 2003-06-03 | Adolor Corporation | Kappa agonist compounds and pharmaceutical formulations thereof |
| US5968968A (en) * | 1996-07-24 | 1999-10-19 | Warner-Lambert Company | Diphenyl-cyclopropenes as selective K-agonists |
| AU6878298A (en) * | 1997-04-30 | 1998-11-24 | Warner-Lambert Company | Peripherally selective kappa opioid agonists |
| KR100631299B1 (ko) * | 1998-04-01 | 2006-10-09 | 카디오메 파마 코포레이션 | 아미노사이클로헥실 에테르 화합물 및 이를 포함하는 약제학적 조성물 |
| WO2000051981A1 (en) * | 1999-03-04 | 2000-09-08 | Nortran Pharmaceuticals Inc. | Aminocycloalkyl cinnamide compounds for arrhythmia and as analgesics and anesthetics |
| US7507545B2 (en) | 1999-03-31 | 2009-03-24 | Cardiome Pharma Corp. | Ion channel modulating activity method |
| AU2002211828A1 (en) * | 2000-10-02 | 2002-04-15 | Merck & Co., Inc. | Inhibitors of prenyl-protein transferase |
| US7057053B2 (en) * | 2000-10-06 | 2006-06-06 | Cardiome Pharma Corp. | Ion channel modulating compounds and uses thereof |
| US7524879B2 (en) * | 2000-10-06 | 2009-04-28 | Cardiome Pharma Corp. | Ion channel modulating compounds and uses thereof |
| DE10252650A1 (de) * | 2002-11-11 | 2004-05-27 | Grünenthal GmbH | Cyclohexyl-Harnstoff-Derivate |
| JP4919661B2 (ja) * | 2003-05-02 | 2012-04-18 | カーディオム ファーマ コーポレイション | アミノシクロヘキシルエーテル化合物およびそれらの用途 |
| US7345086B2 (en) * | 2003-05-02 | 2008-03-18 | Cardiome Pharma Corp. | Uses of ion channel modulating compounds |
| US20090041841A1 (en) * | 2003-05-02 | 2009-02-12 | Cardiome Pharma Corp. | Controlled release tablet formulations for the prevention of arrhythmias |
| WO2005018635A2 (en) * | 2003-08-07 | 2005-03-03 | Cardiome Pharma Corp. | Ion channel modulating activity i |
| US7378409B2 (en) * | 2003-08-21 | 2008-05-27 | Bristol-Myers Squibb Company | Substituted cycloalkylamine derivatives as modulators of chemokine receptor activity |
| US7345087B2 (en) * | 2003-10-31 | 2008-03-18 | Cardiome Pharma Corp. | Aminocyclohexyl ether compounds and uses thereof |
| US7977373B2 (en) | 2004-04-01 | 2011-07-12 | Cardiome Pharma Corp. | Prodrugs of ion channel modulating compounds and uses thereof |
| WO2005097087A2 (en) * | 2004-04-01 | 2005-10-20 | Cardiome Pharma Corp. | Merged ion channel modulating compounds and uses thereof |
| DE102004023506A1 (de) * | 2004-05-10 | 2005-12-01 | Grünenthal GmbH | Kettenverlängerte substituierte Cyclohexyl-1,4-diamin-Derivate |
| EP1868598B1 (en) * | 2004-11-08 | 2014-04-23 | Cardiome Pharma Corp. | A new dosing regimen for ion channel modulating compounds for treating acute atrial fibrillation in a human |
| KR20110022635A (ko) | 2008-06-02 | 2011-03-07 | 시플라 리미티드 | 레보세티리진의 합성방법 및 이에 사용하기 위한 중간체 |
| KR101157936B1 (ko) * | 2009-11-30 | 2012-06-22 | 정종헌 | 마그네틱 교반기의 믹서구조 |
| EP2588081A4 (en) | 2010-06-29 | 2014-12-10 | Verastem Inc | ORAL FORMULATION OF CHINESE INHIBITORS |
| MX343894B (es) | 2010-06-30 | 2016-11-28 | Poniard Pharmaceuticals Inc * | Síntesis y uso de inhibidores de cinasa. |
| CN102731316B (zh) * | 2012-05-21 | 2014-04-16 | 南通市华峰化工有限责任公司 | 一种1，2-n，n`二甲基环己二胺的生产方法 |
| CN111410647B (zh) * | 2019-01-04 | 2021-08-17 | 中国人民解放军军事科学院军事医学研究院 | μ阿片受体偏向性激动剂及其医药用途 |
| AU2020215510A1 (en) | 2019-01-28 | 2021-07-22 | Mitochondria Emotion, Inc. | Trans-4-hydroxycyclohexyl phenyl amide mitofusin activators and methods of use thereof |
| WO2020159576A1 (en) | 2019-01-28 | 2020-08-06 | Mitochondria Emotion, Inc. | Mitofusin activators and methods of use thereof |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4145435A (en) * | 1976-11-12 | 1979-03-20 | The Upjohn Company | 2-aminocycloaliphatic amide compounds |
| US4359476A (en) * | 1981-04-09 | 1982-11-16 | The Upjohn Company | Adjacently substituted cycloalkane-amide analgesics |
| GB2096607B (en) * | 1981-04-09 | 1985-02-27 | Upjohn Co | Aminocycloalkyl amides |
-
1984
- 1984-11-13 US US06/669,922 patent/US4656182A/en not_active Expired - Fee Related
- 1984-11-23 CA CA000468526A patent/CA1234808A/en not_active Expired
- 1984-11-26 IL IL73632A patent/IL73632A/xx unknown
- 1984-11-27 IE IE3037/84A patent/IE57673B1/en not_active IP Right Cessation
- 1984-11-30 AU AU36080/84A patent/AU565236B2/en not_active Ceased
- 1984-12-03 EP EP84308360A patent/EP0147085B1/en not_active Expired - Lifetime
- 1984-12-03 FI FI844751A patent/FI80031C/fi not_active IP Right Cessation
- 1984-12-03 DE DE8484308360T patent/DE3481614D1/de not_active Expired - Fee Related
- 1984-12-04 GR GR81174A patent/GR81174B/el unknown
- 1984-12-04 ES ES538243A patent/ES538243A0/es active Granted
- 1984-12-04 DK DK576184A patent/DK576184A/da not_active Application Discontinuation
- 1984-12-05 NO NO844853A patent/NO165838C/no unknown
- 1984-12-05 HU HU844524A patent/HU200162B/hu not_active IP Right Cessation
- 1984-12-05 NZ NZ210440A patent/NZ210440A/xx unknown
- 1984-12-05 PH PH31534A patent/PH21740A/en unknown
- 1984-12-06 OA OA58462A patent/OA07885A/xx unknown
- 1984-12-06 KR KR1019840007723A patent/KR880002532B1/ko not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| IE57673B1 (en) | 1993-02-24 |
| EP0147085A3 (en) | 1987-02-04 |
| IL73632A0 (en) | 1985-02-28 |
| PH21740A (en) | 1988-02-10 |
| ES8602599A1 (es) | 1985-12-01 |
| AU3608084A (en) | 1985-06-13 |
| DE3481614D1 (de) | 1990-04-19 |
| EP0147085A2 (en) | 1985-07-03 |
| AU565236B2 (en) | 1987-09-10 |
| FI80031C (fi) | 1990-04-10 |
| ES538243A0 (es) | 1985-12-01 |
| US4656182A (en) | 1987-04-07 |
| CA1234808A (en) | 1988-04-05 |
| FI80031B (fi) | 1989-12-29 |
| NO165838B (no) | 1991-01-07 |
| DK576184D0 (da) | 1984-12-04 |
| EP0147085B1 (en) | 1990-03-14 |
| FI844751L (fi) | 1985-06-07 |
| NZ210440A (en) | 1989-01-06 |
| KR880002532B1 (ko) | 1988-11-28 |
| IE843037L (en) | 1985-06-06 |
| HU200162B (en) | 1990-04-28 |
| HUT36777A (en) | 1985-10-28 |
| NO844853L (no) | 1985-06-07 |
| DK576184A (da) | 1985-06-07 |
| KR850004757A (ko) | 1985-07-27 |
| NO165838C (no) | 1991-04-17 |
| OA07885A (en) | 1986-11-20 |
| IL73632A (en) | 1988-01-31 |
| GR81174B (en) | 1985-04-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM | Patent lapsed | ||
| MM | Patent lapsed |
Owner name: WARNER-LAMBERT COMPANY |