DE3481614D1 - Substituierte trans-1,2-diaminocyclohexylamid-verbindungen. - Google Patents

Substituierte trans-1,2-diaminocyclohexylamid-verbindungen.

Info

Publication number
DE3481614D1
DE3481614D1 DE8484308360T DE3481614T DE3481614D1 DE 3481614 D1 DE3481614 D1 DE 3481614D1 DE 8484308360 T DE8484308360 T DE 8484308360T DE 3481614 T DE3481614 T DE 3481614T DE 3481614 D1 DE3481614 D1 DE 3481614D1
Authority
DE
Germany
Prior art keywords
diaminocyclohexylamide
compounds
substituted trans
trans
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8484308360T
Other languages
English (en)
Inventor
David Christopher Horwell
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Warner Lambert Co LLC
Original Assignee
Warner Lambert Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co LLC filed Critical Warner Lambert Co LLC
Application granted granted Critical
Publication of DE3481614D1 publication Critical patent/DE3481614D1/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/86—Carbazoles; Hydrogenated carbazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/60—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/64—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE8484308360T 1983-12-06 1984-12-03 Substituierte trans-1,2-diaminocyclohexylamid-verbindungen. Expired - Fee Related DE3481614D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US55873183A 1983-12-06 1983-12-06
US06/669,922 US4656182A (en) 1983-12-06 1984-11-13 Substituted trans-1,2-diaminocyclohexyl amide compounds

Publications (1)

Publication Number Publication Date
DE3481614D1 true DE3481614D1 (de) 1990-04-19

Family

ID=27071828

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8484308360T Expired - Fee Related DE3481614D1 (de) 1983-12-06 1984-12-03 Substituierte trans-1,2-diaminocyclohexylamid-verbindungen.

Country Status (17)

Country Link
US (1) US4656182A (de)
EP (1) EP0147085B1 (de)
KR (1) KR880002532B1 (de)
AU (1) AU565236B2 (de)
CA (1) CA1234808A (de)
DE (1) DE3481614D1 (de)
DK (1) DK576184A (de)
ES (1) ES538243A0 (de)
FI (1) FI80031C (de)
GR (1) GR81174B (de)
HU (1) HU200162B (de)
IE (1) IE57673B1 (de)
IL (1) IL73632A (de)
NO (1) NO165838C (de)
NZ (1) NZ210440A (de)
OA (1) OA07885A (de)
PH (1) PH21740A (de)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5010085A (en) * 1986-09-10 1991-04-23 E. I. Du Pont De Nemours And Company Benzo-fused cycloalkane and oxa- and thia-cycloalkane trans-1,2-diamine derivatives
ZA876778B (en) * 1986-09-10 1989-05-30 Du Pont Benzo-fused cycloalkane and oxa-and thia-,cycloalkane trans-1,2-diamine derivatives
US4876269A (en) * 1986-09-10 1989-10-24 E. I. Du Pont De Nemours And Company Benoz-fused cycloalkane trans-1,2-diamine derivatives
FR2608598B1 (fr) * 1986-12-23 1989-04-14 Roussel Uclaf Nouveaux derives de l'indane, leur procede de preparation et les nouveaux intermediaires ainsi obtenus, leur application comme medicaments et les compositions les renfermant
GB8803259D0 (en) * 1988-02-12 1988-03-09 Zambeletti Spa L Compounds
US4855316A (en) * 1988-02-18 1989-08-08 Warner-Lambert Company 1,2-diamino-4,5-dimethoxycyclohexyl amide analgesic compounds
FR2627491B1 (fr) * 1988-02-18 1992-01-24 Roussel Uclaf Nouveaux derives du benzocyclohexane et du benzocycloheptane ainsi que leurs sels, leur procede de preparation et les nouveaux intermediaires ainsi obtenus, leur application comme medicaments et les compositions les renfermant
US5051428A (en) * 1988-12-06 1991-09-24 Warner-Lambert Company 2-amino-4 or 5-methoxycyclohexyl amides useful as analgesics
US4906655A (en) * 1989-01-24 1990-03-06 Warner-Lambert Company Novel 1,2-cyclohexylaminoaryl amides useful as analgesic agents
EP0552386A1 (de) * 1992-01-13 1993-07-28 Warner-Lambert Company 2-Amino-3 oder 6-Methoxycyclohexylamidderivate
AU668932B2 (en) * 1992-03-26 1996-05-23 University Of British Columbia, The Method of blocking sodium channels or neuronal tissue
US5506257A (en) * 1992-03-26 1996-04-09 University Of British Columbia Aminocyclohexylamides for antiarrhythmic and anaesthetic uses
ATE211135T1 (de) * 1993-09-24 2002-01-15 Univ British Columbia Aminocyclohexylester und ihre anwendung
US6239154B1 (en) 1996-03-08 2001-05-29 Adolor Corporation Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith
US6057323A (en) * 1996-03-08 2000-05-02 Adolor Corporation Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith
US5688955A (en) * 1996-03-08 1997-11-18 Adolor Corporation Kappa agonist compounds and pharmaceutical formulations thereof
US5646151A (en) * 1996-03-08 1997-07-08 Adolor Corporation Kappa agonist compounds and pharmaceutical formulations thereof
US6750216B2 (en) 1996-03-08 2004-06-15 Adolor Corporation Kappa agonist compounds and pharmaceutical formulations thereof
US5763445A (en) * 1996-03-08 1998-06-09 Adolor Corporation Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith
US6303611B1 (en) 1996-03-08 2001-10-16 Adolor Corporation Kappa agonist compounds and pharmaceutical formulations thereof
USRE38133E1 (en) * 1996-03-08 2003-06-03 Adolor Corporation Kappa agonist compounds and pharmaceutical formulations thereof
US5968968A (en) * 1996-07-24 1999-10-19 Warner-Lambert Company Diphenyl-cyclopropenes as selective K-agonists
AU6878298A (en) * 1997-04-30 1998-11-24 Warner-Lambert Company Peripherally selective kappa opioid agonists
KR100631299B1 (ko) * 1998-04-01 2006-10-09 카디오메 파마 코포레이션 아미노사이클로헥실 에테르 화합물 및 이를 포함하는 약제학적 조성물
WO2000051981A1 (en) * 1999-03-04 2000-09-08 Nortran Pharmaceuticals Inc. Aminocycloalkyl cinnamide compounds for arrhythmia and as analgesics and anesthetics
US7507545B2 (en) 1999-03-31 2009-03-24 Cardiome Pharma Corp. Ion channel modulating activity method
AU2002211828A1 (en) * 2000-10-02 2002-04-15 Merck & Co., Inc. Inhibitors of prenyl-protein transferase
US7057053B2 (en) * 2000-10-06 2006-06-06 Cardiome Pharma Corp. Ion channel modulating compounds and uses thereof
US7524879B2 (en) * 2000-10-06 2009-04-28 Cardiome Pharma Corp. Ion channel modulating compounds and uses thereof
DE10252650A1 (de) * 2002-11-11 2004-05-27 Grünenthal GmbH Cyclohexyl-Harnstoff-Derivate
JP4919661B2 (ja) * 2003-05-02 2012-04-18 カーディオム ファーマ コーポレイション アミノシクロヘキシルエーテル化合物およびそれらの用途
US7345086B2 (en) * 2003-05-02 2008-03-18 Cardiome Pharma Corp. Uses of ion channel modulating compounds
US20090041841A1 (en) * 2003-05-02 2009-02-12 Cardiome Pharma Corp. Controlled release tablet formulations for the prevention of arrhythmias
WO2005018635A2 (en) * 2003-08-07 2005-03-03 Cardiome Pharma Corp. Ion channel modulating activity i
US7378409B2 (en) * 2003-08-21 2008-05-27 Bristol-Myers Squibb Company Substituted cycloalkylamine derivatives as modulators of chemokine receptor activity
US7345087B2 (en) * 2003-10-31 2008-03-18 Cardiome Pharma Corp. Aminocyclohexyl ether compounds and uses thereof
US7977373B2 (en) 2004-04-01 2011-07-12 Cardiome Pharma Corp. Prodrugs of ion channel modulating compounds and uses thereof
WO2005097087A2 (en) * 2004-04-01 2005-10-20 Cardiome Pharma Corp. Merged ion channel modulating compounds and uses thereof
DE102004023506A1 (de) * 2004-05-10 2005-12-01 Grünenthal GmbH Kettenverlängerte substituierte Cyclohexyl-1,4-diamin-Derivate
EP1868598B1 (de) * 2004-11-08 2014-04-23 Cardiome Pharma Corp. Neuer dosierungsplan für ionenkanalmodulierende verbindungen zur behandlung von akutem vorhofflimmern bei menschen
KR20110022635A (ko) 2008-06-02 2011-03-07 시플라 리미티드 레보세티리진의 합성방법 및 이에 사용하기 위한 중간체
KR101157936B1 (ko) * 2009-11-30 2012-06-22 정종헌 마그네틱 교반기의 믹서구조
EP2588081A4 (de) 2010-06-29 2014-12-10 Verastem Inc Orale formulierung aus kinasehemmern
MX343894B (es) 2010-06-30 2016-11-28 Poniard Pharmaceuticals Inc * Síntesis y uso de inhibidores de cinasa.
CN102731316B (zh) * 2012-05-21 2014-04-16 南通市华峰化工有限责任公司 一种1，2-n，n`二甲基环己二胺的生产方法
CN111410647B (zh) * 2019-01-04 2021-08-17 中国人民解放军军事科学院军事医学研究院 μ阿片受体偏向性激动剂及其医药用途
AU2020215510A1 (en) 2019-01-28 2021-07-22 Mitochondria Emotion, Inc. Trans-4-hydroxycyclohexyl phenyl amide mitofusin activators and methods of use thereof
WO2020159576A1 (en) 2019-01-28 2020-08-06 Mitochondria Emotion, Inc. Mitofusin activators and methods of use thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4145435A (en) * 1976-11-12 1979-03-20 The Upjohn Company 2-aminocycloaliphatic amide compounds
US4359476A (en) * 1981-04-09 1982-11-16 The Upjohn Company Adjacently substituted cycloalkane-amide analgesics
GB2096607B (en) * 1981-04-09 1985-02-27 Upjohn Co Aminocycloalkyl amides

Also Published As

Publication number Publication date
IE57673B1 (en) 1993-02-24
EP0147085A3 (en) 1987-02-04
IL73632A0 (en) 1985-02-28
PH21740A (en) 1988-02-10
ES8602599A1 (es) 1985-12-01
AU3608084A (en) 1985-06-13
EP0147085A2 (de) 1985-07-03
FI844751A0 (fi) 1984-12-03
AU565236B2 (en) 1987-09-10
FI80031C (fi) 1990-04-10
ES538243A0 (es) 1985-12-01
US4656182A (en) 1987-04-07
CA1234808A (en) 1988-04-05
FI80031B (fi) 1989-12-29
NO165838B (no) 1991-01-07
DK576184D0 (da) 1984-12-04
EP0147085B1 (de) 1990-03-14
FI844751L (fi) 1985-06-07
NZ210440A (en) 1989-01-06
KR880002532B1 (ko) 1988-11-28
IE843037L (en) 1985-06-06
HU200162B (en) 1990-04-28
HUT36777A (en) 1985-10-28
NO844853L (no) 1985-06-07
DK576184A (da) 1985-06-07
KR850004757A (ko) 1985-07-27
NO165838C (no) 1991-04-17
OA07885A (en) 1986-11-20
IL73632A (en) 1988-01-31
GR81174B (en) 1985-04-05

Similar Documents

Publication Publication Date Title
DE3481614D1 (de) Substituierte trans-1,2-diaminocyclohexylamid-verbindungen.
FI844752A0 (fi) Substituerade trans -1,2-diaminocyklohexyl-amidfoereningar.
FI842400A0 (fi) Naproxen- ochnaproxen-natriumtablet- naproxen-natriumtabletter, vilka frigoers kontrollerat.
FI840821A (fi) Mjuk, fuktresistant pappersprodukt.
FI844472A0 (fi) Nmr-foerestaellningssystem, i vilket anvaends faeltkompensation.
FI852360A0 (fi) Torkningscylinder foer bandmaterialmaskin, isynnerhet pappersmaskin.
FI842803A0 (fi) Vridningselastisk, vibrationsdaempande axelkoppling.
FI852099A0 (fi) Vaermedyna, speciellt foer fordonssaeten.
FI834836A (fi) Sportsko, saerskilt skidsko.
DK486284D0 (da) Cinnamyl-1-2,3-dihydrobenzofuranforbindelser
FI842986A (fi) Flytande, desinficerande stortvaettmedel.
ATE26702T1 (de) N,n-di-n-propyl-4-hydroxy-3methansulfonamidophenylethylamin.
FI834712A (fi) Vridfoerslutning foer smaelta raomaterial, speciellt metallsmaeltor.
FI840600A (fi) Aktiveringsledning foer supraledande anordningar, speciellt magneter.
FI834645A (fi) Vridstoet-, vrid- eller stoetmaskin.
FI843965A0 (fi) Vaetskekyld kaernreaktor, speciellt kokvattenreaktor.
FI845029A0 (fi) Informationstavla, saerskilt foer vaegtrafikanter.
FI852394A0 (fi) Nypdon, speciellt klaednypa.
FI844328A0 (fi) Laos-nyckel-system, speciellt foer laosningsanordningar.
FI844393L (fi) Dammfria kinoxalin-1,4-di-n-oxider.
ATE50993T1 (de) Substituierte trans-1,2-diaminocyclohexylamidverbindungen.
FI841307A0 (fi) Haolstamp, speciellt foer pappers- eller kartongvaror.
FI843461A0 (fi) Stegkonstruktion, foeretraedesvis foer baotar.
ATE32335T1 (de) Substituierte trans-1,2-diaminocyclohexylamidderivate.
FI842053A (fi) Foerfarande foer aostadkommande av en armerad murverksbalk, jaemte anordning foer genomfoerande av foerfarandet.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee